Does varicocelectomy affect DNA fragmentation in infertile patients?

Indian Journal of Urology

Volumn 31, Issue 2, 2015, Pages 116-119

  Telli, Onur ^a   Sarici, Hasmet ^b   Kabar, Mucahit ^b   Ozgur, Berat Cem ^b   Resorlu, Berkan ^b   Bozkurt, Selen ^c  

^a ANKARA UNIVERSITY   (Turkey)

^b ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^c AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Acridine orange test; DNA damage; male infertility; varicocele

Indexed keywords

ACRIDINE ORANGE;

ARTICLE; DNA FRAGMENTATION; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; OLIGOSPERMIA; POSTOPERATIVE PERIOD; PREGNANCY OUTCOME; PREOPERATIVE PERIOD; SEMEN ANALYSIS; SPERM; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; VARICOCELE; VARICOCELECTOMY;

EID: 84926626835     PISSN: 09701591     EISSN: 19983824     Source Type: Journal    
DOI: 10.4103/0970-1591.152811     Document Type: Article

References (23)

1. Chan P. Management options of varicoceles. Indian J Urol 2011; 27: 65-73.
2. Eisenberg ML, Lipshultz LI. Varicocele-induced infertility: Newer insights into its pathophysiology. Indian J Urol 2011; 27: 58-64.
3. Sheehan MM, Ramasamy R, Lamb DJ. Molecular mechanisms involved in varicocele-associated infertility. J Assist Reprod Genet 2014; 31: 521-6.
4. Agarwal A, Sekhon LH. Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified?. Indian J Urol 2011; 27: 74-85.
5. O'Brien J, Zini A. Sperm DNA integrity and male infertility: A review. Urology 2005; 65: 16-22.
6. Fisher MA, Willis J, Zini A. Human sperm DNA integrity: Correlation with sperm cytoplasmic droplets. Urology 2003; 61: 207-11.
7. Saleh RA, Agarwal A, Sharma RK, Said TM, Sikka SC, Thomas AJ Jr. Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertil Steril 2003; 80: 1431-6.
8. Blumer CG, Fariello RM, Restelli AE, Spaine DM, Bertolla RP, Cedenho AP. Sperm nuclear DNA fragmentation and mitochondrial activity in men with varicocele. Fertil Steril 2008; 90: 1716-22.
9. Agarwal A, Deepinder F, Cocuzza M, Agarwal R, Short RA, Sabanegh E, et al. Efficacy of varicocelectomy in improving semen parameters: New meta-analytical approach. Urology 2007; 70: 532-8.
10. Marmar JL, Agarwal A, Prabakaran S, Agarwal R, Short RA, Benoff S, et al. Re-assessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis. Fertil Steril 2007; 88: 639-48.
11. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16: 231-45.
12. Shiraishi K, Matsuyama H, Takihara H. Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. Int J Urol 2012; 19: 538-50.
13. Robinson L, Gallos ID, Conner SJ, Rajkhowa M, Miller D, Lewis S, et al. The effect of sperm DNA fragmentation on miscarriage rates: A systematic review and meta-analysis. Hum Reprod 2012; 27: 2908-17.
14. Khalili MA, Aghaie-Maybodi F, Anvari M, Talebi AR. Sperm nuclear DNA in ejaculates of fertile and infertile men: Correlation with semen parameters. Urol J 2006; 3: 154-9.
15. Evers JL, Collins JA Assessment of efficacy of varicocele repair for male subfertility: A systematic review. Lancet 2003; 361: 1849-52.
16. Kroese AC, de Lange NM, Collins JA, Evers JL. Varicocele surgery, new evidence. Hum Reprod Update 2013; 19: 317.
17. Spanò M, Bonde JP, Hjøllund HI, Kolstad HA, Cordelli E, Leter G. Sperm chromatin damage impairs human fertility. The Danish first pregnancy planner study team. Fertil Steril 2000; 73: 43-50.
18. Hoshi K, Katayose H, Yanagida K, Kimura Y, Sato A. The relationship between acridine orange fluorescence of sperm nuclei and the fertilizing ability of human sperm. Fertil Steril 1996; 66: 634-9.
19. Erenpreiss J, Jepson K, Giwercman A, Tsarev I, Erenpreisa J, Spano M. Toluidine blue cytometry test for sperm DNA conformation: Comparison with the flow cytometric sperm chromatin structure and TUNEL assays. Hum Reprod 2004; 19: 2277-82.
20. Gonzalez-Marin C, Gosálvez J, Roy R. Types, causes, detection and repair of DNA fragmentation in animal and human sperm cells. Int J Mol Sci 2012; 13: 14026-52.
21. Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: An update Am J Reprod Immunol 2008; 59: 2-11.
22. Abbasi M, Alizadeh R, Abolhassani F, Amidi F, Ragerdi KI, Fazelipour S, et al. Effect of aminoguanidine in sperm DNA fragmentation in varicocelized rats: Role of nitric oxide. Reprod Sci 2011; 18: 545-50.
23. Smit M, Romijn JC, Wildhagen MF, Veldhoven JL, Weber RF, Dohle GR. Decreased sperm DNA fragmentation after surgical varicocelectomy is associated with increased pregnancy rate. J Urol 2013; 189: 146-50.