Determination of N-methylcytisine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 990, Issue , 2015, Pages 118-124

  Wang, Shuanghu ^a   Wu, Haiya ^a   Huang, Xueli ^a   Geng, Peiwu ^a   Wen, Congcong ^a   Ma, Jianshe ^a   Zhou, Yunfang ^a   Wang, Xianqin ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

N methylcytisine; Pharmacokinetics; Rat plasma; UPLC MS MS

Indexed keywords

ACETONITRILE; BIOCHEMISTRY; BODY FLUIDS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; POSITIVE IONS;

CHROMATOGRAPHIC SEPARATIONS; INTERNAL STANDARDS; INTRAVENOUS ADMINISTRATION; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC STUDIES; PROTEIN PRECIPITATION; RAT PLASMA; UPLC-MS/MS;

RATS;

ACETONITRILE; AMMONIA; CYTISINE; FORMIC ACID; HORDENINE; N METHYLCYTISINE; UNCLASSIFIED DRUG; ALKALOID; N-METHYLCYTISINE; QUINOLIZINE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG HALF LIFE; ELECTROSPRAY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VOLUME OF DISTRIBUTION; ANIMAL; BLOOD; CHEMISTRY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; PROCEDURES; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

RATTUS;

ALKALOIDS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; LIMIT OF DETECTION; LINEAR MODELS; MALE; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84926619787     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.03.025     Document Type: Article

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