Notch1 Is pan-endothelial at the onset of flow and regulated by flow

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Jahnsen, Espen D ^a,b   Trindade, Alexandre ^c,d   Zaun, Hans C ^a   Lehoux, Stéphanie ^a   Duarte, António ^c,d   Jones, Elizabeth A V ^a,b,e  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF LISBON   (Portugal)

^d INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN RECEPTOR B4; JAGGED1; KRUPPEL LIKE FACTOR 2; MEMBRANE PROTEIN; NOTCH1 RECEPTOR; PROTEIN COUPTFII; PROTEIN DLL1; PROTEIN DLL4; PROTEIN HEY1; PROTEIN NRP1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; HEY1 PROTEIN, MOUSE; NOTCH RECEPTOR; NOTCH1 PROTEIN, MOUSE; NOTCH4 PROTEIN, MOUSE; ONCOPROTEIN;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE SILENCING; HEMODYNAMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHEAR STRESS; SOMITE; TISSUE BLOOD FLOW; TISSUE DIFFERENTIATION; TISSUE SPECIFICITY; UPREGULATION; VASCULAR REMODELING; ANIMAL; BIOMECHANICS; CELL CULTURE; CYTOLOGY; GENE EXPRESSION; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; BIOMECHANICAL PHENOMENA; CELL CYCLE PROTEINS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MICE; PROTO-ONCOGENE PROTEINS; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; REGIONAL BLOOD FLOW; VASCULAR REMODELING;

EID: 84926500454     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122622     Document Type: Article

References (44)

1. Gerety SS, Wang HU, Chen ZF, Anderson DJ. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell. 1999; 4 (3):403-14. PMID: 10518221
2. Wang HU, Chen ZF, Anderson DJ. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998; 93(5):741-53. PMID: 9630219
3. Udan RS, Vadakkan TJ, Dickinson ME. Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac. Development. 2013; 140(19):4041-50. doi: 10. 1242/dev.096255 PMID: 24004946
4. Lucitti JL, Jones EA, Huang C, Chen J, Fraser SE, Dickinson ME. Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development. 2007; 134(18):3317-26. PMID: 17720695
5. le Noble F, Moyon D, Pardanaud L, Yuan L, Djonov V, Matthijsen R, et al. Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development. 2004; 131(2):361-75. PMID: 14681188
6. Moyon D, Pardanaud L, Yuan L, Breant C, Eichmann A. Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo. Development. 2001; 128(17):3359-70. PMID: 11546752
7. Conlon RA, Reaume AG, Rossant J. Notch1 is required for the coordinate segmentation of somites. Development. 1995; 121(5):1533-45. PMID: 7789282
8. Reaume AG, Conlon RA, Zirngibl R, Yamaguchi TP, Rossant J. Expression analysis of a Notch homologue in the mouse embryo. Dev Biol biology. 1992; 154(2):377-87. PMID: 1426644
9. Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol. 2003; 194(3):237-55. PMID: 12548545
10. Louvi A, Artavanis-Tsakonas S. Notch signalling in vertebrate neural development. Nat Rev Neurosci. 2006; 7(2):93-102. PMID: 16429119
11. Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet. 1997; 16(3):243-51. PMID: 9207788
12. Oda T, Elkahloun AG, Pike BL, Okajima K, Krantz ID, Genin A, et al. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet. 1997; 16(3):235-42. PMID: 9207787
13. Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature. 1996; 383(6602):707-10. PMID: 8878478
14. Eldadah ZA, Hamosh A, Biery NJ, Montgomery RA, Duke M, Elkins R, et al. Familial Tetralogy of Fallot caused by mutation in the jagged1 gene. Hum Mol Genet. 2001; 10(2):163-9. PMID: 11152664
15. Lawson ND, Scheer N, Pham VN, Kim CH, Chitnis AB, Campos-Ortega JA, et al. Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development. 2001; 128(19):3675-83. PMID: 11585794
16. Lawson ND, Vogel AM, Weinstein BM. sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell. 2002; 3(1):127-36. PMID: 12110173
17. Chong DC, Koo Y, Xu K, Fu S, Cleaver O. Stepwise arteriovenous fate acquisition during mammalian vasculogenesis. Dev Dyn. 2011; 240(9):2153-65. doi: 10.1002/dvdy.22706 PMID: 21793101
18. Jones EA, Yuan L, Breant C, Watts RJ, Eichmann A. Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos. Development. 2008; 135(14):2479-88. doi: 10.1242/dev.014902 PMID: 18550715
19. Henrique D, Hirsinger E, Adam J, Le Roux I, Pourquie O, Ish-Horowicz D, et al. Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina. Curr Biol: CB. 1997; 7 (9):661-70. PMID: 9285721
20. Uyttendaele H, Marazzi G, Wu G, Yan Q, Sassoon D, Kitajewski J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development. 1996; 122(7):2251-9. PMID: 8681805
21. Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, et al. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A. 2000; 97(25):13655-60. PMID: 11095750
22. McGrath KE, Koniski AD, Malik J, Palis J. Circulation is established in a stepwise pattern in the mammalian embryo. Blood. 2003; 101(5):1669-76. PMID: 12406884
23. Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev. 2001; 108(1-2):161-4. PMID: 11578878
24. Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004; 18(8):901-11. PMID: 15107403
25. Chouinard-Pelletier G, Jahnsen ED, Jones EA. Increased shear stress inhibits angiogenesis in veins and not arteries during vascular development. Angiogenesis. 2013; 16(1):71-83. doi: 10.1007/s10456-012-9300-2 PMID: 22941228
26. Nishii K, Shibata Y. Mode and determination of the initial contraction stage in the mouse embryo heart. Anat Embryol. 2006; 211(2):95-100. PMID: 16320070
27. Jones EA, Baron MH, Fraser SE, Dickinson ME. Measuring hemodynamic changes during mammalian development. Am J Physiol Heart Circ Physiol. 2004; 287(4):H1561-9. PMID: 15155254
28. Masumura T, Yamamoto K, Shimizu N, Obi S, Ando J. Shear stress increases expression of the arterial endothelial marker ephrinB2 in murine ES cells via the VEGF-Notch signaling pathways. Arterioscler Thromb Vasc Biol. 2009; 29(12):2125-31. doi: 10.1161/ATVBAHA.109.193185 PMID: 19797707
29. Watson O, Novodvorsky P, Gray C, Rothman AM, Lawrie A, Crossman DC, et al. Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling. Cardiovasc Res. 2013; 100(2):252-61. doi: 10.1093/cvr/cvt170 PMID: 23812297
30. Caolo V, van den Akker NM, Verbruggen S, Donners MM, Swennen G, Schulten H, et al. Feed-forward signaling by membrane-bound ligand receptor circuit: the case of NOTCH DELTA-like 4 ligand in endothelial cells. J Biol Chem. 2010; 285(52):40681-9. doi: 10.1074/jbc.M110.176065 PMID: 20959466
31. Foldi J, Chung AY, Xu H, Zhu J, Outtz HH, Kitajewski J, et al. Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. J Immunol. 2010; 185 (9):5023-31. doi: 10.4049/jimmunol.1001544 PMID: 20870935
32. Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007; 445(7129):776-80. PMID: 17259973
33. Sainson RC, Aoto J, Nakatsu MN, Holderfield M, Conn E, Koller E, et al. Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB J. 2005; 19(8):1027-9. PMID: 15774577
34. Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM, et al. Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol. 2010; 12(10):943-53. doi: 10.1038/ncb2103 PMID: 20871601
35. Suchting S, Freitas C, le Noble F, Benedito R, Breant C, Duarte A, et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A. 2007; 104(9):3225-30. PMID: 17296941
36. Rowlinson JM, Gering M. Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos. Blood. 2010; 116(12):2046-56. doi: 10.1182/blood-2009-11-252635 PMID: 20511544
37. Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, et al. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem. 2013; 288(35):25477-89. doi: 10.1074/jbc.M113.454850 PMID: 23839946
38. Trindade A, Kumar SR, Scehnet JS, Lopes-da-Costa L, Becker J, Jiang W, et al. Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood. 2008; 112(5):1720-9. doi: 10.1182/blood-2007-09-112748 PMID: 18559979
39. Thurston G, Yancopoulos GD. Gridlock in the blood. Nature. 2001; 414(6860):163-4. PMID: 11700541
40. You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ, Tsai SY. Suppression of Notch signalling by the COUPTFII transcription factor regulates vein identity. Nature. 2005; 435(7038):98-104. PMID: 15875024
41. Buschmann I, Pries A, Styp-Rekowska B, Hillmeister P, Loufrani L, Henrion D, et al. Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis. Development. 2010; 137(13):2187-96. doi: 10.1242/dev.045351 PMID: 20530546
42. dela Paz NG, Walshe TE, Leach LL, Saint-Geniez M, D'Amore PA. Role of shear-stress-induced VEGF expression in endothelial cell survival. J Cell Sci. 2012; 125(Pt 4):831-43. doi: 10.1242/jcs.084301 PMID: 22399811
43. Obi S, Yamamoto K, Shimizu N, Kumagaya S, Masumura T, Sokabe T, et al. Fluid shear stress induces arterial differentiation of endothelial progenitor cells. J Appl Physiol. 2009; 106(1):203-11. doi: 10.1152/ japplphysiol.00197.2008 PMID: 18988767
44. Shay-Salit A, Shushy M, Wolfovitz E, Yahav H, Breviario F, Dejana E, et al. VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proc Natl Acad Sci U S A. 2002; 99(14):9462-7. PMID: 12080144