Methylmercury impairs canonical dopamine metabolism in rat undifferentiated pheochromocytoma (pc12) cells by indirect inhibition of aldehyde dehydrogenase

Toxicological Sciences

Volumn 144, Issue 2, 2015, Pages 347-356

  Tiernan, Chelsea T ^a   Edwin, Ethan A ^b   Hawong, Hae Young ^a,c   Ríos Cabanillas, Mónica ^b   Goudreau, John L ^a,b,d   Atchison, William D ^a,b   Lookingland, Keith J ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c Michigan State University   (United States)

^d East Lansing   (United States)

Author keywords

Aldehyde dehydrogenase; Dopamine metabolism; Methylmercury induced neurotoxicity; PC12 cell

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; ALDEHYDE DEHYDROGENASE; DOPAMINE; LEVODOPA; METHYLMERCURY; NICOTINAMIDE ADENINE DINUCLEOTIDE; DAIDZEIN; ISOFLAVONE DERIVATIVE; METHYLMERCURY DERIVATIVE; ROTENONE;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DOPAMINE METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; OXIDATION; PC12 CELL LINE; PHEOCHROMOCYTOMA CELL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MITOCHONDRION; PATHOLOGY; PHEOCHROMOCYTOMA; PHYSIOLOGY;

RATTUS;

ALDEHYDE DEHYDROGENASE; ANIMALS; DOPAMINE; ISOFLAVONES; METHYLMERCURY COMPOUNDS; MITOCHONDRIA; NAD; PC12 CELLS; PHEOCHROMOCYTOMA; RATS; ROTENONE;

EID: 84926474909     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv001     Document Type: Article

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