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Volumn 11, Issue 8, 2015, Pages 1259-1274

Personalized treatment of early-stage non-small-cell lung cancer: The challenging role of EGFR inhibitors

Author keywords

adjuvant therapy; EGF receptor inhibitors; EGFR mutations; non small cell lung cancer; NSCLC; personalized treatment

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; PROTEIN KINASE INHIBITOR;

EID: 84926472185     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.14.320     Document Type: Review
Times cited : (11)

References (75)
  • 1
    • 34548457234 scopus 로고    scopus 로고
    • The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours
    • Goldstraw P1, Crowley J, Chansky K et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J. Thorac. Oncol. 2(8), 706-714 (2007).
    • (2007) J. Thorac. Oncol. , vol.2 , Issue.8 , pp. 706-714
    • Goldstraw, P.1    Crowley, J.2    Chansky, K.3
  • 2
    • 77956637854 scopus 로고    scopus 로고
    • Stereotactic body radiation therapy (stereotactic ablative radiotherapy) for stage i non-small cell lung cancer - Updates of radiobiology, techniques, and clinical outcomes
    • Hadziahmetovic M1, Loo BW, Timmerman RD et al. Stereotactic body radiation therapy (stereotactic ablative radiotherapy) for stage I non-small cell lung cancer - updates of radiobiology, techniques, and clinical outcomes. Discov. Med. 9(48), 411-417 (2010).
    • (2010) Discov. Med. , vol.9 , Issue.48 , pp. 411-417
    • Hadziahmetovic, M.1    Loo, B.W.2    Timmerman, R.D.3
  • 3
    • 77949883028 scopus 로고    scopus 로고
    • Outcomes after stereotactic lung radiotherapy or wedge resection for stage i non-small-cell lung cancer
    • Grills IS1, Mangona VS, Welsh R et al. Outcomes after stereotactic lung radiotherapy or wedge resection for stage I non-small-cell lung cancer. J. Clin. Oncol. 28(6), 928-935 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.6 , pp. 928-935
    • Grills, I.S.1    Mangona, V.S.2    Welsh, R.3
  • 4
    • 84894429089 scopus 로고    scopus 로고
    • Early-stage non-small cell lung cancer: Surgery, stereotactic radiosurgery, and individualized adjuvant therapy
    • Padda SK, Burt BM, Trakul N, Wakelee HA. Early-stage non-small cell lung cancer: surgery, stereotactic radiosurgery, and individualized adjuvant therapy. Semin. Oncol. 41(1), 40-56 (2014).
    • (2014) Semin. Oncol. , vol.41 , Issue.1 , pp. 40-56
    • Padda, S.K.1    Burt, B.M.2    Trakul, N.3    Wakelee, H.A.4
  • 5
    • 0028811996 scopus 로고
    • Incidence of local recurrence and second primary tumors in resected stage i lung cancer
    • Martini N, Bains MS, Burt ME et al. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J. Thorac. Cardiovasc. Surg. 109(1), 120-129 (1995).
    • (1995) J. Thorac. Cardiovasc. Surg. , vol.109 , Issue.1 , pp. 120-129
    • Martini, N.1    Bains, M.S.2    Burt, M.E.3
  • 6
    • 0036125088 scopus 로고    scopus 로고
    • Stage i non-small cell lung carcinoma: Really an early stage?
    • Rena O, Oliaro A, Cavallo A et al. Stage I non-small cell lung carcinoma: really an early stage? Eur. J. Cardiothorac Surg. 21(3), 514-519 (2002).
    • (2002) Eur. J. Cardiothorac Surg. , vol.21 , Issue.3 , pp. 514-519
    • Rena, O.1    Oliaro, A.2    Cavallo, A.3
  • 7
    • 0346238665 scopus 로고    scopus 로고
    • Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
    • Arriagada R, Bergman B, Dunant A, Le Chevalier T, Pignon JP, Vansteenkiste J; International Adjuvant Lung Cancer Trial Collaborative Group. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N. Engl. J. Med. 350(4), 351-60 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , Issue.4 , pp. 351-360
    • Arriagada, R.1    Bergman, B.2    Dunant, A.3    Le Chevalier, T.4    Pignon, J.P.5    Vansteenkiste, J.6
  • 8
    • 20544455590 scopus 로고    scopus 로고
    • Vinorelbine plus cisplatin vs observation in resected non-small-cell lung cancer
    • Butts CA, Ding K, Seymour L et al. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N. Engl. J. Med. 352(25), 2589-2597 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , Issue.25 , pp. 2589-2597
    • Butts, C.A.1    Ding, K.2    Seymour, L.3
  • 9
    • 73949154000 scopus 로고    scopus 로고
    • Randomized Phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: Updated survival analysis of JBR-10
    • Butts CA, Ding K, Seymour L et al. Randomized Phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10. J. Clin. Oncol. 28(1), 29-34 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.1 , pp. 29-34
    • Butts, C.A.1    Ding, K.2    Seymour, L.3
  • 10
    • 33747847740 scopus 로고    scopus 로고
    • Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): A randomised controlled trial
    • Douillard JY, Rosell R, De Lena M et al. Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial. Lancet Oncol. 7(9), 719-727 (2006).
    • (2006) Lancet Oncol. , vol.7 , Issue.9 , pp. 719-727
    • Douillard, J.Y.1    Rosell, R.2    De Lena, M.3
  • 11
    • 49049109683 scopus 로고    scopus 로고
    • Lung adjuvant cisplatin evaluation: A pooled analysis by the LACE Collaborative Group
    • Pignon JP, Tribodet H, Scagliotti GV et al. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J. Clin. Oncol. 26(21), 3552-3559 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.21 , pp. 3552-3559
    • Pignon, J.P.1    Tribodet, H.2    Scagliotti, G.V.3
  • 12
    • 77950520452 scopus 로고    scopus 로고
    • Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: Two meta-analyses of individual patient data
    • NSCLC Meta-analyses Collaborative Group, Arriagada R, Auperin A, Burdett S et al. Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data. Lancet 375(9722), 1267-1277 (2010).
    • (2010) Lancet , vol.375 , Issue.9722 , pp. 1267-1277
    • Arriagada, R.1    Auperin, A.2    Burdett, S.3
  • 13
    • 55549138045 scopus 로고    scopus 로고
    • Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups
    • Strauss GM, Herndon JE, Maddaus MA et al. Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups. J. Clin. Oncol. 26(31), 5043-5051 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.31 , pp. 5043-5051
    • Strauss, G.M.1    Herndon, J.E.2    Maddaus, M.A.3
  • 14
    • 73949086148 scopus 로고    scopus 로고
    • Long-term results of the international adjuvant lung cancer trial evaluating adjuvant cisplatin-based chemotherapy in resected lung cancer
    • Arriagada R, Dunant A, Pignon JP et al. Long-term results of the international adjuvant lung cancer trial evaluating adjuvant cisplatin-based chemotherapy in resected lung cancer. J. Clin. Oncol. 28(1), 35-42 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.1 , pp. 35-42
    • Arriagada, R.1    Dunant, A.2    Pignon, J.P.3
  • 15
    • 84866761999 scopus 로고    scopus 로고
    • Developments in the treatment of early NSCLC: When to use chemotherapy
    • Besse B, Le Chevalier T. Developments in the treatment of early NSCLC: when to use chemotherapy. Ann. Oncol. 23(Suppl. 10), x52-x59 (2012).
    • (2012) Ann. Oncol. , vol.23 , pp. x52-x59
    • Besse, B.1    Le Chevalier, T.2
  • 16
    • 77950990798 scopus 로고    scopus 로고
    • Survival benefit of neoadjuvant chemotherapy in non-small cell lung cancer: An updated meta-analysis of 13 randomized control trials
    • Song WA, Zhou NK, Wang W et al. Survival benefit of neoadjuvant chemotherapy in non-small cell lung cancer: an updated meta-analysis of 13 randomized control trials. J. Thorac. Oncol. 5(4), 510-516 (2010).
    • (2010) J. Thorac. Oncol. , vol.5 , Issue.4 , pp. 510-516
    • Song, W.A.1    Zhou, N.K.2    Wang, W.3
  • 17
    • 84900022149 scopus 로고    scopus 로고
    • Preoperative chemotherapy for non-small-cell lung cancer: A systematic review and meta-analysis of individual participant data
    • NSCLC Meta-analysis Collaborative Group. Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data. Lancet 383(9928), 1561-1571 (2014).
    • (2014) Lancet , vol.383 , Issue.9928 , pp. 1561-1571
  • 18
    • 84990998430 scopus 로고    scopus 로고
    • Postoperative radiotherapy for non-small cell lung cancer
    • PORT Meta-analysis Trialists Group. Postoperative radiotherapy for non-small cell lung cancer. Cochrane Database Syst. Rev. 2, CD002142 (2005).
    • (2005) Cochrane Database Syst. Rev. , vol.2 , pp. CD002142
  • 19
    • 79956276306 scopus 로고    scopus 로고
    • Role of postoperative radiotherapy in resected non-small cell lung cancer: A reassessment based on new data
    • Le Péchoux C. Role of postoperative radiotherapy in resected non-small cell lung cancer: a reassessment based on new data. Oncologist 16(5), 672-681 (2011).
    • (2011) Oncologist , vol.16 , Issue.5 , pp. 672-681
    • Le Péchoux, C.1
  • 20
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 12(2), 175-180 (2011).
    • (2011) Lancet Oncol. , vol.12 , Issue.2 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 21
    • 84883013481 scopus 로고    scopus 로고
    • Management of non-small-cell lung cancer: Recent developments
    • Reck M, Heigener DF, Mok T, Soria JC, Rabe KF. Management of non-small-cell lung cancer: recent developments. Lancet 382(9893), 709-719 (2013).
    • (2013) Lancet , vol.382 , Issue.9893 , pp. 709-719
    • Reck, M.1    Heigener, D.F.2    Mok, T.3    Soria, J.C.4    Rabe, K.F.5
  • 22
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 141(7), 1117-1134 (2010).
    • (2010) Cell , vol.141 , Issue.7 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 23
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5(5), 341-354 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 24
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch FR, Varella-Garcia M, Bunn PA Jr et al. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J. Clin. Oncol. 21(20), 3798-3807 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.20 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn, P.A.3
  • 25
    • 33749316418 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway: A model for targeted therapy
    • Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin. Cancer Res. 12(18), 5268-5272 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.18 , pp. 5268-5272
    • Scaltriti, M.1    Baselga, J.2
  • 26
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J1, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 19(56), 6550-6565 (2000).
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 27
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 353(2), 123-132 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 28
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366(9496), 1527-1537 (2005).
    • (2005) Lancet , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 29
    • 79959754489 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors for non-small-cell lung cancer: Finding patients who will be responsive
    • Santarpia M, Altavilla G, Salazar MF et al. Tyrosine kinase inhibitors for non-small-cell lung cancer: finding patients who will be responsive. Expert Rev. Respir. Med. 5(3), 413-424 (2011).
    • (2011) Expert Rev. Respir. Med. , vol.5 , Issue.3 , pp. 413-424
    • Santarpia, M.1    Altavilla, G.2    Salazar, M.F.3
  • 30
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361(10), 947-957 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 31
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised Phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised Phase 3 trial. Lancet Oncol. 11(2), 121-128 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 32
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362(25), 2380-2388 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 33
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (EURTAC): A multicentre, open-label, randomised Phase 3 trial
    • Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (EURTAC): a multicentre, open-label, randomised Phase 3 trial. Lancet Oncol. 13(3), 239-246 (2012).
    • (2012) Lancet Oncol. , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 34
    • 77957585027 scopus 로고    scopus 로고
    • Phase i trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
    • Yap TA, Vidal L, Adam J et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J. Clin. Oncol. 28(25), 3965-3972 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.25 , pp. 3965-3972
    • Yap, T.A.1    Vidal, L.2    Adam, J.3
  • 35
    • 84875013524 scopus 로고    scopus 로고
    • Afatinib: Emerging next-generation tyrosine kinase inhibitor for NSCLC
    • Nelson V, Ziehr J, Agulnik M, Johnson M. Afatinib: emerging next-generation tyrosine kinase inhibitor for NSCLC. Targets Ther. 6, 135-143 (2013).
    • Targets Ther. , vol.6 , Issue.2013 , pp. 135-143
    • Nelson, V.1    Ziehr, J.2    Agulnik, M.3    Johnson, M.4
  • 36
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV1, Yang JC, Yamamoto N et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J. Clin Oncol. 31(27), 3327-3334 (2013).
    • (2013) J. Clin Oncol. , vol.31 , Issue.27 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 37
    • 84892997539 scopus 로고    scopus 로고
    • Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open-label, randomised Phase 3 trial
    • Wu YL, Zhou C, Hu CP et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised Phase 3 trial. Lancet Oncol. 15(2), 213-222 (2014).
    • (2014) Lancet Oncol. , vol.15 , Issue.2 , pp. 213-222
    • Wu, Y.L.1    Zhou, C.2    Hu, C.P.3
  • 38
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised Phase III trial
    • Pirker R, Pereira JR, Szczesna A et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised Phase III trial. Lancet 373(9674), 1525-1531 (2009).
    • (2009) Lancet , vol.373 , Issue.9674 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3
  • 39
    • 84899475126 scopus 로고    scopus 로고
    • Relationship between EGFR expression, EGFR mutation status, and the efficacy of chemotherapy plus cetuximab in FLEX study patients with advanced non-small-cell lung cancer
    • Douillard JY, Pirker R, O'Byrne KJ et al. Relationship between EGFR expression, EGFR mutation status, and the efficacy of chemotherapy plus cetuximab in FLEX study patients with advanced non-small-cell lung cancer. J. Thorac. Oncol. 9(5), 717-724 (2014).
    • (2014) J. Thorac. Oncol. , vol.9 , Issue.5 , pp. 717-724
    • Douillard, J.Y.1    Pirker, R.2    O'byrne, K.J.3
  • 40
    • 45149102984 scopus 로고    scopus 로고
    • Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023
    • Kelly K, Chansky K, Gaspar LE et al. Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023. J. Clin. Oncol. 26(15), 2450-2456 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 , pp. 2450-2456
    • Kelly, K.1    Chansky, K.2    Gaspar, L.E.3
  • 41
    • 0036005846 scopus 로고    scopus 로고
    • ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer
    • Raben D, Helfrich B, Chan D et al. ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer. Semin. Oncol. 29, 37-46 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 37-46
    • Raben, D.1    Helfrich, B.2    Chan, D.3
  • 42
    • 17144371349 scopus 로고    scopus 로고
    • Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva)
    • Chinnaiyan P, Huang S, Vallabhaneni G et al. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva). Cancer Res. 65(8), 3328-3335 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.8 , pp. 3328-3335
    • Chinnaiyan, P.1    Huang, S.2    Vallabhaneni, G.3
  • 43
    • 84861601340 scopus 로고    scopus 로고
    • Novel approaches of chemoradiotherapy in unresectable stage IIIA and stage IIIB non-small cell lung cancer
    • Stinchcombe TE, Bogart JA. Novel approaches of chemoradiotherapy in unresectable stage IIIA and stage IIIB non-small cell lung cancer. Oncologist 17(5), 682-693 (2012).
    • (2012) Oncologist , vol.17 , Issue.5 , pp. 682-693
    • Stinchcombe, T.E.1    Bogart, J.A.2
  • 44
    • 84861651412 scopus 로고    scopus 로고
    • Unexpected high lung toxicity from radiation pneumonitis in a Phase I/II trial of concurrent erlotinib with limited field radiation for intermediate prognosis patients with stage III or inoperable stage IIB non-small-cell lung cancer (NSCLC)
    • Wan J, Cohen V, Agulnik J et al. Unexpected high lung toxicity from radiation pneumonitis in a Phase I/II trial of concurrent erlotinib with limited field radiation for intermediate prognosis patients with stage III or inoperable stage IIB non-small-cell lung cancer (NSCLC). Int. J. Radiat. Oncol. Biol. Phys. 75, S110 (2009).
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.75 , pp. S110
    • Wan, J.1    Cohen, V.2    Agulnik, J.3
  • 45
    • 79953777978 scopus 로고    scopus 로고
    • Single-agent gefitinib with concurrent radiotherapy for locally advanced non-small cell lung cancer harboring mutations of the epidermal growth factor receptor
    • Okamoto I, Takahashi T, Okamoto H et al. Single-agent gefitinib with concurrent radiotherapy for locally advanced non-small cell lung cancer harboring mutations of the epidermal growth factor receptor. Lung Cancer 72, 199-204 (2001).
    • (2001) Lung Cancer , vol.72 , pp. 199-204
    • Okamoto, I.1    Takahashi, T.2    Okamoto, H.3
  • 46
    • 54249097770 scopus 로고    scopus 로고
    • Unusual tumor response and toxicity from radiation and concurrent erlotinib for non-small-cell lung cancer
    • Nanda A, Dias-Santagata DC, Stubbs H et al. Unusual tumor response and toxicity from radiation and concurrent erlotinib for non-small-cell lung cancer. Clin. Lung Cancer 9(5), 285-287 (2008).
    • (2008) Clin. Lung Cancer , vol.9 , Issue.5 , pp. 285-287
    • Nanda, A.1    Dias-Santagata, D.C.2    Stubbs, H.3
  • 47
    • 84890896341 scopus 로고    scopus 로고
    • Gefitinib versus placebo in completely resected non-small-cell lung cancer: Results of the NCIC CTG BR19 study
    • Goss GD, O'Callaghan C, Lorimer I et al. Gefitinib versus placebo in completely resected non-small-cell lung cancer: results of the NCIC CTG BR19 study. J. Clin. Oncol. 31(27), 3320-3326 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.27 , pp. 3320-3326
    • Goss, G.D.1    O'callaghan, C.2    Lorimer, I.3
  • 48
    • 79951773393 scopus 로고    scopus 로고
    • Impact on disease-free survival of adjuvant erlotinib or gefitinib in patients with resected lung adenocarcinomas that harbor EGFR mutations
    • Janjigian YY, Park BJ, Zakowski MF et al. Impact on disease-free survival of adjuvant erlotinib or gefitinib in patients with resected lung adenocarcinomas that harbor EGFR mutations. J. Thorac. Oncol. 6(3), 569-575 (2011).
    • (2011) J. Thorac. Oncol. , vol.6 , Issue.3 , pp. 569-575
    • Janjigian, Y.Y.1    Park, B.J.2    Zakowski, M.F.3
  • 49
    • 84870311995 scopus 로고    scopus 로고
    • Distinct clinical course of EGFR-mutant resected lung cancers: Results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib
    • D'Angelo SP, Janjigian YY, Ahye N et al. Distinct clinical course of EGFR-mutant resected lung cancers: results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib. J. Thorac. Oncol. 7(12), 1815-1822 (2012).
    • (2012) J. Thorac. Oncol. , vol.7 , Issue.12 , pp. 1815-1822
    • D'angelo, S.P.1    Janjigian, Y.Y.2    Ahye, N.3
  • 50
    • 84902167170 scopus 로고    scopus 로고
    • Pemetrexed-carboplatin adjuvant chemotherapy with or without gefitinib in resected stage IIIA-N2 non-small cell lung cancer harbouring EGFR mutations: A randomized, Phase II study
    • Li N, Ou W, Ye X et al. Pemetrexed-carboplatin adjuvant chemotherapy with or without gefitinib in resected stage IIIA-N2 non-small cell lung cancer harbouring EGFR mutations: a randomized, Phase II study. Ann. Surg. Oncol. 21(6), 2091-2096 (2014).
    • (2014) Ann. Surg. Oncol. , vol.21 , Issue.6 , pp. 2091-2096
    • Li, N.1    Ou, W.2    Ye, X.3
  • 51
    • 84910604333 scopus 로고    scopus 로고
    • Adjuvant erlotinib versus placebo in non-small cell lung cancer patients with tumors carrying EGFR-sensitizing mutations form the RADIANT trial
    • Abstract 7513
    • Shepherd F, Altorki NK, Eberhardt WE et al. Adjuvant erlotinib versus placebo in non-small cell lung cancer patients with tumors carrying EGFR-sensitizing mutations form the RADIANT trial. J. Clin. Oncol. 32(5s), Abstract 7513 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , Issue.5 S
    • Shepherd, F.1    Altorki, N.K.2    Eberhardt, W.E.3
  • 52
    • 84904797670 scopus 로고    scopus 로고
    • Customized adjuvant Phase II trial in patients with non-small-cell lung cancer: IFCT-0801 TASTE
    • Wislez M, Barlesi F, Besse B et al. Customized adjuvant Phase II trial in patients with non-small-cell lung cancer: IFCT-0801 TASTE. J. Clin. Oncol. 32(12), 1256-1261 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , Issue.12 , pp. 1256-1261
    • Wislez, M.1    Barlesi, F.2    Besse, B.3
  • 53
    • 84919339224 scopus 로고    scopus 로고
    • A randomized, double-blind Phase 3 trial of adjuvant erlotinib (E) versus placebo (P) following complete tumor resection with or without adjuvant chemotherapy in patients (pts) with stage IB-IIIA EGFR positive (IHC/FISH) non-small cell lung cancer (NSCLC): RADIANT results
    • Abstract 7501
    • Kelly K, Altorki NK, Eberhardt WE et al. A randomized, double-blind Phase 3 trial of adjuvant erlotinib (E) versus placebo (P) following complete tumor resection with or without adjuvant chemotherapy in patients (pts) with stage IB-IIIA EGFR positive (IHC/FISH) non-small cell lung cancer (NSCLC): RADIANT results. J. Clin. Oncol. 32(5s), Abstract 7501(2014).
    • (2014) J. Clin. Oncol. , vol.32 , Issue.5 S
    • Kelly, K.1    Altorki, N.K.2    Eberhardt, W.E.3
  • 54
    • 84910636346 scopus 로고    scopus 로고
    • SELECT: A multicenter Phase II trial of adjuvant erlotinib in resected early-stage EGFR mutation-positive NSCLC
    • Abstract 7514
    • Pennell NA, Neal JW, Chaft J et al. SELECT: a multicenter Phase II trial of adjuvant erlotinib in resected early-stage EGFR mutation-positive NSCLC. J. Clin. Oncol. 32(5s), Abstract 7514 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , Issue.5 S
    • Pennell, N.A.1    Neal, J.W.2    Chaft, J.3
  • 55
    • 84892808887 scopus 로고    scopus 로고
    • Vinorelbine plus cisplatin versus gefitinib in resected non-small cell lung cancer harboring activating EGFR mutation (WJOG6410L)
    • Abstract TPS7110
    • Tada H, Takeda K, Nakagawa K et al. Vinorelbine plus cisplatin versus gefitinib in resected non-small cell lung cancer harboring activating EGFR mutation (WJOG6410L). J. Clin. Oncol. 30(Suppl. 15), Abstract TPS7110 (2012).
    • (2012) J. Clin. Oncol. , vol.30
    • Tada, H.1    Takeda, K.2    Nakagawa, K.3
  • 56
    • 84922654016 scopus 로고    scopus 로고
    • Analysis of treatment duration and safety of adjuvant erlotinib (E) versus placebo (P) after surgery in patients (pts) with non-small cell lung cancer (NSCLC): RADIANT trial
    • Abstract 7535
    • O'Brien ME, Eberhardt WE, Altorki NK et al. Analysis of treatment duration and safety of adjuvant erlotinib (E) versus placebo (P) after surgery in patients (pts) with non-small cell lung cancer (NSCLC): RADIANT trial. J. Clin. Oncol. 32(Suppl. 5), Abstract 7535 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • O'brien, M.E.1    Eberhardt, W.E.2    Altorki, N.K.3
  • 57
    • 84926481605 scopus 로고    scopus 로고
    • The SELECT study: A multicenter Phase II trial of adjuvant erlotinib in resected epidermal growth factor recpetor (EGFR) mutation-positive non-small cell lung cancer (NSCLC)
    • Abstract 7010
    • Neal JW, Pennell NA, Govindan R et al. The SELECT study: a multicenter Phase II trial of adjuvant erlotinib in resected epidermal growth factor recpetor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). J. Clin. Oncol. 30(Suppl. 15), Abstract 7010 (2010).
    • (2010) J. Clin. Oncol. , vol.30
    • Neal, J.W.1    Pennell, N.A.2    Govindan, R.3
  • 58
    • 80051742422 scopus 로고    scopus 로고
    • Randomized Phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: Cancer and Leukemia Group B trial 30407
    • Govindan R1, Bogart J, Stinchcombe T et al. Randomized Phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: Cancer and Leukemia Group B trial 30407. J. Clin. Oncol. 29(23), 3120-3125 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.23 , pp. 3120-3125
    • Govindan, R.1    Bogart, J.2    Stinchcombe, T.3
  • 59
    • 79959195283 scopus 로고    scopus 로고
    • Phase II study of cetuximab in combination with chemoradiation in patients with stage IIIA/B non-small-cell lung cancer: RTOG 0324
    • Blumenschein GR Jr, Paulus R et al. Phase II study of cetuximab in combination with chemoradiation in patients with stage IIIA/B non-small-cell lung cancer: RTOG 0324. J. Clin. Oncol. 29(17), 2312-2318 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.17 , pp. 2312-2318
    • Blumenschein, G.R.1    Paulus, R.2
  • 60
    • 84886366457 scopus 로고    scopus 로고
    • A randomized Phase III comparison of standard dose (60 Gy) versus High-Dose (74 Gy) conformal radiotherapy with or without cetuximab in patients with cetuximab for stage III non-small cell lung cancer. Results on radiation dose in RTOG 0617
    • Abstract 7501
    • Bradley J, Paulus R, Komaki R et al. A randomized Phase III comparison of standard dose (60 Gy) versus High-Dose (74 Gy) conformal radiotherapy with or without cetuximab in patients with cetuximab for stage III non-small cell lung cancer. Results on radiation dose in RTOG 0617. J. Clin. Oncol. 31(Suppl.), Abstract 7501 (2013).
    • (2013) J. Clin. Oncol. , vol.31
    • Bradley, J.1    Paulus, R.2    Komaki, R.3
  • 61
    • 84892876295 scopus 로고    scopus 로고
    • An intergroup randomized Phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) chemoradiotherapy +/- cetuximab for stage III non-small cell lung cancer: Results from RTOG 0617
    • Abstract PL03.05
    • Bradley J, Masters G, Hu C et al. An intergroup randomized Phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) chemoradiotherapy +/- cetuximab for stage III non-small cell lung cancer: results from RTOG 0617. J. Thorac. Oncol. S3, Abstract PL03.05 (2013).
    • (2013) J. Thorac. Oncol. , vol.S3
    • Bradley, J.1    Masters, G.2    Hu, C.3
  • 62
    • 84926481604 scopus 로고    scopus 로고
    • Lung cancer: Molecular profiling and genomics. Extended education session
    • Chicago, IL, USA, 31 May
    • Govindan R. Lung cancer: molecular profiling and genomics. Extended education session. Presented at: ASCO Annual Meeting. Chicago, IL, USA, 31 May 2013.
    • (2013) Presented At: ASCO Annual Meeting
    • Govindan, R.1
  • 65
    • 84859187987 scopus 로고    scopus 로고
    • One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: A randomized trial
    • Joensuu H1, Eriksson M, Sundby Hall K et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA 307(12), 1265-1272 (2012).
    • (2012) JAMA , vol.307 , Issue.12 , pp. 1265-1272
    • Joensuu, H.1    Eriksson, M.2    Sundby Hall, K.3
  • 66
    • 79959916680 scopus 로고    scopus 로고
    • MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents
    • Fan W, Tang Z, Yin L et al. MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents. Cancer Res. 71(13), 4494-4505 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.13 , pp. 4494-4505
    • Fan, W.1    Tang, Z.2    Yin, L.3
  • 67
    • 84885228492 scopus 로고    scopus 로고
    • Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer
    • Li R, Hu Z, Sun SY et al. Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol. Cancer Ther. 12(10), 2200-2212 (2013).
    • (2013) Mol. Cancer Ther. , vol.12 , Issue.10 , pp. 2200-2212
    • Li, R.1    Hu, Z.2    Sun, S.Y.3
  • 68
    • 84860466755 scopus 로고    scopus 로고
    • MicroRNA profiling and prediction of recurrence/relapse-free survival in stage i lung cancer
    • Lu Y1, Govindan R, Wang L et al. MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. Carcinogenesis 33(5), 1046-1054 (2012).
    • (2012) Carcinogenesis , vol.33 , Issue.5 , pp. 1046-1054
    • Lu, Y.1    Govindan, R.2    Wang, L.3
  • 69
    • 84901201909 scopus 로고    scopus 로고
    • Can microRNAs improve the management of lung cancer patients? A clinician's perspective
    • Tufman A, Tian F, Huber RM. Can microRNAs improve the management of lung cancer patients? A clinician's perspective. Theranostics 3(12), 953-963 (2013).
    • (2013) Theranostics , vol.3 , Issue.12 , pp. 953-963
    • Tufman, A.1    Tian, F.2    Huber, R.M.3
  • 70
    • 33644819964 scopus 로고    scopus 로고
    • Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    • Yanaihara N, Caplen N, Bowman E et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9(3), 189-198 (2006).
    • (2006) Cancer Cell , vol.9 , Issue.3 , pp. 189-198
    • Yanaihara, N.1    Caplen, N.2    Bowman, E.3
  • 71
    • 84904265894 scopus 로고    scopus 로고
    • The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors
    • Izumchenko E, Chang X, Michailidi C et al. The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors. Cancer Res. 74(14), 3995-4004 (2014).
    • (2014) Cancer Res. , vol.74 , Issue.14 , pp. 3995-4004
    • Izumchenko, E.1    Chang, X.2    Michailidi, C.3
  • 72
    • 84891340358 scopus 로고    scopus 로고
    • Therapeutic resistance in cancer: MicroRNA regulation of EGFR signaling networks
    • Gomez GG, Wykosky J, Zanca C, Furnari FB, Cavenee WK. Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks. Cancer Biol. Med. 10(4), 192-205 (2013).
    • (2013) Cancer Biol. Med. , vol.10 , Issue.4 , pp. 192-205
    • Gomez, G.G.1    Wykosky, J.2    Zanca, C.3    Furnari, F.B.4    Cavenee, W.K.5
  • 73
    • 84864540328 scopus 로고    scopus 로고
    • Tumor response and toxicity of neoadjuvant erlotinib in patients with early-stage non-small-cell lung cancer
    • Schaake EE, Kappers I, Codrington HE et al. Tumor response and toxicity of neoadjuvant erlotinib in patients with early-stage non-small-cell lung cancer. J. Clin. Oncol. 30(22), 2731-2738 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.22 , pp. 2731-2738
    • Schaake, E.E.1    Kappers, I.2    Codrington, H.E.3
  • 74
    • 74949129970 scopus 로고    scopus 로고
    • Phase II study of preoperative gefitinib in clinical stage i non-small-cell lung cancer
    • Lara-Guerra H, Waddell TK, Salvarrey MA et al. Phase II study of preoperative gefitinib in clinical stage I non-small-cell lung cancer. J. Clin. Oncol. 27(36), 6229-6236 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.36 , pp. 6229-6236
    • Lara-Guerra, H.1    Waddell, T.K.2    Salvarrey, M.A.3
  • 75
    • 79955983366 scopus 로고    scopus 로고
    • Molecular characteristics predict clinical outcomes: Prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene
    • Rizvi NA, Rusch V, Pao W et al. Molecular characteristics predict clinical outcomes: prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene. Clin. Cancer Res. 17(10), 3500-3506 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.10 , pp. 3500-3506
    • Rizvi, N.A.1    Rusch, V.2    Pao, W.3


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