Biomarkers for the 21st century: Listening to the microbiome

Toxicological Sciences

Volumn 144, Issue 2, 2015, Pages 208-216

  Dietert, Rodney Reynolds ^a   Silbergeld, Ellen Kovner ^b  

^a C5 Veterinary Medical Center ^*  (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Arsenic; Biomarkers; Disease states; Health assessment; Microbiome; Non communicable diseases

Indexed keywords

BIOLOGICAL MARKER; XENOBIOTIC AGENT;

ARTICLE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; ECOSYSTEM RESTORATION; ENVIRONMENTAL HEALTH; FIRST PASS EFFECT; GENOMICS; HUMAN; IMMUNE SYSTEM; MICROBIAL COMMUNITY; MICROBIAL METABOLISM; MICROBIOME; MICROFLORA; NONHUMAN; SELF CONCEPT; TOXICOKINETICS; XENOBIOTIC METABOLISM; ENVIRONMENTAL EXPOSURE;

BIOMARKERS; ENVIRONMENTAL EXPOSURE; HUMANS; MICROBIOTA;

EID: 84926468887     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv013     Document Type: Article

References (47)

1. Ackland, M. L., Bornhorst, J., Dedoussis, G., Dietert, R. R., Nriagu, J., Pacyna, J., and Pettifer, J. Metals in the environment as risk factors for infectious diseases. In Trace Metals and Infectious Diseases. Strungmann Forum Report (J. O. Nriagu and E. P. Skaar, Eds.), Vol. 16. MIT Press, Cambridge, MA. (forthcoming).
2. Arrieta, M. C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., and Finlay, B. (2014). The intestinal microbiome in early life: Health and disease. Front Immunol. 5, 427.
3. Bäckhed, F. (2011). Programming of host metabolism by the gut microbiota. Ann. Nutr. Metab. 58(Suppl. 2), 44-52.
4. Borre, Y. E., O'Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., and Cryan, J.F. (2014). Microbiota and neurodevelopmental windows: Implications for brain disorders. Trends Mol. Med 20, 509-518.
5. Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012). Gut immune maturation depends on colonization with a host-specific microbiota. Cell 149, 1578-1593.
6. Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., and Dinan, R.G. (2014). Minireview: Gut microbiota: The neglected endocrine organ. Mol. Endocrinol. 28, 1221-1238.
7. Corley, R. A., Mendrala, A. L., Smith, F. A., Staats, D. A., Gargas,M. L., Conolly, R. B., Andersen, M. E., and Reitz, R. H. (1990). Development of a physiologically based pharmacokinetic model for chloroform. Toxicol. Appl. Pharmacol. 103, 512-527, 190.
8. Cryan, J. F., and Dinan, T. G. (2012). Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci 13, 701-712.
9. Dietert, R., and Dietert, J. (2012). The completed self: An immunological view of the human-microbiome superorganism and risk of chronic diseases. Entropy 14, 2036-2065.
10. Dietert, R. R. (2014). The microbiome in early life: Selfcompletion and microbiota protection as health priorities. Birth Defects Res. Part B 101, 333-340.
11. Dishaw, L. J., Flores-Torres, J., Lax, S., Gemayel, K., Leigh, B., Melillo, D., Mueller, M. G., Natale, L., Zucchetti, I., De Santis, R., et al. (2014). The gut of geographically disparate Ciona intestinalis harbors a core microbiota. PLoS One 9, e93386.
12. Faber, F., and Baumler, A. J. (2014). The impact of intestinal inflammation on the nutritional environment of the gut microbiota. Immunol. Lett. 162, 48-53.
13. Feretti, D., Ceretti, E., De Donno, A., Moretti, M., Carducci, A., Bonetta, S., Marrese, M. R., Bonetti, A., Covolo, L., Bagordo, F., et al. (2014). Monitoring air pollution effects on children for supporting public health policy: The protocol of the prospective cohort MAPEC study. BMJ Open 4, e006096.
14. Finucane, M. M., Sharpton, T. J., Laurent, T. J., and Pollard, K. S. (2014). A taxonomic signature of obesity in the microbiome? Getting to the guts of the matter. PLoS One 9, e84689.
15. Gilbert, S. F. (2014). Symbiosis as the way of eukaryotic life: The dependent co-origination of the body. J. Biosci. 39, 201-209.
16. HMP (HumanMicrobiome Project Consortium) (2012). A framework for human microbiome research. Nature 486, 215-221.
17. Isokpehi, R. D., Udensi, U. K., Simmons, S. S., Hollman, A. L., Cain, A. E., Olofinae, S. A., Hassan, O. A., Kashin, Z. A., Enohog, O. A., Fasesan, D. E., et al. (2014). Evaluative profiling of arsenic sensing and regulatory systems in the human microbiome project genomes. Microbiol. Insights 7, 25-34.
18. Khachatryan, Z. A., Ktsoyan, Z. A., Manukyan, G. P., Kelly, D., Ghazaryan, K. A., and Aminov, R. I. (2008). Predominant role of host genetics in controlling the composition of gut microbiota. PLoS One 3, e3064.
19. Klünemann, M., Schmid, M., and Patil, K. R. (2014). Computational tools for modeling xenometabolism of the human gut microbiota. Trends Biotechnol. 32, 157-165.
20. Kruger, N. C., Berlin, P. N., Helpleper, H. J., and Arsene-Ploetze, F. (2013). Bacterial metabolism of environmental arsenic-Mechanisms and biotechnological applications. Appl. Microbiol. Biotechnol. 97, 3827-3841.
21. Krych, L., Hansen, C. H., Hansen, A. K., van den Berg, F. W., and Nielsen, D. S. (2013). Quantitatively different, yet qualitatively alike: A meta-analysis of the mouse core gut microbiome with a view towards the human gut microbiome. PLoS One 8, e62578.
22. Lee, J. V., Shah, S. A., and Wellen, K. E. (2013). Obesity, cancer, and acetyl-CoA metabolism. Drug Discov. Today Dis. Mech. 10, e55-e61.
23. Lu, K., Cable, P. H., Abo, R. P., Ru, H., Graffam, M. E., Schleper, K. A., Parry, N. M., Levine, S., Bodnar, W. M., Wishnook, L. S., et al. (2014a). Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation. Chem. Res. Toxicol. 26, 1893-1903.
24. Lu, K., Mahbub, R., Cable, P., Ru, H., Parry, N. M., Bodnar, W. M., Wishnok, J. S., Styblo, M., Swenberg, J. A., Fox, J. G., et al. (2014b). Gut microbiome phenotypes driven by host genetics affect arsenic metabolism. Chem. Res. Toxicol. 27, 172-174.
25. Marnell, L., Garcia-Vargas, G. G., Chowdhury, U. K., Zakharyan, R. A., Walsh, B., Avram, M. D., Kopplin, M. J., Cebrián, M. E., Silbergeld, E. K., and Aposhian, H. V. (2003). Polymorphisms in the human monomethylarsonic acid (MMAV) reductase/hGSTO1 gene and changes in urinary arsenic profiles. Chem. Res. Toxicol. 16, 1507-1513.
26. McDermott, A. J., and Huffnagle, G. B. (2014). The microbiome and regulation of mucosal immunity. Immunology 142, 24-31.
27. Montiel-Castro, A. J., Báez-Yánez, G. M., and Pacheco-López, G. (2014). Social neuroeconomics: The influence of microbiota in partner-choice and sociality. Curr. Pharm. Des. 20, 4774-4783.
28. Norman, R. E., Carpenter, D. O., Scott, J., Brune, M. N., and Sly, P. D. (2013). Environmental exposures: An underrecognized contribution to noncommunicable diseases. Rev. Environ. Health 28, 59-65.
29. NRC (National Research Council) (1987). Biological markers in environmental health research. Environ. Health Perspect. 74, 3-9.
30. Orr, J. S., Kennedy, A., Anderson-Baucum, E. K., Webb, C. D., Fordahl, S. C., Erikson, K. M., Zhang, Y., Etzerodt, A., Moestrup, S. K., and Hasty, A. H. (2014). Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes 63, 421-432.
31. Perera, F. P., andWeinstein, I. B. (1982).Molecular epidemiology and carcinogen-DNA adduct detection: New approaches to studies of human cancer causation. J. Chron. Dis. 35, 581-600.
32. Perera, F. P., and Weinstein, I. B. (2000). Molecular epidemiology: Recent advances and future directions. Carcinogen 21, 517-524.
33. Putignani, L., Del Chierico, F., Petrucca, A., Vernocchi, P., and Dallapiccola, B. (2014). Human gut microbiota: Dynamic interplay with the host from birth to senescence settled during childhood. Pediatr. Res. 76, 2-10.
34. Sato, M., and Sato, K. (2013). Maternal inheritance of mitochondrial DNA by diverse mechanisms to eliminate paternal mitochondrial DNA. Biochim. Biophys. Acta 1833, 1979-1984.
35. Schläwicke Engström, K., Nermell, B., Concha, G., Strömberg, U., Vahter, M., and Broberg, K. (2009). Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbonmetabolismand reduction reactions. Mutat. Res. 667, 4-14.
36. Selkrig, J., Wong, P., Zhang, X., and Pettersson, S. (2014). Metabolic tinkering by the gut microbiome: Implications for brain development and function. Gut Microbes 5, 369-380.
37. Smith, P., Siddharth, J., Pearson, R., Holway, N., Shaxted, M., Butler, M., Clark, N., Jamontt, J., Watson, R. P., Snmugalingam, D., et al. (2012). Host genetics and environmental factors regulate ecological succession of the mouse colon tissue-associated microbiota. PLoS One 7, e30273.
38. Snedeker, S. M., and Hay, A. G. (2012). Do interactions between gut ecology and environmental chemicals contribute to obesity and diabetes? Environ. Health Perspect. 120, 332-339.
39. Sowada, J., Schmalenberger, A., Ebner, I., Luch, A., and Tralau, T. (2014). Degradation of benzo(a)pyrene by bacterial isolates from human skin. FEMS Microbiol. Ecol. 88, 129-139.
40. Spurgeon, S. L., Jones, R. C., and Ramakrishnan, R. (2008). High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoS One 3, e1662.
41. Tralau, T., Sowada, J., and Luch, A. (2014). Insights on the human microbiome and its xenobiotic metabolism: What is known about its effects on human physiology. Expert Opin. Drug Metab. Toxicol. 1, 1-15 [online ahead of print].
42. Van de Wiele, T., Gallawa, C. M., Kubachka, K. M., Creed, J. T., Basta, N., Dayton, E. A., Whitacre, S., Du Laing, G., and Bradham, K. (2010). Arsenic metabolism by human gut microbiota upon in vitro digestion of contaminated soils. Environ. Health Perspect 118, 1004-1009.
43. Wos-Oxley, M., Bleich, A., Oxley, A. P., Kahl, S., Janus, L. M., Smoczek, A., Nahrstedt, H., Pils, M. C., Taudien, S., Platzer, M., et al. (2012). Comparative evaluation of establishing a human gut microbial community within rodent models. Gut Microbes 3, 234-249.
44. Wu, D., Tao, X., Wu, G., and Liu, P. (2014). Prokaryotic arsenate reductase enhances arsenate resistance in mammalian cells. Rec. Pat. Food Nutr. Agric., Epub ahead of print. DOI: 10.2174/2212798407666141210110248.
45. Yu, Z. M., Fung, B., Murimboh, J. D., Parker, L., and Dummer, T. J. (2014). What is the role of obesity in the aetiology of arsenicrelated disease? Environ. Int.. 66, 115-123.
46. Zhang, A., Sun, H., Wang, P., Han, Y., and Wang, X. (2012). Modern analytical techniques in metabolomics analysis. Analyst 137, 293-300.
47. Zhang, X., Zeng, B., Liu, Z., Liao, Z., Li, W., Wei, H., and Fang, X. (2014). Comparative diversity analysis of gut microbiota in two different human flora-associated mouse strains. Curr. Microbiol. 69, 365-373.