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Volumn 6, Issue FEB, 2015, Pages

HIV drug nucleoside reverse transcriptase inhibitors as promising anti-inflammation therapeutics by targeting P2X7-dependent large pore formation: One stone for two birds?

Author keywords

Anti inflammation; HIV drugs; Large pore formation; Nucleoside reverse transcriptase inhibitors; P2X7 receptor

Indexed keywords


EID: 84926464685     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00038     Document Type: Article
Times cited : (4)

References (7)
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  • 2
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    • Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
    • Fowler, B. J., Gelfand, B. D., Kim, Y., Kerur, N., Tarallo, V., Hirano, Y., et al. (2014). Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science 346, 1000-1003. doi: 10.1126/science.1261754
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  • 3
    • 0036788971 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors
    • North, R. A. (2002). Molecular physiology of P2X receptors. Physiol. Rev. 82, 1013-1067. doi: 10.1152/physrev.00015.2002
    • (2002) Physiol. Rev. , vol.82 , pp. 1013-1067
    • North, R.A.1
  • 4
    • 33750473352 scopus 로고    scopus 로고
    • Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    • Pelegrin, P., and Surprenant, A. (2006). Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 25, 5071-5082. doi: 10.1038/sj.emboj.7601378
    • (2006) EMBO J. , vol.25 , pp. 5071-5082
    • Pelegrin, P.1    Surprenant, A.2
  • 5
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    • Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation
    • Qu, Y., Misaghi, S., Newton, K., Gilmour, L. L., Louie, S., Cupp, J. E., et al. (2011). Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J. Immunol. 186, 6553-6561. doi: 10.4049/jimmunol.1100478
    • (2011) J. Immunol. , vol.186 , pp. 6553-6561
    • Qu, Y.1    Misaghi, S.2    Newton, K.3    Gilmour, L.L.4    Louie, S.5    Cupp, J.E.6
  • 6
    • 84862777282 scopus 로고    scopus 로고
    • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
    • Sorge, R. E., Trang, T., Dorfman, R., Smith, S. B., Beggs, S., Ritchie, J., et al. (2012). Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat. Med. 18, 595-599. doi: 10.1038/nm.2710
    • (2012) Nat. Med. , vol.18 , pp. 595-599
    • Sorge, R.E.1    Trang, T.2    Dorfman, R.3    Smith, S.B.4    Beggs, S.5    Ritchie, J.6
  • 7
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    • The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
    • Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., and Buell, G. (1996). The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272, 735-738. doi: 10.1126/science.272.5262.735
    • (1996) Science , vol.272 , pp. 735-738
    • Surprenant, A.1    Rassendren, F.2    Kawashima, E.3    North, R.A.4    Buell, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.