A shower of second hit events as the cause of multifocal renal cell carcinoma in tuberous sclerosis complex

Human Molecular Genetics

Volumn 24, Issue 7, 2014, Pages 1836-1842

  Tyburczy, Magdalena E ^a   Jozwiak, Sergiusz ^b   Malinowska, Izabela A ^a   Chekaluk, Yvonne ^a   Pugh, Trevor J ^c,d   Wu, Chin Lee ^e   Nussbaum, Robert L ^f   Seepo, Sara ^g   Dzik, Tomasz ^b   Kotulska, Katarzyna ^b   Kwiatkowski, David J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CASE REPORT; CHROMOSOME 16; DISEASE SEVERITY; DNA DETERMINATION; EXOME; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GERMLINE MUTATION; HEMANGIOFIBROMA; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; MALE; MICROSATELLITE MARKER; MISSENSE MUTATION; MULTIPLE CANCER; MUTATIONAL ANALYSIS; NEPHRECTOMY; NEXT GENERATION SEQUENCING; NONSENSE MUTATION; PAPILLARY CARCINOMA; PARTIAL NEPHRECTOMY; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEIZURE; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; TUBEROUS SCLEROSIS; YOUNG ADULT; CHILD; GENETICS; GROWTH, DEVELOPMENT AND AGING; KIDNEY; METABOLISM; MUTATION; PATHOLOGY; PRESCHOOL CHILD;

TUBERIN; TUMOR SUPPRESSOR PROTEIN;

ADOLESCENT; ADULT; CARCINOMA, RENAL CELL; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; KIDNEY; LOSS OF HETEROZYGOSITY; MALE; MUTATION; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 84926457728     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu597     Document Type: Article

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