The fate and impact of pharmaceuticals and personal care products in agricultural soils irrigated with reclaimed water

Critical Reviews in Environmental Science and Technology

Volumn 45, Issue 13, 2015, Pages 1379-1408

  Qin, Qin ^a,b   Chen, Xijuan ^a   Zhuang, Jie ^c  

^a INSTITUTE OF APPLIED ECOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

cropland; plants; PPCPs; reclaimed water irrigation; soil

Indexed keywords

AGRICULTURE; ARID REGIONS; BIOCHEMISTRY; CROPS; ECOLOGY; GROUNDWATER; IRRIGATION; ORGANIC POLLUTANTS; RECLAMATION; SOILS; WATER POLLUTION;

AGRO-ECOLOGICAL CONDITIONS; ARID AND SEMI-ARID REGIONS; CROPLAND; PHARMACEUTICALS AND PERSONAL CARE PRODUCTS; PLANTS; POTENTIAL TECHNOLOGIES; PPCPS; RE-CLAIMED WATER;

SOIL POLLUTION;

COSMETIC; DRUG; ENVIRONMENTAL CHEMICAL; GROUND WATER; PHARMACEUTICALS AND PERSONAL CARE PRODUCT; RAIN; SURFACE WATER; UNCLASSIFIED DRUG; WATER;

AGRICULTURAL ECOSYSTEM; AGRICULTURAL SOIL; ASSESSMENT METHOD; BIOACCUMULATION; CLIMATIC REGION; CROP PLANT; DRUG; ENVIRONMENTAL FATE; IRRIGATION; NUMERICAL MODEL; ORGANIC POLLUTANT; RISK FACTOR; SOIL BIOTA; SOIL POLLUTION; SOIL REMEDIATION;

BIOACCUMULATION; BIODEGRADATION; BIOTRANSFORMATION; CROPLAND; DIETARY INTAKE; ENVIRONMENTAL IMPACT; HEALTH HAZARD; HUMAN; INFUSION; IRRIGATION (AGRICULTURE); NONHUMAN; PERSISTENT ORGANIC POLLUTANT; PLANT; REVIEW; SOIL FAUNA; SOIL MICROFLORA; SOIL ORGANISM; SOIL POLLUTION; VOLATILIZATION; WASTE COMPONENT REMOVAL; WATER CONTAMINATION;

EID: 84926453716     PISSN: 10643389     EISSN: 15476537     Source Type: Journal    
DOI: 10.1080/10643389.2014.955628     Document Type: Review

References (114)

1. Plumlee, M. H., Gurr, C. J., and Reinhard, M. (2012). Recycled water for stream flow augmentation: Benefits, challenges, and the presence of wastewaterderived organic compounds. Science of the Total Environment, 438, 541-548.
2. Kinney, C. A., Furlong, E. T., Werner, S. L., and Cahill, J. D. (2006). Presence and distribution of wastewater-derived pharmaceuticals in soil irrigated with reclaimed water. Environmental Toxicology and Chemistry, 25, 317-326.
3. Hamilton, A. J., Stagnitti, F., Xiong, X., Kreidl, S. L., Benke, K. K., and Maher, P. (2007). Wastewater irrigation: The state of play. Vadose Zone Journal, 6, 823-840.
4. Dodgen, L. K., Li, J., Parker, D., and Gan, J. J. (2013). Uptake and accumulation of four PPCP/EDCs in two leafy vegetables. Environmental Pollution, 182, 150-156.
5. Chen, W., Lu, S., Jiao, W., Wang, M., and Chang, A. C. (2013). Reclaimed water: A safe irrigation water source? Environmental Development, 8, 74-83.
6. Ternes, T. A., Bonerz, M., Herrmann, N., Teiser, B., and Andersen, H. R. (2007). Irrigation of treated wastewater in Braunschweig, Germany: An option to remove pharmaceuticals and musk fragrances. Chemosphere, 66, 894-904.
7. Davis, M. L., and Cornwell, D. F. (1998). Introduction to environmental engineering, 3rd edn. New York, NY: McGraw-Hill Higher Education.
8. Anderson, P., Denslow, N., Drewes, J. E., Olivieri, A., Schlenk, D., and Snyder, S. (2010). Final report monitoring strategies for chemicals of emerging concern (CECs) in recycled water. Sacramento, CA: State Water Resources Control Board.
9. Avnimelech, Y. (1993). Irrigation with sewage effluents: The Israeli experience. Environmental Science and Technology, 27, 1278-1281.
10. Chang, D., and Ma, Z. (2012). Wastewater reclamation and reuse in Beijing: Influence factors and policy implications. Desalination, 297, 72-78.
11. Daughton, C. G., and Ternes, T. A. (1999). Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environmental Health Perspectives, 107, 907-938.
12. Bu, Q., Wang, B., Huang, J., Deng, S., and Yu, G. (2013). Pharmaceuticals and personal care products in the aquatic environment in China: A review. Journal of Hazardous Materials, 262, 189-211.
13. Ayscough, N. J., Fawell, J., Franklin, G., and Young W. (2000). Review of human pharmaceuticals in the environment. Bristol: UK Environmental Agency.
14. Rimkus, G. G. (1999). Polycyclic musk fragrances in the aquatic environment. Toxicology Letters, 111, 37-56.
15. Xu, W. H., Zhang, G., Zou, S. C., Li, X. D., and Liu, Y. C. (2007). Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Environmental Pollution, 145, 672-679.
16. Jones, O., Voulvoulis, N., and Lester, J. (2001). Human pharmaceuticals in the aquatic environment a review. Environmental Technology, 22, 1383-1394.
17. Reyes-Contreras, C., Matamoros, V., Ruiz, I., Soto, M., and Bayona, J. M. (2011). Evaluation of PPCPs removal in a combined anaerobic digesterconstructed wetland pilot plant treating urban wastewater. Chemosphere, 84, 1200-1207.
18. Tauxe-Wuersch, A., De Alencastro, L. F., Grandjean, D., and Tarradellas, J. (2005). Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment. Water Reaserch, 39, 1761-1772.
19. Andreozzi, R., Marotta, R., Pinto, G., and Pollio, A. (2002). Carbamazepine in water persistence in the environment, ozonation treatment and preliminary assessment on algal toxicity. Water Reaserch, 36, 2869-2877.
20. Ternes, T. A. (1998). Occurrence of drugs in German sewage treatment plants and rivers. Water Research, 32, 3245-3260.
21. Esplugas, S., Bila, D. M., Krause, L. G., and Dezotti, M. (2007). Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents. Journal of Hazardous Materials, 149, 631-642.
22. Karnjanapiboonwong, A., Suski, J. G., Shah, A. A., Cai, Q., Morse, A. N., and Anderson, T. A. (2011). Occurrence of PPCPs at a wastewater treatment plant and in soil and groundwater at a land application site. Water, Air, & Soil Pollution, 216, 257-273.
23. Calderón-Preciado, D., Jiménez-Cartagena, C., Matamoros, V., and Bayona, J. (2011). Screening of 47 organic microcontaminants in agricultural irrigation waters and their soil loading. Water Research, 45, 221-231.
24. Chen, W., Xu, J., Lu, S., Jiao, W., Wu, L., and Chang, A. C. (2013). Fates and transport of PPCPs in soil receiving reclaimed water irrigation. Chemosphere, 93, 2621-2630.
25. Durán-Álvarez, J. C., Prado-Pano, B., and Jiménez-Cisneros, B. (2012). Sorption and desorption of carbamazepine, naproxen and triclosan in a soil irrigated with raw wastewater: Estimation of the sorption parameters by considering the initial mass of the compounds in the soil. Chemosphere, 88, 84-90.
26. Chefetz, B., Mualem, T., and Ben-Ari, J. (2008). Sorption and mobility of pharmaceutical compounds in soil irrigated with reclaimed wastewater. Chemosphere, 73, 1335-1343.
27. Xu, J., Wu, L., and Chang, A. C. (2009). Degradation and adsorption of selected pharmaceuticals and personal care products (PPCPs) in agricultural soils. Chemosphere, 77, 1299-1305.
28. Fang, Y., Karnjanapiboonwong, A., Chase, D. A., Wang, J., Morse, A. N., and Anderson, T. A. (2012). Occurrence, fate, and persistence of gemfibrozil in water and soil. Environmental Toxicology and Chemistry, 31, 550-555.
29. Fent, K., Weston, A. A., and Caminada, D. (2006). Ecotoxicology of human pharmaceuticals. Aquatic Toxicology, 76, 122-159.
30. Gibson, R., Duran-Alvarez, J. C., Estrada, K. L., Chavez, A., and Jimenez Cisneros, B. (2010). Accumulation and leaching potential of some pharmaceuticals and potential endocrine disruptors in soils irrigated with wastewater in the Tula Valley, Mexico. Chemosphere, 81, 1437-1445.
31. Harrow, D. I., Felker, J. M., and Baker, K. H. (2011). Impacts of triclosan in greywater on soil microorganisms. Applied and Environmental Soil Science, 2011, 1-8.
32. Herklotz, P. A., Gurung, P., Vanden Heuvel, B., and Kinney, C. A. (2010). Uptake of human pharmaceuticals by plants grown under hydroponic conditions. Chemosphere, 78, 1416-1421.
33. Karnjanapiboonwong, A., Chase, D. A., Cañas, J. E., Jackson, W. A., Maul, J. D., Morse, A. N., and Anderson, T. A. (2011). Uptake of 17 α-ethynylestradiol and triclosan in pinto bean, Phaseolus vulgaris. Ecotoxicology and Environmental Safety, 74, 1336-1342.
34. Qiu, Z., Wang, L., and Zhou, Q. (2013). Effects of bisphenol A on growth, photosynthesis and chlorophyll fluorescence in above-ground organs of soybean seedlings. Chemosphere, 90, 1274-1280.
35. Calderón-Preciado, D., Matamoros, V., Savé, R., Muñoz, P., Biel, C., and Bayona, J. (2013). Uptake of microcontaminants by crops irrigated with reclaimed water and groundwater under real field greenhouse conditions. Environmental Science and Pollution Research International, 20, 3629-3638.
36. Ashton, D., Hilton, M., and Thomas, K. V. (2004). Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom. Science of the Total Environment, 333, 167-184.
37. Zhang, D., Gersberg, R. M., Ng, W. J., and Tan, S. K. (2014). Removal of pharmaceuticals and personal care products in aquatic plant-based systems: A review. Environmental Pollution, 184, 620-639.
38. Estevez, E., Hernandez-Moreno, J. M., Fernandez-Vera, J. R., and Palacios-Diaz, M. P. (2014). Ibuprofen adsorption in four agricultural volcanic soils. Science of the Total Environment, 468C-469C, 406-414.
39. Xu, J., Wu, L., Chen, W., and Chang, A. C. (2009). Adsorption and degradation of ketoprofen in soils. Journal of Environmental Quality, 38, 1177-1182.
40. Drillia, P., Stamatelatou, K., and Lyberatos, G. (2005). Fate and mobility of pharmaceuticals in solid matrices. Chemosphere, 60, 1034-1044.
41. Balogh, T., Revitt, D. M., Jones, H., and Lundy, L. (2011). Factors influencing the infiltration of pharmaceuticals through soils. Paper presented at 12th International Conference on Urban Drainage, Porto Alegre/Brazil, September 11-16, 2011.
42. Carter, L. J., Harris, E., Williams, M., Ryan, J. J., Kookana, R. S., and Boxall, A. B. (2014). Fate and uptake of pharmaceuticals in soil-plant systems. Journal of Agricultural and Food Chemistry, 62, 816-825.
43. Carr, D. L., Morse, A. N., Zak, J. C., and Anderson, T. A. (2010). Microbially mediated degradation of common pharmaceuticals and personal care products in soil under aerobic and reduced oxygen conditions. Water, Air, and Soil Pollution, 216, 633-642.
44. Ying, G. G., Yu, X. Y., and Kookana, R. S. (2007). Biological degradation of triclocarban and triclosan in a soil under aerobic and anaerobic conditions and comparison with environmental fate modelling. Environmental Pollution, 150, 300-305.
45. Cha, J., and Cupples, A. M. (2009). Detection of the antimicrobials triclocarban and triclosan in agricultural soils following land application of municipal biosolids. Water Research, 43, 2522-2530.
46. Ying, G. G., and Kookana, R. S. (2005). Sorption and degradation of estrogenlike-endocrine disrupting chemicals in soil. Environmental Toxicology and Chemistry, 24, 2640-2645.
47. Lin, K., and Gan, J. (2011). Sorption and degradation of wastewater-associated non-steroidal anti-inflammatory drugs and antibiotics in soils. Chemosphere, 83, 240-246.
48. Halling-Sørensen, B., Nors Nielsen, S., Lanzky, P., Ingerslev, F., Holten Lützhøft, H., and Jørgensen, S. (1998). Occurrence, fate and effects of pharmaceutical substances in the environment-A review. Chemosphere, 36, 357-393.
49. Sangsupan, H. A., Radcliffe, D. E., Hartel, P. G., Jenkins, M. B., Vencill, W. K., and Cabrera, M. L. (2006). Sorption and transport of 17 β-estradiol and testosterone in undisturbed soil columns. Journal of Environmental Quality, 35, 2261-2272.
50. Pedersen, J. A., Soliman, M., and Suffet, I. (2005). Human pharmaceuticals, hormones, and personal care product ingredients in runoff from agricultural fields irrigated with treated wastewater. Journal of Agricultural and Food Chemistry, 53, 1625-1632.
51. Lapworth, D., Gooddy, D., Allen, D., and Old, G. (2009). Understanding groundwater, surface water, and hyporheic zone biogeochemical processes in a Chalk catchment using fluorescence properties of dissolved and colloidal organic matter. Journal of Geophysical Research: Biogeosciences (2005-2012), 114, G00F02.
52. Lapworth, D. J., Baran, N., Stuart, M. E., and Ward, R. S. (2012). Emerging organic contaminants in groundwater: A review of sources, fate and occurrence. Environmental Pollution, 163, 287-303.
53. Schnell, S., Bols, N. C., Barata, C., and Porte, C. (2009). Single and combined toxicity of pharmaceuticals and personal care products (PPCPs) on the rainbow trout liver cell line RTL-W1. Aquatic Toxicology, 93, 244-252.
54. Alder, A., McArdell, C., Golet, E., Kohler, H. P., Molnar, E., Thi, N. A. P., Siegrist, H., Suter, M. F., and Giger, W. (2004). Environmental exposure of antibiotics in wastewaters, sewage sludges and surface waters in Switzerland. Springer Verlag: Berlin Heidelberg.
55. Zhang, X., Brar, S. K., Yan, S., Tyagi, R. D., and Surampalli, R. Y. (2013). Fate and transport of fragrance materials in principal environmental sinks. Chemosphere, 93, 857-869.
56. Peters, R. J., Beeltje, H., and Van Delft, R. J. (2008). Xeno-estrogenic compounds in precipitation. Journal of Environmental Monitoring, 10, 760-769.
57. Liu, J. L., and Wong, M. H. (2013). Pharmaceuticals and personal care products (PPCPs): A review on environmental contamination in China. Environment International, 59, 208-224.
58. Amorim, M. J., Oliveira, E., Soares, A. M., and Scott-Fordsmand, J. J. (2010). Predicted no effect concentration (PNEC) for triclosan to terrestrial species (invertebrates and plants). Environment International, 36, 338-343.
59. Dietz, A. C., and Schnoor, J. L. (2001). Advances in phytoremediation. Environmental Health Perspectives, 109, 163-168.
60. Wu, C., Spongberg, A. L., Witter, J. D., Fang, M., and Czajkowski, K. P. (2010). Uptake of pharmaceutical and personal care products by soybean plants from soils applied with biosolids and irrigated with contaminated water. Environmental Science and Technology, 44, 6157-6161.
61. Wu, X., Ernst, F., Conkle, J. L., and Gan, J. (2013). Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables. Environment International, 60C, 15-22.
62. Briggs, G. G., Bromilow, R. H., and Evans, A. A. (1982). Relationships between lipophilicity and root uptake and translocation of non-ionised chemicals by barley. Pesticide Science, 13, 495-504.
63. Pilon-Smits, E. (2005). Phytoremediation. Annual Review of Plant Biology, 56, 15-39.
64. Reiss, R., Lewis, G., and Griffin, J. (2009). An ecological risk assessment for triclosan in the terrestrial environment. Environmental Toxicology and Chemistry, 28, 1546-1556.
65. Boxall, A. B., Rudd, M. A., Brooks, B. W., Caldwell, D. J., Choi, K., Hickmann, S., Innes, E., Ostapyk, K., Staveley, J. P., and Verslycke, T. (2012). Pharmaceuticals and personal care products in the environment: What are the big questions? Environmental Health Perspectives, 120, 1221-1229.
66. Waller, N. J., and Kookana, R. S. (2009). Effect of triclosan on microbial activity in Australian soils. Envrionmental Toxicology and Chemistry, 28, 65-70.
67. Colinas, C., Ingham, E., and Molina, R. (1994). Population responses of target and non-target forest soil organisms to selected biocides. Soil Biology and Biochemistry, 26, 41-47.
68. Westergaard, K., Müller, A., Christensen, S., Bloem, J., and Sørensen, S. (2001). Effects of tylosin as a disturbance on the soil microbial community. Soil Biology and Biochemistry, 33, 2061-2071.
69. Liu, F., Ying, G. G., Yang, L. H., and Zhou, Q. X. (2009). Terrestrial ecotoxicological effects of the antimicrobial agent triclosan. Ecotoxicology and Environmental Safety, 72, 86-92.
70. Girardi, C., Greve, J., Lamshoft, M., Fetzer, I., Miltner, A., Schaffer, A., and Kastner, M. (2011). Biodegradation of ciprofloxacin in water and soil and its effects on the microbial communities. Journal of Hazardous Materials, 198, 22-30.
71. Conkle, J. L., and White, J. R. (2012). An initial screening of antibiotic effects on microbial respiration in wetland soils. Journal of Environmental Science and Health, Part A, 47, 1381-1390.
72. Thiele-Bruhn, S., and Beck, I. C. (2005). Effects of sulfonamide and tetracycline antibiotics on soil microbial activity and microbial biomass. Chemosphere, 59, 457-465.
73. Gagné, F., Blaise, C., Fournier, M., and Hansen, P. D. (2006). Effects of selected pharmaceutical products on phagocytic activity in Elliptio complanata mussels. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 143, 179-186.
74. Gagné, F., Blaise, C., and Andre, C. (2006). Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes. Ecotoxicology and Environmental Safety, 64, 329-336.
75. Li, X. Y., Luo, Y. R., Yun, M. X., Wang, J., and Wang, J. J. (2010). Effects of 1- methyl-3-octylimidazolium bromide on the anti-oxidant system of earthworm. Chemosphere, 78, 853-858.
76. Lin, D., Zhou, Q., Xie, X., and Liu, Y. (2010). Potential biochemical and genetic toxicity of triclosan as an emerging pollutant on earthworms (Eisenia fetida). Chemosphere, 81, 1328-1333.
77. Römbke, J., Krogh, K. A., Moser, T., Scheffczyk, A., and Liebig, M. (2010). Effects of the veterinary pharmaceutical ivermectin on soil invertebrates in laboratory tests. Archives of Environmental Contamination and Toxicology, 58, 332-340.
78. Feigin, A., Vaisman, I., and Bielorai, H. (1984). Drip irrigation of cotton with treated municipal effluents: II. Nutrient availability in soil. Journal of Environmental Quality, 13, 234-238.
79. Vaisman, I., Shalhevet, J., Kipnis, T., and Feigin, A. (1981). Reducing groundwater pollution from municipal waste-water irrigation of rhodes grass grown on sand dunes. Journal of Environmental Quality, 10, 434-439.
80. Shore, L. S., Kapulnik, Y., Ben-Dor, B., Fridman, Y., Wininger, S., and Shemesh, M. (1992). Effects of estrone and 17 β-estradiol on vegetative growth of Medicago sativa. Physiologia Plantarum, 84, 217-222.
81. Ferrara, G., Loffredo, E., and Senesi, N. (2006). Phytotoxic, clastogenic and bioaccumulation effects of the environmental endocrine disruptor bisphenol A in various crops grown hydroponically. Planta, 223, 910-916.
82. Adamakis, I. D., Panteris, E., Cherianidou, A., and Eleftheriou, E. P. (2013). Effects of bisphenol A on the microtubule arrays in root meristematic cells of Pisum sativum L. Mutation Research, 750, 111-120.
83. Wei, X., Wu, S. C., Nie, X. P., Yediler, A., and Wong, M. H. (2009). The effects of residual tetracycline on soil enzymatic activities and plant growth. Journal of Environmental Science and Health, Part B, 44, 461-471.
84. Chia, T. F., and He, J. (1999). Photosynthetic capacity in Oncidium (Orchidaceae) plants after virus eradication. Environmental and Experimental Botany, 42, 11-16.
85. Stevens, K. J., Kim, S. Y., Adhikari, S., Vadapalli, V., and Venables, B. J. (2009). Effects of triclosan on seed germination and seedling development of three wetland plants: Sesbania herbacea, Eclipta prostrata, and Bidens frondosa. Environmental Toxicology and Chemistry, 28, 2598-2609.
86. Liu, F., Ying, G. G., Tao, R., Zhao, J. L., Yang, J. F., and Zhao, L. F. (2009). Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. Environmental Pollution, 157, 1636-1642.
87. Jadhav, V., Jadhav, A., Chandagade, C., and Raut, P. (2012). Genotoxicity of bisphenol A on root meristem cells of Allium cepa: A cytogenetic approach. Asian Journal of Water, Environment and Pollution, 9, 39-43.
88. Allmyr, M., Adolfsson-Erici, M., McLachlan, M. S., and Sandborgh-Englund, G. (2006). Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. Science of the Total Environment, 372, 87-93.
89. Carballa, M., Omil, F., and Lema, J. M. (2008). Comparison of predicted and measured concentrations of selected pharmaceuticals, fragrances and hormones in Spanish sewage. Chemosphere, 72, 1118-1123.
90. 14C-triclosan in human gingival fibroblasts. Journal of Pharmaceutical Sciences, 92, 1648-1653.
91. Delgado, L. F., Charles, P., Glucina, K., and Morlay, C. (2012). The removal of endocrine disrupting compounds, pharmaceutically activated compounds and cyanobacterial toxins during drinking water preparation using activated carbon-A review. Science of the Total Environment, 435, 509-525.
92. Salem Attia, T. M., Hu, X. L., and Qiang, Y. D. (2013). Synthesized magnetic nanoparticles coated zeolite for the adsorption of pharmaceutical compounds from aqueous solution using batch and column studies. Chemosphere, 93, 2076-2085.
93. Lee, C. O., Howe, K. J., and Thomson, B. M. (2012). Ozone and biofiltration as an alternative to reverse osmosis for removing PPCPs and micropollutants from treated wastewater. Water Research, 46, 1005-1014.
94. Ternes, T. A., Stüber, J., Herrmann, N., McDowell, D., Ried, A., Kampmann, M., and Teiser, B. (2003). Ozonation: A tool for removal of pharmaceuticals, contrast media and musk fragrances from wastewater? Water Research, 37, 1976-1982.
95. Snyder, S. A., Wert, E., Lei, H. D., Westerhoff, P., and Yoon, Y. (2007). Removal of EDCs and pharmaceuticals in drinking and reuse treatment processes. Denver, CO: American Water Works Association Research Foundation (AWWARF).
96. Onesios, K. M., and Bouwer, E. J. (2012). Biological removal of pharmaceuticals and personal care products during laboratory soil aquifer treatment simulation with different primary substrate concentrations. Water Research, 46, 2365-2375.
97. Bekele, E., Toze, S., Patterson, B., and Higginson, S. (2011). Managed aquifer recharge of treated wastwater: Water quality changes resulting from infiltration through the vadose zone. Water Research, 45, 5764-5772.
98. Unold, M., Kasteel, R., Groeneweg, J., and Vereecken, H. (2009). Transport and transformation of sulfadiazine in soil columns packed with a silty loam and a loamy sand. Journal of Contaminant Hydrology, 103, 38-47.
99. Shenker, M., Harush, D., Ben-Ari, J., and Chefetz, B. (2011). Uptake of carbamazepine by cucumber plants-A case study related to irrigation with reclaimed wastewater. Chemosphere, 82, 905-910.
100. Borgman, O., and Chefetz, B. (2013). Combined effects of biosolids application and irrigation with reclaimed wastewater on transport of pharmaceutical compounds in arable soils. Water Research, 47, 3431-3443.
101. Bedoux, G., Roig, B., Thomas, O., Dupont, V., and Bot, B. L. (2012) Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environmental Science and Pollution Research Interantional, 19, 1044-1065.
102. Nakada, N., Tanishima, T., Shinohara, H., Kiri, K., and Takada, H. (2006). Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Research, 40, 3297-3303.
103. Wang, Y., Hu, W., Cao, Z., Fu, X., and Zhu, T. (2005). Occurrence of endocrinedisrupting compounds in reclaimed water from Tianjin, China. Analytical and Bioanalytical Chemistry, 383, 857-863.
104. Vieno, N., Tuhkanen, T., and Kronberg, L. (2007). Elimination of pharmaceuticals in sewage treatment plants in Finland. Water Research, 41, 1001-1012.
105. Zorita, S., Martensson, L., and Mathiasson, L. (2009). Occurrence and removal of pharmaceuticals in a municipal sewage treatment system in the south of Sweden. Science of the Total Environment, 407, 2760-2770.
106. Flint, S., Markle, T., Thompson, S., and Wallace, E. (2012). Bisphenol A exposure, effects, and policy: A wildlife perspective. Journal of Environmental Management, 104, 19-34.
107. Xu, J., Wu, L., Chen, W., Jiang, P., and Chang, A. C. S. (2009). Pharmaceuticals and personal care products (PPCPs), and endocrine disrupting compounds (EDCs) in runoff from a potato field irrigated with treated wastewater in southern California. Journal of Health Science, 55, 306-310.
108. Chen, F., Ying, G. G., Kong, L. X., Wang, L., Zhao, J. L., Zhou, L. J., and Zhang, L. J. (2011). Distribution and accumulation of endocrine-disrupting chemicals and pharmaceuticals in wastewater irrigated soils in Hebei, China. Environmental Pollution, 159, 1490-1498.
109. Liu, F., Ying, G. G., Yang, J. F., Zhou, L. J., Tao, R., Wang, L., Zhang, L. J., and Peng, P. A. (2010). Dissipation of sulfamethoxazole, trimethoprim and tylosin in a soil under aerobic and anoxic conditions. Environmental Chemistry, 7, 370-376.
110. Yang, J. F., Ying, G. G., Zhou, L. J., Liu, S., and Zhao, J. L. (2009). Dissipation of oxytetracycline in soils under different redox conditions. Environmental Pollution, 157, 2704-2709.
111. Wu, C., Spongberg, A. L., and Witter, J. D. (2008). Determination of the persistence of pharmaceuticals in biosolids using liquid-chromatography tandem mass spectrometry. Chemosphere, 73, 511-518.
112. Yu, Y., Liu, Y., and Wu, L. (2013). Sorption and degradation of pharmaceuticals and personal care products (PPCPs) in soils. Environmental Science and Pollution Research, 20, 4261-4267.
113. Sanchez-Brunete, C., Miguel, E., and Tadeo, J. L. (2009). Determination of tetrabromobisphenol-A, tetrachlorobisphenol-A and bisphenol-A in soil by ultrasonic assisted extraction and gas chromatography-mass spectrometry. Journal of Chromatography A, 1216, 5497-5503.
114. Chase, D. A., Karnjanapiboonwong, A., Fang, Y., Cobb, G. P., Morse, A. N., and Anderson, T. A. (2012). Occurrence of synthetic musk fragrances in effluent and non-effluent impacted environments. Science of the Total Environment, 416, 253-260.