Bcl-xl blocks a mitochondrial inner membrane channel and prevents Ca2+ overload-mediated cell death

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Tornero, Daniel ^a,b   Posadas, Inmaculada ^a,c   Ceña, Valentín ^a,c  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; CALCIUM ION; CASPASE 3; CASPASE 9; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; PROTEIN BCL X; 1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; 1,2-BIS(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID ACETOXYMETHYL ESTER; ABT-737; BIPHENYL DERIVATIVE; CALCIUM; CASPASE; DRUG DERIVATIVE; EGTAZIC ACID; ION CHANNEL; IONOMYCIN; NITROPHENOL; PIPERAZINE DERIVATIVE; SULFONAMIDE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE CONDUCTANCE; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MEMBRANE CHANNEL; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; NEUROMODULATION; NEUROPROTECTION; NEUROTOXICITY; PATCH CLAMP; PROTEIN FUNCTION; SINGLE CELL ANALYSIS; CHANNEL GATING; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PERMEABILITY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

APOPTOSIS; BCL-X PROTEIN; BIOLOGICAL TRANSPORT; BIPHENYL COMPOUNDS; CALCIUM; CASPASES; CELL LINE, TUMOR; EGTAZIC ACID; GENE EXPRESSION REGULATION; HUMANS; ION CHANNEL GATING; ION CHANNELS; IONOMYCIN; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; NITROPHENOLS; PATCH-CLAMP TECHNIQUES; PERMEABILITY; PIPERAZINES; SINGLE-CELL ANALYSIS; SULFONAMIDES;

EID: 79957936182     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020423     Document Type: Article

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