Impaired T cell responsiveness to Interleukin-6 in hematological patients with Invasive aspergillosis

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Camargo, Jose F ^a   Bhimji, Alyajahan ^a,b   Kumar, Deepali ^a   Kaul, Rupert ^a,b   Pavan, Rhea ^a   Schuh, Andre ^a,c   Seftel, Matthew ^a,c   Lipton, Jeffrey H ^a,c   Gupta, Vikas ^a,c   Humar, Atul ^a   Husain, Shahid ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DECTIN 1; GAMMA INTERFERON; INTERLEUKIN 6; PENTRAXIN 3; STAT1 PROTEIN; STAT3 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; C REACTIVE PROTEIN; CLEC7A PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INTERLEUKIN 17; LECTIN; SERUM AMYLOID P; STAT1 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CHEMOTHERAPY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; FLOW CYTOMETRY; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INVASIVE ASPERGILLOSIS; MEMORY CD4+ T LYMPHOCYTE; MONOCYTE; MUCORMYCOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SUPERNATANT; T LYMPHOCYTE; TH17 CELL; ADOLESCENT; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BIOSYNTHESIS; BLOOD; CELL CULTURE; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MUCORALES; PATHOGENICITY; PHOSPHORYLATION; YOUNG ADULT;

ASPERGILLUS;

ADOLESCENT; ADULT; AGED; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; C-REACTIVE PROTEIN; CELLS, CULTURED; CROSS-SECTIONAL STUDIES; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-6; LECTINS, C-TYPE; MIDDLE AGED; MUCORALES; MUCORMYCOSIS; PHOSPHORYLATION; SERUM AMYLOID P-COMPONENT; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TH17 CELLS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; YOUNG ADULT;

EID: 84926434346     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123171     Document Type: Article

References (31)

1. Jenq RR, van den Brink MR. Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer. Nat Rev Cancer 2010; 10(3):213-221. doi: 10.1038/nrc2804 PMID: 20168320
2. Kontoyiannis DP, Marr KA, Park BJ, Alexander BD, Anaissie EJ, Walsh TJ et al. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin Infect Dis 2010; 50(8):1091-1100. doi: 10.1086/651263 PMID: 20218877
3. Neofytos D, Horn D, Anaissie E, Steinbach W, Olyaei A, Fishman J et al. Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry. Clin Infect Dis 2009; 48(3):265-273. doi: 10. 1086/595846 PMID: 19115967
4. Marr KA, Carter RA, Boeckh M, Martin P, Corey L. Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 2002; 100(13):4358-4366. PMID: 12393425
5. Roilides E, Kontoyiannis DP, Walsh TJ. Host defenses against zygomycetes. Clin Infect Dis 2012; 54 Suppl 1:S61-6. doi: 10.1093/cid/cir869.:S61-S66. PMID: 22247447
6. De PB, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 2008; 46(12):1813-1821. doi: 10.1086/588660 PMID: 18462102
7. Camargo JF, Kulkarni H, Agan BK, Gaitan AA, Beachy LA, Srinivas S et al. Responsiveness of T cells to interleukin-7 is associated with higher CD4+ T cell counts in HIV-1-positive individuals with highly active antiretroviral therapy-induced viral load suppression. J Infect Dis 2009; 199(12):1872-1882. doi: 10.1086/598858 PMID: 19432535
8. Camargo JF, Husain S. Immune correlates of protection in human invasive aspergillosis. Clin Infect Dis 2014; 59(4):569-577. doi: 10.1093/cid/ciu337 PMID: 24803380
9. Jaillon S, Peri G, Delneste Y, Fremaux I, Doni A, Moalli F et al. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 2007; 204(4):793-804. PMID: 17389238
10. Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M et al. Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. N Engl J Med 2014; 370(5):421-432. doi: 10.1056/ NEJMoa1211161 PMID: 24476432
11. Biagi E, Col M, Migliavacca M, Dell'Oro M, Silvestri D, Montanelli A et al. PTX3 as a potential novel tool for the diagnosis and monitoring of pulmonary fungal infections in immuno-compromised pediatric patients. J Pediatr Hematol Oncol 2008; 30(12):881-885. doi: 10.1097/MPH.0b013e318180bc1d PMID: 19131771
12. Brown GD. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol 2006; 6 (1):33-43. PMID: 16341139
13. Cunha C, Di IM, Bozza S, Giovannini G, Zagarella S, Zelante T et al. Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. Blood 2010; 116 (24):5394-5402. doi: 10.1182/blood-2010-04-279307 PMID: 20807886
14. Bochud PY, Chien JW, Marr KA, Leisenring WM, Upton A, Janer M et al. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 2008; 359(17):1766- 1777. doi: 10. 1056/NEJMoa0802629 PMID: 18946062
15. Sainz J, Lupianez CB, Segura-Catena J, Vazquez L, Rios R, Oyonarte S et al. Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection. PLoS One 2012; 7(2): e32273. doi: 10.1371/journal.pone.0032273 PMID: 22384201
16. Bellocchio S, Gaziano R, Bozza S, Rossi G, Montagnoli C, Perruccio K et al. Liposomal amphotericin B activates antifungal resistance with reduced toxicity by diverting Toll-like receptor signalling from TLR-2 to TLR-4. J Antimicrob Chemother 2005; 55(2):214-222. PMID: 15649994
17. Ringhoffer S, Rojewski M, Dohner H, Bunjes D, Ringhoffer M. T-cell reconstitution after allogeneic stem cell transplantation: assessment by measurement of the sjTREC/betaTREC ratio and thymic naive T cells. Haematologica 2013; 98(10):1600-1608. doi: 10.3324/haematol.2012.072264 PMID: 23585532
18. Chamilos G, Ganguly D, Lande R, Gregorio J, Meller S, Goldman WE et al. Generation of IL-23 producing dendritic cells (DCs) by airborne fungi regulates fungal pathogenicity via the induction of T(H)-17 responses. PLoS One 2010; 5(9):e12955. doi: 10.1371/journal.pone.0012955 PMID: 20886035
19. Rivera A, Hohl TM, Collins N, Leiner I, Gallegos A, Saijo S et al. Dectin-1 diversifies Aspergillus fumiga-tus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med 2011; 208(2):369-381. doi: 10.1084/jem.20100906 PMID: 21242294
20. Shuai K, Liu B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol 2003; 3 (11):900-911. PMID: 14668806
21. Krutzik PO, Nolan GP. Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A 2003; 55(2):61-70. PMID: 14505311
22. Krutzik PO, Irish JM, Nolan GP, Perez OD. Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Clin Immunol 2004; 110(3):206-221. PMID: 15047199
23. Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud O, Gjertsen BT et al. Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell 2004; 118(2):217-228. PMID: 15260991
24. Lee AW, Sharp ER, O'Mahony A, Rosenberg MG, Israelski DM, Nolan GP et al. Single-cell, phosphoe-pitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection. J Virol 2008; 82(7):3702-3712. doi: 10.1128/JVI.01582-07 PMID: 18216116
25. Huang X, Guo Y, Bao C, Shen N. Multidimensional single cell based STAT phosphorylation profiling identifies a novel biosignature for evaluation of systemic lupus erythematosus activity. PLoS One 2011; 6(7):e21671. doi: 10.1371/journal.pone.0021671 PMID: 21799742
26. Muranski P, Restifo NP. Essentials of Th17 cell commitment and plasticity. Blood 2013; 121(13):2402-2414. doi: 10.1182/blood-2012-09-378653 PMID: 23325835
27. Vinh DC, Sugui JA, Hsu AP, Freeman AF, Holland SM. Invasive fungal disease in autosomal-dominant hyper-IgE syndrome. J Allergy Clin Immunol 2010; 125(6):1389-1390. doi: 10.1016/j.jaci.2010.01.047 PMID: 20392475
28. Chandesris MO, Melki I, Natividad A, Puel A, Fieschi C, Yun L et al. Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey. Medicine (Baltimore) 2012; 91(4):e1-19. doi: 10.1097/MD.0b013e31825f95b9 PMID: 22751495
29. Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 2008; 452(7188):773-776. doi: 10.1038/nature06764 PMID: 18337720
30. Potenza L, Vallerini D, Barozzi P, Riva G, Forghieri F, Zanetti E et al. Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients. Blood 2011; 118(20):5416-5419. doi: 10.1182/blood-2011-07-366526 PMID: 21931119
31. Cenci E, Mencacci A, Casagrande A, Mosci P, Bistoni F, Romani L. Impaired antifungal effector activity but not inflammatory cell recruitment in interleukin-6-deficient mice with invasive pulmonary aspergillosis. J Infect Dis 2001; 184(5):610-617. PMID: 11494166