BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle

Journal of Biological Chemistry

Volumn 290, Issue 14, 2015, Pages 9111-9121

  Perry, Mark M ^a   Durham, Andrew L ^a   Austin, Philip J ^a   Adcock, Ian M ^a   Chung, Kian Fan ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; CELL PROLIFERATION; IMMUNOLOGY; MUSCLE; PROTEINS;

AIRWAY REMODELING; AIRWAY SMOOTH MUSCLES; CYTOKINE EXPRESSION; HEALTHY INDIVIDUALS; HISTONE ACETYLATION; MRNA EXPRESSION; QUANTITATIVE RT-PCR; TRANSFORMING GROWTH FACTORS;

DISEASES;

4 (4 CHLOROPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETIC ACID TERT BUTYL ESTER; 6 (4 CHLOROPHENYL) N ETHYL 8 METHOXY 1 METHYL 4H [1,2,4]TRIAZOLO[4,3 A][1,4]BENZODIAZEPINE 4 ACETAMIDE; BROXURIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; INTERLEUKIN 6; INTERLEUKIN 8; MEMBRANE PROTEIN; MESSENGER RNA; MYC PROTEIN; PROTEIN BRD4; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CYTOKINE;

ADULT; AIRWAY REMODELING; AIRWAY SMOOTH MUSCLE; ANTIINFLAMMATORY ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; ASTHMA; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER; TRANSCRIPTION INITIATION SITE; CELL CULTURE; GENETICS; METABOLISM; PHYSIOLOGY; TRACHEA;

ASTHMA; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; GENE KNOCKDOWN TECHNIQUES; HUMANS; RNA, MESSENGER; TRACHEA; TRANSFORMING GROWTH FACTOR BETA;

EID: 84926434236     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.612671     Document Type: Article

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