Effects of cognitive behaviour therapy for worry on persecutory delusions in patients with psychosis (WIT): A parallel, single-blind, randomised controlled trial with a mediation analysis

The Lancet Psychiatry

Volumn 2, Issue 4, 2015, Pages 305-313

  Freeman, Daniel ^a   Dunn, Graham ^b,c   Startup, Helen ^a,d   Pugh, Katherine ^a,d   Cordwell, Jacinta ^e   Mander, Helen ^e   Černis, Emma ^a   Wingham, Gail ^e   Shirvell, Katherine ^e   Kingdon, David ^e  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d SUSSEX PARTNERSHIP NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; COGNITIVE THERAPY; CONTROLLED STUDY; DELUSIONAL DISORDER; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT WORRY; PENN STATE WORRY QUESTIONNAIRE; PERSECUTORY DELUSION; PSYCHOSIS; PSYCHOTIC SYMPTOMS RATING SCALE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SINGLE BLIND PROCEDURE; SUICIDE ATTEMPT; ADOLESCENT; ANXIETY; DELUSIONS; MIDDLE AGED; PARANOID DISORDERS; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; PSYCHOTIC DISORDERS; SCHIZOPHRENIA, PARANOID;

ADOLESCENT; ADULT; AGED; ANXIETY; COGNITIVE THERAPY; DELUSIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; PARANOID DISORDERS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SCHIZOPHRENIA, PARANOID; SINGLE-BLIND METHOD;

EID: 84926433235     PISSN: 22150366     EISSN: 22150374     Source Type: Journal    
DOI: 10.1016/S2215-0366(15)00039-5     Document Type: Article

References (43)

1. Freeman D, Garety P Advances in understanding and treating persecutory delusions. Soc Psychiatry Psychiatr Epidemiol 2014, 49:1179-1189.
2. Kendler KS, Campbell J Interventionist causal models in psychiatry: repositioning the mind-body problem. Psychol Med 2009, 39:881-887.
3. Freeman D, Garety PA Worry, worry processes and dimensions of delusions. Behav Cogn Psychother 1999, 27:47-62.
4. Freeman D, Pugh K, Vorontsova N, Antley A, Slater M Testing the continuum of delusional beliefs: an experimental study using virtual reality. J Abnorm Psychol 2010, 119:83-92.
5. Freeman D, Stahl D, McManus S, et al. Insomnia, worry, anxiety and depression as predictors of the occurrence and persistence of paranoid thinking. Soc Psychiatry Psychiatr Epidemiol 2012, 47:1195-1203.
6. Freeman D, Thompson C, Vorontsova N, et al. Paranoia and post-traumatic stress disorder in the months after a physical assault: a longitudinal study examining shared and differential predictors. Psychol Med 2013, 43:2673-2684.
7. Freeman D, Pugh K, Antley A, et al. A virtual reality study of paranoid thinking in the general population. Br J Psychiatry 2008, 192:258-263.
8. Startup H, Freeman D, Garety PA Persecutory delusions and catastrophic worry in psychosis: developing the understanding of delusion distress and persistence. Behav Res Ther 2007, 45:523-537.
9. Vorontsova N, Garety P, Freeman D Cognitive factors maintaining persecutory delusions in psychosis. J Abnorm Psychol 2013, 122:1121-1131.
10. Morrison AP, Wells A Relationships between worry, psychotic experiences and emotional distress in patients with schizophrenia spectrum diagnoses and comparisons with anxious and non-patient groups. Behav Res Ther 2007, 45:1593-1600.
11. Hartley S, Haddock G, Vasconcelos E, Emsley R, Barrowclough C An experience sampling study of worry and rumination in psychosis. Psychol Med 2014, 44:1605-1614.
12. Foster C, Startup H, Potts L, Freeman D A randomised controlled trial of a worry intervention for individuals with persistent persecutory delusions. J Behav Ther Exp Psychiatry 2010, 41:45-51.
13. The cement of the universe: a study of causation 1974, Oxford University Press, Oxford. J.L. Mackie (Ed.).
14. Freeman D, Dunn G, Startup H, Kingdon D The effects of reducing worry in patients with persecutory delusions: study protocol for a randomized controlled trial. Trials 2012, 13:223.
15. Freeman D, Garety PA Comments on the content of persecutory delusions: does the definition need clarification?. Br J Clin Psychol 2000, 39:407-414.
16. Haddock G, McCarron J, Tarrier N, Faragher FB Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychol Med 1999, 29:879-889.
17. Startup HM, Erickson TM The Penn State Worry Questionnaire (PSWQ). Worry and its psychological disorders 2006, 101-120. Wiley, Chichester. G.C.L. Davey, A. Wells (Eds.).
18. Freeman D, Freeman J How to keep calm and carry on 2013, Pearson, Harlow.
19. Blackburn I, James I, Milne D, et al. The revised cognitive therapy scale (CTS-R). Behav Cogn Psychother 2001, 29:431-446. (2001).
20. Beecham J, Knapp M Costing psychiatric interventions. Measuring Mental Health Needs 1992, 163-184. Gaskell, London. G. Thornicroft, C.R. Brewin, J.K. Wing (Eds.).
21. Meyer TJ, Miller ML, Metzger RL, Borkovec TD Development and validation of the Penn State Worry Questionnaire. Behav Res Ther 1990, 28:487-495.
22. Kay SR Positive and negative syndromes in schizophrenia 1991, Brunner, New York.
23. Green C, Freeman D, Kuipers E, et al. Measuring ideas of persecution and reference: the Green et al Paranoid Thought Scales (G-PTS). Psychol Med 2008, 38:101-111.
24. Ehring T, Zetsche U, Weidacker K, Wahl K, Schönfeld S, Ehlers A The Perseverative Thinking Questionnaire (PTQ): validation of a content-independent measure of repetitive negative thinking. J Behav Ther Exp Psychiatry 2011, 42:225-232.
25. Greenwood K, Sweeney A, Williams S, et al. CHoice of Outcome In Cbt for psychosEs (CHOICE): the development of a new service user-led outcome measure of CBT for psychosis. Schizophr Bull 2010, 36:126-135.
26. Tennant R, Hiller L, Fishwick R, et al. The Warwick-Edinburgh Mental Well-being Scale (WEMWBS): development and UK validation. Health Qual Life Outcomes 2007, 5:63.
27. Wechsler D Wechsler Abbreviated Scale of Intelligence (WASI) 1991, The Psychological Corporation, San Antonio TX, (1999).
28. Marsden J, Gossop G, Stewart D, et al. The Maudsley Addition Profile (MAP). Addiction 1998, 93:1857-1867.
29. Weinman J, Petrie KJ, Moss-Morris R, Horne R The illness pq. Psychol Health 1996, 11:431-445.
30. Garety PA, Freeman D, Jolley S, et al. Reasoning, emotions and delusional conviction in psychosis. J Abnorm Psychol 2005, 114:373-384.
31. Wechsler D Wechsler Adult Intelligence Scale-III/Wechsler Memory Scale 1997, The Psychological Corporation, San Antonio, TX. Third edition technical manual.
32. Freeman D, Startup H, Dunn G, et al. Understanding jumping to conclusions in patients with persecutory delusions: working memory and intolerance of uncertainty. Psychol Med 2014, 44:3017-3024.
33. StataCorp Stata Statistical Software: Release 13 2013, StataCorp LP, College Station, TX.
34. Little RJA, Rubin DB Statistical Analysis with Missing Data 2002, Wiley, New York, Chichester and New York. 2nd ed.
35. Muthén LK, Muthén BO Mplus User's Guide 1998-2012, Muthén & Muthén, Los Angeles, CA. 7th edn.
36. Baron R, Kenny DA The moderator-mediator variable distinction in social psychological research. J Pers Soc Psychol 1986, 5:1173-1182.
37. McArdle JJ Latent variable modelling of differences and changes in longitudinal data. Annu Rev Clin Psychology 2009, 60:577-605.
38. Emsley R, Dunn G, White IR Modelling mediation and moderation of treatment effects in randomised controlled trials of complex interventions. Stat Meth Med Res 2010, 19:237-270.
39. Dunn G Statistical evaluation of measurement errors: design and analysis of reliability studies 2004, Arnold, London. 2nd edn.
40. Hanrahan F, Field A, Jones F, Davey G A meta-analysis of cognitive therapy for worry in generalised anxiety disorder. Clin Psychol Rev 2013, 33:120-132.
41. van der Gaag M, Smit F, Bechdolf A, et al. Preventing a first episode of psychosis: a meta-analysis of randomized controlled prevention trials of 12 month and longer-term follow-ups. Schizophr Res 2013, 149:56-62.
42. Bullock J, Green D, Ha S Yes, but what's the mechanism? (don't expect an easy answer). J Pers Soc Psychol 2010, 98:550-558.
43. van der Gaag M, Valmaggia L, Smit F The effects of individually tailored formulation-based cognitive behavioural therapy in auditory hallucinations and delusions: a meta-analysis. Schizophr Res 2014, 156:30-37.