Optimizing the order of hypotheses in serial testing of multiple endpoints in clinical trials

Statistics in Medicine

Volumn 34, Issue 9, 2015, Pages 1467-1482

  Zhang, Zhiwei ^a   Wang, Chenguang ^b   Troendle, James F ^c  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Chain procedure; Fixed sequence; Hierarchical testing; Multiple comparisons; Multiplicity; Secondary endpoint

Indexed keywords

ADULT; ALGORITHM; ARTICLE; ASTHMA; CLINICAL DECISION MAKING; CLINICAL RESEARCH; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE CONTROL; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; EFFECT SIZE; ENDPOINTS; GREEDY ALGORITHM; HUMAN; HYPOTHESIS; LEARNING ALGORITHM; MAJOR CLINICAL STUDY; MATHEMATICAL ANALYSIS; METHODOLOGY; MIGRAINE WITH AURA; NAUSEA; PHONOPHOBIA; PHOTOPHOBIA; PROBABILITY; PROCESS OPTIMIZATION; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SIMULATION; STATISTICAL PARAMETERS; BIOMETRY; CLINICAL TRIAL (TOPIC); COMPARATIVE STUDY; COMPUTER SIMULATION; MIGRAINE DISORDERS; OUTCOME ASSESSMENT; PROCEDURES; SAMPLE SIZE; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ALGORITHMS; ASTHMA; BIOMETRY; CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; MIGRAINE DISORDERS; OUTCOME ASSESSMENT (HEALTH CARE); QUALITY OF LIFE; SAMPLE SIZE; TREATMENT OUTCOME;

EID: 84926408557     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.6425     Document Type: Article

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