메뉴 건너뛰기




Volumn 78, Issue , 2015, Pages 1-11

VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes

Author keywords

Blood brain barrier; Dendritic spines; Diabetes; Hippocampus; Learning and memory; Vascular endothelial growth factor

Indexed keywords

PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN A;

EID: 84926374530     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.03.022     Document Type: Article
Times cited : (43)

References (79)
  • 1
    • 84873051124 scopus 로고    scopus 로고
    • White matter microstructural integrity in youth with type 1 diabetes
    • Antenor-Dorsey J.A., et al. White matter microstructural integrity in youth with type 1 diabetes. Diabetes 2013, 62:581-589.
    • (2013) Diabetes , vol.62 , pp. 581-589
    • Antenor-Dorsey, J.A.1
  • 2
    • 84865502441 scopus 로고    scopus 로고
    • Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex
    • Argandona E.G., et al. Effect of intracortical vascular endothelial growth factor infusion and blockade during the critical period in the rat visual cortex. Brain Res. 2012, 1473:141-154.
    • (2012) Brain Res. , vol.1473 , pp. 141-154
    • Argandona, E.G.1
  • 3
    • 33644827598 scopus 로고    scopus 로고
    • Chronic treatment with vascular endothelial growth factor preserves agonist-evoked vascular responses in the streptozotocin-induced diabetic rat
    • Bardal S., et al. Chronic treatment with vascular endothelial growth factor preserves agonist-evoked vascular responses in the streptozotocin-induced diabetic rat. Diabetologia 2006, 49:811-818.
    • (2006) Diabetologia , vol.49 , pp. 811-818
    • Bardal, S.1
  • 4
    • 28444455190 scopus 로고    scopus 로고
    • The impact of diabetes on cognition: what can be learned from rodent models?
    • Biessels G.J., Gispen W.H. The impact of diabetes on cognition: what can be learned from rodent models?. Neurobiol. Aging 2005, 26(Suppl. 1):36-41.
    • (2005) Neurobiol. Aging , vol.26 , pp. 36-41
    • Biessels, G.J.1    Gispen, W.H.2
  • 5
    • 0028239773 scopus 로고
    • Cerebral function in diabetes mellitus
    • Biessels G.J., et al. Cerebral function in diabetes mellitus. Diabetologia 1994, 37:643-650.
    • (1994) Diabetologia , vol.37 , pp. 643-650
    • Biessels, G.J.1
  • 6
    • 0029821906 scopus 로고    scopus 로고
    • Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats
    • Biessels G.J., et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes 1996, 45:1259-1266.
    • (1996) Diabetes , vol.45 , pp. 1259-1266
    • Biessels, G.J.1
  • 7
    • 0032572613 scopus 로고    scopus 로고
    • Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment
    • Biessels G.J., et al. Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain Res. 1998, 800:125-135.
    • (1998) Brain Res. , vol.800 , pp. 125-135
    • Biessels, G.J.1
  • 8
    • 0032899849 scopus 로고    scopus 로고
    • Neurophysiological changes in the central and peripheral nervous system of streptozotocin-diabetic rats. Course of development and effects of insulin treatment
    • Biessels G.J., et al. Neurophysiological changes in the central and peripheral nervous system of streptozotocin-diabetic rats. Course of development and effects of insulin treatment. Brain 1999, 122(Pt 4):757-768.
    • (1999) Brain , vol.122 , pp. 757-768
    • Biessels, G.J.1
  • 9
    • 38149065205 scopus 로고    scopus 로고
    • Cognition and diabetes: a lifespan perspective
    • Biessels G.J., et al. Cognition and diabetes: a lifespan perspective. Lancet Neurol. 2008, 7:184-190.
    • (2008) Lancet Neurol. , vol.7 , pp. 184-190
    • Biessels, G.J.1
  • 10
    • 14644440529 scopus 로고    scopus 로고
    • The effects of type 1 diabetes on cognitive performance: a meta-analysis
    • Brands A.M., et al. The effects of type 1 diabetes on cognitive performance: a meta-analysis. Diabetes Care 2005, 28:726-735.
    • (2005) Diabetes Care , vol.28 , pp. 726-735
    • Brands, A.M.1
  • 11
    • 36048972030 scopus 로고    scopus 로고
    • Predictors of cognitive impairment in type 1 diabetes
    • Brismar T., et al. Predictors of cognitive impairment in type 1 diabetes. Psychoneuroendocrinology 2007, 32:1041-1051.
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 1041-1051
    • Brismar, T.1
  • 12
    • 21444439235 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress
    • Caldwell R.B., et al. Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr. Drug Targets 2005, 6:511-524.
    • (2005) Curr. Drug Targets , vol.6 , pp. 511-524
    • Caldwell, R.B.1
  • 13
    • 3542999278 scopus 로고    scopus 로고
    • VEGF links hippocampal activity with neurogenesis, learning and memory
    • Cao L., et al. VEGF links hippocampal activity with neurogenesis, learning and memory. Nat. Genet. 2004, 36:827-835.
    • (2004) Nat. Genet. , vol.36 , pp. 827-835
    • Cao, L.1
  • 14
    • 0036445830 scopus 로고    scopus 로고
    • Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders
    • Carmeliet P., Storkebaum E. Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin. Cell Dev. Biol. 2002, 13:39-53.
    • (2002) Semin. Cell Dev. Biol. , vol.13 , pp. 39-53
    • Carmeliet, P.1    Storkebaum, E.2
  • 15
    • 79953797393 scopus 로고    scopus 로고
    • Intact performance on feature-ambiguous discriminations in rats with lesions of the perirhinal cortex
    • Clark R.E., et al. Intact performance on feature-ambiguous discriminations in rats with lesions of the perirhinal cortex. Neuron 2011, 70:132-140.
    • (2011) Neuron , vol.70 , pp. 132-140
    • Clark, R.E.1
  • 16
    • 0346216156 scopus 로고    scopus 로고
    • Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI
    • den Heijer T., et al. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia 2003, 46:1604-1610.
    • (2003) Diabetologia , vol.46 , pp. 1604-1610
    • den Heijer, T.1
  • 17
    • 0027529604 scopus 로고
    • Moderate hyperglycemia worsens acute blood-brain barrier injury after forebrain ischemia in rats
    • Dietrich W.D., et al. Moderate hyperglycemia worsens acute blood-brain barrier injury after forebrain ischemia in rats. Stroke 1993, 24:111-116.
    • (1993) Stroke , vol.24 , pp. 111-116
    • Dietrich, W.D.1
  • 18
    • 0033634813 scopus 로고    scopus 로고
    • Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    • Feng G., et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000, 28:41-51.
    • (2000) Neuron , vol.28 , pp. 41-51
    • Feng, G.1
  • 19
    • 78751532276 scopus 로고    scopus 로고
    • High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes
    • Franc D.T., et al. High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes. Diabetes 2011, 60:315-319.
    • (2011) Diabetes , vol.60 , pp. 315-319
    • Franc, D.T.1
  • 20
    • 56549112905 scopus 로고    scopus 로고
    • Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy
    • Francis G.J., et al. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008, 131:3311-3334.
    • (2008) Brain , vol.131 , pp. 3311-3334
    • Francis, G.J.1
  • 21
    • 0030992061 scopus 로고    scopus 로고
    • Binding properties of glutamate receptors in streptozotocin-induced diabetes in rats
    • Gagne J., et al. Binding properties of glutamate receptors in streptozotocin-induced diabetes in rats. Diabetes 1997, 46:841-846.
    • (1997) Diabetes , vol.46 , pp. 841-846
    • Gagne, J.1
  • 22
    • 56149102506 scopus 로고    scopus 로고
    • Cognitive function in children with type 1 diabetes: a meta-analysis
    • Gaudieri P.A., et al. Cognitive function in children with type 1 diabetes: a meta-analysis. Diabetes Care 2008, 31:1892-1897.
    • (2008) Diabetes Care , vol.31 , pp. 1892-1897
    • Gaudieri, P.A.1
  • 23
    • 33847652525 scopus 로고    scopus 로고
    • Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes
    • Gold S.M., et al. Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes. Diabetologia 2007, 50:711-719.
    • (2007) Diabetologia , vol.50 , pp. 711-719
    • Gold, S.M.1
  • 24
    • 0141503519 scopus 로고    scopus 로고
    • Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling
    • Haigh J.J., et al. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev. Biol. 2003, 262:225-241.
    • (2003) Dev. Biol. , vol.262 , pp. 225-241
    • Haigh, J.J.1
  • 25
    • 0024261783 scopus 로고
    • Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycemia
    • Harik S.I., LaManna J.C. Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycemia. J. Neurochem. 1988, 51:1924-1929.
    • (1988) J. Neurochem. , vol.51 , pp. 1924-1929
    • Harik, S.I.1    LaManna, J.C.2
  • 26
    • 33845915580 scopus 로고    scopus 로고
    • Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases
    • Hawkins B.T., et al. Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases. Diabetologia 2007, 50:202-211.
    • (2007) Diabetologia , vol.50 , pp. 202-211
    • Hawkins, B.T.1
  • 27
    • 48949117573 scopus 로고    scopus 로고
    • Diabetes, cognitive function, and the blood-brain barrier
    • Huber J.D. Diabetes, cognitive function, and the blood-brain barrier. Curr. Pharm. Des. 2008, 14:1594-1600.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 1594-1600
    • Huber, J.D.1
  • 28
    • 77956231757 scopus 로고    scopus 로고
    • The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
    • Iadecola C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol. 2010, 120:287-296.
    • (2010) Acta Neuropathol. , vol.120 , pp. 287-296
    • Iadecola, C.1
  • 29
    • 0025363792 scopus 로고
    • Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats
    • Jakobsen J., et al. Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats. Diabetes 1990, 39:437-440.
    • (1990) Diabetes , vol.39 , pp. 437-440
    • Jakobsen, J.1
  • 30
    • 0000481740 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia
    • Jin K.L., et al. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:10242-10247.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 10242-10247
    • Jin, K.L.1
  • 31
    • 80051668327 scopus 로고    scopus 로고
    • Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control
    • Kelly-Cobbs A., et al. Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control. Acta Physiol (Oxf.) 2011, 203:245-251.
    • (2011) Acta Physiol (Oxf.) , vol.203 , pp. 245-251
    • Kelly-Cobbs, A.1
  • 32
    • 14644410374 scopus 로고    scopus 로고
    • Experimental diabetic neuropathy with spontaneous recovery: is there irreparable damage?
    • Kennedy J.M., Zochodne D.W. Experimental diabetic neuropathy with spontaneous recovery: is there irreparable damage?. Diabetes 2005, 54:830-837.
    • (2005) Diabetes , vol.54 , pp. 830-837
    • Kennedy, J.M.1    Zochodne, D.W.2
  • 33
    • 84887902234 scopus 로고    scopus 로고
    • Higher glucose levels associated with lower memory and reduced hippocampal microstructure
    • Kerti L., et al. Higher glucose levels associated with lower memory and reduced hippocampal microstructure. Neurology 2013, 81:1746-1752.
    • (2013) Neurology , vol.81 , pp. 1746-1752
    • Kerti, L.1
  • 34
    • 0022002617 scopus 로고
    • Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta
    • King G.L., et al. Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J. Clin. Invest. 1985, 75:1028-1036.
    • (1985) J. Clin. Invest. , vol.75 , pp. 1028-1036
    • King, G.L.1
  • 35
    • 0025726779 scopus 로고
    • Regional density of perfused capillaries and cerebral blood flow in untreated short-term and long-term streptozotocin diabetes
    • Knudsen G.M., et al. Regional density of perfused capillaries and cerebral blood flow in untreated short-term and long-term streptozotocin diabetes. J. Cereb. Blood Flow Metab. 1991, 11:361-365.
    • (1991) J. Cereb. Blood Flow Metab. , vol.11 , pp. 361-365
    • Knudsen, G.M.1
  • 36
    • 34547941252 scopus 로고    scopus 로고
    • Autocrine VEGF signaling is required for vascular homeostasis
    • Lee S., et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell 2007, 130:691-703.
    • (2007) Cell , vol.130 , pp. 691-703
    • Lee, S.1
  • 37
    • 79960016949 scopus 로고    scopus 로고
    • Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways
    • Lee C.C., et al. Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways. Neuropharmacology 2011, 61:867-879.
    • (2011) Neuropharmacology , vol.61 , pp. 867-879
    • Lee, C.C.1
  • 38
    • 77449105172 scopus 로고    scopus 로고
    • Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia
    • Li W., et al. Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia. Diabetes 2010, 59:228-235.
    • (2010) Diabetes , vol.59 , pp. 228-235
    • Li, W.1
  • 39
    • 0032983337 scopus 로고    scopus 로고
    • Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1
    • Liu J., et al. Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1. J. Biol. Chem. 1999, 274:15781-15785.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15781-15785
    • Liu, J.1
  • 40
    • 84864843499 scopus 로고    scopus 로고
    • Effects of vascular endothelial growth factor in ischemic stroke
    • Ma Y., et al. Effects of vascular endothelial growth factor in ischemic stroke. J. Neurosci. Res. 2012, 90(10):1873-1882.
    • (2012) J. Neurosci. Res. , vol.90 , Issue.10 , pp. 1873-1882
    • Ma, Y.1
  • 41
    • 0037459810 scopus 로고    scopus 로고
    • Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats
    • Manschot S.M., et al. Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats. Brain Res. 2003, 966:274-282.
    • (2003) Brain Res. , vol.966 , pp. 274-282
    • Manschot, S.M.1
  • 42
    • 33745317068 scopus 로고    scopus 로고
    • Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes
    • Manschot S.M., et al. Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. Diabetes 2006, 55:1106-1113.
    • (2006) Diabetes , vol.55 , pp. 1106-1113
    • Manschot, S.M.1
  • 43
    • 20444400160 scopus 로고    scopus 로고
    • Alteration in dendritic morphology of cortical neurons in rats with diabetes mellitus induced by streptozotocin
    • Martinez-Tellez R., et al. Alteration in dendritic morphology of cortical neurons in rats with diabetes mellitus induced by streptozotocin. Brain Res. 2005, 1048:108-115.
    • (2005) Brain Res. , vol.1048 , pp. 108-115
    • Martinez-Tellez, R.1
  • 44
    • 84890873628 scopus 로고    scopus 로고
    • Expression of VEGF and Flk-1 and Flt-1 receptors during blood-brain barrier (BBB) impairment following Phoneutria nigriventer spider venom exposure
    • Mendonca M.C., et al. Expression of VEGF and Flk-1 and Flt-1 receptors during blood-brain barrier (BBB) impairment following Phoneutria nigriventer spider venom exposure. Toxins (Basel) 2013, 5:2572-2588.
    • (2013) Toxins (Basel) , vol.5 , pp. 2572-2588
    • Mendonca, M.C.1
  • 45
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris R.G., et al. Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297:681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1
  • 46
    • 0028269978 scopus 로고
    • Rhinal cortex lesions and object recognition in rats
    • Mumby D.G., Pinel J.P. Rhinal cortex lesions and object recognition in rats. Behav. Neurosci. 1994, 108:11-18.
    • (1994) Behav. Neurosci. , vol.108 , pp. 11-18
    • Mumby, D.G.1    Pinel, J.P.2
  • 47
    • 84876942810 scopus 로고    scopus 로고
    • Vascular growth factors in neuropsychiatry
    • Newton S.S., et al. Vascular growth factors in neuropsychiatry. Cell. Mol. Life Sci. 2013, 70:1739-1752.
    • (2013) Cell. Mol. Life Sci. , vol.70 , pp. 1739-1752
    • Newton, S.S.1
  • 48
    • 84875546097 scopus 로고    scopus 로고
    • VEGF reverts the cognitive impairment induced by a focal traumatic brain injury during the development of rats raised under environmental enrichment
    • Ortuzar N., et al. VEGF reverts the cognitive impairment induced by a focal traumatic brain injury during the development of rats raised under environmental enrichment. Behav. Brain Res. 2013, 246:36-46.
    • (2013) Behav. Brain Res. , vol.246 , pp. 36-46
    • Ortuzar, N.1
  • 49
    • 0033784198 scopus 로고    scopus 로고
    • Partial hippocampal inactivation: effects on spatial memory performance in aged and young rats
    • Poe G.R., et al. Partial hippocampal inactivation: effects on spatial memory performance in aged and young rats. Behav. Neurosci. 2000, 114:940-949.
    • (2000) Behav. Neurosci. , vol.114 , pp. 940-949
    • Poe, G.R.1
  • 50
    • 0035480581 scopus 로고    scopus 로고
    • Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task
    • Popovic M., et al. Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task. Behav. Brain Res. 2001, 122:201-207.
    • (2001) Behav. Brain Res. , vol.122 , pp. 201-207
    • Popovic, M.1
  • 51
    • 84861843350 scopus 로고    scopus 로고
    • Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling
    • Prakash R., et al. Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes 2012, 61:1533-1542.
    • (2012) Diabetes , vol.61 , pp. 1533-1542
    • Prakash, R.1
  • 52
    • 84874123482 scopus 로고    scopus 로고
    • Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes
    • Prakash R., et al. Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes. PLoS ONE 2013, 8:e56264.
    • (2013) PLoS ONE , vol.8 , pp. e56264
    • Prakash, R.1
  • 53
    • 79961175318 scopus 로고    scopus 로고
    • The neurovascular link in health and disease: molecular mechanisms and therapeutic implications
    • Quaegebeur A., et al. The neurovascular link in health and disease: molecular mechanisms and therapeutic implications. Neuron 2011, 71:406-424.
    • (2011) Neuron , vol.71 , pp. 406-424
    • Quaegebeur, A.1
  • 54
    • 84926389854 scopus 로고    scopus 로고
    • Delayed inhibition of VEGF signaling after stroke attenuates blood brain barrier breakdown and improves functional recovery in a co-morbidity dependent manner
    • Reeson P., et al. Delayed inhibition of VEGF signaling after stroke attenuates blood brain barrier breakdown and improves functional recovery in a co-morbidity dependent manner. J. Neurosci. 2015, 35:5128-5143.
    • (2015) J. Neurosci. , vol.35 , pp. 5128-5143
    • Reeson, P.1
  • 55
    • 67649973540 scopus 로고    scopus 로고
    • Role and therapeutic potential of VEGF in the nervous system
    • Ruiz de Almodovar C., et al. Role and therapeutic potential of VEGF in the nervous system. Physiol. Rev. 2009, 89:607-648.
    • (2009) Physiol. Rev. , vol.89 , pp. 607-648
    • Ruiz de Almodovar, C.1
  • 56
    • 77449116707 scopus 로고    scopus 로고
    • The final frontier: how does diabetes affect the brain?
    • Seaquist E.R. The final frontier: how does diabetes affect the brain?. Diabetes 2010, 59:4-5.
    • (2010) Diabetes , vol.59 , pp. 4-5
    • Seaquist, E.R.1
  • 57
    • 77950927761 scopus 로고    scopus 로고
    • Cognitive function and event-related potentials in children with type 1 diabetes mellitus
    • Shehata G., Eltayeb A. Cognitive function and event-related potentials in children with type 1 diabetes mellitus. J. Child Neurol. 2010, 25:469-474.
    • (2010) J. Child Neurol. , vol.25 , pp. 469-474
    • Shehata, G.1    Eltayeb, A.2
  • 58
    • 16644382257 scopus 로고    scopus 로고
    • Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    • Storkebaum E., et al. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat. Neurosci. 2005, 8:85-92.
    • (2005) Nat. Neurosci. , vol.8 , pp. 85-92
    • Storkebaum, E.1
  • 59
    • 59049100683 scopus 로고    scopus 로고
    • Impact of energy intake and expenditure on neuronal plasticity
    • Stranahan A.M., Mattson M.P. Impact of energy intake and expenditure on neuronal plasticity. Neuromol. Med. 2008, 10:209-218.
    • (2008) Neuromol. Med. , vol.10 , pp. 209-218
    • Stranahan, A.M.1    Mattson, M.P.2
  • 60
    • 39749137437 scopus 로고    scopus 로고
    • Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
    • Stranahan A.M., et al. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat. Neurosci. 2008, 11:309-317.
    • (2008) Nat. Neurosci. , vol.11 , pp. 309-317
    • Stranahan, A.M.1
  • 61
    • 55549139200 scopus 로고    scopus 로고
    • Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    • Stranahan A.M., et al. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008, 18:1085-1088.
    • (2008) Hippocampus , vol.18 , pp. 1085-1088
    • Stranahan, A.M.1
  • 62
    • 84861477961 scopus 로고    scopus 로고
    • An experimental study of VEGF induced changes in vasoactivity in pig retinal arterioles and the influence of an anti-VEGF agent
    • Su E.N., et al. An experimental study of VEGF induced changes in vasoactivity in pig retinal arterioles and the influence of an anti-VEGF agent. BMC Ophthalmol. 2012, 12:10.
    • (2012) BMC Ophthalmol. , vol.12 , pp. 10
    • Su, E.N.1
  • 63
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    • Sun Y., et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 2003, 111:1843-1851.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1843-1851
    • Sun, Y.1
  • 64
    • 0020674881 scopus 로고
    • A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat
    • Sutherland R.J., et al. A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat. Behav. Brain Res. 1983, 7:133-153.
    • (1983) Behav. Brain Res. , vol.7 , pp. 133-153
    • Sutherland, R.J.1
  • 65
    • 84859551517 scopus 로고    scopus 로고
    • Diabetes impairs cortical plasticity and functional recovery following ischemic stroke
    • Sweetnam D., et al. Diabetes impairs cortical plasticity and functional recovery following ischemic stroke. J. Neurosci. 2012, 32:5132-5143.
    • (2012) J. Neurosci. , vol.32 , pp. 5132-5143
    • Sweetnam, D.1
  • 66
    • 84889059035 scopus 로고    scopus 로고
    • Diabetes augments in vivo microvascular blood flow dynamics after stroke
    • Tennant K.A., Brown C.E. Diabetes augments in vivo microvascular blood flow dynamics after stroke. J. Neurosci. 2013, 33:19194-19204.
    • (2013) J. Neurosci. , vol.33 , pp. 19194-19204
    • Tennant, K.A.1    Brown, C.E.2
  • 67
    • 67349222548 scopus 로고    scopus 로고
    • Sensorimotor behavioral effects of endothelin-1 induced small cortical infarcts in C57BL/6 mice
    • Tennant K.A., Jones T.A. Sensorimotor behavioral effects of endothelin-1 induced small cortical infarcts in C57BL/6 mice. J. Neurosci. Methods 2009, 181:18-26.
    • (2009) J. Neurosci. Methods , vol.181 , pp. 18-26
    • Tennant, K.A.1    Jones, T.A.2
  • 68
    • 33746349818 scopus 로고    scopus 로고
    • Diabetes, leukoencephalopathy and rage
    • Toth C., et al. Diabetes, leukoencephalopathy and rage. Neurobiol. Dis. 2006, 23:445-461.
    • (2006) Neurobiol. Dis. , vol.23 , pp. 445-461
    • Toth, C.1
  • 69
  • 70
    • 38649096949 scopus 로고    scopus 로고
    • VEGF as a potential target for therapeutic intervention in depression
    • Warner-Schmidt J.L., Duman R.S. VEGF as a potential target for therapeutic intervention in depression. Curr. Opin. Pharmacol. 2008, 8:14-19.
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 14-19
    • Warner-Schmidt, J.L.1    Duman, R.S.2
  • 71
    • 84892388917 scopus 로고    scopus 로고
    • A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes
    • Warren C.M., et al. A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes. Sci. Signal. 2014, 7:ra1.
    • (2014) Sci. Signal. , vol.7 , pp. ra1
    • Warren, C.M.1
  • 72
    • 12144252887 scopus 로고    scopus 로고
    • Transient inactivation of perirhinal cortex disrupts encoding, retrieval, and consolidation of object recognition memory
    • Winters B.D., Bussey T.J. Transient inactivation of perirhinal cortex disrupts encoding, retrieval, and consolidation of object recognition memory. J. Neurosci. 2005, 25:52-61.
    • (2005) J. Neurosci. , vol.25 , pp. 52-61
    • Winters, B.D.1    Bussey, T.J.2
  • 73
    • 84855362074 scopus 로고    scopus 로고
    • Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by increasing superoxide production
    • Won S.J., et al. Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by increasing superoxide production. Ann. Neurol. 2011, 70:583-590.
    • (2011) Ann. Neurol. , vol.70 , pp. 583-590
    • Won, S.J.1
  • 74
    • 58149229589 scopus 로고    scopus 로고
    • The brain in the age of old: the hippocampal formation is targeted differentially by diseases of late life
    • Wu W., et al. The brain in the age of old: the hippocampal formation is targeted differentially by diseases of late life. Ann. Neurol. 2008, 64:698-706.
    • (2008) Ann. Neurol. , vol.64 , pp. 698-706
    • Wu, W.1
  • 75
    • 80055000205 scopus 로고    scopus 로고
    • Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats
    • Ye X., et al. Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats. Exp. Neurol. 2011, 232:299-308.
    • (2011) Exp. Neurol. , vol.232 , pp. 299-308
    • Ye, X.1
  • 76
    • 64349107251 scopus 로고    scopus 로고
    • Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic
    • Zhang Z.G., Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol. 2009, 8:491-500.
    • (2009) Lancet Neurol. , vol.8 , pp. 491-500
    • Zhang, Z.G.1    Chopp, M.2
  • 77
    • 0033797255 scopus 로고    scopus 로고
    • VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
    • Zhang Z.G., et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J. Clin. Invest. 2000, 106:829-838.
    • (2000) J. Clin. Invest. , vol.106 , pp. 829-838
    • Zhang, Z.G.1
  • 78
    • 84867607875 scopus 로고    scopus 로고
    • Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain
    • Zhao Q., et al. Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complement. Altern. Med. 2012, 12:188.
    • (2012) BMC Complement. Altern. Med. , vol.12 , pp. 188
    • Zhao, Q.1
  • 79
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.