-
1
-
-
84862026304
-
Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
-
Bokemeyer C, Van Cutsem E, Rougier P, et al. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer 2012; 48: 1466-75.
-
(2012)
Eur J Cancer
, vol.48
, pp. 1466-1475
-
-
Bokemeyer, C.1
Van Cutsem, E.2
Rougier, P.3
-
2
-
-
84883680951
-
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
-
Douillard JY, Oliner KS, Siena S, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 2013; 12: 1023-34.
-
(2013)
N Engl J Med
, vol.12
, pp. 1023-1034
-
-
Douillard, J.Y.1
Oliner, K.S.2
Siena, S.3
-
3
-
-
84885836502
-
Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation
-
Giampieri R, Scartozzi M, Del Prete M, et al. Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation. Crit Rev Oncol Hematol 2013; 88: 272-83.
-
(2013)
Crit Rev Oncol Hematol
, vol.88
, pp. 272-283
-
-
Giampieri, R.1
Scartozzi, M.2
Del Prete, M.3
-
4
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-45.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
6
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumours that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung KY, Shia J, Kemeny NE, et al. Cetuximab shows activity in colorectal cancer patients with tumours that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005; 23: 1803-10.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
-
7
-
-
42649145667
-
Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
-
Amado RG, Wolf M, Peeters M, et al. Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer. J Clin Oncol 2008; 26: 1626-34.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
8
-
-
34147103678
-
Open-Label Phase III Trial of Panitumumab Plus Best Supportive Care Compared With Best Supportive Care Alone in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer
-
Van Cutsem E, Peeters M, Siena S, et al. Open-Label Phase III Trial of Panitumumab Plus Best Supportive Care Compared With Best Supportive Care Alone in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer. J Clin Oncol 2007; 25: 1658-64.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
9
-
-
84908573757
-
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): A randomised, open-label, phase 3 trial
-
Heinemann V, von Weikersthal LF, Decker T, et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol 2014; 15: 1065-75.
-
(2014)
Lancet Oncol
, vol.15
, pp. 1065-1075
-
-
Heinemann, V.1
Von Weikersthal, L.F.2
Decker, T.3
-
10
-
-
79952607191
-
The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab
-
Scartozzi M, Mandolesi A, Giampieri R, et al. The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab. Oncologist 2011; 16: 53-60.
-
(2011)
Oncologist
, vol.16
, pp. 53-60
-
-
Scartozzi, M.1
Mandolesi, A.2
Giampieri, R.3
-
11
-
-
84864314650
-
Analysis of HER-3, insulin growth factor-1, nuclear factor-kB and epidermal growth factor receptor gene copy number in the prediction of clinical outcome for K-RAS wild-type colorectal cancer patients receiving irinotecan-cetuximab
-
Scartozzi M, Giampieri R, Maccaroni E, et al. Analysis of HER-3, insulin growth factor-1, nuclear factor-kB and epidermal growth factor receptor gene copy number in the prediction of clinical outcome for K-RAS wild-type colorectal cancer patients receiving irinotecan-cetuximab. Ann Oncol 2012; 23: 1706-12.
-
(2012)
Ann Oncol
, vol.23
, pp. 1706-1712
-
-
Scartozzi, M.1
Giampieri, R.2
Maccaroni, E.3
-
12
-
-
77956996167
-
Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan
-
Scartozzi M, Mandolesi A, Giampieri R, et al. Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan. Int J Cancer. 2010; 127: 1941-7.
-
(2010)
Int J Cancer
, vol.127
, pp. 1941-1947
-
-
Scartozzi, M.1
Mandolesi, A.2
Giampieri, R.3
-
13
-
-
84875107275
-
Use of HER2 gene amplification to identify patients with metastatic colorectal cancer resistant to anti-EGFR monoclonal antibodies
-
abstr 474
-
Barbara C, Martin V, Molinari F, et al. Use of HER2 gene amplification to identify patients with metastatic colorectal cancer resistant to anti-EGFR monoclonal antibodies. J Clin Oncol 30, 2012 (suppl 4; abstr 474).
-
(2012)
J Clin Oncol
, vol.30
-
-
Barbara, C.1
Martin, V.2
Molinari, F.3
-
14
-
-
73349094741
-
Analysis of PTEN, BRAF, and EGFR Status in determining benefit from Cetuximab therapy in Wild-Type KRAS metastatic colon cancer
-
Laurent-Puig P, Cayre A, Manceau G, et al. Analysis of PTEN, BRAF, and EGFR Status in determining benefit from Cetuximab therapy in Wild-Type KRAS metastatic colon cancer. J Clin Oncol 2009; 27: 5924-30.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5924-5930
-
-
Laurent-Puig, P.1
Cayre, A.2
Manceau, G.3
-
15
-
-
17844362179
-
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: A cohort study
-
Moroni M, Veronese S, Benvenuti S, et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005; 6: 279-86.
-
(2005)
Lancet Oncol
, vol.6
, pp. 279-286
-
-
Moroni, M.1
Veronese, S.2
Benvenuti, S.3
-
16
-
-
34548258303
-
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with Panitumumab
-
Sartore-Bianchi A, Moroni M, Veronese S, et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with Panitumumab. J Clin Oncol 2007; 25: 3238-45.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3238-3245
-
-
Sartore-Bianchi, A.1
Moroni, M.2
Veronese, S.3
-
17
-
-
70049091759
-
Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: A fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis
-
Scartozzi M, Bearzi I, Mandolesi A, et al. Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis. BMC Cancer 2009; 9(303).
-
(2009)
BMC Cancer
, vol.9
, Issue.303
-
-
Scartozzi, M.1
Bearzi, I.2
Mandolesi, A.3
-
18
-
-
77449101632
-
Activating KRAS mutations and overexpression of epidermal growth factor receptor as independent predictors in metastatic colorectal cancer patients treated with cetuximab
-
Yen LC, Uen YH, Wu DC, et al. Activating KRAS mutations and overexpression of epidermal growth factor receptor as independent predictors in metastatic colorectal cancer patients treated with cetuximab. Ann Surg 2010; 251: 254-60.
-
(2010)
Ann Surg
, vol.251
, pp. 254-260
-
-
Yen, L.C.1
Uen, Y.H.2
Wu, D.C.3
-
19
-
-
46349092797
-
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients
-
Capuzzo F, Varella-Garcia M, Finocchiaro G, et al. Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br J Cancer. 2008; 99: 83-9.
-
(2008)
Br J Cancer
, vol.99
, pp. 83-89
-
-
Capuzzo, F.1
Varella-Garcia, M.2
Finocchiaro, G.3
-
20
-
-
53249123419
-
Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: A fluorescent in situ hybridization study
-
Personeni N, Fieuws S, Piessevaux H, et al. Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study. Clin Cancer Res 2008; 14: 5869-76.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5869-5876
-
-
Personeni, N.1
Fieuws, S.2
Piessevaux, H.3
-
21
-
-
79251472776
-
EGFR Fluorescence In situ Hybridization Pattern of Chromosome 7 Disomy Predicts Resistance to Cetuximab in KRAS Wild-type Metastatic Colorectal Cancer Patients
-
Li YH, Wang F, Shen L, et al. EGFR Fluorescence In situ Hybridization Pattern of Chromosome 7 Disomy Predicts Resistance to Cetuximab in KRAS Wild-type Metastatic Colorectal Cancer Patients. Clin Cancer Res 2011; 17: 382-90.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 382-390
-
-
Li, Y.H.1
Wang, F.2
Shen, L.3
-
22
-
-
33745254202
-
Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab
-
Zhang W, Gordon M, Press OA, et al. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab. Pharmacogenet Genomics 2006; 16: 475-83.
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 475-483
-
-
Zhang, W.1
Gordon, M.2
Press, O.A.3
-
23
-
-
77953276067
-
Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer
-
Pander J, Gelderblom H, Antonini NF, et al. Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer. Eur J Cancer 2010; 46: 1829-34.
-
(2010)
Eur J Cancer
, vol.46
, pp. 1829-1834
-
-
Pander, J.1
Gelderblom, H.2
Antonini, N.F.3
-
24
-
-
80054760645
-
Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer
-
Park JH, Han SW, Oh DY, et al. Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer. Cancer Chemother Pharmacol 2011; 68: 1045-55.
-
(2011)
Cancer Chemother Pharmacol
, vol.68
, pp. 1045-1055
-
-
Park, J.H.1
Han, S.W.2
Oh, D.Y.3
-
25
-
-
65549143792
-
The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer
-
Garm Spindler KL, Pallisgaard N, Rasmussen AA, et al. The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer. Ann Oncol 2009; 20: 879-84.
-
(2009)
Ann Oncol
, vol.20
, pp. 879-884
-
-
Garm Spindler, K.L.1
Pallisgaard, N.2
Rasmussen, A.A.3
-
26
-
-
82055175693
-
Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer
-
Dahan L, Norguet E, Etienne-Grimaldi MC, et al. Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer. BMC Cancer 2011; 11: 496.
-
(2011)
BMC Cancer
, vol.11
, pp. 496
-
-
Dahan, L.1
Norguet, E.2
Etienne-Grimaldi, M.C.3
-
27
-
-
59449091688
-
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab
-
Lurje G, Nagashima F, Zhang W, et al. Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. Clin Cancer Res 2008; 14: 7884-95.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7884-7895
-
-
Lurje, G.1
Nagashima, F.2
Zhang, W.3
-
28
-
-
79957599577
-
Epidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients
-
Scartozzi M, Bearzi I, Mandolesi A, et al. Epidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients. Br J Cancer 2011; 104: 1786-90.
-
(2011)
Br J Cancer
, vol.104
, pp. 1786-1790
-
-
Scartozzi, M.1
Bearzi, I.2
Mandolesi, A.3
-
29
-
-
39349083477
-
EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer
-
Presented as poster at the 2007 ASCO Annual Meeting, Abstract No: 4021, citation on, June 20 Supplement
-
Finocchiaro G, Cappuzzo F, Jänne PA, et al. EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer. Presented as poster at the 2007 ASCO Annual Meeting, Abstract No: 4021, citation on J Clin Oncol, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 4021.
-
(2007)
J Clin Oncol, 2007 ASCO Annual Meeting Proceedings Part I
, vol.25
, Issue.18S
, pp. 4021
-
-
Finocchiaro, G.1
Cappuzzo, F.2
Jänne, P.A.3
-
30
-
-
77954215850
-
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
-
Tol J, Dijkstra JR, Klomp M, et al. Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. Eur J Cancer 2010; 46: 1997-2009.
-
(2010)
Eur J Cancer
, vol.46
, pp. 1997-2009
-
-
Tol, J.1
Dijkstra, J.R.2
Klomp, M.3
-
31
-
-
46349092797
-
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients
-
Cappuzzo F, Varella-Garcia M, Finocchiaro G, et al. Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br J Cancer 2008; 99: 83-9.
-
(2008)
Br J Cancer
, vol.99
, pp. 83-89
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Finocchiaro, G.3
-
32
-
-
80755123221
-
Is there a role for IGF1R and c-Met pathways in resistance to cetuximab in metastatic colorectal cancer?
-
Inno A, Di Salvatore M, Cenci T, et al. Is there a role for IGF1R and c-Met pathways in resistance to cetuximab in metastatic colorectal cancer? Clin Colorectal Cancer 2011; 10: 325-32.
-
(2011)
Clin Colorectal Cancer
, vol.10
, pp. 325-332
-
-
Inno, A.1
Di Salvatore, M.2
Cenci, T.3
-
33
-
-
78349233164
-
Germline polymorphisms in genes involved in the IGF1 pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients
-
Winder T, Zhang W, Yang D, et al. Germline polymorphisms in genes involved in the IGF1 pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients. Clin Cancer Res. 2010; 16: 5591-602.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5591-5602
-
-
Winder, T.1
Zhang, W.2
Yang, D.3
-
34
-
-
77956996167
-
Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan
-
Scartozzi M, Mandolesi A, Giampieri R, et al. Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan. Int J Cancer 2010; 127: 1941-7.
-
(2010)
Int J Cancer
, vol.127
, pp. 1941-1947
-
-
Scartozzi, M.1
Mandolesi, A.2
Giampieri, R.3
-
35
-
-
79551693356
-
HGF rescues colorectal cancer cells from EGFR inhibition via Met activation
-
Liska D, Chen CT, Bachleitner-Hofmann T, et al. HGF rescues colorectal cancer cells from EGFR inhibition via Met activation. Clin Cancer Res 2011; 17: 472-82.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 472-482
-
-
Liska, D.1
Chen, C.T.2
Bachleitner-Hofmann, T.3
-
36
-
-
0037358220
-
Met receptor overexpression and oncogenic Ki-ras mutation cooperate to enhance tumorigenicity of colon cancer cells in vivo
-
Long IS, Han K, Li M, et al. Met receptor overexpression and oncogenic Ki-ras mutation cooperate to enhance tumorigenicity of colon cancer cells in vivo. Mol Cancer Res 2003; 1: 393-401.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 393-401
-
-
Long, I.S.1
Han, K.2
Li, M.3
-
37
-
-
84856717005
-
Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer
-
Montagut C, Dalmases A, Bellosillo B, et al. Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer. Nat Med 2012; 22; 18: 221-3.
-
(2012)
Nat Med
, vol.22
, Issue.18
, pp. 221-223
-
-
Montagut, C.1
Dalmases, A.2
Bellosillo, B.3
-
38
-
-
80052818921
-
State of the art and future perspectives for the use of insulin-like growth factor receptor 1 (IGF-1R) targeted treatment strategies in solid tumors
-
Scartozzi M, Bianconi M, Maccaroni E, et al. State of the art and future perspectives for the use of insulin-like growth factor receptor 1 (IGF-1R) targeted treatment strategies in solid tumors. Discov Med 2011; 11: 144-53.
-
(2011)
Discov Med
, vol.11
, pp. 144-153
-
-
Scartozzi, M.1
Bianconi, M.2
Maccaroni, E.3
-
39
-
-
77953193972
-
Dalotuzumab, a recombinant humanized mAb targeted against IGFR1 for the treatment of cancer
-
Scartozzi M, Bianconi M, Maccaroni E, et al. Dalotuzumab, a recombinant humanized mAb targeted against IGFR1 for the treatment of cancer. Curr Opin Mol Ther 2010; 12: 361-71.
-
(2010)
Curr Opin Mol Ther
, vol.12
, pp. 361-371
-
-
Scartozzi, M.1
Bianconi, M.2
Maccaroni, E.3
|