Annexin V-induced rat Leydig cell proliferation involves Ect2 via RhoA/ROCK signaling pathway

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Jing, Jun ^a   Chen, Li ^a   Fu, Hai Yan ^a   Fan, Kai ^a   Yao, Qi ^a   Ge, Yi Feng ^a   Lu, Jin Chun ^a   Yao, Bing ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMIDE; ECT2 PROTEIN, HUMAN; LIPOCORTIN 5; ONCOPROTEIN; PYRIDINE DERIVATIVE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL PROLIFERATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LEYDIG CELL TUMOR; MALE; PATHOLOGY; RAT; SIGNAL TRANSDUCTION;

AMIDES; ANIMALS; ANNEXIN A5; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEYDIG CELL TUMOR; MALE; PROTO-ONCOGENE PROTEINS; PYRIDINES; RATS; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84926344810     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09437     Document Type: Article

References (41)

1. Crompton, M. R., Moss, S. E., Crumpton, M. J. Diversity in the lipocortin/calpactin family. Cell 55, 1-3 (1988).
2. Wallner, B. P. et al. Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. Nature 320, 77-81 (1986).
3. Pepinsky, R. B. et al. Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. J Biol Chem 263, 10799-10811 (1988).
4. Iwasaki, A. et al. Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: a new lipocortin-like protein. J Biochem 102, 1261-1273 (1987).
5. Shibata, S., Sato, H., Maki, M. Calphobindins (Placental Annexins) inhibit protein kinase C. J Biochem 112, 552-556 (1992).
6. Huber, R. et al. The calcium binding sites in human annexin V by crystal structure analysis at 2. 0 A resolution. FEBS Lett 275, 15-21 (1990).
7. Gerke, V., Moss, S. E. Annexins: from structure to function. Physiol Rev 82, 331-371 (2002).
8. Kawaminami, M. et al. Association of annexin V with prolactin in the rat anterior pituitary gland. Biochem Biophys Res Commun 186, 894-898 (1992).
9. Kawaminami, M. et al. Prolactin inhibits annexin 5 expression and apoptosis in the corpus luteum of pseudopregnant rats: involvement of local gonadotropinreleasing hormone. Endocrinology 144, 3625-3631 (2003).
10. Kawaminami, M. et al. Ovariectomy enhances the expression and nuclear translocation of annexin 5 in rat anterior pituitary gonadotrophs. Mol Cell Endocrinol 141, 73-78 (1998).
11. Kawaminami, M. et al. Immunocytochemical localization of annexin 5, a calciumdependent phospholipid-binding protein, in rat endocrine organs. Cell Tissue Res 292, 85-89 (1998).
12. Kawaminami, M. et al. Gonadotropin-releasing hormone stimulates annexin 5 messenger ribonucleic acid expression in the anterior pituitary cells. Biochem Biophys Res Commun 291, 915-920 (2002).
13. Kawaminami, M. et al. Annexin 5 messenger ribonucleic acid expression in pituitary gonadotropes is induced by gonadotropin-releasing hormone (GnRH) and modulates GnRH stimulation of gonadotropin release. Neuroendocrinology 75, 2-11 (2002).
14. Spreca, A. et al. Immunocytochemical localization of annexin V (CaBP33), a Ca(21)-dependent phospholipid-and membrane-binding protein, in the rat nervous system and skeletal muscles and in the porcine heart. J Cell Physiol 152, 587-598 (1992).
15. Giambanco, I. et al. Immunohistochemical localization of annexin V (CaBP33) in rat organs. J Histochem Cytochem 39, 1189-1198 (1991).
16. Yao, B., Kawaminami, M. Stimulation of annexin A5 expression by gonadotropin releasing hormone (GnRH) in the Leydig cells of rats. J Reprod Dev 54, 259-264 (2008).
17. Ge, R. S. et al. Gene expression in rat Leydig cells during development from the progenitor to adult stage: a cluster analysis. Biol Reprod 72, 1405-15 (2005).
18. Yao, B. et al. Gonadotropin-releasing hormone positively regulates steroidogenesis via extracellular signal-regulated kinase in rat Leydig cells. Asia Journal of Andrology 13, 438-445 (2011).
19. Jing, J. et al. Differentially expressed proteins in the process of annexin 5 stimulating testosterone secretion from rat Leydig cells. ZhonghuaNan Ke Xue 18, 29-34 (2012).
20. Miki, T. et al. Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature 362, 462-465 (1993).
21. Saito, S. et al. Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains. J Cell Biochem 90, 819-836 (2003).
22. Deguchi, M. et al. Expression of survivin during liver regeneration. Biochem Biophys Res Commun 297, 59-64 (2002).
23. Sakata, H. et al. ARho-specific exchange factor Ect2 is induced from S toMphases in regenerating mouse liver. Hepatology 32, 193-9 (2000).
24. Tatsumoto, T. et al. Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J Cell Biol 147, 921-928 (1999).
25. Salhia, B. et al. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol 173, 1828-38 (2008).
26. Petronczki, M. et al. Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell 12, 713-725 (2007).
27. Kimura, K. et al. Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J Biol Chem 275, 17233-17236 (2000).
28. Kim, J. E. et al. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem 280, 5733-5739 (2005).
29. Priya, R., Yap, A. S., Gomez, G. A. E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens. Differentiation 86, 133-40 (2013).
30. Matthews, H. K. et al. Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Dev Cell 23, 371-83 (2012).
31. Frenette, P. et al. An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis. PLoS One 7, e34888 (2012).
32. Cook, D. R. et al. The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration. Genes Cancer 2, 932-42 (2011).
33. Gao, Y. et al. Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Dev Cell 22, 573-84 (2012).
34. Loria, A., Longhini, K. M., Glotzer, M. The RhoGAP domain of CYK-4 has an essential role in RhoA activation. Curr Biol 22, 213-9 (2012).
35. Su, K. C., Takaki, T., Petronczki, M. Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis. Dev Cell 21, 1104-15 (2011).
36. Elbaz, J. et al. Epithelial cell transforming protein 2 (ECT2) depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles. Endocrinology 151, 755-65 (2010).
37. Morin, P., Flors, C., Olson, M. F. Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis. Eur J Cell Biol 88, 495-507 (2009).
38. Huff, L. P. et al. The role of Ect2 nuclear RhoGEF sctivity in ovarian cancer cell transformation. Genes Cancer 4, 460-75 (2013).
39. Tao, X. Q. et al. Expression of rat annexin 5 and its effect on human sperm motility in vitro. Zhonghua Nan Ke Xue 16, 400-4 (2010).
40. Svechnikov, K., Sultana, T., Soder, O. Age-dependent stimulation of Leydig cell steroidogenesis by interleukin-1 isoforms. Mol Cell Endocrinol 182, 193-201 (2001).
41. Payne, A. H., Downing, J. R., Wong, K. L. Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 106, 1424-1429 (1980).