Microfluidics and Nanotechnology for Detection of Global Infectious Diseases

Proceedings of the IEEE

Volumn 103, Issue 2, 2015, Pages 150-160

  Damhorst, Gregory L ^a   Murtagh, Maurine ^b   Rodriguez, William R ^c   Bashir, Rashid ^a  

^a University of Illinois at Urbana Champaign   (United States)

^b Murtagh Group LLC   (United States)

^c Daktari Diagnostics   (United States)

Author keywords

Biosensors; diagnostics; global health; HIV AIDS; infectious diseases; malaria; microfluidics; nanotechnology; point of care; tuberculosis

Indexed keywords

BIOSENSORS; DIAGNOSIS; MICROFLUIDICS; NANOTECHNOLOGY; PLASMA DIAGNOSTICS; VIRUSES;

GLOBAL HEALTH; HIV/AIDS; INFECTIOUS DISEASE; MALARIA; POINT OF CARE; TUBERCULOSIS;

DISEASES;

EID: 84926344779     PISSN: 00189219     EISSN: 15582256     Source Type: Journal    
DOI: 10.1109/JPROC.2014.2385078     Document Type: Review

References (58)

1. United Nations, "The millennium development goals report 2014," New York, NY, USA, 2014.
2. W. H. Organization, "Global tuberculosis report 2013," Geneva, Switzerland, 2013.
3. World Health Organization, "World health statistics 2014," 2014.
4. World Health Organization, "Roll back Malaria partnership: A decade of partnership and results," Geneva, Switzerland, 2011.
5. A. N. Abou Tayoun, P. R. Burchard, I. Malik, A. Scherer, and G. J. Tsongalis, "Democratizing molecular diagnostics for the developing world," Amer. J. Clin. Pathol., vol. 141, no. 1, pp. 17-24, Jan. 2014.
6. RAND Corporation, "Estimating the global health impact of improved diagnostic tools for the developing world," 2007.
7. C. F. Rowley, "Developments in CD4 and viral load monitoring in resource-limited settings," Clin. Infect. Dis., vol. 58, no. 3, pp. 407-412, Mar. 2014.
8. World Health Organization, "Malaria World Report 2013," World Health Organization, Aug. 2013.
9. World Health Organization, "Global health observatory (GHO): HIV/AIDS," 2012. [Online]. Available: http://www.who.int/gho/hiv/en/
10. W. H. Organization, "Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and Rifampicin resistance: Xpert MTB/RIF," 2011.
11. K. Dheda, M. Ruhwald, G. Theron, J. Peter, and W. C. Yam, "Point-of-care diagnosis of tuberculosis: Past, present and future," Respirology, vol. 18, no. 2, pp. 217-232, Mar. 2013.
12. World Health Organization, "TB diagnostics and laboratory strengthening," 2014, [Accessed: 22-Feb-2015]. [Online]. Available: http://who.int/tb/laboratory/mtbrifrollout/en/
13. Foundation for Innovative New Diagnostics, "Price for Xpert MTB/RIF and FIND country list," 2013, [Accessed: 08-Dec-2014]. [Online]. Available: http://www.finddiagnostics.org/about/what-we-do/successes/find-negotiated-prices/xpert-mtb-rif.html
14. C. Toumazou, L. M. Shepherd, S. C. Reed, G. I. Chen, A. Patel, D. M. Garner, C.-J. Wang, C.-P. Ou, K. Amin-Desai, P. Athanasiou, H. Bai, I. M. Q. Brizido, B. Caldwell, D. Coomber-Alford, P. Georgiou, K. S. Jordan, J. C. Joyce, M. La Mura, D. Morley, S. Sathyavruthan, S. Temelso, R. E. Thomas, and L. Zhang, "Simultaneous DNA amplification and detection using a pH-sensing semiconductor system," Nat. Methods, vol. 11, pp. 1-8, Jun. 2013.
15. M. T. Glynn, D. J. Kinahan, and J. Ducré, "CD4 counting technologies for HIV therapy monitoring in resource-poor settings - State-of-the-art and emerging microtechnologies," Lab Chip, vol. 13, no. 14, pp. 2731-2748, Jul. 2013.
16. J. Davis, D. W. Inglis, K. J. Morton, D. Lawrence, L. R. Huang, S. Y. Chou, J. C. Sturm, and R. H. Austin, "Deterministic hydrodynamics: Taking blood apart," PNAS, vol. 103, no. 40, pp. 14779-14784, Oct. 2006.
17. S. Nagrath, L. V Sequist, S. Maheswaran, D. W. Bell, D. Irimia, L. Ulkus, M. R. Smith, E. L. Kwak, S. Digumarthy, A. Muzikansky, P. Ryan, U. J. Balis, R. G. Tompkins, D. Haber, and M. Toner, "Isolation of rare circulating tumour cells in cancer patients by microchip technology," Nature, vol. 450, no. 7173, pp. 1235-1239, Dec. 2007.
18. C. Liu, M. Mauk, R. Gross, F. D. Bushman, P. H. Edelstein, R. G. Collman, and H. H. Bau, "Membrane-based, sedimentation-assisted plasma separator for point-of-care applications," Anal. Chem., vol. 85, no. 21, pp. 10463-10470, Nov. 2013.
19. Z. T. F. Yu, K. M. Aw Yong, and J. Fu, "Microfluidic blood cell sorting: Now and beyond," Small, vol. 10, no. 9, pp. 1687-1703, May 2014.
20. W. Tian and E. Finehout, "Microfluidic diagnostic systems for the rapid detection and quantification of pathogens," Microfluid. Biol. Appl., pp. 1-52, 2009.
21. L. Lafleur, D. Stevens, K. McKenzie, S. Ramachandran, P. Spicar-Mihalic, M. Singhal, A. Arjyal, J. Osborn, P. Kauffman, P. Yager, and B. Lutz, "Progress toward multiplexed sample-to-result detection in low resource settings using microfluidic immunoassay cards," Lab Chip, vol. 12, no. 6, pp. 1119-1127, Mar. 2012.
22. N. Watkins, B. M. Venkatesan, M. Toner, W. Rodriguez, and R. Bashir, "A robust electrical microcytometer with 3-dimensional hydrofocusing," Lab Chip, vol. 9, no. 22, pp. 3177-3184, Nov. 2009.
23. S. Yang, A. Undar, and J. D. Zahn, "A microfluidic device for continuous, real time blood plasma separation," Lab Chip, vol. 6, no. 7, pp. 871-880, Jul. 2006.
24. E. Ozkumur, A. M. Shah, J. C. Ciciliano, B. L. Emmink, D. T. Miyamoto, E. Brachtel, M. Yu, P. Chen, B. Morgan, J. Trautwein, A. Kimura, S. Sengupta, S. L. Stott, N. M. Karabacak, T. a Barber, J. R. Walsh, K. Smith, P. S. Spuhler, J. P. Sullivan, R. J. Lee, D. T. Ting, X. Luo, A. T. Shaw, A. Bardia, L. Sequist, D. N. Louis, S. Maheswaran, R. Kapur, D. a Haber, and M. Toner, "Inertial focusing for tumor antigen-dependent and-independent sorting of rare circulating tumor cells," Sci. Transl. Med., vol. 5, no. 179, p. 179ra47, Apr. 2013.
25. P. Sethu, L. L. Moldawer, M. N. Mindrinos, P. O. Scumpia, C. L. Tannahill, J. Wilhelmy, P. Efron, B. H. Brownstein, R. G. Tompkins, and M. Toner, "Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis," Anal. Chem., vol. 78, no. 15, pp. 5453-5461, Aug. 2006.
26. N. N. Watkins, U. Hassan, G. Damhorst, H. Ni, A. Vaid, W. Rodriguez, and R. Bashir, "Microfluidic CD4+ and CD8+ T Lymphocyte Counters for Point-of-Care HIV Diagnostics Using Whole Blood," Sci. Transl. Med., vol. 5, no. 214, p. 214ra170, Dec. 2013.
27. P. Sethu, M. Anahtar, L. L. Moldawer, R. G. Tompkins, and M. Toner, "Continuous flow microfluidic device for rapid erythrocyte analysis," Anal. Chem., vol. 76, no. 21, pp. 6247-6253, Nov. 2004.
28. X. Cheng, Y. Liu, D. Irimia, U. Demirci, L. Yang, L. Zamir, W. R. Rodríguez, M. Toner, and R. Bashir, "Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices," Lab Chip, vol. 7, no. 6, pp. 746-755, Jun. 2007.
29. N. N. Watkins, S. Sridhar, X. Cheng, G. D. Chen, M. Toner, W. Rodriguez, and R. Bashir, "A microfabricated electrical differential counter for the selective enumeration of CD4+ T lymphocytes," Lab Chip, vol. 11, no. 8, pp. 1437-1447, Apr. 2011.
30. S. Wang, M. Esfahani, U. Gurkan, F. Inci, D. R. Kuritzkes, and U. Demirci, "Efficient on-chip isolation of HIV subtypes," Lab Chip, vol. 12, no. 8, pp. 1508-1515, Mar. 2012.
31. G. Chen, C. J. Alberts, W. Rodriguez, and M. Toner, "Concentration and purification of human immunodeficiency virus type 1 virions by microfluidic separation of superparamagnetic nanoparticles," Anal. Chem., vol. 82, no. 2, pp. 723-728, Jan. 2010.
32. E. Kim, J. Stanton, and B. Korber, "Detection of HIV-1 p24 Gag in plasma by a nanoparticle-based bio-barcode-amplification method," Nanomedicine, vol. 3, no. 3, 2008.
33. M. Liong, A. N. Hoang, J. Chung, N. Gural, C. B. Ford, C. Min, R. R. Shah, R. Ahmad, M. Fernandez-Suarez, S. M. Fortune, M. Toner, H. Lee, and R. Weissleder, "Magnetic barcode assay for genetic detection of pathogens," Nat. Commun., vol. 4, p. 1752, Jan. 2013.
34. P. Gascoyne, C. Mahidol, M. Ruchirawat, J. Satayavivad, P. Watcharasit, and F. F. Becker, "Microsample preparation by dielectrophoresis: Isolation of malaria," Lab Chip, vol. 2, no. 2, pp. 70-75, May 2002.
35. K.-H. Han and A. Bruno Frazier, "Continuous magnetophoretic separation of blood cells in microdevice format," J. Appl. Phys., vol. 96, no. 10, p. 5797, 2004.
36. B. Kuswandi, N. J. Huskens, and W. Verboom, "Optical sensing systems for microfluidic devices: A review," Anal. Chim. Acta, vol. 601, no. 2, pp. 141-155, Oct. 2007.
37. W. H. Organization, Fluorescent light-emitting diode (LED) microscopy for diagnosis of tuberculosis: Policy statement," 2011.
38. J.-H. Kim, W.-H. Yeo, Z. Shu, S. D. Soelberg, S. Inoue, D. Kalyanasundaram, J. Ludwig, C. E. Furlong, J. J. Riley, K. M. Weigel, G. Cangelosi, K. Oh, K.-H. Lee, D. Gao, and J.-H. Chung, "Immunosensor towards low-cost, rapid diagnosis of tuberculosis," Lab Chip, vol. 12, no. 8, pp. 1437-1440, Apr. 2012.
39. E. Liandris, M. Gazouli, M. Andreadou, L. a Sechi, V. Rosu, and J. Ikonomopoulos, "Detection of pathogenic mycobacteria based on functionalized quantum dots coupled with immunomagnetic separation," PLoS One, vol. 6, no. 5, p. e20026, Jan. 2011.
40. F. Shen, B. Sun, J. E. Kreutz, E. K. Davydova, W. Du, P. L. Reddy, L. J. Joseph, and R. F. Ismagilov, "Multiplexed quantification of nucleic acids with large dynamic range using multivolume digital RT-PCR on a rotational SlipChip tested with HIV and hepatitis C viral load," J. Amer. Chem. Soc., vol. 133, no. 44, pp. 17705-17712, Nov. 2011.
41. P. V Baptista, M. Koziol-Montewka, J. Paluch-Oles, G. Doria, and R. Franco, "Gold-nanoparticle-probe-based assay for rapid and direct detection of Mycobacterium tuberculosis DNA in clinical samples," Clin. Chem., vol. 52, no. 7, pp. 1433-1434, Jul. 2006.
42. L. B. Silva, B. Veigas, G. Doria, P. Costa, J. Inácio, R. Martins, E. Fortunato, and P. V Baptista, "Portable optoelectronic biosensing platform for identification of mycobacteria from the Mycobacterium tuberculosis complex," Biosens. Bioelectron., vol. 26, no. 5, pp. 2012-2017, Jan. 2011.
43. B. Veigas, J. M. Jacob, M. N. Costa, D. S. Santos, M. Viveiros, J. Inácio, R. Martins, P. Barquinha, E. Fortunato, and P. V. Baptista, "Gold on paper-paper platform for Au-nanoprobe TB detection," Lab Chip, vol. 12, no. 22, pp. 4802-4808, Nov. 2012.
44. S. Wang, S. Tasoglu, P. Z. Chen, M. Chen, R. Akbas, S. Wach, C. I. Ozdemir, U. A. Gurkan, F. F. Giguel, D. R. Kuritzkes, and U. Demirci, "Micro-a-fluidics ELISA for rapid CD4 cell count at the point-of-care," Sci. Rep., vol. 4, p. 3796, Jan. 2014.
45. Z. Gorocs and A. Ozcan, "On-chip biomedical imaging," IEEE Rev. Biomed. Eng., pp. 29-46, 2013.
46. S. Moon, H. O. Keles, A. Ozcan, A. Khademhosseini, E. Haeggstrom, D. Kuritzkes, and U. Demirci, "Integrating microfluidics and lensless imaging for point-of-care testing," Biosens. Bioelectron., vol. 24, no. 11, pp. 3208-3214, Jul. 2009.
47. F. Inci, O. Tokel, S. Wang, U. A. Gurkan, S. Tasoglu, D. R. Kuritzkes, and U. Demirci, "Nanoplasmonic quantitative detection of intact viruses from unprocessed whole blood," ACS Nano, May 2013.
48. H. Shafiee, E. Lidstone, M. Jahangir, F. Inci, E. Hanhauser, T. J. Henrich, D. R. Kuritzkes, B. T. Cunningham, and U. Demirci, "Nanostructured optical photonic crystal biosensor for HIV viral load measurement," Sci. Rep., vol. 4, p. 4116, Jan. 2014.
49. D. Holmes, D. Pettigrew, C. H. C. H. Reccius, J. D. Gwyer, C. van Berkel, J. Holloway, D. E. Davies, H. Morgan, C. Van Berkel, and D. Morganti, "Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry," Lab Chip, vol. 9, no. 20, pp. 2881-2889, Oct. 2009.
50. E. Du, S. Ha, M. Diez-Silva, M. Dao, S. Suresh, and A. P. Chandrakasan, "Electric impedance microflow cytometry for characterization of cell disease states," Lab Chip, vol. 13, no. 19, pp. 3903-3909, Oct. 2013.
51. S. Ha, M. Diez-Silva, E. Du, S. Kim, and J. Han, "Microfluidic electric impedance spectroscopy for malaria diagnosis," Miniaturized Syst. Chem. Life Sci., pp. 1960-1962, 2012.
52. Y. Liu, T. Kwa, and A. Revzin, "Simultaneous detection of cell-secreted TNF-α and IFN-γ using micropatterned aptamer-modified electrodes," Biomaterials, vol. 33, no. 30, pp. 7347-7355, Oct. 2012.
53. Y. Liu, N. Tuleouva, E. Ramanculov, and A. Revzin, "Aptamer-based electrochemical biosensor for interferon gamma detection," Anal. Chem., vol. 82, no. 19, pp. 8131-8136, Oct. 2010.
54. M. De Souza Castilho and T. Laube, "Magneto immunoassays for Plasmodium falciparum histidine-rich protein 2 related to malaria based on magnetic nanoparticles," Anal. Chem., pp. 5570-5577, 2011.
55. M. K. Sharma, V. K. Rao, S. Merwyn, G. S. Agarwal, S. Upadhyay, and R. Vijayaraghavan, "A novel piezoelectric immunosensor for the detection of malarial Plasmodium falciparum histidine rich protein-2 antigen," Talanta, vol. 85, no. 4, pp. 1812-1817, Sep. 2011.
56. Q. Guo, S. J. Reiling, P. Rohrbach, and H. Ma, "Microfluidic biomechanical assay for red blood cells parasitized by Plasmodium falciparum," Lab Chip, Feb. 2012.
57. D. Gao, H. Liu, Y. Jiang, and J.-M. Lin, "Recent advances in microfluidics combined with mass spectrometry: Technologies and applications," Lab Chip, vol. 13, no. 17, pp. 3309-3322, Sep. 2013.
58. World Health Organization, "Global health observatory data repository," 2013. [Online]. Available: http://apps.who.int/gho/data/