Variations in the Binding Pocket of an Inhibitor of the Bacterial Division Protein FtsZ across Genotypes and Species

PLoS Computational Biology

Volumn 11, Issue 3, 2015, Pages

  Miguel, Amanda ^a   Hsin, Jen ^a   Liu, Tianyun ^a   Tang, Grace ^a   Altman, Russ B ^a   Huang, Kerwyn Casey ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BINDING SITES; CELL PROLIFERATION; DIMERS; NUCLEOTIDES; POLYMERIZATION; PROTEINS;

ANTIBIOTICS RESISTANCE; BACTERIAL SPECIES; BINDING POCKETS; BINDING-SITES; DRUG TARGETS; DYNAMICS SIMULATION; MICROENVIRONMENTS; NEW APPROACHES; PATHOGENIC BACTERIUM; TARGETS SELECTION;

MOLECULAR DYNAMICS;

ANTIINFECTIVE AGENT; FTSZ PROTEIN; NUCLEOTIDE; PC 190723; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CYTOSKELETON PROTEIN; FTSZ PROTEIN, BACTERIA; PC190723; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ALGORITHM; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG MECHANISM; GENOTYPE; HYDROLYSIS; MITOSIS INHIBITION; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN POLYMERIZATION; SPECIES DIFFERENCE; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECT; GENETICS; METABOLISM;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; BINDING SITES; CYTOSKELETAL PROTEINS; DRUG RESISTANCE, BACTERIAL; MOLECULAR DYNAMICS SIMULATION; PYRIDINES; STAPHYLOCOCCUS AUREUS; THIAZOLES;

EID: 84926335263     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004117     Document Type: Article

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