Instant preparation of a biodegradable injectable polymer formulation exhibiting a temperature-responsive sol-gel transition

Polymer Journal

Volumn 46, Issue 9, 2014, Pages 632-635

  Yoshida, Yasuyuki ^a   Takahashi, Akihiro ^a   Kuzuya, Akinori ^a   Ohya, Yuichi ^a  

^a KANSAI UNIVERSITY   (Japan)

Author keywords

Biodegradable polymer; Injectable polymer; Temperature responsive sol gel transition

Indexed keywords

EID: 84926334880     PISSN: 00323896     EISSN: 13490540     Source Type: Journal    
DOI: 10.1038/pj.2014.30     Document Type: Note

References (20)

1. Park, M. H., Joo, M. K., Choi, B. G. & Jeong, B. Biodegradable thermogels. Acc. Chem. Res. 45, 424-433 (2012).
2. Moon, H. J., Ko, D. Y., Park, M. H., Joo, M. K. & Jeong, B. Temperature-responsive compounds as in situ gelling biomedical materials. Chem. Soc. Rev. 41, 4860-4883 (2012).
3. Nagahama, K., Takahashi, A. & Ohya, Y. Biodegradable polymers exhibiting temperature-responsive sol-gel transition as injectable biomedical materials. React. Funct. Polym. 73, 979-985 (2013).
4. Yu, L. & Ding, J. Injectable hydrogels as unique biomedical materials. Chem. Soc. Rev. 37, 1473-1481 (2008).
5. Jeong, B., Bae, Y. H., Lee, D. S. & Kim, S. W. Biodegradable block copolymers as injectable drug-delivery systems. Nature 388, 860-862 (1997).
6. Fujiwara, T., Mukose, T., Yamaoka, T., Yamane, H., Sakurai, S. & Kimura, Y. Novel thermo-responsive formation of a hydrogel by stereo-complexation between PLLA-PEG-PLLA and PDLA-PEG-PDLA block copolymers. Macromol. Biosci. 1, 204-208 (2001).
7. Jeong, B., Bae, Y. H. & Kim, S. W. Thermoreversible gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions. Macromolecules 32, 7064-7069 (1999).
8. Hwang, M. J., Suh, J. M., Bae, Y. H., Kim, S. W. & Jeong, B. Caprolactonic poloxamer analog: PEG-PCL-PEG. Biomacromolecules 6, 885-890 (2005).
9. Lee, D. S., Shim, M. S., Kim, S. W., Lee, H., Park, I. & Chang, T. Novel thermoreversible gelation of biodegradable PLGA-block-PEO-block-PLGA triblock copolymers in aqueous solution. Macromol. Rapid Commun. 22, 587-592 (2001).
10. Nagahama, K., Ouchi, T. & Ohya, Y. Temperature-induced hydrogels through selfassembly of cholesterol-substituted star PEG-b-PLLA copolymers: an injectable scaffold for tissue engineering. Adv. Funct. Mater. 18, 1220-1231 (2008).
11. Nagahama, K., Imai, Y., Nakayama, T., Ohumura, J., Ouchi, T. & Ohya, Y. Thermosensitive sol-gel transition of poly(depsipeptide-co-lactide)-g-PEG copolymers in aqueous solution. Polymer (Guildf). 50, 3547-3555 (2009).
12. Bae, S. J., Suh, J. M., Sohn, Y. S., Bae, Y. H., Kim, S. W. & Jeong, B. Thermogelling poly(caprolactone-b-ethylene glycol-b-caprolactone) aqueous solutions. Macromolecules 38, 5260-5265 (2005).
13. Yu, L., Sheng, W., Yang, D. & Ding, J. Design of molecular parameters to achieved block copolymers with a powder form at dry state and a temperature-induced sol-gel transition in water without unexpected gelling prior to heating. Macromol. Res. 21, 207-215 (2013).
14. Jiang, Z., You, Y., Gu, Q., Hao, J. & Deng, X. Effect of microstructures on the phase transition behavior of P(CL-GL)-PEG-P(CL-GL) triblock copolymer aqueous solutions. Macromol. Rapid Commun. 29, 1264-1268 (2008).
15. Jiang, Z., You, Y., Deng, X. & Hao, J. Injectable hydrogels of poly(e-caprolactone-co-glycolide)-poly(ethylene glycol)-poly(e-caprolactone-co-glycolide) triblock copolymer aqueous solutions. Polymer (Guildf). 48, 4786-4792 (2007).
16. Dobrzynski, P., Li, S., Kasperczyk, J., Bero, M., Gasc, F. & Vert, M. Structure-property relationships of copolymers obtained by ring-opening polymerization of glycolide and ε-caprolactone. Part 1. Synthesis and characterization. Biomacromolecules 6, 483-488 (2005).
17. Pack, J. W., Kim, S. H., Cho, I.-W., Park, S. Y. & Kim, Y. H. Microstructure analysis and thermal property of copolymers made of glycolide and e-caprolactone by stannous octoate. J. Polym. Sci. A Polym. Chem. 40, 544-554 (2002).
18. Kwoka, K. Y., Adamia, R. C., Hestera, K. C., Parkb, Y., Thomasa, S. & Rice, K. G. Strategies for maintaining the particle size of peptide DNA condensates following freeze-drying. Int. J. Pharm. 203, 31-88 (2000).
19. Jeong, B., Bae, Y. H. & Kim, S. W. Thermoreversible gelation PEG-PLGA-PEG triblock copolymer aqueous solution. Macromolecules 32, 7064-7069 (1999).
20. Zhang, H., Yu, L. & Ding, J. Roles of hydrophilic homopolymers on the hydrophobic-association-induced physical gelling of amphiphilic block copolymers in water. Macromolecules 41, 6493-6499 (2008).