TLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis

Scientific Reports

Volumn 4, Issue , 2015, Pages

  Yin, Chaoran ^a   Zhang, Ting ^a   Qiao, Liangjun ^a   Du, Jia ^b   Li, Shuang ^b   Zhao, Hengguang ^b   Wang, Fangfang ^a   Huang, Qiaorong ^a   Meng, Wentong ^a   Zhu, Hongyan ^a   Bu, Hong ^a   Li, Hui ^b   Xu, Hong ^a   Mo, Xianming ^a  

^a SICHUAN UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOQUINOLINE DERIVATIVE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; IMIQUIMOD; TOLL LIKE RECEPTOR 7;

AGONISTS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECTS; EPIDERMIS; GENETICS; HAIR FOLLICLE; KERATINOCYTE; METABOLISM; MOUSE; PATHOLOGY; REGENERATION; SKIN; STEM CELL; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; TRANSGENIC MOUSE; TRANSPLANTATION;

AMINOQUINOLINES; ANIMALS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; EPIDERMIS; GREEN FLUORESCENT PROTEINS; HAIR FOLLICLE; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REGENERATION; SKIN; STEM CELL TRANSPLANTATION; STEM CELLS; TISSUE ENGINEERING; TOLL-LIKE RECEPTOR 7;

EID: 84926313417     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05831     Document Type: Article

References (36)

1. Blanpain, C. & Fuchs, E. Epidermal stem cells of the skin. Annu Rev Cell Dev Biol 22, 339-373 (2006).
2. Blanpain, C. & Fuchs, E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol 10, 207-217 (2009).
3. Tani, H., Morris, R. J. & Kaur, P. Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci U S A 97, 10960-10965 (2000).
4. Trempus, C. S. et al. Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 120, 501-511 (2003).
5. Hemmi, H. et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3, 196-200 (2002).
6. Ermertcan, A. T., Ozturk, F. & Gunduz, K. Toll-like receptors and skin. J Eur Acad Dermatol Venereol 25, 997-1006 (2011).
7. Garantziotis, S., Hollingsworth, J.W., Zaas, A. K. & Schwartz, D. A. The effect of toll-like receptors and toll-like receptor genetics in human disease. Annu Rev Med 59, 343-359 (2008).
8. Hari, A., Flach, T. L., Shi, Y. & Mydlarski, P. R. Toll-like receptors: role in dermatological disease. Mediators Inflamm 2010, 437246 (2010).
9. Saitoh, S. & Miyake, K. Regulatory molecules required for nucleotide-sensing Toll-like receptors. Immunol Rev 227, 32-43 (2009).
10. Lee, J. et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A 103, 1828-1833 (2006).
11. Spaner, D. E. &Masellis, A. Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia. Leukemia 21, 53-60 (2007).
12. Barrat, F. J. et al.Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors andmay promote systemic lupus erythematosus. J Exp Med 202, 1131-1139 (2005).
13. Letada, P. R., Sparling, J. D. & Norwood, C. Imiquimod in the treatment of alopecia universalis. Cutis 79, 138-140 (2007).
14. Zhang, Y. et al. Nuclear factor kappa B signaling initiates early differentiation of neural stem cells. Stem Cells 30, 510-524 (2012).
15. Jensen, K. B., Driskell, R. R. & Watt, F. M. Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat Protoc 5, 898-911 (2010).
16. Pawar, R. D. et al. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 18, 1721-1731 (2007).
17. Smits, E. L., Ponsaerts, P., Berneman, Z.N.&Van Tendeloo, V. F. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy. Oncologist 13, 859-875 (2008).
18. Panteleyev, A. A. et al. Keratin 17 gene expression during the murine hair cycle. J Invest Dermatol 108, 324-329 (1997).
19. Jones, P. H. &Watt, F. M. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73, 713-724 (1993).
20. Carlson, M. W., Alt-Holland, A., Egles, C. & Garlick, J. A. Three-dimensional tissue models of normal and diseased skin. Curr Protoc Cell Biol Chapter 19, Unit 19 19 (2008).
21. Gangatirkar, P., Paquet-Fifield, S., Li, A., Rossi, R. & Kaur, P. Establishment of 3D organotypic cultures using human neonatal epidermal cells. Nat Protoc 2, 178-186 (2007).
22. Kordon, E. C. & Smith, G. H. An entire functional mammary glandmay comprise the progeny from a single cell. Development 125, 1921-1930 (1998).
23. Schneider, T. E. et al.Measuring stem cell frequency in epidermis: a quantitative in vivo functional assay for long-term repopulating cells. Proc Natl Acad Sci U S A 100, 11412-11417 (2003).
24. Snippert, H. J. et al. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327, 1385-1389 (2010).
25. Jensen, K. B. et al. Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell 4, 427-439 (2009).
26. Schon, M. P. & Schon, M. Imiquimod:mode of action. Br J Dermatol 157 Suppl 2, 8-13 (2007).
27. Mashiah, J. & Brenner, S. Possible mechanisms in the induction of pemphigus foliaceus by topical imiquimod treatment. Arch Dermatol 141, 908-909; author reply 909 (2005).
28. Al-Dujaili, Z. & Hsu, S. Imiquimod-induced vitiligo. Dermatol Online J 13, 10 (2007).
29. Gilliet, M. et al. Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch Dermatol 140, 1490-1495 (2004).
30. Pawar, R. D. et al. Toll-like receptor-7 modulates immune complex glomerulonephritis. J Am Soc Nephrol 17, 141-149 (2006).
31. Aaronson, D. S. & Horvath, C. M. A road map for those who don't know JAKSTAT. Science 296, 1653-1655 (2002).
32. Darnell, J. E., Jr. STATs and gene regulation. Science 277, 1630-1635 (1997).
33. Darnell, J. E., Jr., Kerr, I. M. & Stark, G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994).
34. Platanias, L. C. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 5, 375-386 (2005).
35. Varinou, L. et al. Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. Immunity 19, 793-802 (2003).
36. Jin, L. & Wang, G. Keratin 17: A Critical Player in the Pathogenesis of Psoriasis. Med Res Rev 34, 438-454 (2013).