Clinical implications of systemic inflammatory response markers as independent prognostic factors for advanced pancreatic cancer

Pancreatology

Volumn 15, Issue 2, 2015, Pages 145-150

  Qi, Q ^a,b   Geng, Y ^a,b   Sun, M ^a   Wang, P ^a,b   Chen, Z ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

LMR; NLR; Pancreatic cancer; PLR; Prognosis; Systemic inflammatory response

Indexed keywords

GEMCITABINE; BIOLOGICAL MARKER;

ADULT; ADVANCED CANCER; ARTICLE; BLOOD CELL RATIO; CANCER CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER PROGNOSIS; CANCER STAGING; CLINICAL FEATURE; DESCRIPTIVE RESEARCH; DISEASE MARKER; FEMALE; HUMAN; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; LYMPHOCYTE MONOCYTE RATIO; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NEUTROPHIL COUNT; NEUTROPHIL LYMPHOCYTE RATIO; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PLATELET LYMPHOCYTE RATIO; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SYSTEMIC INFLAMMATORY RESPONSE MARKER; THROMBOCYTE COUNT; ADENOCARCINOMA; AGED; DISEASE COURSE; KAPLAN MEIER METHOD; MIDDLE AGED; MULTIVARIATE ANALYSIS; PANCREATIC NEOPLASMS; PREDICTIVE VALUE; PROGNOSIS; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADENOCARCINOMA; AGED; BIOMARKERS; DISEASE PROGRESSION; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LEUKOCYTE COUNT; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PANCREATIC NEOPLASMS; PLATELET COUNT; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 84926249193     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2014.12.004     Document Type: Article

References (27)

1. R. Siegel, J. Ma, Z. Zou, and A. Jemal Cancer statistics CA Cancer J Clin 64 2014 9 29
2. D. Li, K. Xie, R. Wolff, and J.L. Abbruzzese Pancreatic cancer Lancet 363 2004 1049 1057
3. H.A. Burris 3rd, M.J. Moore, J. Andersen, M.R. Green, M.L. Rothenberg, and M.R. Modiano Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 1997 2403 2413
4. P. Wang, L. Zhuang, J. Zhang, J. Fan, J. Luo, and H. Chen The serum mir-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and mir-21 expression confers chemoresistance by targeting FasL Mol Oncol 7 2013 334 345
5. P. Wang, J. Fan, Z. Chen, Z.Q. Meng, J.M. Luo, and J.H. Lin Low-level expression of smad7 correlates with lymph node metastasis and poor prognosis in patients with pancreatic cancer Ann Surg Oncol 16 2009 826 835
6. M. Stotz, A. Gerger, F. Eisner, J. Szkandera, H. Loibner, and A.L. Ress Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer Br J Cancer 109 2013 416 421
7. J. Szkandera, G. Absenger, B. Liegl-Atzwanger, M. Pichler, M. Stotz, and H. Samonigg Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients Br J Cancer 108 2013 1677 1683
8. J. Szkandera, A. Gerger, B. Liegl-Atzwanger, G. Absenger, M. Stotz, and H. Samonigg Validation of the prognostic relevance of plasma c-reactive protein levels in soft-tissue sarcoma patients Br J Cancer 109 2013 2316 2322
9. J. Szkandera, A. Gerger, B. Liegl-Atzwanger, G. Absenger, M. Stotz, and J. Friesenbichler The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas Int J Cancer 2014
10. H.J. Son, J.W. Park, H.J. Chang, D.Y. Kim, B.C. Kim, and S.Y. Kim Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer Ann Surg Oncol 20 2013 2908 2913
11. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill Cancer-related inflammation Nature 454 2008 436 444
12. I. Gukovsky, N. Li, J. Todoric, A. Gukovskaya, and M. Karin Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer Gastroenterology 144 2014 1199-209 e4
13. J. Szkandera, M. Stotz, F. Eisner, G. Absenger, T. Stojakovic, and H. Samonigg External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients PLoS One 8 2013 e78225
14. P. Sanjay, R.S. de Figueiredo, H. Leaver, S. Ogston, C. Kulli, and F.M. Polignano Preoperative serum c-reactive protein levels and post-operative lymph node ratio are important predictors of survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma JOP 13 2012 199 204
15. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
16. A. Mantovani Cancer: inflaming metastasis Nature 457 2009 36 37
17. A. Mantovani, B. Bottazzi, F. Colotta, S. Sozzani, and L. Ruco The origin and function of tumor-associated macrophages Immunol Today 13 1992 265 270
18. S.K. Bunt, L. Yang, P. Sinha, V.K. Clements, J. Leips, and S. Ostrand-Rosenberg Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression Cancer Res 67 2007 10019 10026
19. E.Y. Lin, A.V. Nguyen, R.G. Russell, and J.W. Pollard Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy J Exp Med 193 2001 727 740
20. M. De Palma, M.A. Venneri, R. Galli, L. Sergi Sergi, L.S. Politi, and M. Sampaolesi Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors Cancer Cell 8 2005 211 226
21. A. Sica, and V. Bronte Altered macrophage differentiation and immune dysfunction in tumor development J Clin Invest 117 2007 1155 1166
22. A. Mantovani, S. Sozzani, M. Locati, P. Allavena, and A. Sica Macrophage polarization: tumor-associated macrophages as a paradigm for polarized m2 mononuclear phagocytes Trends Immunol 23 2002 549 555
23. C. Feig, A. Gopinathan, A. Neesse, D.S. Chan, N. Cook, and D.A. Tuveson The pancreas cancer microenvironment Clin Cancer Res 18 2012 4266 4276
24. E. Tassi, F. Gavazzi, L. Albarello, V. Senyukov, R. Longhi, and P. Dellabona Carcinoembryonic antigen-specific but not antiviral cd4+ t cell immunity is impaired in pancreatic carcinoma patients J Immunol 181 2008 6595 6603
25. B. Ebrahimi, S.L. Tucker, D. Li, J.L. Abbruzzese, and R. Kurzrock Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis Cancer 101 2004 2727 2736
26. K.C. Fearon, D.J. Glass, and D.C. Guttridge Cancer cachexia: mediators, signaling, and metabolic pathways Cell Metab 16 2012 153 166
27. F. Balkwill, K.A. Charles, and A. Mantovani Smoldering and polarized inflammation in the initiation and promotion of malignant disease Cancer Cell 7 2005 211 217