Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma

Modern Pathology

Volumn 27, Issue 11, 2014, Pages 1479-1488

  Roden, Anja C ^a   García, Joaquín J ^a   Wehrs, Rebecca N ^a   Colby, Thomas V ^b   Khoor, Andras ^c   Leslie, Kevin O ^b   Chen, Longwen ^b  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

^c MAYO CLINIC   (United States)

Author keywords

MAML2 rearrangement; napsin; p40; p63; primary pulmonary mucoepidermoid carcinoma; TTF 1

Indexed keywords

NAPSIN A; PROTEIN P40; PROTEIN P63; THYROID TRANSCRIPTION FACTOR 1; TUMOR MARKER; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; DNA BINDING PROTEIN; MAML2 PROTEIN, HUMAN; NAPSA PROTEIN, HUMAN; NUCLEAR PROTEIN; TP63 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ADENOSQUAMOUS CARCINOMA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER GRADING; CANCER MORPHOLOGY; CANCER RADIOTHERAPY; CANCER SURGERY; CARCINOMA IN SITU; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE IDENTIFICATION; GENE REARRANGEMENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; KERATINIZATION; LIVER METASTASIS; LUNG ADENOCARCINOMA; MALE; MAMMALIAN MASTERMIND LIKE 2 GENE; MEDICAL HISTORY; MEDICAL RECORD REVIEW; METASTASIS POTENTIAL; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY MUCOEPIDERMOID CARCINOMA; RADIOFREQUENCY ABLATION; SQUAMOUS CELL LUNG CARCINOMA; TUMOR ABLATION; TUMOR DIFFERENTIATION; TUMOR GENE; CARCINOMA, MUCOEPIDERMOID; CHEMISTRY; GENETICS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; PATHOLOGY; PREDICTIVE VALUE; TIME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ASPARTIC ACID ENDOPEPTIDASES; CARCINOMA, MUCOEPIDERMOID; CHILD; DNA-BINDING PROTEINS; FEMALE; GENE REARRANGEMENT; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM GRADING; NUCLEAR PROTEINS; PREDICTIVE VALUE OF TESTS; TIME FACTORS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 84926214915     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2014.72     Document Type: Article

References (36)

1. Welsh JH, Maxson T, Jaksic T, et al. Tracheobronchial mucoepidermoid carcinoma in childhood and adolescence: case report and review of the literature. Int J Pediatr Otorhinolaryngol 1998;45:265-273.
2. Turnbull AD, Huvos AG, Goodner JT, et al. Mucoepi-dermoid tumors of bronchial glands. Cancer 1971; 28:539-544.
3. Brandwein MS, Ivanov K, Wallace DI, et al. Mucoepi-dermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 2001;25:835-845.
4. Molina JR, Aubry MC, Lewis JE, et al. Primary salivary gland-type lung cancer: spectrum of clinical presentation, histopathologic and prognostic factors. Cancer 2007;110:2253-2259.
5. Chenevert J, Barnes LE, Chiosea SI. Mucoepidermoid carcinoma: a five-decade journey. Virchows Arch 2011;458:133-140.
6. Camelo-Piragua SI, Habib C, Kanumuri P, et al. Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature. Hum Pathol 2009;40:887-892.
7. Garcia JJ, Hunt JL, Weinreb I, et al. Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. Hum Pathol 2011;42:2001-2009.
8. Clauditz TS, Gontarewicz A, Wang CJ, et al. 11q21 Rearrangement is a Frequent and Highly Specific Genetic Alteration in Mucoepidermoid Carcinoma. Diagn Mol Pathol 2012;21:134-137.
9. Seethala RR, Dacic S, Cieply K, et al. A reappraisal of the MECT1/MAML2 translocation in salivary mucoe-pidermoid carcinomas. Am J Surg Pathol 2010;34: 1106-1121.
10. Chiosea SI, Dacic S, Nikiforova MN, et al. Prospective testing of mucoepidermoid carcinoma for the MAML2 translocation: clinical implications. Laryngoscope 2012;122:1690-1694.
11. Achcar Rde O, Nikiforova MN, Dacic S, et al. Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. Hum Pathol 2009;40:854-860.
12. Macarenco RS, Uphoff TS, Gilmer HF, et al. Salivary gland-type lung carcinomas: an EGFR immunohistochemical, molecular genetic, and muta-tional analysis study. Mod Pathol 2008;21:1168-1175.
13. Yousem SA, Nicholson AG. Mucoepidermoid carcinoma, In: Travis WD, Brambilla E, Mueller-Hermelink HK, Harris CC(eds) Tumours of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon, France; 2004, pp 63-64.
14. Erickson-Johnson MR, Seys AR, Roth CW, et al. Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. Mod Pathol 2009;22:1541-1547.
15. Di Tommaso L, Foschini MP, Ragazzini T, et al. Mucoepidermoid carcinoma of the breast. Virchows Arch 2004;444:13-19.
16. Achcar Rde O, Nikiforova MN, Dacic S, et al. Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. Hum Pathol 2009;40:854-860.
17. Riedlinger WF, Hurley MY, Dehner LP, et al. Mucoepidermoid carcinoma of the skin: a distinct entity from adenosquamous carcinoma: a case study with a review of the literature. Am J Surg Pathol 2005;29:131-135.
18. Roden AC, Erickson-Johnson MR, Yi ES, et al. Analysis of MAML2 rearrangement in mucoepidermoid carcinoma of the thymus. Hum Pathol 2013;44: 2799-2805.
19. Zhu F, Liu Z, Hou Y, et al. Primary salivary gland-type lung cancer: clinicopathological analysis of 88 cases from china. J Thorac Oncol. 2013;8:1578-1584.
20. Chen MM, Roman SA, Sosa JA, et al. Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients. Head Neck 2014;36:158-163.
21. Travis WD, Brambilla E, Muller-Hermelink HK, et al. Pathology and genetics of tumors of the lung, pleura, thymus and heart, In: Kleihues P, Sobin LH (eds) WHO Classification of Tumors, 2nd edn. IARC Press: Lyon, France; 2004, pp 63-64.
22. Auclair PL, Goode RK, Ellis GL. Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases. Cancer 1992;69:2021-2030.
23. Bilal H, Handra-Luca A, Bertrand JC, et al. P63 is expressed in basal and myoepithelial cells of human normal and tumor salivary gland tissues. J Histochem Cytochem 2003;51:133-139.
24. Sams RN, Gnepp DR. P63 expression can be used in differential diagnosis of salivary gland acinic cell and mucoepidermoid carcinomas. Head Neck Pathol 2013;7:64-68.
25. Tonon G, Modi S, Wu L, et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 2003;33:208-213.
26. Wu L, Liu J, Gao P, et al. Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. Embo J 2005;24:2391-2402.
27. Okabe M, Miyabe S, Nagatsuka H, et al. MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res. 2006;12: 3902-3907.
28. Seethala RR, Dacic S, Cieply K, et al. A reappraisal of the MECT1/MAML2 translocation in salivary mucoepider-moid carcinomas. Am J Surg Pathol. 2010;34:1106-1121.
29. Tirado Y, Williams MD, Hanna EY, et al. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer 2007;46:708-715.
30. Whithaus K, Fukuoka J, Prihoda TJ, et al. Evaluation of napsin A, cytokeratin 5/6, p63, and thyroid transcription factor 1 in adenocarcinoma versus squamous cell carcinoma of the lung. Arch Pathol Lab Med. 2012; 136:155-162.
31. Bishop JA, Teruya-Feldstein J, Westra WH, et al. p40 (DeltaNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol. 2012;25:405-415.
32. Nonaka D. A study of DeltaNp63 expression in lung non-small cell carcinomas. Am J Surg Pathol. 2012;36: 895-899.
33. Rekhtman N, Ang DC, Sima CS, et al. Immunohisto-chemical algorithm for differentiation of lung adeno-carcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens. Mod Pathol. 2011;24:1348-1359.
34. Cadioli A, Rossi G, Costantini M, et al. Lung cancer histologic and immunohistochemical heterogeneity in the era of molecular therapies: analysis of 172 consecutive surgically resected, entirely sampled pulmonary carcinomas. Am J Surg Pathol 2014;38: 502-509.
35. Ordonez NG. A word of caution regarding napsin A expression in squamous cell carcinomas of the lung. Am J Surg Pathol 2012;36:396-401.
36. Turner BM, Cagle PT, Sainz IM, et al. Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray. Arch Pathol Lab Med 2012;136: 163-171.