Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 4, 2015, Pages 1031-1043.e6

  Sala Cunill, Anna ^a,b,c   Björkqvist, Jenny ^c,d   Senter, Riccardo ^c,e   Guilarte, Mar ^a,b   Cardona, Victoria ^a,b   Labrador, Moises ^a,b   Nickel, Katrin F ^c,d,f   Butler, Lynn ^c,d,f   Luengo, Olga ^a,b   Kumar, Parvin ^c,d   Labberton, Linda ^c,d   Long, Andy ^f   Di Gennaro, Antonio ^c,d   Kenne, Ellinor ^c,d   Jämsä, Anne ^c,d   Krieger, Thorsten ^f   Schlüter, Hartmut ^f   Fuchs, Tobias ^c,d,f   Flohr, Stefanie ^g   Hassiepen, Ulrich ^g   Cumin, Frederic ^g   McCrae, Keith ^h   Maas, Coen ⁱ   Stavrou, Evi ^j   Renné, Thomas ^c,d,f   more..

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF PADOVA   (Italy)

^f UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^g NOVARTIS PHARMA AG   (Switzerland)

^h LERNER RESEARCH INSTITUTE   (United States)

ⁱ UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^j CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Anaphylaxis; bradykinin; contact system; mast cell; mouse models; tryptase

Indexed keywords

BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 12; BLOOD CLOTTING FACTOR 12A; BRADYKININ; BRADYKININ B2 RECEPTOR; ECALLANTIDE; HEPARIN; HIGH MOLECULAR WEIGHT KININOGEN; ICATIBANT; KININOGEN; NITRIC OXIDE; PLASMA CONTACT SYSTEM PROTEIN; PLASMA KALLIKREIN; PLASMA PROTEIN; SERINE PROTEINASE INHIBITOR; TRYPTASE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ADULT; AGED; ALLERGIC REACTION; ANAPHYLAXIS; ANIMAL MODEL; ARTICLE; B2R GENE; BLOOD CLOTTING; BLOOD PRESSURE REGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE; GENE DELETION; HUMAN; HYPOTENSION; IMMUNE RESPONSE; IMMUNOBLOTTING; IN VIVO STUDY; MALE; MAST CELL; MAST CELL DEGRANULATION; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTHROMBIN TIME; SIGNAL TRANSDUCTION; SYSTEMIC ANAPHYLAXIS; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DISEASE MODEL; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MIDDLE AGED; TIME; YOUNG ADULT;

ADULT; AGED; ANAPHYLAXIS; ANIMALS; BIOLOGICAL MARKERS; BRADYKININ; DISEASE MODELS, ANIMAL; FACTOR XII; FEMALE; HUMANS; HYPERSENSITIVITY; HYPOTENSION; KININOGENS; MALE; MAST CELLS; MICE, KNOCKOUT; MIDDLE AGED; RECEPTOR, BRADYKININ B2; SIGNAL TRANSDUCTION; TIME FACTORS; YOUNG ADULT;

EID: 84926205053     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.057     Document Type: Article

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