Risk factors associated with laboratory-confirmed bloodstream infections in a tertiary neonatal intensive care unit

Pediatric Infectious Disease Journal

Volumn 33, Issue 10, 2014, Pages 1027-1032

  Padula, Michael A ^a,b   Dewan, Maya L ^a   Shah, Samir S ^c   Padula, Amy M ^d   Srinivasan, Lakshmi ^a,b   McGowan, Karin L ^e   Mahoney, Kaitilin R ^a   Harris, Mary C ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d STANFORD UNIVERSITY   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apnea; Bloodstream infection; Central venous line; Enteral contrast; Hypotension; NICU

Indexed keywords

APNEA; ARTICLE; BLOOD CULTURE; BLOODSTREAM INFECTION; CANDIDIASIS; CENTRAL VENOUS CATHETER; COHORT ANALYSIS; ENTEROBACTERIACEAE INFECTION; ENTEROCOCCAL INFECTION; ESCHERICHIA COLI INFECTION; FEMALE; HUMAN; HYPOTENSION; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE COMPLICATION; MEDICAL RECORD; NEWBORN INTENSIVE CARE; NEWBORN MORBIDITY; NEWBORN MORTALITY; NEWBORN SEPSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; STAPHYLOCOCCUS INFECTION; TERTIARY HEALTH CARE; TOTAL PARENTERAL NUTRITION; NEWBORN; PATHOLOGY; SEPSIS; TERTIARY CARE CENTER;

APNEA; COHORT STUDIES; FEMALE; HUMANS; HYPOTENSION; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; MALE; PROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; TERTIARY CARE CENTERS;

EID: 84926194678     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000000386     Document Type: Article

References (37)

1. Schulman J, Stricof R, Stevens TP, et al.; New York State Regional Perinatal Care Centers. Statewide NICU central-line-associated bloodstream infection rates decline after bundles and checklists. Pediatrics. 2011;127:436-444.
2. Kaplan HC, Lannon C, Walsh MC, et al.; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011;127:427-435.
3. Pessoa-Silva CL, Hugonnet S, Pfister R, et al. Reduction of health care associated infection risk in neonates by successful hand hygiene promotion. Pediatrics. 2007;120:e382-e390.
4. Stoll BJ, Hansen NI, Adams-Chapman I, et al.; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA. 2004;292:2357-2365.
5. Bassler D, Stoll BJ, Schmidt B, et al.; Trial of Indomethacin Prophylaxis in Preterms Investigators. Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infection. Pediatrics. 2009;123:313-318.
6. Spitzer AR, Kirkby S, Kornhauser M. Practice variation in suspected neonatal sepsis: a costly problem in neonatal intensive care. J Perinatol. 2005;25:265-269.
7. Fanaroff AA, Korones SB, Wright LL, et al. Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infants. The National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Infect Dis J. 1998;17:593-598.
8. Ohlin A, Björkqvist M, Montgomery SM, et al. Clinical signs and CRP values associated with blood culture results in neonates evaluated for suspected sepsis. Acta Paediatr. 2010;99:1635-1640.
9. Haque KN. Definitions of bloodstream infection in the newborn. Pediatr Crit Care Med. 2005;6(3 suppl):S45-S49.
10. Healy CM, Palazzi DL, Edwards MS, et al. Features of invasive staphylococcal disease in neonates. Pediatrics. 2004;114:953-961.
11. Modi N, Doré CJ, Saraswatula A, et al. A case definition for national and international neonatal bloodstream infection surveillance. Arch Dis Child Fetal Neonatal Ed. 2009;94:F8-12.
12. Leighton P, Cortina-Borja M, Millar M, Kempley S, Gilbert R. Riskadjusted comparisons of bloodstream infection rates in neonatal intensivecare units. Clin Microbiol Infect. 2012;18:1206-1211.
13. Committee on Fetus and Newborn. Levels of neonatal care. Pediatrics. 2012;130:587-597.
14. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36:309-332.
15. Dudeck M, Horan T, Peterson K. National Healthcare Safety Network (NHSN) report, data summary for 2009, device-associated module. Am J Infect Control. 2011.
16. Cole CR, Frem JC, Schmotzer B, et al. The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. J Pediatr. 2010;156:941-947.e1.
17. Cole CR, Hansen NI, Higgins RD, et al.; Eunice Kennedy Shriver National Institute of Child Health and Human Development's Neonatal Research Network. Bloodstream infections in very low birth weight infants with intestinal failure. J Pediatr. 2012;160:54-9.e2.
18. Abu-Sharar Z, Robinson A, Lavoie PM. Incidence of septicemia immediately after elective gastrointestinal contrast procedures in infants: a cohort study. J Pediatr Surg. 2010;45:507-512.
19. Day HA, Cho CT. Letter: barium enema septicemia. JAMA. 1974;227:1258.
20. Brand IR, Arthur RJ. Contrast enemas after necrotising enterocolitis: a case for prophylaxis? Pediatr Radiol. 1992;22:571-572.
21. Geffers M, Christine, Gastmeier M, et al. Use of central venous catheter and peripheral venous catheter as risk factors for nosocomial bloodstream infection in very-low-birth-weight infants. Infect Control Hosp Epidemiol. 2010;31:395-401.
22. Rubin LG, Sánchez PJ, Siegel J, et al.; Pediatric Prevention Network. Evaluation and treatment of neonates with suspected late-onset sepsis: a survey of neonatologists' practices. Pediatrics. 2002;110:e42.
23. Barbadoro P, Marigliano A, D'Errico MM, et al. Gestational age as a single predictor of health care-associated bloodstream infections in neonatal intensive care unit patients. Am J Infect Control. 2011;39:159-162.
24. Bentlin MR, de Souza Rugolo L M S. Late-onset Sepsis: Epidemiology, Evaluation, and Outcome. NeoReviews. 2010;11:e426-e35.
25. Clark R, Powers R, White R, et al. Nosocomial infection in the NICU: a medical complication or unavoidable problem? J Perinatol. 2004;24:382-388.
26. Bianconi S, Gudavalli M, Sutija VG, et al. Ranitidine and late-onset sepsis in the neonatal intensive care unit. J Perinat Med. 2007;35:147-150.
27. Terrin G, Passariello A, De Curtis M, et al. Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns. Pediatrics. 2012;129:e40-e45.
28. Bizzarro M, Raskind C, Baltimore R. Seventy-five years of neonatal sepsis at Yale: 1928-2003. Pediatrics. 2005.
29. Craft A, Finer N. Nosocomial coagulase negative staphylococcal (CoNS) catheter-related sepsis in preterm infants: definition, diagnosis, prophylaxis, and prevention. J Perinatol. 2001;21:186-192.
30. Cheung GY, Otto M. Understanding the significance of Staphylococcus epidermidis bacteremia in babies and children. Curr Opin Infect Dis. 2010;24:208-216.
31. Isaacs D. A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units. Arch Dis Child Fetal Neonatal Ed. 2003;88:89F-93F.
32. Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110(2 pt 1):285-291.
33. Benjamin DK Jr, DeLong ER, Cotten CM, et al. Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia. J Perinatol. 2004;24:169-174.
34. Benjamin DK, DeLong E, Cotten CM, et al. Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia. J Perinatol. 2004;24:175-180.
35. Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Matched case-control analysis of polymicrobial bloodstream infection in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2008;29:914-920.
36. Shah SS, Downes KJ, Elliott MR, et al. How long does it take to "rule out" bacteremia in children with central venous catheters? Pediatrics. 2008;121:135-141.
37. Downes KJ, Metlay JP, Bell LM, et al. Polymicrobial bloodstream infections among children and adolescents with central venous catheters evaluated in ambulatory care. Clin Infect Dis. 2008;46:387-394.