Sex-specific effects of cardiovascular risk factors on endothelium-dependent dilation and endothelin activity in middle-aged women and men

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Brar, Vijaywant ^a   Gill, Sartaj ^b   Cardillo, Carmine ^c   Tesauro, Manfredi ^d   Panza, Julio A ^e   Campia, Umberto ^a  

^a WASHINGTON HOSPITAL CENTER   (United States)

^b Prince Georges Hospital Center   (United States)

^c CATHOLIC UNIVERSITY   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e WESTCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; NITROPRUSSIDE SODIUM; CYCLO(TRP-ASP-PRO-VAL-LEU); CYCLOPEPTIDE; ENDOTHELIN RECEPTOR ANTAGONIST; VASODILATOR AGENT;

ADULT; AGED; ARM BLOOD FLOW; ARTICLE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RESPONSE; CARDIOVASCULAR RISK; CONTROLLED STUDY; ENDOTHELIUM DEPENDENT DILATION; FEMALE; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; PLETHYSMOGRAPHY; PROTEIN FUNCTION; RISK ASSESSMENT; SEX DIFFERENCE; VASODILATATION; BLOOD FLOW; CARDIOVASCULAR DISEASES; DRUG EFFECTS; FOREARM; INTRAARTERIAL DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RISK FACTOR; SEXUAL DEVELOPMENT; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; CARDIOVASCULAR DISEASES; ENDOTHELIN RECEPTOR ANTAGONISTS; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; HUMANS; INFUSIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; NITROPRUSSIDE; PEPTIDES, CYCLIC; REGIONAL BLOOD FLOW; RISK FACTORS; SEX CHARACTERISTICS; VASODILATION; VASODILATOR AGENTS;

EID: 84926052274     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121810     Document Type: Article

References (21)

1. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K et al. Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009; 119: 480-486. doi: 10.1161/CIRCULATIONAHA. 108.191259 PMID: 19171871
2. Davignon J and Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004; 109: III27-32. PMID: 15198963
3. Campia U, Choucair WK, Bryant MB, Quyyumi AA, Cardillo C, Panza JA. Role of cyclooxygenase products in the regulation of vascular tone and in the endothelial vasodilator function of normal, hypertensive, and hypercholesterolemic humans. The American journal of cardiology 2002; 89: 286-290. PMID: 11809430
4. rd and Panza JA. Role of endothelin in the increased vascular tone of patients with essential hypertension. Hypertension 1999; 33: 753-758. PMID: 10024340
5. rd and Panza JA. Increased activity of endogenous endothelin in patients with hypercholesterolemia. Journal of the American College of Cardiology 36: 1483-1488. PMID: 11079646
6. Cardillo C, Campia U, Bryant MB and Panza JA. Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation 2002; 106: 1783-1787. PMID: 12356630
7. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002; 106: 653-658. PMID: 12163423
8. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. Journal of the American College of Cardiology 1994; 24: 471-476. PMID: 8034885
9. Stauffer BL, Westby CM, Greiner JJ, Van Guilder GP and Desouza CA. Sex differences in endothelin- 1-mediated vasoconstrictor tone in middle-aged and older adults. American journal of physiology Regulatory, integrative and comparative physiology 2010; 298: R261-265. doi: 10.1152/ajpregu.00626.2009 PMID: 19939973
10. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. The Journal of clinical endocrinology and metabolism 2000; 85: 2402-2410. PMID: 10902785
11. Campia U, Matuskey LA and Panza JA. Peroxisome proliferator-activated receptor-gamma activation with pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factors. Circulation 2006; 113: 867-875. PMID: 16461819
12. Bohm F, Ahlborg G and Pernow J. Endothelin-1 inhibits endothelium-dependent vasodilatation in the human forearm: reversal by ETA receptor blockade in patients with atherosclerosis. Clinical science 2002; 102: 321-327. PMID: 11869173
13. Schnabel RB, Biener MP, Wilde S, Sinning CR, Ojeda FM, Zeller T et al. Sex differences in noninvasive vascular function in the community. Journal of hypertension 2013; 31: 1437-1446; discussion 1446. doi: 10.1097/HJH.0b013e328360f755 PMID: 23666420
14. Panza JA, Casino PR, Kilcoyne CM and Quyyumi AA. Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that the abnormality is not at the muscarinic receptor level. Journal of the American College of Cardiology 1994; 23: 1610-1616. PMID: 7515084
15. Perticone F, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F et al. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. Diabetes 2001; 50: 159-165. PMID: 11147782
16. Moreau KL, Hildreth KL, Meditz AL, Deane KD and Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. The Journal of clinical endocrinology and metabolism 2001; 97: 4692-4700.
17. Barton M and Yanagisawa M. Endothelin: 20 years from discovery to therapy. Canadian journal of physiology and pharmacology 2008; 86: 485-498. doi: 10.1139/Y08-059 PMID: 18758495
18. Cardillo C, Campia U, Kilcoyne CM, Bryant MB and Panza JA. Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension. Circulation 2002; 105: 452-456. PMID: 11815427
19. Natarajan S, Liao Y, Cao G, Lipsitz SR and McGee DL. Sex differences in risk for coronary heart disease mortality associated with diabetes and established coronary heart disease. Archives of internal medicine 2003; 163: 1735-1740. PMID: 12885690
20. Wexler DJ, Grant RW, Meigs JB, Nathan DM and Cagliero E. Sex disparities in treatment of cardiac risk factors in patients with type 2 diabetes. Diabetes care 2005; 28: 514-520. PMID: 15735180
21. Gouni-Berthold I, Berthold HK, Mantzoros CS, Bohm M and KroneW(2008) Sex disparities in the treatment and control of cardiovascular risk factors in type 2 diabetes. Diabetes care 31: 1389-1391. doi: 10.2337/dc08-0194 PMID: 18375411