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Volumn 30, Issue S1, 2015, Pages 78-84

Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma

Author keywords

E Cadherin; Epithelial mesenchymal transition; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Pancreatoduodenectomy; Tumor budding

Indexed keywords

BETA CATENIN; CYTOKERATIN; UVOMORULIN; VIMENTIN; CADHERIN;

EID: 84925955019     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12752     Document Type: Article
Times cited : (70)

References (44)
  • 1
    • 84890546918 scopus 로고    scopus 로고
    • 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades
    • He J, Ahuja N, Makary MA etal. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. HPB (Oxford) 2013; 16(1): 83-90.
    • (2013) HPB (Oxford) , vol.16 , Issue.1 , pp. 83-90
    • He, J.1    Ahuja, N.2    Makary, M.A.3
  • 3
    • 84865258873 scopus 로고    scopus 로고
    • Evolution of the Whipple procedure at the Massachusetts General Hospital
    • Fernández-Del Castillo C, Morales-Oyarvide V, McGrath D etal. Evolution of the Whipple procedure at the Massachusetts General Hospital. Surgery 2012; 152 (3 Suppl. 1): S56-63.
    • (2012) Surgery , vol.152 , Issue.3 , pp. S56-S63
    • Fernández-Del Castillo, C.1    Morales-Oyarvide, V.2    McGrath, D.3
  • 4
    • 42949126637 scopus 로고    scopus 로고
    • Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature
    • Garcea G, Dennison AR, Pattenden CJ, Neal CP, Sutton CD, Berry DP. Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature. JOP 2008; 9: 99-132.
    • (2008) JOP , vol.9 , pp. 99-132
    • Garcea, G.1    Dennison, A.R.2    Pattenden, C.J.3    Neal, C.P.4    Sutton, C.D.5    Berry, D.P.6
  • 5
    • 84878838725 scopus 로고    scopus 로고
    • Survival among pancreaticoduodenectomy patients treated for pancreatic head cancer <1 or 2cm
    • Franko J, Hugec V, Lopes TL, Goldman CD. Survival among pancreaticoduodenectomy patients treated for pancreatic head cancer <1 or 2cm. Ann. Surg. Oncol. 2013; 20: 357-361.
    • (2013) Ann. Surg. Oncol. , vol.20 , pp. 357-361
    • Franko, J.1    Hugec, V.2    Lopes, T.L.3    Goldman, C.D.4
  • 6
    • 84865249073 scopus 로고    scopus 로고
    • Pancreatic ductal adenocarcinoma: long-term survival does not equal cure
    • Ferrone CR, Pieretti-Vanmarcke R, Bloom JP etal. Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Surgery 2012; 152 (3 Suppl. 1): S43-49.
    • (2012) Surgery , vol.152 , Issue.3 , pp. S43-S49
    • Ferrone, C.R.1    Pieretti-Vanmarcke, R.2    Bloom, J.P.3
  • 7
    • 84871298277 scopus 로고    scopus 로고
    • Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer
    • Winter JM, Yeo CJ, Brody JR. Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer. J. Surg. Oncol. 2012; 107(1): 15-22.
    • (2012) J. Surg. Oncol. , vol.107 , Issue.1 , pp. 15-22
    • Winter, J.M.1    Yeo, C.J.2    Brody, J.R.3
  • 8
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 9
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not-routes towards metastasis
    • Brabletz T. To differentiate or not-routes towards metastasis. Nat. Rev. Cancer 2012; 12: 425-436.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 425-436
    • Brabletz, T.1
  • 10
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat. Rev. Cancer 2005; 5: 744-749.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 12
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ etal. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 13
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner U, Schubert J, Burk UC etal. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell Biol. 2009; 11: 1487-1495.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3
  • 14
  • 15
    • 84881055538 scopus 로고    scopus 로고
    • Tumor budding cells, cancer stem cells and epithelial-mesenchymal transition-type cells in pancreatic cancer
    • Karamitopoulou E. Tumor budding cells, cancer stem cells and epithelial-mesenchymal transition-type cells in pancreatic cancer. Front. Oncol. 2012; 2: 1-5.
    • (2012) Front. Oncol. , vol.2 , pp. 1-5
    • Karamitopoulou, E.1
  • 16
    • 84861457224 scopus 로고    scopus 로고
    • Tumour budding: a promising parameter in colorectal cancer
    • Lugli A, Karamitopoulou E, Zlobec I. Tumour budding: a promising parameter in colorectal cancer. Br. J. Cancer 2012; 106: 1713-1717.
    • (2012) Br. J. Cancer , vol.106 , pp. 1713-1717
    • Lugli, A.1    Karamitopoulou, E.2    Zlobec, I.3
  • 17
    • 77957933011 scopus 로고    scopus 로고
    • Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas
    • Ohike N, Coban I, Kim GE etal. Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas. Am. J. Surg. Pathol. 2010; 34: 1417-1424.
    • (2010) Am. J. Surg. Pathol. , vol.34 , pp. 1417-1424
    • Ohike, N.1    Coban, I.2    Kim, G.E.3
  • 18
    • 84878106508 scopus 로고    scopus 로고
    • The prognostic value of tumor budding in invasive breast cancer
    • Liang F, Cao W, Wang Y, Li L, Zhang G, Wang Z. The prognostic value of tumor budding in invasive breast cancer. Pathol. Res. Pract. 2013; 209: 269-275.
    • (2013) Pathol. Res. Pract. , vol.209 , pp. 269-275
    • Liang, F.1    Cao, W.2    Wang, Y.3    Li, L.4    Zhang, G.5    Wang, Z.6
  • 19
    • 84860508366 scopus 로고    scopus 로고
    • Characterization of the immunophenotype of the tumor budding and its prognostic implications in squamous cell carcinoma of the lung
    • Taira T, Ishii G, Nagai K etal. Characterization of the immunophenotype of the tumor budding and its prognostic implications in squamous cell carcinoma of the lung. Lung Cancer 2012; 76: 423-430.
    • (2012) Lung Cancer , vol.76 , pp. 423-430
    • Taira, T.1    Ishii, G.2    Nagai, K.3
  • 20
    • 84874933766 scopus 로고    scopus 로고
    • Tumour budding is a strong and independent prognostic factor in pancreatic cancer
    • Karamitopoulou E, Zlobec I, Born D etal. Tumour budding is a strong and independent prognostic factor in pancreatic cancer. Eur. J. Cancer 2012; 49(5): 1032-1039.
    • (2012) Eur. J. Cancer , vol.49 , Issue.5 , pp. 1032-1039
    • Karamitopoulou, E.1    Zlobec, I.2    Born, D.3
  • 23
    • 84900367176 scopus 로고
    • Squamous-cell epithelioma of the lip: a study of five hundred and thirty-seven cases
    • Broders A. Squamous-cell epithelioma of the lip: a study of five hundred and thirty-seven cases. J. Am. Med. Assoc. 1920; 74: 656-664.
    • (1920) J. Am. Med. Assoc. , vol.74 , pp. 656-664
    • Broders, A.1
  • 24
    • 84870893807 scopus 로고    scopus 로고
    • Albert C. Broders' paradigm shifts involving the prognostication and definition of cancer
    • Wright JR Jr. Albert C. Broders' paradigm shifts involving the prognostication and definition of cancer. Arch. Pathol. Lab. Med. 2012; 136: 1437-1446.
    • (2012) Arch. Pathol. Lab. Med. , vol.136 , pp. 1437-1446
    • Wright, J.R.1
  • 25
    • 33845599552 scopus 로고    scopus 로고
    • Tumour budding in colorectal carcinoma
    • Prall F. Tumour budding in colorectal carcinoma. Histopathology 2007; 50: 151-162.
    • (2007) Histopathology , vol.50 , pp. 151-162
    • Prall, F.1
  • 26
    • 84856462406 scopus 로고    scopus 로고
    • Survival after resection of pancreatic adenocarcinoma: results from a single institution over three decades
    • Winter JM, Brennan MF, Tang LH etal. Survival after resection of pancreatic adenocarcinoma: results from a single institution over three decades. Ann. Surg. Oncol. 2012; 19: 169-175.
    • (2012) Ann. Surg. Oncol. , vol.19 , pp. 169-175
    • Winter, J.M.1    Brennan, M.F.2    Tang, L.H.3
  • 27
    • 3242671534 scopus 로고    scopus 로고
    • Prognostic nomogram for patients undergoing resection for adenocarcinoma of the pancreas
    • Brennan MF, Kattan MW, Klimstra D, Conlon K. Prognostic nomogram for patients undergoing resection for adenocarcinoma of the pancreas. Ann. Surg. 2004; 240: 293-298.
    • (2004) Ann. Surg. , vol.240 , pp. 293-298
    • Brennan, M.F.1    Kattan, M.W.2    Klimstra, D.3    Conlon, K.4
  • 28
    • 44449111555 scopus 로고    scopus 로고
    • Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    • Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 2008; 68: 3645-3654.
    • (2008) Cancer Res. , vol.68 , pp. 3645-3654
    • Onder, T.T.1    Gupta, P.B.2    Mani, S.A.3    Yang, J.4    Lander, E.S.5    Weinberg, R.A.6
  • 29
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 2009; 119: 1420-1428.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 30
    • 0032568370 scopus 로고    scopus 로고
    • E-cadherin germline mutations in familial gastric cancer
    • Guilford P, Hopkins J, Harraway J etal. E-cadherin germline mutations in familial gastric cancer. Nature 1998; 392: 402-405.
    • (1998) Nature , vol.392 , pp. 402-405
    • Guilford, P.1    Hopkins, J.2    Harraway, J.3
  • 31
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    • Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev. 2009; 28: 151-166.
    • (2009) Cancer Metastasis Rev. , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 32
    • 77950683362 scopus 로고    scopus 로고
    • Interplay of cadherin-mediated cell adhesion and canonical wnt signaling
    • Heuberger J, Birchmeier W. Interplay of cadherin-mediated cell adhesion and canonical wnt signaling. Cold Spring Harb. Perspect. Biol. 2010; 2: a002915.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2 , pp. a002915
    • Heuberger, J.1    Birchmeier, W.2
  • 33
    • 84856191525 scopus 로고    scopus 로고
    • Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers
    • White BD, Chien AJ, Dawson DW. Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology 2012; 142: 219-232.
    • (2012) Gastroenterology , vol.142 , pp. 219-232
    • White, B.D.1    Chien, A.J.2    Dawson, D.W.3
  • 34
    • 0035964349 scopus 로고    scopus 로고
    • Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    • Brabletz T, Jung A, Reu S etal. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc. Natl Acad. Sci. U.S.A. 2001; 98: 10356-10361.
    • (2001) Proc. Natl Acad. Sci. U.S.A. , vol.98 , pp. 10356-10361
    • Brabletz, T.1    Jung, A.2    Reu, S.3
  • 35
    • 33749024777 scopus 로고    scopus 로고
    • Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    • Christiansen JJ, Rajasekaran AK. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res. 2006; 66: 8319-8326.
    • (2006) Cancer Res. , vol.66 , pp. 8319-8326
    • Christiansen, J.J.1    Rajasekaran, A.K.2
  • 36
    • 43449107352 scopus 로고    scopus 로고
    • Most pancreatic cancer resections are R1 resections
    • Esposito I, Kleeff J, Bergmann F etal. Most pancreatic cancer resections are R1 resections. Ann. Surg. Oncol. 2008; 15: 1651-1660.
    • (2008) Ann. Surg. Oncol. , vol.15 , pp. 1651-1660
    • Esposito, I.1    Kleeff, J.2    Bergmann, F.3
  • 37
    • 65749106750 scopus 로고    scopus 로고
    • Impact of margin status on survival following pancreatoduodenectomy for cancer: the Leeds Pathology Protocol (LEEPP)
    • Menon KV, Gomez D, Smith AM, Anthoney A, Verbeke CS. Impact of margin status on survival following pancreatoduodenectomy for cancer: the Leeds Pathology Protocol (LEEPP). HPB (Oxford) 2009; 11: 18-24.
    • (2009) HPB (Oxford) , vol.11 , pp. 18-24
    • Menon, K.V.1    Gomez, D.2    Smith, A.M.3    Anthoney, A.4    Verbeke, C.S.5
  • 38
    • 84865486585 scopus 로고    scopus 로고
    • Selective reoperation for locally recurrent or metastatic pancreatic ductal adenocarcinoma following primary pancreatic resection
    • Thomas RM, Truty MJ, Nogueras-Gonzalez GM etal. Selective reoperation for locally recurrent or metastatic pancreatic ductal adenocarcinoma following primary pancreatic resection. J. Gastrointest. Surg. 2012; 16: 1696-1704.
    • (2012) J. Gastrointest. Surg. , vol.16 , pp. 1696-1704
    • Thomas, R.M.1    Truty, M.J.2    Nogueras-Gonzalez, G.M.3
  • 39
    • 36448987851 scopus 로고    scopus 로고
    • Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?
    • Gleisner AL, Assumpcao L, Cameron JL etal. Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified? Cancer 2007; 110: 2484-2492.
    • (2007) Cancer , vol.110 , pp. 2484-2492
    • Gleisner, A.L.1    Assumpcao, L.2    Cameron, J.L.3
  • 40
    • 60149108795 scopus 로고    scopus 로고
    • Resection of primary pancreatic cancer and liver metastasis: a systematic review
    • Michalski CW, Erkan M, Hüser N etal. Resection of primary pancreatic cancer and liver metastasis: a systematic review. Dig. Surg. 2008; 25: 473-480.
    • (2008) Dig. Surg. , vol.25 , pp. 473-480
    • Michalski, C.W.1    Erkan, M.2    Hüser, N.3
  • 41
    • 79251650171 scopus 로고    scopus 로고
    • Pancreatic resections for advanced M1-pancreatic carcinoma: the value of synchronous metastasectomy
    • Internet Cited 9 Sep 2013. Available from URL:
    • Seelig SK, Burkert B, Chromik AM, Tannapfel A, Uhl W, Seelig MH. Pancreatic resections for advanced M1-pancreatic carcinoma: the value of synchronous metastasectomy. HPB Surg. [Internet] 2010; 2010: 1-6. Cited 9 Sep 2013. Available from URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010622/
    • (2010) HPB Surg. , vol.2010 , pp. 1-6
    • Seelig, S.K.1    Burkert, B.2    Chromik, A.M.3    Tannapfel, A.4    Uhl, W.5    Seelig, M.H.6
  • 42
    • 84870199815 scopus 로고    scopus 로고
    • The impact of simultaneous liver resection for occult liver metastases of pancreatic adenocarcinoma
    • Internet Cited 9 Sep 2013. Available from URL:
    • Klein F, Puhl G, Guckelberger O etal. The impact of simultaneous liver resection for occult liver metastases of pancreatic adenocarcinoma. Gastroenterol. Res. Pract. [Internet] 2012; 2012: 1-8. Cited 9 Sep 2013. Available from URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508736/
    • (2012) Gastroenterol. Res. Pract. , vol.2012 , pp. 1-8
    • Klein, F.1    Puhl, G.2    Guckelberger, O.3
  • 43
    • 84875210349 scopus 로고    scopus 로고
    • Re-resection for isolated local recurrence of pancreatic cancer is feasible, safe, and associated with encouraging survival
    • Strobel O, Hartwig W, Hackert T etal. Re-resection for isolated local recurrence of pancreatic cancer is feasible, safe, and associated with encouraging survival. Ann. Surg. Oncol. 2013; 20: 964-972.
    • (2013) Ann. Surg. Oncol. , vol.20 , pp. 964-972
    • Strobel, O.1    Hartwig, W.2    Hackert, T.3
  • 44
    • 71549116725 scopus 로고    scopus 로고
    • Survival data justifies resection for pancreatic metastases
    • Strobel O, Hackert T, Hartwig W etal. Survival data justifies resection for pancreatic metastases. Ann. Surg. Oncol. 2009; 16: 3340-3349.
    • (2009) Ann. Surg. Oncol. , vol.16 , pp. 3340-3349
    • Strobel, O.1    Hackert, T.2    Hartwig, W.3


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