메뉴 건너뛰기




Volumn 107, Issue 1, 2013, Pages 15-22

Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer

Author keywords

biomarkers; pancreatic cancer; pancreatic ductal adenocarcinoma; predictive markers; prognostic markers

Indexed keywords

3 HYDROXYBUTYRIC ACID; BRCA1 PROTEIN; BRCA2 PROTEIN; CA 125 ANTIGEN; CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; FANCONI ANEMIA GROUP C PROTEIN; FANCONI ANEMIA GROUP G PROTEIN; FLICE INHIBITORY PROTEIN; GEMCITABINE; HISTONE H4; LACTIC ACID; MANNOSE BINDING LECTIN 2; MESOTHELIN; MESSENGER RNA; MICRORNA 155; MICRORNA 21; MICRORNA 210; MITOMYCIN; MUCIN 1; MUCIN 2; PROTEIN P53; PROTEIN S 100; SMAD4 PROTEIN; TRANSCRIPTION FACTOR FOSB; TRIMETHYLAMINE OXIDE; TUMOR MARKER; UNINDEXED DRUG;

EID: 84871298277     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.23192     Document Type: Article
Times cited : (204)

References (86)
  • 1
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E, et al.: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360: 1408-1417.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 2
    • 59249097606 scopus 로고    scopus 로고
    • The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status
    • Jover R, Zapater P, Castells A, et al.: The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status. Eur J Cancer 2009; 45: 365-373.
    • (2009) Eur J Cancer , vol.45 , pp. 365-373
    • Jover, R.1    Zapater, P.2    Castells, A.3
  • 3
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
    • Ribic CM, Sargent DJ, Moore MJ, et al.: Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003; 349: 247-257.
    • (2003) N Engl J Med , vol.349 , pp. 247-257
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3
  • 4
    • 60749102639 scopus 로고    scopus 로고
    • Association of GUCY2C expression in lymph nodes with time to recurrence, disease-free survival in pN0 colorectal cancer
    • Waldman SA, Hyslop T, Schulz S, et al.: Association of GUCY2C expression in lymph nodes with time to recurrence, disease-free survival in pN0 colorectal cancer. JAMA 2009; 301: 745-752.
    • (2009) JAMA , vol.301 , pp. 745-752
    • Waldman, S.A.1    Hyslop, T.2    Schulz, S.3
  • 5
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group
    • Early Breast Cancer Trialists' Collaborative Group. Tamoxifen for early breast cancer: An overview of the randomised trials. Lancet 1998; 351: 1451-1467.
    • (1998) Lancet , vol.351 , pp. 1451-1467
  • 6
    • 80052728749 scopus 로고    scopus 로고
    • Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: Joint analysis of data from NCCTG N9831 and NSABP B-31
    • Perez EA, Romond EH, Suman VJ, et al.: Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: Joint analysis of data from NCCTG N9831 and NSABP B-31. J Clin Oncol 2011; 29: 3366-3373.
    • (2011) J Clin Oncol , vol.29 , pp. 3366-3373
    • Perez, E.A.1    Romond, E.H.2    Suman, V.J.3
  • 7
    • 33744814477 scopus 로고    scopus 로고
    • Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    • Paik S, Tang G, Shak S, et al.: Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J Clin Oncol 2006; 24: 3726-3734.
    • (2006) J Clin Oncol , vol.24 , pp. 3726-3734
    • Paik, S.1    Tang, G.2    Shak, S.3
  • 8
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al.: Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364: 2507-2516.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 9
    • 49149129916 scopus 로고    scopus 로고
    • Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study
    • Shedden K, Taylor JM, Enkemann SA, et al.: Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study. Nat Med 2008; 14: 822-827.
    • (2008) Nat Med , vol.14 , pp. 822-827
    • Shedden, K.1    Taylor, J.M.2    Enkemann, S.A.3
  • 10
    • 50549085619 scopus 로고    scopus 로고
    • Gene panel model predictive of outcome in men at high-risk of systemic progression and death from prostate cancer after radical retropubic prostatectomy
    • Cheville JC, Karnes RJ, Therneau TM, et al.: Gene panel model predictive of outcome in men at high-risk of systemic progression and death from prostate cancer after radical retropubic prostatectomy. J Clin Oncol 2008; 26: 3930-3936.
    • (2008) J Clin Oncol , vol.26 , pp. 3930-3936
    • Cheville, J.C.1    Karnes, R.J.2    Therneau, T.M.3
  • 11
    • 0023851586 scopus 로고
    • Evaluation of the utility of a radioimmunoassay for serum CA19-9 levels in patients before and after treatment of carcinoma of the pancreas
    • Glenn J, Steinberg WM, Kurtzman SH, et al.: Evaluation of the utility of a radioimmunoassay for serum CA19-9 levels in patients before and after treatment of carcinoma of the pancreas. J Clin Oncol 1988; 6: 462-468.
    • (1988) J Clin Oncol , vol.6 , pp. 462-468
    • Glenn, J.1    Steinberg, W.M.2    Kurtzman, S.H.3
  • 12
    • 0024577341 scopus 로고
    • Evaluation of a serologic marker, CA19-9, in the diagnosis of pancreatic cancer
    • Pleskow DK, Berger HJ, Gyves J, et al.: Evaluation of a serologic marker, CA19-9, in the diagnosis of pancreatic cancer. Ann Intern Med 1989; 110: 704-709.
    • (1989) Ann Intern Med , vol.110 , pp. 704-709
    • Pleskow, D.K.1    Berger, H.J.2    Gyves, J.3
  • 13
    • 65449141024 scopus 로고    scopus 로고
    • A compendium of potential biomarkers of pancreatic cancer
    • Harsha HC, Kandasamy K, Ranganathan P, et al.: A compendium of potential biomarkers of pancreatic cancer. PLoS Med 2009; 6: e1000046.
    • (2009) PLoS Med , vol.6
    • Harsha, H.C.1    Kandasamy, K.2    Ranganathan, P.3
  • 14
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69: 89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 15
    • 18844468498 scopus 로고    scopus 로고
    • Lewis and secretor gene dosages affect CA 19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients
    • Narimatsu H, Iwasaki H, Nakayama F, et al.: Lewis and secretor gene dosages affect CA 19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res 1998; 58: 512-518.
    • (1998) Cancer Res , vol.58 , pp. 512-518
    • Narimatsu, H.1    Iwasaki, H.2    Nakayama, F.3
  • 16
    • 0018578870 scopus 로고
    • Colorectal carcinoma antigens detected by hybridoma antibodies
    • Koprowski H, Steplewski Z, Mitchell K, et al.: Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet 1979; 5: 957-971.
    • (1979) Somatic Cell Genet , vol.5 , pp. 957-971
    • Koprowski, H.1    Steplewski, Z.2    Mitchell, K.3
  • 17
    • 58049202340 scopus 로고    scopus 로고
    • Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: A prospective validation by RTOG 9704
    • Berger AC, Garcia M Jr, Hoffman JP, et al.: Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: A prospective validation by RTOG 9704. J Clin Oncol 2008; 26: 5918-5922.
    • (2008) J Clin Oncol , vol.26 , pp. 5918-5922
    • Berger, A.C.1    Garcia Jr., M.2    Hoffman, J.P.3
  • 18
    • 0023637227 scopus 로고
    • Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer
    • Tempero MA, Uchida E, Takasaki H, et al.: Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer. Cancer Res 1987; 47: 5501-5503.
    • (1987) Cancer Res , vol.47 , pp. 5501-5503
    • Tempero, M.A.1    Uchida, E.2    Takasaki, H.3
  • 19
    • 0032783998 scopus 로고    scopus 로고
    • Role of tumour markers, cytogenetics
    • Lamerz R,: Role of tumour markers, cytogenetics. Ann Oncol 1999; 10: 145-149.
    • (1999) Ann Oncol , vol.10 , pp. 145-149
    • Lamerz, R.1
  • 20
    • 0026339391 scopus 로고
    • The study of the mass screening of persons without symptoms and of the screening of outpatients with gastrointestinal complaints or icterus for pancreatic cancer in Japan, using CA 19-9 and elastase-1 or ultrasonography
    • Homma T, Tsuchiya R,: The study of the mass screening of persons without symptoms and of the screening of outpatients with gastrointestinal complaints or icterus for pancreatic cancer in Japan, using CA 19-9 and elastase-1 or ultrasonography. Int J Pancreatol 1991; 9: 119-124.
    • (1991) Int J Pancreatol , vol.9 , pp. 119-124
    • Homma, T.1    Tsuchiya, R.2
  • 21
    • 67649580268 scopus 로고    scopus 로고
    • CA 19-9 to differentiate benign and malignant masses in chronic pancreatitis: Is there any benefit?
    • Bedi MM, Gandhi MD, Jacob G, et al.: CA 19-9 to differentiate benign and malignant masses in chronic pancreatitis: Is there any benefit? Indian J Gastroenterol 2009; 28: 24-27.
    • (2009) Indian J Gastroenterol , vol.28 , pp. 24-27
    • Bedi, M.M.1    Gandhi, M.D.2    Jacob, G.3
  • 22
    • 79960939958 scopus 로고    scopus 로고
    • The clinical utility and limitations of serum carbohydrate antigen (CA19-9) as a diagnostic tool for pancreatic cancer and cholangiocarcinoma
    • Singh S, Tang SJ, Sreenarasimhaiah J, et al.: The clinical utility and limitations of serum carbohydrate antigen (CA19-9) as a diagnostic tool for pancreatic cancer and cholangiocarcinoma. Dig Dis Sci 2011; 56: 2491-2496.
    • (2011) Dig Dis Sci , vol.56 , pp. 2491-2496
    • Singh, S.1    Tang, S.J.2    Sreenarasimhaiah, J.3
  • 23
    • 77952973346 scopus 로고    scopus 로고
    • Predictive and prognostic value of CA 19-9 in resected pancreatic adenocarcinoma
    • Barton JG, Bois JP, Sarr MG, et al.: Predictive and prognostic value of CA 19-9 in resected pancreatic adenocarcinoma. J Gastrointest Surg 2009; 13: 2050-2058.
    • (2009) J Gastrointest Surg , vol.13 , pp. 2050-2058
    • Barton, J.G.1    Bois, J.P.2    Sarr, M.G.3
  • 24
    • 79961021004 scopus 로고    scopus 로고
    • Pancreatic cancer surgery in the new millennium: Better prediction of outcome
    • Hartwig W, Hackert T, Hinz U, et al.: Pancreatic cancer surgery in the new millennium: Better prediction of outcome. Ann Surg 2011; 254: 311-319.
    • (2011) Ann Surg , vol.254 , pp. 311-319
    • Hartwig, W.1    Hackert, T.2    Hinz, U.3
  • 25
    • 77956340670 scopus 로고    scopus 로고
    • Prognostic impact of perioperative serum CA 19-9 levels in patients with resectable pancreatic cancer
    • Kondo N, Murakami Y, Uemura K, et al.: Prognostic impact of perioperative serum CA 19-9 levels in patients with resectable pancreatic cancer. Ann Surg Oncol 2010; 17: 2321-2329.
    • (2010) Ann Surg Oncol , vol.17 , pp. 2321-2329
    • Kondo, N.1    Murakami, Y.2    Uemura, K.3
  • 26
    • 69249222645 scopus 로고    scopus 로고
    • CA 19-9 serum levels in obstructive jaundice: Clinical value in benign and malignant conditions
    • Marrelli D, Caruso S, Pedrazzani C, et al.: CA 19-9 serum levels in obstructive jaundice: Clinical value in benign and malignant conditions. Am J Surg 2009; 198: 333-339.
    • (2009) Am J Surg , vol.198 , pp. 333-339
    • Marrelli, D.1    Caruso, S.2    Pedrazzani, C.3
  • 27
    • 0028063153 scopus 로고
    • Diagnosis of pancreatic cancer and prediction of unresectability using the tumor-associated antigen CA19-9
    • Forsmark CE, Lambiase L, Vogel SB,: Diagnosis of pancreatic cancer and prediction of unresectability using the tumor-associated antigen CA19-9. Pancreas 1994; 9: 731-734.
    • (1994) Pancreas , vol.9 , pp. 731-734
    • Forsmark, C.E.1    Lambiase, L.2    Vogel, S.B.3
  • 28
    • 58149279658 scopus 로고    scopus 로고
    • Preoperative CA 19-9 and the yield of staging laparoscopy in patients with radiographically resectable pancreatic adenocarcinoma
    • Maithel SK, Maloney S, Winston C, et al.: Preoperative CA 19-9 and the yield of staging laparoscopy in patients with radiographically resectable pancreatic adenocarcinoma. Ann Surg Oncol 2008; 15: 3512-3520.
    • (2008) Ann Surg Oncol , vol.15 , pp. 3512-3520
    • Maithel, S.K.1    Maloney, S.2    Winston, C.3
  • 29
    • 84861608121 scopus 로고    scopus 로고
    • The prognostic and predictive value of serum CA19.9 in pancreatic cancer
    • Humphris JL, Chang DK, Johns AL, et al.: The prognostic and predictive value of serum CA19.9 in pancreatic cancer. Ann Oncol 2012.
    • (2012) Ann Oncol
    • Humphris, J.L.1    Chang, D.K.2    Johns, A.L.3
  • 30
    • 55249091643 scopus 로고    scopus 로고
    • The impact of resection margin status and postoperative CA 19-9 levels on survival and patterns of recurrence after postoperative high-dose radiotherapy with 5-FU-based concurrent chemotherapy for resectable pancreatic cancer
    • Kinsella TJ, Seo Y, Willis J, et al.: The impact of resection margin status and postoperative CA 19-9 levels on survival and patterns of recurrence after postoperative high-dose radiotherapy with 5-FU-based concurrent chemotherapy for resectable pancreatic cancer. Am J Clin Oncol 2008; 31: 446-453.
    • (2008) Am J Clin Oncol , vol.31 , pp. 446-453
    • Kinsella, T.J.1    Seo, Y.2    Willis, J.3
  • 31
    • 33745552215 scopus 로고    scopus 로고
    • Perioperative CA 19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma
    • Ferrone CR, Finkelstein DM, Thayer SP, et al.: Perioperative CA 19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma. J Clin Oncol 2006; 24: 2897-2902.
    • (2006) J Clin Oncol , vol.24 , pp. 2897-2902
    • Ferrone, C.R.1    Finkelstein, D.M.2    Thayer, S.P.3
  • 32
    • 33748931490 scopus 로고    scopus 로고
    • Improving resectability of hepatic colorectal metastases: Expert consensus statement
    • Abdalla EK, Adam R, Bilchik AJ, et al.: Improving resectability of hepatic colorectal metastases: Expert consensus statement. Ann Surg Oncol 2006; 13: 1271-1280.
    • (2006) Ann Surg Oncol , vol.13 , pp. 1271-1280
    • Abdalla, E.K.1    Adam, R.2    Bilchik, A.J.3
  • 33
    • 0031242791 scopus 로고    scopus 로고
    • Prediction of recurrence and survival by post-resection CA 19-9 values in patients with adenocarcinoma of the pancreas
    • Montgomery RC, Hoffman JP, Riley LB, et al.: Prediction of recurrence and survival by post-resection CA 19-9 values in patients with adenocarcinoma of the pancreas. Ann Surg Oncol 1997; 4: 551-556.
    • (1997) Ann Surg Oncol , vol.4 , pp. 551-556
    • Montgomery, R.C.1    Hoffman, J.P.2    Riley, L.B.3
  • 34
    • 70449589304 scopus 로고    scopus 로고
    • Very high serum CA 19-9 levels: A contraindication to pancreaticoduodenectomy?
    • Turrini O, Schmidt CM, Moreno J, et al.: Very high serum CA 19-9 levels: A contraindication to pancreaticoduodenectomy? J Gastrointest Surg 2009; 13: 1791-1797.
    • (2009) J Gastrointest Surg , vol.13 , pp. 1791-1797
    • Turrini, O.1    Schmidt, C.M.2    Moreno, J.3
  • 35
    • 80051613675 scopus 로고    scopus 로고
    • Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: Correlation of Smad4(Dpc4) immunostaining with pattern of disease progression
    • Crane CH, Varadhachary GR, Yordy JS, et al.: Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: Correlation of Smad4(Dpc4) immunostaining with pattern of disease progression. J Clin Oncol 2011; 29: 3037-3043.
    • (2011) J Clin Oncol , vol.29 , pp. 3037-3043
    • Crane, C.H.1    Varadhachary, G.R.2    Yordy, J.S.3
  • 36
    • 79958830331 scopus 로고    scopus 로고
    • A phase 2 trial of gemcitabine, 5-fluorouracil, and radiation therapy in locally advanced nonmetastatic pancreatic adenocarcinoma: Cancer and leukemia group B (CALGB) 80003
    • Mamon HJ, Niedzwiecki D, Hollis D, et al.: A phase 2 trial of gemcitabine, 5-fluorouracil, and radiation therapy in locally advanced nonmetastatic pancreatic adenocarcinoma: Cancer and leukemia group B (CALGB) 80003. Cancer 2011; 117: 2620-2628.
    • (2011) Cancer , vol.117 , pp. 2620-2628
    • Mamon, H.J.1    Niedzwiecki, D.2    Hollis, D.3
  • 37
    • 77954134715 scopus 로고    scopus 로고
    • CA 19-9 as a predictor of tumor response and survival in patients with advanced pancreatic cancer treated with gemcitabine based chemotherapy
    • Hammad N, Heilbrun LK, Philip PA, et al.: CA 19-9 as a predictor of tumor response and survival in patients with advanced pancreatic cancer treated with gemcitabine based chemotherapy. Asia Pac J Clin Oncol 2010; 6: 98-105.
    • (2010) Asia Pac J Clin Oncol , vol.6 , pp. 98-105
    • Hammad, N.1    Heilbrun, L.K.2    Philip, P.A.3
  • 38
    • 27144435114 scopus 로고    scopus 로고
    • CA 19-9 as a prognostic factor in inoperable pancreatic cancer: The implication for clinical trials
    • Maisey NR, Norman AR, Hill A, et al.: CA 19-9 as a prognostic factor in inoperable pancreatic cancer: The implication for clinical trials. Br J Cancer 2005; 93: 740-743.
    • (2005) Br J Cancer , vol.93 , pp. 740-743
    • Maisey, N.R.1    Norman, A.R.2    Hill, A.3
  • 39
    • 0032780681 scopus 로고    scopus 로고
    • CA19-9: A pedictor of response in pancreatic cancer treated with gemcitabine and cisplatin
    • Heinemann V, Schermuly MM, Stieber P, et al.: CA19-9: A pedictor of response in pancreatic cancer treated with gemcitabine and cisplatin. Anticancer Res 1999; 19: 2433-2435.
    • (1999) Anticancer Res , vol.19 , pp. 2433-2435
    • Heinemann, V.1    Schermuly, M.M.2    Stieber, P.3
  • 40
    • 58049134458 scopus 로고    scopus 로고
    • Serum CA 19-9 decline compared to radiographic response as a surrogate for clinical outcomes in patients with metastatic pancreatic cancer receiving chemotherapy
    • Wong D, Ko AH, Hwang J, et al.: Serum CA 19-9 decline compared to radiographic response as a surrogate for clinical outcomes in patients with metastatic pancreatic cancer receiving chemotherapy. Pancreas 2008; 37: 269-274.
    • (2008) Pancreas , vol.37 , pp. 269-274
    • Wong, D.1    Ko, A.H.2    Hwang, J.3
  • 41
    • 0242491491 scopus 로고    scopus 로고
    • Prognostic value of CA 19-9 levels in patients with inoperable adenocarcinoma of the pancreas treated with gemcitabine
    • Ziske C, Schlie C, Gorschluter M, et al.: Prognostic value of CA 19-9 levels in patients with inoperable adenocarcinoma of the pancreas treated with gemcitabine. Br J Cancer 2003; 89: 1413-1417.
    • (2003) Br J Cancer , vol.89 , pp. 1413-1417
    • Ziske, C.1    Schlie, C.2    Gorschluter, M.3
  • 42
    • 0022972347 scopus 로고
    • Tumour marker antigen CA125 in pancreatic cancer: A comparison with CA 19-9 and CEA
    • Haglund C,: Tumour marker antigen CA125 in pancreatic cancer: A comparison with CA 19-9 and CEA. Br J Cancer 1986; 54: 897-901.
    • (1986) Br J Cancer , vol.54 , pp. 897-901
    • Haglund, C.1
  • 43
    • 0023759096 scopus 로고
    • A clinical evaluation of monoclonal (CA19-9, CA50, CA12-5) and polyclonal (CEA, TPA) antibody-defined antigens for the diagnosis of pancreatic cancer
    • Benini L, Cavallini G, Zordan D, et al.: A clinical evaluation of monoclonal (CA19-9, CA50, CA12-5) and polyclonal (CEA, TPA) antibody-defined antigens for the diagnosis of pancreatic cancer. Pancreas 1988; 3: 61-66.
    • (1988) Pancreas , vol.3 , pp. 61-66
    • Benini, L.1    Cavallini, G.2    Zordan, D.3
  • 44
    • 23844519729 scopus 로고    scopus 로고
    • Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer
    • Alldinger I, Dittert D, Peiper M, et al.: Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer. Pancreatology 2005; 5: 370-379.
    • (2005) Pancreatology , vol.5 , pp. 370-379
    • Alldinger, I.1    Dittert, D.2    Peiper, M.3
  • 45
    • 9144241047 scopus 로고    scopus 로고
    • Highly expressed genes in pancreatic ductal adenocarcinomas: A comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
    • Iacobuzio-Donahue CA, Ashfaq R, Maitra A, et al.: Highly expressed genes in pancreatic ductal adenocarcinomas: A comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 2003; 63: 8614-8622.
    • (2003) Cancer Res , vol.63 , pp. 8614-8622
    • Iacobuzio-Donahue, C.A.1    Ashfaq, R.2    Maitra, A.3
  • 46
    • 4544317212 scopus 로고    scopus 로고
    • Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis
    • Missiaglia E, Blaveri E, Terris B, et al.: Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. Int J Cancer 2004; 112: 100-112.
    • (2004) Int J Cancer , vol.112 , pp. 100-112
    • Missiaglia, E.1    Blaveri, E.2    Terris, B.3
  • 47
    • 77954214387 scopus 로고    scopus 로고
    • Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray
    • Morse DL, Balagurunathan Y, Hostetter G, et al.: Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. Biochem Pharmacol 2010; 80: 748-754.
    • (2010) Biochem Pharmacol , vol.80 , pp. 748-754
    • Morse, D.L.1    Balagurunathan, Y.2    Hostetter, G.3
  • 48
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al.: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321: 1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 49
    • 7044237450 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of human pancreatic juice
    • Gronborg M, Bunkenborg J, Kristiansen TZ, et al.: Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res 2004; 3: 1042-1055.
    • (2004) J Proteome Res , vol.3 , pp. 1042-1055
    • Gronborg, M.1    Bunkenborg, J.2    Kristiansen, T.Z.3
  • 50
    • 33645680173 scopus 로고    scopus 로고
    • Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma
    • Hwang TL, Liang Y, Chien KY, et al.: Overexpression and elevated serum levels of phosphoglycerate kinase 1 in pancreatic ductal adenocarcinoma. Proteomics 2006; 6: 2259-2272.
    • (2006) Proteomics , vol.6 , pp. 2259-2272
    • Hwang, T.L.1    Liang, Y.2    Chien, K.Y.3
  • 51
    • 69449090896 scopus 로고    scopus 로고
    • The identification of phosphoglycerate kinase-1 and histone H4 autoantibodies in pancreatic cancer patient serum using a natural protein microarray
    • Patwa TH, Li C, Poisson LM, et al.: The identification of phosphoglycerate kinase-1 and histone H4 autoantibodies in pancreatic cancer patient serum using a natural protein microarray. Electrophoresis 2009; 30: 2215-2226.
    • (2009) Electrophoresis , vol.30 , pp. 2215-2226
    • Patwa, T.H.1    Li, C.2    Poisson, L.M.3
  • 52
    • 70649090978 scopus 로고    scopus 로고
    • Identification of serum biomarkers for pancreatic adenocarcinoma by proteomic analysis
    • Guo J, Wang W, Liao P, et al.: Identification of serum biomarkers for pancreatic adenocarcinoma by proteomic analysis. Cancer Sci 2009; 100: 2292-2301.
    • (2009) Cancer Sci , vol.100 , pp. 2292-2301
    • Guo, J.1    Wang, W.2    Liao, P.3
  • 53
    • 77953941731 scopus 로고    scopus 로고
    • Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: Up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2
    • Rong Y, Jin D, Hou C, et al.: Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: Up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2. BMC Gastroenterol 2010; 10: 68.
    • (2010) BMC Gastroenterol , vol.10 , pp. 68
    • Rong, Y.1    Jin, D.2    Hou, C.3
  • 54
    • 77955051683 scopus 로고    scopus 로고
    • Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis
    • Xue A, Scarlett CJ, Chung L, et al.: Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis. Br J Cancer 2010; 103: 391-400.
    • (2010) Br J Cancer , vol.103 , pp. 391-400
    • Xue, A.1    Scarlett, C.J.2    Chung, L.3
  • 55
    • 79951833553 scopus 로고    scopus 로고
    • Serum biomarker panels for the detection of pancreatic cancer
    • Brand RE, Nolen BM, Zeh HJ, et al.: Serum biomarker panels for the detection of pancreatic cancer. Clin Cancer Res 2011; 17: 805-816.
    • (2011) Clin Cancer Res , vol.17 , pp. 805-816
    • Brand, R.E.1    Nolen, B.M.2    Zeh, H.J.3
  • 56
    • 84856682672 scopus 로고    scopus 로고
    • Urine metabolic signature of pancreatic ductal adenocarcinoma by (1) h nuclear magnetic resonance: Identification, mapping, and evolution
    • Napoli C, Sperandio N, Lawlor RT, et al.: Urine metabolic signature of pancreatic ductal adenocarcinoma by (1) h nuclear magnetic resonance: Identification, mapping, and evolution. J Proteome Res 2012; 11: 1274-1283.
    • (2012) J Proteome Res , vol.11 , pp. 1274-1283
    • Napoli, C.1    Sperandio, N.2    Lawlor, R.T.3
  • 57
    • 78651446213 scopus 로고    scopus 로고
    • Feasibility of identifying pancreatic cancer based on serum metabolomics
    • Bathe OF, Shaykhutdinov R, Kopciuk K, et al.: Feasibility of identifying pancreatic cancer based on serum metabolomics. Cancer Epidemiol Biomarkers Prev 2011; 20: 140-147.
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 140-147
    • Bathe, O.F.1    Shaykhutdinov, R.2    Kopciuk, K.3
  • 58
    • 85027942122 scopus 로고    scopus 로고
    • Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis
    • OuYang D, Xu J, Huang H, et al.: Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis. Appl Biochem Biotechnol 2011; 165: 148-154.
    • (2011) Appl Biochem Biotechnol , vol.165 , pp. 148-154
    • Ouyang, D.1    Xu, J.2    Huang, H.3
  • 59
    • 70449700281 scopus 로고    scopus 로고
    • MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease
    • Wang J, Chen J, Chang P, et al.: MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev Res (Phila) 2009; 2: 807-813.
    • (2009) Cancer Prev Res (Phila) , vol.2 , pp. 807-813
    • Wang, J.1    Chen, J.2    Chang, P.3
  • 60
    • 79959588396 scopus 로고    scopus 로고
    • Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer
    • LaConti JJ, Shivapurkar N, Preet A, et al.: Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer. PLoS ONE 2011; 6: e20687.
    • (2011) PLoS ONE , vol.6
    • Laconti, J.J.1    Shivapurkar, N.2    Preet, A.3
  • 61
    • 45349107664 scopus 로고    scopus 로고
    • Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection
    • Shi C, Fukushima N, Abe T, et al.: Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. Cancer Biol Ther 2008; 7: 353-360.
    • (2008) Cancer Biol Ther , vol.7 , pp. 353-360
    • Shi, C.1    Fukushima, N.2    Abe, T.3
  • 62
    • 67749113684 scopus 로고    scopus 로고
    • Results of a phase i trial of 12 patients with locally advanced pancreatic carcinoma combining gefitinib, paclitaxel, and 3-dimensional conformal radiation: Report of toxicity and evaluation of circulating K-ras as a potential biomarker of response to therapy
    • Olsen CC, Schefter TE, Chen H, et al.: Results of a phase I trial of 12 patients with locally advanced pancreatic carcinoma combining gefitinib, paclitaxel, and 3-dimensional conformal radiation: Report of toxicity and evaluation of circulating K-ras as a potential biomarker of response to therapy. Am J Clin Oncol 2009; 32: 115-121.
    • (2009) Am J Clin Oncol , vol.32 , pp. 115-121
    • Olsen, C.C.1    Schefter, T.E.2    Chen, H.3
  • 63
    • 84857917306 scopus 로고    scopus 로고
    • K-ras mutations in the plasma correspond to computed tomographic findings in patients with pancreatic cancer
    • Dabritz J, Preston R, Hanfler J, et al.: K-ras mutations in the plasma correspond to computed tomographic findings in patients with pancreatic cancer. Pancreas 2012; 41: 323-325.
    • (2012) Pancreas , vol.41 , pp. 323-325
    • Dabritz, J.1    Preston, R.2    Hanfler, J.3
  • 64
    • 3042780578 scopus 로고    scopus 로고
    • Low value of detection of KRAS2 mutations in circulating DNA to differentiate chronic pancreatitis to pancreatic cancer
    • Marchese R, Muleti A, Brozzetti S, et al.: Low value of detection of KRAS2 mutations in circulating DNA to differentiate chronic pancreatitis to pancreatic cancer. Br J Cancer 2004; 90: 2243.
    • (2004) Br J Cancer , vol.90 , pp. 2243
    • Marchese, R.1    Muleti, A.2    Brozzetti, S.3
  • 65
    • 83355166957 scopus 로고    scopus 로고
    • Validation study of a quantitative multigene reverse transcriptase- polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer
    • Gray RG, Quirke P, Handley K, et al.: Validation study of a quantitative multigene reverse transcriptase-polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer. J Clin Oncol 2011; 29: 4611-4619.
    • (2011) J Clin Oncol , vol.29 , pp. 4611-4619
    • Gray, R.G.1    Quirke, P.2    Handley, K.3
  • 66
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G, et al.: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004; 351: 2817-2826.
    • (2004) N Engl J Med , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 67
    • 84863278019 scopus 로고    scopus 로고
    • Integrative survival-based molecular profiling of human pancreatic cancer
    • Donahue TR, Tran LM, Hill R, et al.: Integrative survival-based molecular profiling of human pancreatic cancer. Clin Cancer Res 2012; 18: 1352-1363.
    • (2012) Clin Cancer Res , vol.18 , pp. 1352-1363
    • Donahue, T.R.1    Tran, L.M.2    Hill, R.3
  • 68
    • 77955048480 scopus 로고    scopus 로고
    • A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma
    • Stratford JK, Bentrem DJ, Anderson JM, et al.: A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. PLoS Med 2010; 7: e1000307.
    • (2010) PLoS Med , vol.7
    • Stratford, J.K.1    Bentrem, D.J.2    Anderson, J.M.3
  • 69
    • 84871300796 scopus 로고    scopus 로고
    • A novel survival-based tissue microarray of pancreatic cancer identifies clinical useful candidate biomarkers
    • Winter JM, Tang LH, Klimstra DS, et al.: A novel survival-based tissue microarray of pancreatic cancer identifies clinical useful candidate biomarkers. PloS One 2012.
    • (2012) PloS One
    • Winter, J.M.1    Tang, L.H.2    Klimstra, D.S.3
  • 70
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • Iacobuzio-Donahue CA, Fu B, Yachida S, et al.: DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol 2009; 27: 1806-1813.
    • (2009) J Clin Oncol , vol.27 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3
  • 72
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD, et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347: 472-480.
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    Von Mehren, M.2    Blanke, C.D.3
  • 73
    • 12644253827 scopus 로고    scopus 로고
    • Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
    • Goggins M, Goggins M, Schutte M, et al.: Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996; 56: 5360-5364.
    • (1996) Cancer Res , vol.56 , pp. 5360-5364
    • Goggins, M.1    Goggins, M.2    Schutte, M.3
  • 74
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB,: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 75
    • 64849092309 scopus 로고    scopus 로고
    • Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    • Jones S, Hruban RH, Kamiyama M, et al.: Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 2009; 324: 217.
    • (2009) Science , vol.324 , pp. 217
    • Jones, S.1    Hruban, R.H.2    Kamiyama, M.3
  • 76
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al.: Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 123-134.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 77
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al.: Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434: 917-921.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 78
    • 33846333535 scopus 로고    scopus 로고
    • Targeting Fanconi anemia/BRCA2 pathway defects in cancer: The significance of preclinical pharmacogenomic models
    • Gallmeier E, Kern SE,: Targeting Fanconi anemia/BRCA2 pathway defects in cancer: The significance of preclinical pharmacogenomic models. Clin Cancer Res 2007; 13: 4-10.
    • (2007) Clin Cancer Res , vol.13 , pp. 4-10
    • Gallmeier, E.1    Kern, S.E.2
  • 79
    • 80054820265 scopus 로고    scopus 로고
    • An emerging entity: Pancreatic adenocarcinoma associated with a known BRCA mutation: Clinical descriptors, treatment implications, and future directions
    • Lowery MA, Kelsen DP, Stadler ZK, et al.: An emerging entity: Pancreatic adenocarcinoma associated with a known BRCA mutation: Clinical descriptors, treatment implications, and future directions. Oncologist 2011; 16: 1397-1402.
    • (2011) Oncologist , vol.16 , pp. 1397-1402
    • Lowery, M.A.1    Kelsen, D.P.2    Stadler, Z.K.3
  • 80
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M, et al.: FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011; 364: 1817-1825.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 81
    • 78751559414 scopus 로고    scopus 로고
    • Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer
    • Villarroel MC, Rajeshkumar NV, Garrido-Laguna I, et al.: Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer. Mol Cancer Ther 2011; 10: 3-8.
    • (2011) Mol Cancer Ther , vol.10 , pp. 3-8
    • Villarroel, M.C.1    Rajeshkumar, N.V.2    Garrido-Laguna, I.3
  • 82
    • 79951906119 scopus 로고    scopus 로고
    • Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers
    • Von Hoff DD, Stephenson JJ Jr, Rosen P, et al.: Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. J Clin Oncol 2010; 28: 4877-4883.
    • (2010) J Clin Oncol , vol.28 , pp. 4877-4883
    • Von Hoff, D.D.1    Stephenson Jr., J.J.2    Rosen, P.3
  • 83
    • 46649083576 scopus 로고    scopus 로고
    • Adenoviral-mediated overexpression of human equilibrative nucleoside transporter 1 (hENT1) enhances gemcitabine response in human pancreatic cancer
    • Perez-Torras S, Garcia-Manteiga J, Mercade E, et al.: Adenoviral-mediated overexpression of human equilibrative nucleoside transporter 1 (hENT1) enhances gemcitabine response in human pancreatic cancer. Biochem Pharmacol 2008; 76: 322-329.
    • (2008) Biochem Pharmacol , vol.76 , pp. 322-329
    • Perez-Torras, S.1    Garcia-Manteiga, J.2    Mercade, E.3
  • 84
    • 77956222392 scopus 로고    scopus 로고
    • HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients
    • Richards NG, Rittenhouse DW, Freydin B, et al.: HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients. Ann Surg 2010; 252: 499-505; discussion 505-506.
    • (2010) Ann Surg , vol.252 , pp. 499-505
    • Richards, N.G.1    Rittenhouse, D.W.2    Freydin, B.3
  • 85
    • 66349114705 scopus 로고    scopus 로고
    • The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase
    • Costantino CL, Witkiewicz AK, Kuwano Y, et al.: The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res 2009; 69: 4567-4572.
    • (2009) Cancer Res , vol.69 , pp. 4567-4572
    • Costantino, C.L.1    Witkiewicz, A.K.2    Kuwano, Y.3
  • 86
    • 84856462406 scopus 로고    scopus 로고
    • Survival after resection of pancreatic adenocarcinoma: Results from a single institution over three decades
    • Winter JM, Brennan MF, Tang LH, et al.: Survival after resection of pancreatic adenocarcinoma: Results from a single institution over three decades. Ann Surg Oncol 2012; 19: 169-175.
    • (2012) Ann Surg Oncol , vol.19 , pp. 169-175
    • Winter, J.M.1    Brennan, M.F.2    Tang, L.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.