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Volumn 18, Issue 1, 2015, Pages 16-21

Predictive significance of p53, Ki-67, and Bcl-2 expression for pathologic complete response after neoadjuvant chemotherapy for triple-negative breast cancer

Author keywords

Biological markers; Neoadjuvant therapy; Triple negative breast neoplasms; Tumor suppressor protein p53

Indexed keywords

CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; FLUOROURACIL; KI 67 ANTIGEN; METHOTREXATE; PROGESTERONE RECEPTOR; PROTEIN BCL 2; PROTEIN P53;

EID: 84925946400     PISSN: 17386756     EISSN: 20929900     Source Type: Journal    
DOI: 10.4048/jbc.2015.18.1.16     Document Type: Article
Times cited : (43)

References (24)
  • 1
    • 38849149595 scopus 로고    scopus 로고
    • Prognostic impact of clinicopathologic parameters in stage ii/iii breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: Paradoxical features of the triple negative breast cancer
    • Keam B, Im SA, Kim HJ, Oh DY, Kim JH, Lee SH, et al. Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer. BMC Cancer 2007;7:203.
    • (2007) BMC Cancer , vol.7 , pp. 203
    • Keam, B.1    Im, S.A.2    Kim, H.J.3    Oh, D.Y.4    Kim, J.H.5    Lee, S.H.6
  • 2
    • 41649102048 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    • Liedtke C, Mazouni C, Hess KR, André F, Tordai A, Mejia JA, et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 2008;26:1275-81.
    • (2008) J Clin Oncol , vol.26 , pp. 1275-1281
    • Liedtke, C.1    Mazouni, C.2    Hess, K.R.3    André, F.4    Tordai, A.5    Mejia, J.A.6
  • 3
    • 33645779551 scopus 로고    scopus 로고
    • Evaluation of her-2/neu amplification and other biological markers as predictors of response to neoadjuvant anthracycline-based chemotherapy in primary breast cancer: The role of anthracycline dose intensity
    • Bozzetti C, Musolino A, Camisa R, Bisagni G, Flora M, Bassano C, et al. Evaluation of HER-2/neu amplification and other biological markers as predictors of response to neoadjuvant anthracycline-based chemotherapy in primary breast cancer: the role of anthracycline dose intensity. Am J Clin Oncol 2006;29:171-7.
    • (2006) Am J Clin Oncol , vol.29 , pp. 171-177
    • Bozzetti, C.1    Musolino, A.2    Camisa, R.3    Bisagni, G.4    Flora, M.5    Bassano, C.6
  • 4
    • 58749085047 scopus 로고    scopus 로고
    • Changes and predictive and prognostic value of the mitotic index, ki-67, cyclin d1, and cyclo-oxygenase-2 in 710 operable breast cancer patients treated with neoadjuvant chemotherapy
    • Penault-Llorca F, Abrial C, Raoelfils I, Chollet P, Cayre A, MouretReynier MA, et al. Changes and predictive and prognostic value of the mitotic index, Ki-67, cyclin D1, and cyclo-oxygenase-2 in 710 operable breast cancer patients treated with neoadjuvant chemotherapy. Oncologist 2008;13:1235-45.
    • (2008) Oncologist , vol.13 , pp. 1235-1245
    • Penault-Llorca, F.1    Abrial, C.2    Raoelfils, I.3    Chollet, P.4    Cayre, A.5    Mouretreynier, M.A.6
  • 5
    • 0027162207 scopus 로고
    • Apoptosis of lung cancer cells caused by some anti-cancer agents (mmc, cpt-11, adm) is inhibited by bcl-2
    • Ohmori T, Podack ER, Nishio K, Takahashi M, Miyahara Y, Takeda Y, et al. Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2. Biochem Biophys Res Commun 1993;192:30-6.
    • (1993) Biochem Biophys Res Commun , vol.192 , pp. 30-36
    • Ohmori, T.1    Podack, E.R.2    Nishio, K.3    Takahashi, M.4    Miyahara, Y.5    Takeda, Y.6
  • 6
    • 33947207819 scopus 로고    scopus 로고
    • Her-2, p53, p21 and hormonal receptors proteins expression as predictive factors of response and prognosis in locally advanced breast cancer treated with neoadjuvant docetaxel plus epirubicin combination
    • Tiezzi DG, Andrade JM, Ribeiro-Silva A, Zola FE, Marana HR, Tiezzi MG. HER-2, p53, p21 and hormonal receptors proteins expression as predictive factors of response and prognosis in locally advanced breast cancer treated with neoadjuvant docetaxel plus epirubicin combination. BMC Cancer 2007;7:36.
    • (2007) BMC Cancer , vol.7 , pp. 36
    • Tiezzi, D.G.1    Andrade, J.M.2    Ribeiro-Silva, A.3    Zola, F.E.4    Marana, H.R.5    Tiezzi, M.G.6
  • 7
    • 12244271483 scopus 로고    scopus 로고
    • Correlation of p53 status with outcome of neoadjuvant chemotherapy using paclitaxel and doxorubicin in stage iiib breast cancer
    • Anelli A, Brentani RR, Gadelha AP, Amorim De Albuquerque A, Soares F. Correlation of p53 status with outcome of neoadjuvant chemotherapy using paclitaxel and doxorubicin in stage IIIB breast cancer. Ann Oncol 2003;14:428-32.
    • (2003) Ann Oncol , vol.14 , pp. 428-432
    • Anelli, A.1    Brentani, R.R.2    Gadelha, A.P.3    Amorim De Albuquerque, A.4    Soares, F.5
  • 8
    • 0033971806 scopus 로고    scopus 로고
    • Tp53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients
    • Kandioler-Eckersberger D, Ludwig C, Rudas M, Kappel S, Janschek E, Wenzel C, et al. TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients. Clin Cancer Res 2000;6:50-6.
    • (2000) Clin Cancer Res , vol.6 , pp. 50-56
    • Kandioler-Eckersberger, D.1    Ludwig, C.2    Rudas, M.3    Kappel, S.4    Janschek, E.5    Wenzel, C.6
  • 9
    • 77953873255 scopus 로고    scopus 로고
    • Immunohistochemical expression of pten and phosphorylated akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy
    • Yonemori K, Tsuta K, Shimizu C, Hatanaka Y, Hashizume K, Ono M, et al. Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy. Med Oncol 2009;26:344-9.
    • (2009) Med Oncol , vol.26 , pp. 344-349
    • Yonemori, K.1    Tsuta, K.2    Shimizu, C.3    Hatanaka, Y.4    Hashizume, K.5    Ono, M.6
  • 10
    • 64249146434 scopus 로고    scopus 로고
    • Ki-67 expression gives additional prognostic information on st. Gallen 2007 and adjuvant! online risk categories in early breast cancer
    • Jung SY, Han W, Lee JW, Ko E, Kim E, Yu JH, et al. Ki-67 expression gives additional prognostic information on St. Gallen 2007 and Adjuvant! Online risk categories in early breast cancer. Ann Surg Oncol 2009;16:1112-21.
    • (2009) Ann Surg Oncol , vol.16 , pp. 1112-1121
    • Jung, S.Y.1    Han, W.2    Lee, J.W.3    Ko, E.4    Kim, E.5    Yu, J.H.6
  • 11
    • 48949119494 scopus 로고    scopus 로고
    • Clinical response after two cycles compared to her2, ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast
    • von Minckwitz G, Sinn HP, Raab G, Loibl S, Blohmer JU, Eidtmann H, et al. Clinical response after two cycles compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast. Breast Cancer Res 2008;10:R30.
    • (2008) Breast Cancer Res , vol.10 , pp. R30
    • Von Minckwitz, G.1    Sinn, H.P.2    Raab, G.3    Loibl, S.4    Blohmer, J.U.5    Eidtmann, H.6
  • 12
    • 0033926876 scopus 로고    scopus 로고
    • Gorzegno g, et al. P53 but not bcl-2 immunostaining is predictive of poor clinical complete response to primary chemotherapy in breast cancer patients
    • Bottini A, Berruti A, Bersiga A, Brizzi MP, Brunelli A, Gorzegno G, et al. p53 but not bcl-2 immunostaining is predictive of poor clinical complete response to primary chemotherapy in breast cancer patients. Clin Cancer Res 2000;6:2751-8.
    • (2000) Clin Cancer Res , vol.6 , pp. 2751-2758
    • Bottini, A.1    Berruti, A.2    Bersiga, A.3    Brizzi, M.P.4    Brunelli, A.5
  • 13
    • 33746891199 scopus 로고    scopus 로고
    • Cooperating investigators of the eortc. Tumour response to preoperative anthracycline-based chemotherapy in operable breast cancer: The predictive role of p53 expression
    • Mieog JS, van der Hage JA, van de Vijuer MJ, van de Velde CJ; Cooperating Investigators of the EORTC. Tumour response to preoperative anthracycline-based chemotherapy in operable breast cancer: the predictive role of p53 expression. Eur J Cancer 2006;42:1369-79.
    • (2006) Eur J Cancer , vol.42 , pp. 1369-1379
    • Mieog, J.S.1    Van Der Hage, J.A.2    Van De Vijuer, M.J.3    Van De Velde, C.J.4
  • 14
    • 47549107072 scopus 로고    scopus 로고
    • Triple negative breast cancer: Molecular profiling and prognostic impact in adjuvant anthracycline-treated patients
    • Tan DS, Marchió C, Jones RL, Savage K, Smith IE, Dowsett M, et al. Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients. Breast Cancer Res Treat 2008; 111:27-44.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 27-44
    • Tan, D.S.1    Marchió, C.2    Jones, R.L.3    Savage, K.4    Smith, I.E.5    Dowsett, M.6
  • 15
    • 84860390436 scopus 로고    scopus 로고
    • Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis
    • Keam B, Im SA, Lee KH, Han SW, Oh DY, Kim JH, et al. Ki-67 can be used for further classification of triple negative breast cancer into two subtypes with different response and prognosis. Breast Cancer Res 2011;13:R22.
    • (2011) Breast Cancer Res , vol.13 , pp. R22
    • Keam, B.1    Im, S.A.2    Lee, K.H.3    Han, S.W.4    Oh, D.Y.5    Kim, J.H.6
  • 16
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • Carey LA, Dees EC, Sawyer L, Gatti L, Moore DT, Collichio F, et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 2007;13:2329-34.
    • (2007) Clin Cancer Res , vol.13 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3    Gatti, L.4    Moore, D.T.5    Collichio, F.6
  • 17
    • 84863102966 scopus 로고    scopus 로고
    • Value of tp53 status for predicting response to neoadjuvant chemotherapy in breast cancer: A meta-analysis
    • Chen MB, Zhu YQ, Xu JY, Wang LQ, Liu CY, Ji ZY, et al. Value of TP53 status for predicting response to neoadjuvant chemotherapy in breast cancer: a meta-analysis. PLoS One 2012;7:e39655.
    • (2012) Plos One , vol.7
    • Chen, M.B.1    Zhu, Y.Q.2    Xu, J.Y.3    Wang, L.Q.4    Liu, C.Y.5    Ji, Z.Y.6
  • 19
    • 79551648294 scopus 로고    scopus 로고
    • Pathological tumor response to neoadjuvant chemotherapy using anthracycline and taxanes in patients with triple-negative breast cancer
    • Sakuma K, Kurosumi M, Oba H, Kobayashi Y, Takei H, Inoue K, et al. Pathological tumor response to neoadjuvant chemotherapy using anthracycline and taxanes in patients with triple-negative breast cancer. Exp Ther Med 2011;2:257-64.
    • (2011) Exp Ther Med , vol.2 , pp. 257-264
    • Sakuma, K.1    Kurosumi, M.2    Oba, H.3    Kobayashi, Y.4    Takei, H.5    Inoue, K.6
  • 21
    • 0029007175 scopus 로고
    • Effects of estrogen on apoptotic pathways in human breast cancer cell line mcf-7
    • Wang TT, Phang JM. Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. Cancer Res 1995;55:2487-9.
    • (1995) Cancer Res , vol.55 , pp. 2487-2489
    • Wang, T.T.1    Phang, J.M.2
  • 22
    • 0028917190 scopus 로고
    • Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer
    • Gasparini G, Barbareschi M, Doglioni C, Palma PD, Mauri FA, Boracchi P, et al. Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer. Clin Cancer Res 1995;1:189-98.
    • (1995) Clin Cancer Res , vol.1 , pp. 189-198
    • Gasparini, G.1    Barbareschi, M.2    Doglioni, C.3    Palma, P.D.4    Mauri, F.A.5    Boracchi, P.6
  • 23
    • 0030015547 scopus 로고    scopus 로고
    • Expression of bcl-2 in node-negative breast cancer is associated with various prognostic factors, but does not predict response to one course of perioperative chemotherapy
    • van Slooten HJ, Clahsen PC, van Dierendonck JH, Duval C, Pallud C, Mandard AM, et al. Expression of Bcl-2 in node-negative breast cancer is associated with various prognostic factors, but does not predict response to one course of perioperative chemotherapy. Br J Cancer 1996; 74:78-85.
    • (1996) Br J Cancer , vol.74 , pp. 78-85
    • Van Slooten, H.J.1    Clahsen, P.C.2    Van Dierendonck, J.H.3    Duval, C.4    Pallud, C.5    Mandard, A.M.6
  • 24
    • 67650351514 scopus 로고    scopus 로고
    • A prognostic model based on nodal status and ki-67 predicts the risk of recurrence and death in breast cancer patients with residual disease after preoperative chemotherapy
    • Guarneri V, Piacentini F, Ficarra G, Frassoldati A, D’Amico R, Giovannelli S, et al. A prognostic model based on nodal status and Ki-67 predicts the risk of recurrence and death in breast cancer patients with residual disease after preoperative chemotherapy. Ann Oncol 2009;20: 1193-8.
    • (2009) Ann Oncol , vol.20 , pp. 1193-1198
    • Guarneri, V.1    Piacentini, F.2    Ficarra, G.3    Frassoldati, A.4    D’Amico, R.5    Giovannelli, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.