메뉴 건너뛰기




Volumn 29, Issue 2, 2006, Pages 171-177

Evaluation of HER-2/neu amplification and other biological markers as predictors of response to neoadjuvant anthracycline-based chemotherapy in primary breast cancer: The role of anthracycline dose intensity

Author keywords

Anthracyclines; Breast cancer; HER 2 neu; Neoadjuvant chemotherapy

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; ESTROGEN RECEPTOR; FLUOROURACIL; KI 67 ANTIGEN; METHOTREXATE; PROGESTERONE RECEPTOR; ANTHRACYCLINE; TUMOR MARKER;

EID: 33645779551     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/01.coc.0000204405.96572.f9     Document Type: Review
Times cited : (34)

References (44)
  • 1
    • 0022406444 scopus 로고
    • Amplification of a novel v-erbB-related gene in a human mammary carcinoma
    • King CR, Kraus MH, Aaronson SA. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science. 1985;229:974-976.
    • (1985) Science , vol.229 , pp. 974-976
    • King, C.R.1    Kraus, M.H.2    Aaronson, S.A.3
  • 2
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 3
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. 1989;244:707-712.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 4
    • 0026576399 scopus 로고
    • HER-2/neu in node-negative breast cancer: Prognostic significance of overexpression influenced by the presence of in situ carcinoma
    • Allred DC, Clark GM, Tandon AK, et al. HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma. J Clin Oncol. 1992;10:599-605.
    • (1992) J Clin Oncol , vol.10 , pp. 599-605
    • Allred, D.C.1    Clark, G.M.2    Tandon, A.K.3
  • 5
    • 0026625217 scopus 로고
    • Prognostic importance of c-erbB-2 expression in breast cancer
    • International (Ludwig) Breast Cancer Study Group
    • Gusterson BA, Gelber RD, Goldhirsch A, et al. Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group. J Clin Oncol. 1992;10:1049-1056.
    • (1992) J Clin Oncol , vol.10 , pp. 1049-1056
    • Gusterson, B.A.1    Gelber, R.D.2    Goldhirsch, A.3
  • 6
    • 0032772856 scopus 로고    scopus 로고
    • Effect of c-erbB(2) and estrogen receptor status on survival of women with primary breast cancer treated with adjuvant cyclophosphamide/methotrexate/ fluorouracil
    • Miles DW, Harris WH, Gillett CE, et al. Effect of c-erbB(2) and estrogen receptor status on survival of women with primary breast cancer treated with adjuvant cyclophosphamide/methotrexate/fluorouracil. Int J Cancer. 1999;84:354-359.
    • (1999) Int J Cancer , vol.84 , pp. 354-359
    • Miles, D.W.1    Harris, W.H.2    Gillett, C.E.3
  • 7
    • 0035863383 scopus 로고    scopus 로고
    • Response to cyclophosphamide, methotrexate, and fluorouracil in lymph node-positive breast cancer according to HER-2 overexpression and other tumor biologic variables
    • Menard S, Valagussa P, Pilotti S, et al. Response to cyclophosphamide, methotrexate, and fluorouracil in lymph node-positive breast cancer according to HER-2 overexpression and other tumor biologic variables. J Clin Oncol. 2001;19:329-335.
    • (2001) J Clin Oncol , vol.19 , pp. 329-335
    • Menard, S.1    Valagussa, P.2    Pilotti, S.3
  • 8
    • 0028354305 scopus 로고
    • C-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer
    • Muss HB, Thor AD, Berry DA, et al. C-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer. N Engl J Med. 1994;330:1260-1266.
    • (1994) N Engl J Med , vol.330 , pp. 1260-1266
    • Muss, H.B.1    Thor, A.D.2    Berry, D.A.3
  • 9
    • 0032538040 scopus 로고    scopus 로고
    • erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer
    • Paik S, Bryant J, Park C, et al. erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer. J Natl Cancer Inst. 1998;90:1361-1370.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1361-1370
    • Paik, S.1    Bryant, J.2    Park, C.3
  • 10
    • 0013437947 scopus 로고    scopus 로고
    • Prognostic and predictive value of HER-2/neu in a randomized trial comparing CMF to CEF in premenopausal women with axillary lymph node positive breast cancer (NCIC CTG MA. 5)
    • Pritchard K, O'Malley F, Andrulis I, et al. Prognostic and predictive value of HER-2/neu in a randomized trial comparing CMF to CEF in premenopausal women with axillary lymph node positive breast cancer (NCIC CTG MA. 5). Proc Am Soc Clin Oncol. 2002;21:42A
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Pritchard, K.1    O'Malley, F.2    Andrulis, I.3
  • 11
    • 0034694659 scopus 로고    scopus 로고
    • HER-2 and choice of adjuvant chemotherapy for invasive breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-15
    • Paik S, Bryant J, Tan-Chiu E, et al. HER-2 and choice of adjuvant chemotherapy for invasive breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-15. J Natl Cancer Inst. 2000;92:1991-1998.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1991-1998
    • Paik, S.1    Bryant, J.2    Tan-Chiu, E.3
  • 12
    • 0036091354 scopus 로고    scopus 로고
    • HER-2 amplification and topoisomerase IIα gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil
    • Di Leo A, Gancberg D, Larsimont D, et al. HER-2 amplification and topoisomerase IIα gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin Cancer Res. 2002;8:1107-1116.
    • (2002) Clin Cancer Res , vol.8 , pp. 1107-1116
    • Di Leo, A.1    Gancberg, D.2    Larsimont, D.3
  • 13
    • 0026718827 scopus 로고
    • ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization
    • Kallioniemi OP, Kallioniemi A, Kurisu W, et al. ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc Natl Acad Sci USA. 1992;89:5321-5325.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5321-5325
    • Kallioniemi, O.P.1    Kallioniemi, A.2    Kurisu, W.3
  • 14
    • 0029884715 scopus 로고    scopus 로고
    • Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization
    • Pauletti G, Godolphin W, Press MF, et al. Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization. Oncogene. 1996;13:63-72.
    • (1996) Oncogene , vol.13 , pp. 63-72
    • Pauletti, G.1    Godolphin, W.2    Press, M.F.3
  • 15
    • 0037099732 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu gene amplification and overexpression: Comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens
    • Press MF, Slamon DJ, Flom KJ, et al. Evaluation of HER-2/neu gene amplification and overexpression: comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens. J Clin Oncol. 2002;20:3095-3105.
    • (2002) J Clin Oncol , vol.20 , pp. 3095-3105
    • Press, M.F.1    Slamon, D.J.2    Flom, K.J.3
  • 16
    • 0036737229 scopus 로고    scopus 로고
    • HER-2/neu amplification detected by fluorescence in situ hybridization in fine needle aspirates from primary breast cancer
    • Bozzetti C, Nizzoli R, Guazzi A, et al. HER-2/neu amplification detected by fluorescence in situ hybridization in fine needle aspirates from primary breast cancer. Ann Oncol. 2002;13:1398-1403.
    • (2002) Ann Oncol , vol.13 , pp. 1398-1403
    • Bozzetti, C.1    Nizzoli, R.2    Guazzi, A.3
  • 17
    • 0141891477 scopus 로고    scopus 로고
    • HER-2/neu amplification by fluorescence in situ hybridization in cytologic samples from distant metastatic sites of breast carcinoma
    • Bozzetti C, Personeni N, Nizzoli R, et al. HER-2/neu amplification by fluorescence in situ hybridization in cytologic samples from distant metastatic sites of breast carcinoma. Cancer (Cancer Cytopathlogy). 2003;99:310-315.
    • (2003) Cancer (Cancer Cytopathlogy) , vol.99 , pp. 310-315
    • Bozzetti, C.1    Personeni, N.2    Nizzoli, R.3
  • 18
    • 9144242764 scopus 로고    scopus 로고
    • Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy
    • Petit T, Wilt M, Velten M, et al. Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy. Eur J Cancer. 2004;40:205-211.
    • (2004) Eur J Cancer , vol.40 , pp. 205-211
    • Petit, T.1    Wilt, M.2    Velten, M.3
  • 19
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J, Lemke H, Baisch H, et al. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984;133:1710-1715.
    • (1984) J Immunol , vol.133 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3
  • 21
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 22
    • 0013886333 scopus 로고    scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 1996;50:163-170.
    • (1996) Cancer Chemother Rep , vol.50 , pp. 163-170
    • Mantel, N.1
  • 23
    • 0000336139 scopus 로고
    • Regression models and life tables
    • Cox DR. Regression models and life tables. J R Stat Soc. 1972;34:187-220.
    • (1972) J R Stat Soc , vol.34 , pp. 187-220
    • Cox, D.R.1
  • 24
    • 0032547342 scopus 로고    scopus 로고
    • Dose and dose intensity are determinants of outcome in the adjuvant treatment of breast cancer
    • The Cancer and Leukemina Group B.
    • Budman DR, Berry DA, Cirrincione CT, et al. Dose and dose intensity are determinants of outcome in the adjuvant treatment of breast cancer. The Cancer and Leukemina Group B. J Natl Cancer Inst. 1998;90:1205-1211.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1205-1211
    • Budman, D.R.1    Berry, D.A.2    Cirrincione, C.T.3
  • 25
    • 0034327895 scopus 로고    scopus 로고
    • Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: A direct comparison of fluorescence in situ Hybridization and immunohistochemistry
    • Pauletti G, Dandekar S, Rong H, et al. Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: a direct comparison of fluorescence in situ Hybridization and immunohistochemistry. J Clin Oncol. 2000;18:3651-3664.
    • (2000) J Clin Oncol , vol.18 , pp. 3651-3664
    • Pauletti, G.1    Dandekar, S.2    Rong, H.3
  • 26
    • 0032538050 scopus 로고    scopus 로고
    • ErbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer
    • Thor AD, Berry DA, Budman DR, et al. ErbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer. J Natl Cancer Inst. 1998;90:1346-1360.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1346-1360
    • Thor, A.D.1    Berry, D.A.2    Budman, D.R.3
  • 27
    • 0000822847 scopus 로고    scopus 로고
    • Initial report of the SWOG biological correlative study of c-erbB-2 expression as a predictor of outcome in a trial comparing adjuvant CAF T with tamoxifen (T) alone
    • Ravdin PM, Green S, Albain KS, et al. Initial report of the SWOG biological correlative study of c-erbB-2 expression as a predictor of outcome in a trial comparing adjuvant CAF T with tamoxifen (T) alone. Proc Am Soc Clin Oncol. 1998;17:97A.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Ravdin, P.M.1    Green, S.2    Albain, K.S.3
  • 28
    • 0028274962 scopus 로고
    • Dose and dose intensity of adjuvant chemotherapy for stage II, node-positive breast carcinoma
    • Wood WC, Budman DR, Korzun AH, et al. Dose and dose intensity of adjuvant chemotherapy for stage II, node-positive breast carcinoma. N Engl J Med. 1994;330:1253-1259.
    • (1994) N Engl J Med , vol.330 , pp. 1253-1259
    • Wood, W.C.1    Budman, D.R.2    Korzun, A.H.3
  • 29
    • 0029848257 scopus 로고    scopus 로고
    • Primary chemotherapy in breast invasive carcinoma: Predictive value of the immunohistochemical detection of hormonal receptors, p53, c-erbB-2, MiB1, pS2, and GSTπ
    • MacGrogan G, Mauriac L, Durand M, et al. Primary chemotherapy in breast invasive carcinoma: predictive value of the immunohistochemical detection of hormonal receptors, p53, c-erbB-2, MiB1, pS2, and GSTπ. Br J Cancer. 1996;74:1458-1465.
    • (1996) Br J Cancer , vol.74 , pp. 1458-1465
    • MacGrogan, G.1    Mauriac, L.2    Durand, M.3
  • 30
    • 0033009904 scopus 로고    scopus 로고
    • c-erbB-2 (HER-2/neu) protein and drug resistance in breast cancer patients treated with induction chemotherapy
    • Vargas-Roig LM, Gago FE, Tello O, et al. c-erbB-2 (HER-2/neu) protein and drug resistance in breast cancer patients treated with induction chemotherapy. Int J Cancer. 1999;84:129-134.
    • (1999) Int J Cancer , vol.84 , pp. 129-134
    • Vargas-Roig, L.M.1    Gago, F.E.2    Tello, O.3
  • 31
    • 17044460519 scopus 로고    scopus 로고
    • ErbB-2 overexpression in breast carcinomas: No positive correlation with complete pathological response to preoperative high-dose anthracycline-based chemotherapy
    • Vincent-Salomon A, Carton M, Freneaux P, et al. ErbB-2 overexpression in breast carcinomas: no positive correlation with complete pathological response to preoperative high-dose anthracycline-based chemotherapy. Eur J Cancer. 2000;36:586-591.
    • (2000) Eur J Cancer , vol.36 , pp. 586-591
    • Vincent-Salomon, A.1    Carton, M.2    Freneaux, P.3
  • 32
    • 0037377712 scopus 로고    scopus 로고
    • Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma
    • Zhang F, Yang Y, Smith T, et al. Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma. Cancer. 2003;97:1758-1765.
    • (2003) Cancer , vol.97 , pp. 1758-1765
    • Zhang, F.1    Yang, Y.2    Smith, T.3
  • 33
    • 0037428704 scopus 로고    scopus 로고
    • Breast cancer response to neoadjuvant chemotherapy: Predictive markers and relation with outcome
    • Faneyte IF, Schrama JG, Peterse JL, et al. Breast cancer response to neoadjuvant chemotherapy: predictive markers and relation with outcome. Br J Cancer. 2003;288:406-412.
    • (2003) Br J Cancer , vol.288 , pp. 406-412
    • Faneyte, I.F.1    Schrama, J.G.2    Peterse, J.L.3
  • 34
    • 0034896257 scopus 로고    scopus 로고
    • Chemotherapy response of breast cancer depends oh HER-2 status and anthracycline dose intensity in the neoadjuvant setting
    • Petit T, Borel C, Ghnassia JP, et al. Chemotherapy response of breast cancer depends oh HER-2 status and anthracycline dose intensity in the neoadjuvant setting. Clin Cancer Res. 2001;7:1577-1581.
    • (2001) Clin Cancer Res , vol.7 , pp. 1577-1581
    • Petit, T.1    Borel, C.2    Ghnassia, J.P.3
  • 35
    • 0036554731 scopus 로고    scopus 로고
    • Amplification and overexpression of topoisomerase IIα predict response to anthracycline-based therapy in locally advanced breast cancer
    • Coon JS, Marcus E, Gupta-Burt S, et al. Amplification and overexpression of topoisomerase IIα predict response to anthracycline-based therapy in locally advanced breast cancer. Clin Cancer Res. 2002;8:1061-1067.
    • (2002) Clin Cancer Res , vol.8 , pp. 1061-1067
    • Coon, J.S.1    Marcus, E.2    Gupta-Burt, S.3
  • 36
    • 0036550613 scopus 로고    scopus 로고
    • Scarf-Bloom-Richardson (SBR) grading: A pleiotropic marker of chemosensitivity in invasive ductal breast carcinomas treated by neoadjuvant chemotherapy
    • Amat S, Penault-Llorca F, Cure H, et al. Scarf-Bloom-Richardson (SBR) grading: a pleiotropic marker of chemosensitivity in invasive ductal breast carcinomas treated by neoadjuvant chemotherapy. Int J Oncol. 2002;20:791-796.
    • (2002) Int J Oncol , vol.20 , pp. 791-796
    • Amat, S.1    Penault-Llorca, F.2    Cure, H.3
  • 37
    • 12244252332 scopus 로고    scopus 로고
    • Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy
    • Aas T, Geisler S, Eide GE, et al. Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy. Eur J Cancer. 2003;39:438-446.
    • (2003) Eur J Cancer , vol.39 , pp. 438-446
    • Aas, T.1    Geisler, S.2    Eide, G.E.3
  • 38
    • 0032763581 scopus 로고    scopus 로고
    • Biological markers as indicators of response to primary and adjuvant chemotherapy in breast cancer
    • Daidone MG, Veneroni S, Benini E, et al. Biological markers as indicators of response to primary and adjuvant chemotherapy in breast cancer. Int J Cancer. 1999;84:580-586.
    • (1999) Int J Cancer , vol.84 , pp. 580-586
    • Daidone, M.G.1    Veneroni, S.2    Benini, E.3
  • 39
    • 0027373149 scopus 로고
    • Cell cycle modifications of breast cancers during neoadjuvant chemotherapy: A flow cytometry study on fine needle aspirates
    • Remvikos Y, Jouve M, Beuzeboc P, et al. Cell cycle modifications of breast cancers during neoadjuvant chemotherapy: a flow cytometry study on fine needle aspirates. Eur J Cancer. 1993;29:1843-1848.
    • (1993) Eur J Cancer , vol.29 , pp. 1843-1848
    • Remvikos, Y.1    Jouve, M.2    Beuzeboc, P.3
  • 40
    • 0033118545 scopus 로고    scopus 로고
    • Prediction of response to primary chemotherapy for operable breast cancer
    • Colleoni M, Orvieto E, Nole F, et al. Prediction of response to primary chemotherapy for operable breast cancer. Eur J Cancer. 1999;35:574-579.
    • (1999) Eur J Cancer , vol.35 , pp. 574-579
    • Colleoni, M.1    Orvieto, E.2    Nole, F.3
  • 41
    • 2942521162 scopus 로고    scopus 로고
    • Breast Cancer Study Group: Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy
    • Vincent-Salomon A, Rousseau A, Jouve M, et al. Breast Cancer Study Group: proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy. Eur J Cancer. 2004;40:1502-1508.
    • (2004) Eur J Cancer , vol.40 , pp. 1502-1508
    • Vincent-Salomon, A.1    Rousseau, A.2    Jouve, M.3
  • 42
    • 0038612855 scopus 로고    scopus 로고
    • Role of proliferation in HER2 status predicted response to doxorubicin
    • Campiglio M, Somenzi G, Olgiati C, et al. Role of proliferation in HER2 status predicted response to doxorubicin. Int J Cancer. 2003;105:568-573.
    • (2003) Int J Cancer , vol.105 , pp. 568-573
    • Campiglio, M.1    Somenzi, G.2    Olgiati, C.3
  • 43
    • 0033870292 scopus 로고    scopus 로고
    • Amplification and deletion of topoisomerase II associate with erbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer
    • Jarvinen TA, Tanner M, Rantanen V, et al. Amplification and deletion of topoisomerase II associate with erbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am J Pathol. 2000;156:839-847.
    • (2000) Am J Pathol , vol.156 , pp. 839-847
    • Jarvinen, T.A.1    Tanner, M.2    Rantanen, V.3
  • 44
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van't Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415:530-536.
    • (2002) Nature , vol.415 , pp. 530-536
    • Van'T Veer, L.J.1    Dai, H.2    Van De Vijver, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.