The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice

Journal of Gastroenterology and Hepatology (Australia)

Volumn 30, Issue S1, 2015, Pages 60-65

  Sakanaka, Taisuke ^a   Inoue, Takuya ^a   Yorifuji, Naoki ^a   Iguchi, Munetaka ^a   Fujiwara, Kaori ^a   Narabayashi, Ken ^a   Kakimoto, Kazuki ^a   Nouda, Sadaharu ^a   Okada, Toshihiko ^a   Kuramoto, Takanori ^a   Ishida, Kumi ^a   Abe, Yosuke ^a   Takeuchi, Toshihisa ^a   Umegaki, Eiji ^a   Akiba, Yasutada ^b   Kaunitz, Jonathan D ^b   Higuchi, Kazuhide ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dextran sulfate sodium; DPPIV; GLP 2; Sitagliptin; TGR5

Indexed keywords

BETULIC ACID; BILE ACID RECEPTOR TGR5; DEXTRAN SULFATE; DRINKING WATER; GLUCAGON LIKE PEPTIDE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; RECEPTOR; SITAGLIPTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; G PROTEIN COUPLED RECEPTOR; GLUCAGON-LIKE PEPTIDE-2 (3-33); GPBAR1 PROTEIN, MOUSE; PEPTIDE FRAGMENT; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; COLON; CONTROLLED STUDY; DEXTRAN SULFATE SODIUM INDUCED COLITIS; DISEASE ACTIVITY; DISEASE CONTROL; FIBROBLAST; INTESTINE INJURY; L CELL LINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; AGONISTS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DOSE RESPONSE; METABOLISM;

ANIMALS; COLITIS; CYTOKINES; DEXTRAN SULFATE; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCAGON-LIKE PEPTIDE 2; INFLAMMATION MEDIATORS; MALE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; RECEPTORS, G-PROTEIN-COUPLED; SITAGLIPTIN PHOSPHATE; TRITERPENES;

EID: 84925937841     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12740     Document Type: Article

References (27)

1. Akiba Y, Kaunitz JD. Duodenal chemosensing and mucosal defenses. Digestion 2011; 83: 25-31.
2. Engelstoft MS, Egerod KL, Holst B, Schwartz TW. A gut feeling for obesity: 7TM sensors on enteroendocrine cells. Cell Metab. 2008; 8: 447-449.
3. Yazbeck R, Howarth GS, Abbott CA. Growth factor based therapies and intestinal disease: is glucagon-like peptide-2 the new way forward? Cytokine Growth Factor Rev. 2009; 20: 175-184.
4. Drozdowski L, Thomson AB. Intestinal hormones and growth factors: effects on the small intestine. World J. Gastroenterol. 2009; 15: 385-406.
5. Drucker DJ, Erlich P, Asa SL, Brubaker PL. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. U.S.A. 1996; 93: 7911-7916.
6. Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, O'Keefe SJ. Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome. Gut 2011; 60: 902-914.
7. Katsuma S, Hirasawa A, Tsujimoto G. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem. Biophys. Res. Commun. 2005; 329: 386-390.
8. Reimann F, Habib AM, Tolhurst G, Parker HE, Rogers GJ, Gribble FM. Glucose sensing in L cells: a primary cell study. Cell Metab. 2008; 8: 532-539.
9. Inoue T, Wang JH, Higashiyama M etal. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am. J. Physiol. Gastrointest. Liver Physiol. 2012; 303: G810-G816.
10. Pitman MR, Sulda ML, Kuss B, Abbott CA. Dipeptidyl peptidase 8 and 9-guilty by association? Front. Biosci. 2009; 14: 3619-3633.
11. Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD. Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. Eur. J. Biochem. 2000; 267: 6140-6150.
12. Murthy SN, Cooper HS, Shim H, Shah RS, Ibrahim SA, Sedergran DJ. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig. Dis. Sci. 1993; 38: 1722-1734.
13. Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM. Regulation of interleukin 12 p40 expression through a NF-kB half-site. Mol. Cell. Biol. 1995; 15: 5258-5267.
14. Knop FK. Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes? Am. J. Physiol. Endocrinol. Metab. 2010; 299: E10-13.
15. Poole DP, Godfrey C, Cattaruzza F etal. Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol. Motil. 2010; 22: 814-825.
16. Foord SM, Bonner TI, Neubig RR etal. International Union of Pharmacology. XLVI. G protein coupled receptor list. Pharmacol. Rev. 2005; 57: 279-288.
17. Tiwari A, Miti P. TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders. Drug Discov. Today 2009; 14: 523-530.
18. Eissele R, Göke R, Willemer S etal. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur. J. Clin. Invest. 1992; 22: 283-291.
19. Yazbeck R, Howarth GS, Geier MS, Demuth HU, Abbott CA. Inhibiting dipeptidyl peptidase activity partially ameliorates colitis in mice. Front. Biosci. 2008; 13: 6850-6858.
20. Abbott CA, Yazbeck R, Geier MS, Demuth HU, Howarth GS. Dipeptidyl peptidases and inflammatory bowel disease. Adv. Exp. Med. Biol. 2006; 575: 155-162.
21. Ban H, Bamba S, Imaeda H etal. The DPP-IV inhibitor ER-319711 has a proliferative effect on the colonic epithelium and a minimal effect in the amelioration of colitis. Oncol. Rep. 2011; 25: 1699-1703.
22. Yazbeck R, Sulda ML, Howarth GS etal. Dipeptidyl peptidase expression during experimental colitis in mice. Inflamm. Bowel Dis. 2010; 16: 1340-1351.
23. Ajami K, Abbott CA, McCaughan GW, Gorrell MD. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. Biochim. Biophys. Acta 2004; 1679: 18-28.
24. Geier MS, Tenikoff D, Yazbeck R, McCaughan GW, Abbott CA, Howarth GS. Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV. J. Cell. Physiol. 2005; 204: 687-692.
25. Ellingsgaard H, Hauselmann I, Schuler B etal. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat. Med. 2011; 17: 1481-1489.
26. Mimura S, Ando T, Ishiguro K etal. Dipeptidyl peptidase-4 inhibitor anagliptin facilitates restoration of dextran sulfate sodium-induced colitis. Scand. J. Gastroenterol. 2013; 48: 1152-1159.
27. Jonnalagadda SC, Corsello MA, Sleet CE. Betulin-betulinic acid natural product based analogs as anti-cancer agents. Anticancer Agents Med. Chem. 2013; 13: 1477-1499.