Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

Plant Biotechnology Journal

Volumn 12, Issue 8, 2014, Pages 1098-1107

  Lai, Huafang ^a   He, Junyun ^a   Hurtado, Jonathan ^a,b   Stahnke, Jake ^a,b   Fuchs, Anja ^c   Mehlhop, Erin ^c,f   Gorlatov, Sergey ^d   Loos, Andreas ^e   Diamond, Michael S ^c,d   Chen, Qiang ^a,b  

^a AZ 85281   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MacroGenics Inc   (United States)

^e UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Glycoengineered plants; Glycosylation; Plant made biologics; ScFv Fc; Single chain antibody; West Nile virus

Indexed keywords

MAMMALIA; MUS; NICOTIANA BENTHAMIANA; WEST NILE VIRUS;

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PLANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; VIRUS ANTIBODY; VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN;

ANIMAL; C57BL MOUSE; GENE EXPRESSION; GLYCOSYLATION; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; SERODIAGNOSIS; SURFACE PLASMON RESONANCE; TOBACCO; WEST NILE FEVER; WEST NILE VIRUS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; GENE EXPRESSION; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G; MICE; MICE, INBRED C57BL; NEUTRALIZATION TESTS; PLANTIBODIES; SINGLE-CHAIN ANTIBODIES; SURFACE PLASMON RESONANCE; TOBACCO; VIRAL ENVELOPE PROTEINS; WEST NILE FEVER; WEST NILE VIRUS;

EID: 84925932871     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/pbi.12217     Document Type: Article

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