Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

Plant Biotechnology Journal

Volumn 10, Issue 1, 2012, Pages 95-104

  Lai, Huafang ^a   He, Junyun ^a   Engle, Michael ^b   Diamond, Michael S ^b   Chen, Qiang ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ebola virus; Geminiviral replicon system; Lettuce; Plant antibody; Plant vaccine; West Nile virus

Indexed keywords

BACTERIAL DNA; CAPSID PROTEIN; GREEN FLUORESCENT PROTEIN; MONOCLONAL ANTIBODY; NORWALK VIRUS CAPSID; T DNA; T-DNA; VIRUS ANTIBODY;

ARTICLE; BIOSYNTHESIS; BIOTECHNOLOGY; CYTOLOGY; EBOLA VIRUS; GEMINIVIRUS; GENE VECTOR; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; LETTUCE; METABOLISM; METHODOLOGY; PLANT LEAF; REPLICON; VIRION; VIROLOGY; WEST NILE FLAVIVIRUS;

ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; BIOTECHNOLOGY; CAPSID PROTEINS; DNA, BACTERIAL; EBOLAVIRUS; GEMINIVIRIDAE; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; LETTUCE; PLANT LEAVES; REPLICON; VIRION; WEST NILE VIRUS;

BEAN YELLOW DWARF VIRUS; EBOLA VIRUS; LACTUCA; MIRIDAE; NICOTIANA; NICOTIANA TABACUM; NOROVIRUS; NORWALK VIRUS; WEST NILE VIRUS;

EID: 83055181327     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/j.1467-7652.2011.00649.x     Document Type: Article

References (44)

1. Ahlquist, P., Schwartz, M., Chen, J., Kushner, D., Hao, L. and Dye, B.T. (2005) Viral and host determinants of RNA virus vector replication and expression. Vaccine, 23, 1784-1787.
2. Buck, K.W. (1999) Replication of tobacco mosaic virus RNA. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 354, 613-627.
3. Canizares, M.C., Nicholson, L. and Lomonossoff, G.P. (2005) Use of viral vectors for vaccine production in plants. Immunol. Cell Biol. 83, 263-270.
4. Castilho, A., Strasser, R., Stadlmann, J., Grass, J., Jez, J., Gattinger, P., Kunert, R., Quendler, H., Pabst, M., Leonard, R., Altmann, F. and Steinkellner, H. (2010) In planta protein sialylation through overexpression of the respective mammalian pathway. J. Biol. Chem. 285, 15923-15930.
5. Chen, Q (2008) Expression and purification of pharmaceutical proteins in plants. Biol. Eng. 1, 291-321.
6. Chen, Q. (2011a) Expression and manufacture of pharmaceutical proteins in genetically engineered horticultural plants. In Transgenic Horticultural Crops: Challenges and Opportunities-Essays by Experts (Mou, B. and Scorza, R., eds), pp. 86-126, Boca Raton, FL: Taylor & Francis.
7. Chen, Q. (2011b) Turning a new leaf. Eur. Biopharm. Rev. 3, 64-68.
8. Chen, Q., He, J., Phoolcharoen, W. and Mason, H.S. (2011) Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Hum. Vaccines, 7, 331-338.
9. Conley, A.J., Zhu, H., Le, L.C., Jevnikar, A.M., Lee, B.H., Brandle, J.E. and Menassa, R. (2010) Recombinant protein production in a variety of Nicotiana hosts: a comparative analysis. Plant Biotechnol. J. 9, 434-444.
10. Daniell, H. (2006) Production of biopharmaceuticals and vaccines in plants via the chloroplast genome. Biotechnol. J. 1, 1071-1079.
11. Davies, H.M. (2010) Commercialization of whole-plant systems for biomanufacturing of protein products: evolution and prospects. Plant Biotechnol. J. 8, 845-861.
12. Davoodi-Semiromi, A., Schreiber, M., Nalapalli, S., Verma, D., Singh, N.D., Banks, R.K., Chakrabarti, D. and Daniell, H. (2010) Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery. Plant Biotechnol. J. 8, 223-242.
13. De Muynck, B., Navarre, C. and Boutry, M. (2010) Production of antibodies in plants: status after twenty years. Plant Biotechnol. J. 8, 529-563.
14. Dunoyer, P., Lecellier, C.-H., Parizotto, E.A., Himber, C. and Voinnet, O. (2004) Probing the MicroRNA and small interfering RNA pathways with virus-encoded suppressors of RNA silencing. Plant Cell Online, 16, 1235-1250.
15. Faye, L. and Gomord, V. (2010) Success stories in molecular farming-a brief overview. Plant Biotechnol. J. 8, 525-528.
16. Fuchs, A., Pinto, A.K., Schwaeble, W.J. and Diamond, M.S. (2011) The lectin pathway of complement activation contributes to protection from West Nile virus infection. Virology, 412, 101-109.
17. Giritch, A., Marillonnet, S., Engler, C., van Eldik, G., Botterman, J., Klimyuk, V. and Gleba, Y. (2006) Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors. Proc. Natl. Acad. Sci. U. S. A. 103, 14701-14706.
18. Gomord, V., Fitchette, A.C., Menu-Bouaouiche, L., Saint-Jore-Dupas, C., Plasson, C., Michaud, D. and Faye, L. (2010) Plant-specific glycosylation patterns in the context of therapeutic protein production. Plant Biotechnol. J. 8, 564-587.
19. Huang, Z., Chen, Q., Hjelm, B., Arntzen, C. and Mason, H. (2009) A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnol. Bioeng. 103, 706-714.
20. Huang, Z., Phoolcharoen, W., Lai, H., Piensook, K., Cardineau, G., Zeitlin, L., Whaley, K., Arntzen, C.J., Mason, H. and Chen, Q. (2010) High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotechnol. Bioeng. 106, 9-17.
21. Jiang, X., Wang, M., Graham, D.Y. and Estes, M.K. (1992) Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein. J. Virol. 66, 6527-6532.
22. Kapusta, J., Modelska, A., Figlerowicz, M., Pniewski, T., Letellier, M., Lisowa, O., Yusibov, V., Koprowski, H., Plucienniczak, A. and Legocki, A.B. (1999) A plant-derived edible vaccine against hepatitis B vaccine. FASEB J. 13, 1796-1799.
23. Komarova, T.V., Baschieri, S., Donini, M., Marusic, C., Benvenuto, E. and Dorokhov, Y.L. (2010) Transient expression systems for plant-derived biopharmaceuticals. Expert Rev. Vaccines, 9, 859-876.
24. Lai, H., Engle, M., Fuchs, A., Keller, T., Johnson, S., Gorlatov, S., Diamond, M.S. and Chen, Q. (2010) Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice. Proc. Natl. Acad. Sci. U. S. A. 107, 2419-2424.
25. Lakatos, L., Szittya, G., Silhavy, D. and Burgyan, J. (2004) Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses. EMBO J. 23, 876-884.
26. Lico, C., Chen, Q. and Santi, L. (2008) Viral vectors for production of recombinant proteins in plants. J. Cell. Physiol. 216, 366-377.
27. Liu, L., Pinner, M.S., Davies, J.W. and Stanley, J. (1999) Adaptation of the geminivirus bean yellow dwarf virus to dicotyledonous hosts involves both virion-sense and complementary-sense genes. J. Gen. Virol. 80, 501-506.
28. Negrouk, V., Eisner, G., Lee, H., Han, K., Taylor, D. and Wong, H. (2005) Highly efficient transient expression of functional recombinant antibodies in lettuce. Plant Sci. 169, 433-438.
29. Obermeier, C., Sears, J.L., Liu, H.Y., Schlueter, K.O., Ryder, E.J., Duffus, J.E., Koike, S.T. and Wisler, G.C. (2001) Characterization of distinct tombusviruses that cause diseases of lettuce and tomato in the Western United States. Phytopathology, 91, 797-806.
30. Oliphant, T., Engle, M., Nybakken, G., Doane, C., Johnson, S., Huang, L., Gorlatov, S., Mehlhop, E., Marri, A., Chung, K.M., Ebel, G.D., Kramer, L.D., Fremont, D.H. and Diamond, M.S. (2005) Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat. Med. 11, 522-530.
31. Park, M.R., Park, S.H., Cho, S.Y. and Kim, K.H. (2009) Nicotiana benthamiana protein, NbPCIP1, interacting with potato virus X coat protein plays a role as susceptible factor for viral infection. Virology, 386, 257-269.
32. Paul, M. and Ma, J.K.C. (2010) Plant-made immunogens and effective delivery strategies. Expert Rev. Vaccines, 9, 821-833.
33. Phoolcharoen, W., Bhoo, S.H., Lai, H., Ma, J., Arntzen, C.J., Chen, Q. and Mason, H.S. (2011) Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotechnol. J. 9, 776-787.
34. Platis, D. and Labrou, N.E. (2008) Affinity chromatography for the purification of therapeutic proteins from transgenic maize using immobilized histamine. J. Sep. Sci. 31, 636-645.
35. Roque, A.C.A., Lowe, C.R. and Taipa, M.A. (2004) Antibodies and genetically engineered related molecules: production and purification. Biotechnol. Prog. 20, 639-654.
36. Rosales-Mendoza, S., Soria- Guerra, R.E., Moreno-Fierros, L., Alpuche- Solis, A.G., Martinez-Gonzalez, L. and Korban, S.S. (2010) Expression of an immunogenic F1-V fusion protein in lettuce as a plant-based vaccine against plague. Planta, 232, 409-416.
37. Rybicki, E. (2010) Plant-made vaccines for humans and animals. Plant Biotechnol. J. 8, 620-637.
38. Sainsbury, F., Thuenemann, E.C. and Lomonossoff, G.P. (2009) pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants. Plant Biotechnol. J. 7, 682-693.
39. Santi, L., Batchelor, L., Huang, Z., Hjelm, B., Kilbourne, J., Arntzen, C.J., Chen, Q. and Mason, H.S. (2008) An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine, 26, 1846-1854.
40. Simmons, C. and VanderGheynst, J. (2007) Transient co-expression of post-transcriptional gene silencing suppressors and β-glucuronidase in harvested lettuce leaf tissue does not improve recombinant protein accumulation in planta. Biotechnol. Lett. 29, 641-645.
41. Teng, K., Chen, H., Lai, J., Zhang, Z., Fang, Y., Xia, R., Zhou, X., Guo, H. and Xie, Q. (2010) Involvement of C4 protein of beet severe curly top virus (Family Geminiviridae) in virus movement. PLoS ONE, 5, e11280.
42. Vézina, L.-P., Faye, L., Lerouge, P., D' Aoust, M.-A., Marquet-Blouin, E., Burel, C., Lavoie, P.-O., Bardor, M. and Gomord, V. (2009) Transient co-expression for fast and high-yield production of antibodies with human-like N-glycans in plants. Plant Biotechnol. J. 7, 442-455.
43. Voinnet, O., Rivas, S., Mestre, P. and Baulcombe, D. (2003) An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus. Plant J. 33, 949-956.
44. Webster, D.E., Smith, S.D., Pickering, R.J., Strugnell, R.A., Dry, I.B. and Wesselingh, S.L. (2006) Measles virus hemagglutinin protein expressed in transgenic lettuce induces neutralising antibodies in mice following mucosal vaccination. Vaccine, 24, 3538-3544.