Discovery of ghrelin O-acyltransferase

Endocrine Development

Volumn 25, Issue , 2013, Pages 16-24

  Mohan, Haneesha ^a   Unniappan, Suraj ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GHRELIN O ACYLTRANSFERASE; MESSENGER RNA; UNCLASSIFIED DRUG; ACYLTRANSFERASE;

ACID SECRETION; ARTICLE; ATTENUATION; BODY WEIGHT; ENERGY BALANCE; GLUCOSE METABOLISM; GROWTH HORMONE RELEASE; HUMAN; INSULIN RELEASE; METABOLIC DISORDER; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH; ENZYME ACTIVITY; ENZYME METABOLISM; PROTEIN FUNCTION;

ACYLATION; ACYLTRANSFERASES; ANIMALS; GHRELIN; HISTORY, 21ST CENTURY; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; TISSUE DISTRIBUTION;

EID: 84925882443     PISSN: 14217082     EISSN: 16622979     Source Type: Book Series    
DOI: 10.1159/000346039     Document Type: Article

References (27)

1. Deghenghi R: Structural requirements of growth hormone secretagogues; in Bercu BB, Walker RF (eds): Growth Hormone Secretagogues in Clinical Practice. New York, Marcel Dekker, 1998, pp 27-35.
2. Bowers CY, Reynolds GA, Momany FA: New advances on the regulation of growth hormone (GH) secretion. Int J Neurol 1984; 18:188-205.
3. Smith RG, Sun Y, Betancourt L, Asnicar M: Growth hormone secretagogues: prospects and potential pitfalls. Best Pract Res Clin Endocrinol Metab 2004; 18: 333-347
4. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsing-hji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH: A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996; 273:974-977
5. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
6. Smith GP: The therapeutic potential of cholecystoki-nin. Int J Obes 1984; 8:35-38.
7. Kojima M, Kangawa K: Ghrelin: Structure and function. Physiol Rev 2005; 85:495-522.
8. Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL: Identification of the acyltransferase that oc-tanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008; 132:387-396.
9. Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE: Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci USA 2008; 105:6320-6325.
10. Hofmann, K: A superfamily of membrane-bound O-acyltransferases with implications for Wnt signaling. Trends Biochem Sci 2000; 25:111-112.
11. Kadowaki T, Wilder E, Klingensmith J, Zachary K, Perrimon N: The segment polarity gene porcupine encodes a putative multitrans-membrane protein involved in Wingless processing. Genes Dev 1996; 10: 3116-3128.
12. Zhu X, Cao Y, Voogd K, Steiner DF: On the processing of proghrelin to ghrelin. J Biol Chem 2006; 281: 38867-38870.
13. Ohgusu H, Shirouzu K, Nakamura Y, Nakashima Y, Ida T, Sato T, Kojima M: Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor. Biochem Biophys Res Commun 2009; 386:153-158.
14. González CR, Vázquez MJ, López M, Diéguez C: Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa. J Mol Endocrinol 2008; 41:415-421.
15. Stengel A, Goebel M, Wang L, Taché Y, Sachs G, Lambrecht NW: Differential distribution of ghre-lin-O-acyltransferase (GOAT) immunoreactive cells in the mouse International Journal of Peptides 5 and rat gastric oxyntic mucosa. Biochem Biophys Res Commun 2010; 392:67-71.
16. An W, Li Y, Xu G, Zhao J, Xiang X, Ding L, Li J, Guan Y, Wang X, Tang C, Li X, Mulholland M, Zhang W: Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cell Physiol Biochem 2010; 26: 707-716.
17. Gahete MD, Córdoba-Chacón J, Salvatori R, Casta-ño JP, Kineman RD, Luque RM: Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach. Mol Cell Endocrinol 2010; 317:154-160.
18. Xu G, Li Y, An W, Li S, Guan Y, Wang N, Tang C, Wang X, Zhu Y, Li X, Mulholland MW, Zhang W: Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake. Endocrinology 2009; 150:3637-3644.
19. Reimer RA, Maurer AD, Lau DC, Auer RN: Longterm dietary restriction influences plasma ghrelin and GOAT mRNA level in rats. Physiol Behav 2010; 99:605-610.
20. Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, Schürmann A, Joost HG, Jandacek RJ, Hale JE, Heiman ML, Tschöp MH: GOAT links dietary lipids with the endocrine control of energy balance. Nat Med 2009; 15:741-745.
21. Zhao TJ, Liang G, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL, Brown MS: Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci USA 2010; 107:7467-7472.
22. Soriano-Guillén L, Barrios V, Campos-Barros A, Argente J: Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation. J Pe-diatr 2004;144:36-42.
23. Yang Y, Zhao TJ, Goldstein JL, Brown MS: Inhibition of ghrelin O-acyltransferase (GOAT) by oc-tanoylated pentapeptides. Proc Natl Acad Sci USA 2008; 105:10750-10755.
24. Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukher-jee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, Cole PA: Glucose and weight control in mice with a designed ghrelin O-acyltrans-ferase inhibitor. Science 2010; 330:1689-1692.
25. An W, Li Y, Xu G, Zhao J, Xiang X, Ding L, Li J, Guan Y, Wang X, Tang C, Li X, Mulholland M, Zhang W: Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cell Physiol Biochem 2010; 26: 707-716.
26. Bando M, Iwakura H, Ariyasu H, Hosoda H, Yama-da G, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T: Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo. Am J Physiol Endocrinol Metab 2012; 302:E403-E408.
27. Kang K, Schmahl J, Lee JM, Garcia K, Patil K, Chen A, Keene M, Murphy A, Sleeman MW: Mouse ghre-lin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption. FASEB J 2012; 26:259-271.