Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling

Journal of Hematology and Oncology

Volumn 8, Issue 1, 2015, Pages

  Yin, Xin ^a   Zhang, Bo Heng ^a   Zheng, Su Su ^a   Gao, Dong Mei ^a   Qiu, Shuang Jian ^a   Wu, Wei Zhong ^a   Ren, Zheng Gang ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition; Hepatocellular carcinoma; Nanog; Oct4; Stat3

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; BETA CATENIN; BMI1 PROTEIN; BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; NERVE CELL ADHESION MOLECULE; OCTAMER TRANSCRIPTION FACTOR 4; STAT3 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VIMENTIN; WNT PROTEIN; HOMEODOMAIN PROTEIN; NANOG PROTEIN, HUMAN; POU5F1 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER RESISTANCE; CANCER SIZE; CANCER STEM CELL; CARCINOGENICITY; CELL COUNT; CELL PROLIFERATION; CELL RENEWAL; CELL STRUCTURE; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; L CELL LINE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER METASTASIS; LUNG METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR INVASION; ANIMAL; BAGG ALBINO MOUSE; CHROMATIN IMMUNOPRECIPITATION; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOPRECIPITATION; LIVER TUMOR; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; EPITHELIAL-MESENCHYMAL TRANSITION; FLUORESCENT ANTIBODY TECHNIQUE; HETEROGRAFTS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOPRECIPITATION; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; NANOG HOMEOBOX PROTEIN; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SNAIL FAMILY TRANSCRIPTION FACTORS; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84925880717     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-015-0119-3     Document Type: Article

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