Both ERK1 and ERK2 are required for enterovirus 71 (EV71) efficient replication

Viruses

Volumn 7, Issue 3, 2015, Pages 1344-1356

  Zhu, Meng ^a   Duan, Hao ^a   Gao, Meng ^a   Zhang, Hao ^a   Peng, Yihong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

ERK1; ERK2; EV71; Virus replication

Indexed keywords

GENOMIC RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; VIRUS PROTEIN; ENZYME INHIBITOR; MAPK1 PROTEIN, HUMAN;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; ENTEROVIRUS 71; GENE AMPLIFICATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MAP KINASE ASSAY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA CELL LINE; RNA EXTRACTION; RNA SYNTHESIS; VIRION; VIRUS GENE; VIRUS INFECTION; VIRUS REPLICATION; WESTERN BLOTTING; CELL LINE; ENTEROVIRUS A; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

HUMAN ENTEROVIRUS 71;

CELL LINE; ENTEROVIRUS A, HUMAN; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; HOST-PATHOGEN INTERACTIONS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; VIRUS REPLICATION;

EID: 84925880472     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v7031344     Document Type: Article

References (37)

1. The Picornavirus Pages: Enterovirus A. Available online: http://www.picornaviridae.com/enterovirus/ev-a/ev-a.htm (accessed on 12 February 2015).
2. Lin, J.Y.; Chen, T.C.; Weng, K.F.; Chang, S.C.; Chen, L.L.; Shih, S.R. Viral and host proteins involved in picornavirus life cycle. J. Biomed. Sci. 2009, 16, e103.
3. Yi, L.; Lu, J.; Kung, H.F.; He, M.L. The virology and developments toward control of human enterovirus 71. Crit. Rev. Microbiol. 2011, 37, 313-327.
4. Wang, S.M.; Liu, C.C. Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine. Expert Rev. Anti Infect. Ther. 2014, 12, 447-456.
5. Tung, W.H.; Hsieh, H.L.; Lee, I.T.; Yang, C.M. Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway. J. Cell Biochem. 2011, 112, 559-570.
6. Wang, B.; Zhang, H.; Zhu, M.; Luo, Z.; Peng, Y. MEK1-ERKs signal cascade is required for the replication of Enterovirus 71 (EV71). Antivir. Res. 2012, 93, 110-117.
7. Cai, Y.; Liu, Y.; Zhang, X. Suppression of coronavirus replication by inhibition of the MEK signaling pathway. J. Virol. 2007, 81, 446-456.
8. Pleschka, S.; Wolff, T.; Ehrhardt, C.; Hobom, G.; Planz, O.; Rapp, U.R.; Ludwig, S. Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nat. Cell Biol. 2001, 3, 301-305.
9. Zhang, H.; Feng, H.; Luo, L.; Zhou, Q.; Luo, Z.; Peng, Y. Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2. Virus Res. 2010, 150, 22-27.
10. Panteva, M.; Korkaya, H.; Jameel, S. Hepatitis viruses and the MAPK pathway: Is this a survival strategy? Virus Res. 2003, 92, 131-140.
11. Luo, H.; Yanagawa, B.; Zhang, J.; Luo, Z.; Zhang, M.; Esfandiarei, M.; Carthy, C.; Wilson, J.E.; Yang, D.; McManus, B.M. Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. J. Virol. 2002, 76, 3365-3373.
12. Murphy, L.O.; Blenis, J. MAPK signal specificity: The right place at the right time. Trends Biochem. Sci. 2006, 31, 268-275.
13. McCubrey, J.A.; Steelman, L.S.; Chappell, W.H.; Abrams, S.L.; Wong, E.W.; Chang, F.; Lehmann, B.; Terrian, D.M.; Milella, M.; Tafuri A., et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim. Biophys. Acta 2007, 1773, 1263-1284.
14. Zhang, W.; Liu, H.T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 2002, 12, 9-18.
15. Kim, E.K.; Choi, E.J. Pathological roles of MAPK signaling pathways in human diseases. Biochim. Biophys. Acta 2010, 1802, 396-405.
16. Deschenes-Simard, X.; Kottakis, F.; Meloche, S.; Ferbeyre, G. ERKs in cancer: Friends or foes? Cancer Res. 2014, 74, 412-419.
17. Arthur, J.S.; Ley, S.C. Mitogen-activated protein kinases in innate immunity. Nat. Rev. Immunol. 2013, 13, 679-692.
18. Tanti, J.F.; Jager, J. Cellular mechanisms of insulin resistance: Role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr. Opin. Pharmacol. 2009, 9, 753-762.
19. Chambard, J.C.; Lefloch, R.; Pouyssegur, J.; Lenormand, P. ERK implication in cell cycle regulation. Biochim. Biophys. Acta 2007, 1773, 1299-1310.
20. Boulton, T.G.; Nye, S.H.; Robbins, D.J.; Ip, N.Y.; Radziejewska, E.; Morgenbesser, S.D.; DePinho, R.A.; Panayotatos, N.; Cobb, M.H.; Yancopoulos, G.D. ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991, 65, 663-675.
21. Roskoski, R., Jr. ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol. Res. 2012, 66, 105-143.
22. Lefloch, R.; Pouyssegur, J.; Lenormand, P. Total ERK1/2 activity regulates cell proliferation. Cell Cycle 2009, 8, 705-711.
23. Yoon, S.; Seger, R. The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions. Growth Factors 2006, 24, 21-44.
24. Krens, S.F.; He, S.; Lamers, G.E.; Meijer, A.H.; Bakkers, J.; Schmidt, T.; Spaink, H.P.; Snaar-Jagalska, B.E. Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Dev. Biol. 2008, 319, 370-383.
25. Vantaggiato, C.; Formentini, I.; Bondanza, A.; Bonini, C.; Naldini, L.; Brambilla, R. ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. J. Biol. 2006, 5, e14.
26. Lloyd, A.C. Distinct functions for ERKs? J. Biol. 2006, 5, e13.
27. Cargnello, M.; Roux, P.P. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol. Mol. Biol. Rev. 2011, 75, 50-83.
28. Wang, B.; Ding, L.X.; Deng, J.; Zhang, H.; Zhu, M.; Yi, T.; Liu, J.; Xu, P.; Lu, F.M.; Peng, Y.H. Replication of EV71 was suppressed by MEK1/2 inhibitor U0126. Chin. J. Biochem. Mol. Biol. 2010, 26, 538-545.
29. Dimitri, C.A.; Dowdle, W.; MacKeigan, J.P.; Blenis, J.; Murphy, L.O. Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Curr. Biol. 2005, 15, 1319-1324.
30. Lu, J.; He, Y.Q.; Yi, L.N.; Zan, H.; Kung, H.F.; He, M.L. Viral kinetics of enterovirus 71 in human abdomyosarcoma cells. World J. Gastroenterol. 2011, 17, 4135-4142.
31. Rodriguez, M.E.; Brunetti, J.E.; Wachsman, M.B.; Scolaro, L.A.; Castilla, V. Raf/MEK/ERK pathway activation is required for Junin virus replication. J. Gen. Virol. 2014, 95, 799-805.
32. Pleschka, S. RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade. Biol. Chem. 2008, 389, 1273-1282.
33. Yao, Y.; Li, W.; Wu, J.; Germann, U.A.; Su, M.S.; Kuida, K.; Boucher, D.M. Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc. Natl. Acad. Sci. USA 2003, 100, 12759-12764.
34. Pages, G.; Guerin, S.; Grall, D.; Bonino, F.; Smith, A.; Anjuere, F.; Auberger, P.; Pouyssegur, J. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 1999, 286, 1374-1377.
35. Nekrasova, T.; Shive, C.; Gao, Y.; Kawamura, K.; Guardia, R.; Landreth, G.; Forsthuber, T.G. ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis. J. Immunol. 2005, 175, 2374-2380.
36. Yu, C. Distinct roles for ERK1 and ERK2 in pathophysiology of CNS. Front. Biol. 2012, 7, 267-276.
37. Lefloch, R.; Pouyssegur, J.; Lenormand, P. Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol. Cell Biol. 2008, 28, 511-527.