Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation

Circulation: Cardiovascular Genetics

Volumn 7, Issue 5, 2014, Pages 615-624

  Ding, Ning ^a,b   Chen, Guoqiang ^a,c   Hoffman, Rosemary ^a   Loughran, Patricia A ^a   Sodhi, Chhinder P ^d   Hackam, David J ^d   Billiar, Timothy R ^a   Neal, Matthew D ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^d CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Blood platelets; Hemorrhagic; Inflammation; Shock; Toll like receptor 4

Indexed keywords

INTERLEUKIN 6; TOLL LIKE RECEPTOR 4; PEROXIDASE; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; CONTROLLED STUDY; CYTOKINE RELEASE; HEMORRHAGIC SHOCK; INFLAMMATION; LIVER INJURY; LUNG INJURY; MALE; MOUSE; NONHUMAN; ORGAN INJURY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RESUSCITATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOELASTOGRAPHY; ANIMAL; BLOOD; BLOOD CLOTTING PARAMETERS; C57BL MOUSE; CYTOLOGY; ENDOTOXEMIA; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HEMOSTASIS; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PHYSIOLOGY; PROCEDURES; THROMBOCYTE;

MUS;

ANIMALS; BLOOD COAGULATION DISORDERS; BLOOD PLATELETS; ENDOTOXEMIA; GENE DELETION; GENE EXPRESSION REGULATION; HEMOSTASIS; INFLAMMATION; INTERLEUKIN-6; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEROXIDASE; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; RESUSCITATION; SHOCK, HEMORRHAGIC; THROMBELASTOGRAPHY; TOLL-LIKE RECEPTOR 4;

EID: 84925874073     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000398     Document Type: Article

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