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Volumn 26, Issue 1, 2015, Pages 103-111

Digoxin ameliorates autoimmune arthritis via suppression of Th17 differentiation

Author keywords

Digoxin; IL 17 producing T cells; Regulatory T cells; Rheumatoid arthritis; ROR t

Indexed keywords

DIGOXIN; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 21; INTERLEUKIN 6; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT;

EID: 84925798527     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.03.017     Document Type: Article
Times cited : (54)

References (21)
  • 2
    • 0029914194 scopus 로고    scopus 로고
    • Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?
    • G.S. Firestein Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum. 39 1996 1781 1790
    • (1996) Arthritis Rheum. , vol.39 , pp. 1781-1790
    • Firestein, G.S.1
  • 3
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • G.S. Firestein Evolving concepts of rheumatoid arthritis Nature 423 2003 356 361
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 4
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • I.B. McInnes, and G. Schett The pathogenesis of rheumatoid arthritis N. Engl. J. Med. 365 2011 2205 2219
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 5
    • 57349153093 scopus 로고    scopus 로고
    • Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis
    • P.J. Egan, A. van Nieuwenhuijze, I.K. Campbell, and I.P. Wicks Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis Arthritis Rheum. 58 2008 3720 3729
    • (2008) Arthritis Rheum. , vol.58 , pp. 3720-3729
    • Egan, P.J.1    Van Nieuwenhuijze, A.2    Campbell, I.K.3    Wicks, I.P.4
  • 7
    • 0037371262 scopus 로고    scopus 로고
    • IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance
    • Baltimore, Md: 1950
    • E. Lubberts, L. van den Bersselaar, B. Oppers-Walgreen, P. Schwarzenberger, C.J. Coenen-de Roo, and J.K. Kolls et al. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance J. Immunol. 170 2003 2655 2662 (Baltimore, Md: 1950)
    • (2003) J. Immunol. , vol.170 , pp. 2655-2662
    • Lubberts, E.1    Van Den Bersselaar, L.2    Oppers-Walgreen, B.3    Schwarzenberger, P.4    Coenen-De Roo, C.J.5    Kolls, J.K.6
  • 8
    • 84896312888 scopus 로고    scopus 로고
    • Gene-associated retinoid-interferon-induced mortality 19 (GRIM-19) attenuates autoimmune arthritis by regulation of Th17 and Treg cells
    • Y.M. Moon, J. Lee, S.Y. Lee, Y.M. Her, J.G. Ryu, and E.K. Kim et al. Gene-associated retinoid-interferon-induced mortality 19 (GRIM-19) attenuates autoimmune arthritis by regulation of Th17 and Treg cells Arthritis Rheum. 66 2014 569 578
    • (2014) Arthritis Rheum. , vol.66 , pp. 569-578
    • Moon, Y.M.1    Lee, J.2    Lee, S.Y.3    Her, Y.M.4    Ryu, J.G.5    Kim, E.K.6
  • 9
    • 84898645573 scopus 로고    scopus 로고
    • STA-21, a promising STAT3 inhibitor that reciprocally regulates Th17 and Treg, inhibits osteoclastogenesis and alleviates autoimmune inflammation
    • J.S. Park, S.K. Kwok, M.A. Lim, E.K. Kim, J.G. Ryu, and S.M. Kim et al. STA-21, a promising STAT3 inhibitor that reciprocally regulates Th17 and Treg, inhibits osteoclastogenesis and alleviates autoimmune inflammation Arthritis Rheum. 66 2014 918 929
    • (2014) Arthritis Rheum. , vol.66 , pp. 918-929
    • Park, J.S.1    Kwok, S.K.2    Lim, M.A.3    Kim, E.K.4    Ryu, J.G.5    Kim, S.M.6
  • 10
    • 84899507144 scopus 로고    scopus 로고
    • JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T cells and Th17 cells
    • Baltimore, Md: 1950
    • J.S. Park, J. Lee, M.A. Lim, E.K. Kim, S.M. Kim, and J.G. Ryu et al. JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T cells and Th17 cells J. Immunol. 192 2014 4417 4424 (Baltimore, Md: 1950)
    • (2014) J. Immunol. , vol.192 , pp. 4417-4424
    • Park, J.S.1    Lee, J.2    Lim, M.A.3    Kim, E.K.4    Kim, S.M.5    Ryu, J.G.6
  • 11
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    • X.O. Yang, B.P. Pappu, R. Nurieva, A. Akimzhanov, H.S. Kang, and Y. Chung et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma Immunity 28 2008 29 39
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3    Akimzhanov, A.4    Kang, H.S.5    Chung, Y.6
  • 12
    • 0031051347 scopus 로고    scopus 로고
    • The effect of digoxin on mortality and morbidity in patients with heart failure
    • The effect of digoxin on mortality and morbidity in patients with heart failure N. Engl. J. Med. 336 1997 525 533
    • (1997) N. Engl. J. Med. , vol.336 , pp. 525-533
  • 13
    • 0026776709 scopus 로고
    • Na, K-ATPase expression in normal and failing human left ventricle
    • P.D. Allen, T.A. Schmidt, J.D. Marsh, and K. Kjeldsen Na, K-ATPase expression in normal and failing human left ventricle Basic Res. Cardiol. 87 Suppl. 1 1992 87 94
    • (1992) Basic Res. Cardiol. , vol.87 , pp. 87-94
    • Allen, P.D.1    Schmidt, T.A.2    Marsh, J.D.3    Kjeldsen, K.4
  • 14
    • 79955538365 scopus 로고    scopus 로고
    • Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity
    • J.R. Huh, M.W. Leung, P. Huang, D.A. Ryan, M.R. Krout, and R.R. Malapaka et al. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity Nature 472 2011 486 490
    • (2011) Nature , vol.472 , pp. 486-490
    • Huh, J.R.1    Leung, M.W.2    Huang, P.3    Ryan, D.A.4    Krout, M.R.5    Malapaka, R.R.6
  • 15
    • 80052423903 scopus 로고    scopus 로고
    • Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production
    • S. Fujita-Sato, S. Ito, T. Isobe, T. Ohyama, K. Wakabayashi, and K. Morishita et al. Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production J. Biol. Chem. 286 2011 31409 31417
    • (2011) J. Biol. Chem. , vol.286 , pp. 31409-31417
    • Fujita-Sato, S.1    Ito, S.2    Isobe, T.3    Ohyama, T.4    Wakabayashi, K.5    Morishita, K.6
  • 17
    • 0031886916 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial
    • M.L. Barnett, J.M. Kremer, E.W. St Clair, D.O. Clegg, D. Furst, and M. Weisman et al. Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial Arthritis Rheum. 41 1998 290 297
    • (1998) Arthritis Rheum. , vol.41 , pp. 290-297
    • Barnett, M.L.1    Kremer, J.M.2    St Clair, E.W.3    Clegg, D.O.4    Furst, D.5    Weisman, M.6
  • 18
    • 24744435115 scopus 로고    scopus 로고
    • Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
    • M. Camps, T. Ruckle, H. Ji, V. Ardissone, F. Rintelen, and J. Shaw et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis Nat. Med. 11 2005 936 943
    • (2005) Nat. Med. , vol.11 , pp. 936-943
    • Camps, M.1    Ruckle, T.2    Ji, H.3    Ardissone, V.4    Rintelen, F.5    Shaw, J.6
  • 19
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of CD4 + T cell lineage differentiation
    • L. Zhou, M.M. Chong, and D.R. Littman Plasticity of CD4 + T cell lineage differentiation Immunity 30 2009 646 655
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1    Chong, M.M.2    Littman, D.R.3
  • 21
    • 84864303294 scopus 로고    scopus 로고
    • The origins, function, and regulation of T follicular helper cells
    • C.S. Ma, E.K. Deenick, M. Batten, and S.G. Tangye The origins, function, and regulation of T follicular helper cells J. Exp. Med. 209 2012 1241 1253
    • (2012) J. Exp. Med. , vol.209 , pp. 1241-1253
    • Ma, C.S.1    Deenick, E.K.2    Batten, M.3    Tangye, S.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.