Nanotechnology and nanoparticle toxicity: A case for precaution

Nanotechnology Risk, Ethics and Law

Volumn , Issue , 2013, Pages 154-166

  Vyvyan Howard, C ^a   Ikah, December S K ^b  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84925775472     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.4324/9781849772051     Document Type: Chapter

References (41)

1. Abbey, D. E., Ostro, B. E. et al (1995) ‘Chronic respiratory symptoms associated with estimated long-term ambient concentrations of fine particulates less than 2.5 microns in aerodynamic diameter (PM2.5) and other air pollutants’, Journal of Exposure Analysis and Environmental Epidemiology, vol 5, pp137–159
2. Ackermann-Liebrich, U., Leuenberger, P. et al (1997) ‘Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team’, American Journal of Respiratory and Critical Care Medicine, vol 155, pp122–129
3. Afaq, F, Abidi, P. et al (1998) ‘Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide’, Journal of Applied Toxicology, vol 18, pp307–312
4. Agricola (1556) De Re Metallica, Basel, Froben
5. Akiyoshi, K., Sasaki, Y. et al (1999) ‘Chaperone-like activity of hydrogel nanoparticles of hydrophobized pullulan: thermal stabilization with refolding of carbonic anhydrase B’, Bioconjugate Chemistry, vol 10, pp321–324
6. Alyaudtin, R. N. and Reichel, A. (2001) ‘Interaction of poly(butylcyanoacrylate) nanoparticles with the blood–brain barrier in vivo and in vitro’, Journal of Drug Targeting, vol 9, pp209–221
7. Anderson, H. R. (2000) ‘Differential epidemiology of ambient aerosols’, Philosophical Transactions of the Royal Society of London, Series A – Mathematical, Physical and Engineering Sciences, vol 358, pp2771–2785
8. Auerbach, O., Cuyler Hammond, E. (1965) ‘Smoking in relation to atherosclerosis of the coronary arteries’, New England Journal of Medicine, vol 273, pp775–779
9. Billsten, P., Freskgard, P. O. et al (1997) ‘Adsorption to silica nanoparticles of human carbonic anhydrase II and truncated forms induce a molten-globule-like structure’, FEBS Letters, vol 402, pp67–72
10. Cass, G. R., Hughes, L. S. et al (2000) ‘The chemical composition of atmospheric ultrafine particles’, Philosophical Transactions of the Royal Society of London, Series A – Mathematical, Physical and Engineering Sciences, vol 358, pp2581–2592
11. Dockery, D. W., Speizer, F. E. et al (1989) ‘Effects of inhalable particles on respiratory health of children’, American Review of Respiratory Disease, vol 139, 587–594
12. Dockery D. W., Pope C. A. et al (1993) ‘An association between air-pollution and mortality in six United States cities’, New England Journal of Medicine, vol 329, pp1753–1759
13. Donaldson, J., Stone, V. and MacNee, W. (1999) ‘The toxicology of ultrafine particles’, in Maynard R. L. and Howard C. V. (eds) Particulate Matter: Properties and Effects upon Health, Oxford, BIOS Scientific Publishers Ltd, pp115–129
14. Donaldson K., Stone V. et al (2000) ‘Ultrafine particles: mechanisms of lung injury’, Philosophical Transactions of the Royal Society of London, Series A – Mathematical, Physical and Engineering Sciences, vol 358, pp2741–2749
15. Eakins J. D. and Lally A. E. (1984) ‘The transfer to land of actinide bearing sediments from the Irish Sea by spray’, Science of the Total Environment, vol 35, pp23–32
16. EU (2004) Nanotechnologies: A Preliminary Risk Analysis on The Basis of a Workshop Organized in Brussels on 1–2 March 2004 by the Health and Consumer Protection Directorate General of the European Commission http://europa.eu.int/comm/health/ph_risk/events_risk_en.htm
17. Foley, S., Crowley, C. et al (2002) ‘Cellular localisation of a water-soluble fullerene derivative’, Biochemical and Biophysical Research Communications, vol 294, pp116–119
18. Gumbleton, M. (2001) ‘Caveolae as potential macromolecule trafficking compartments within alveolar epithelium’, Advanced Drug Delivery Reviews, vol 49, pp281–300
19. Harrison, R. M. (1999) ‘Sources and behaviour of atmospheric particulate matter’, in Maynard, R. L. and Howard, C. V. (eds) Particulate Matter: Properties and Effects upon Health, Oxford, BIOS Scientific Publishers (ISBN 1 85996 172 X), pp63–84.
20. HEI (2000) Reanalysis of the Harvard Six Cities Study and the American Cancer Society Study of Particulate Air Pollution and Mortality. A Special Report of the Institute’s Particle Epidemiology Reanalysis Project, downloaded 240304 from www.healtheffects.org/Pubs/Rean-ExecSumm.pdf
21. Ishii, D., Kinbara, K., Ishida, Y., Ishii, N., Okochi, M., Yohda, M. and Aida, T (2003) ‘Chaperonin-mediated stabilization and ATP-triggered release of semiconductor nanoparticles’, Nature, vol 423, pp628–632.
22. Jefferson, D. A. and Tilley, E. E. M. (1999) ‘The structural and physical chemistry of nanoparticles’, in Maynard, R. L. and Howard, C. V. (eds) Particulate Matter: Properties and Effects upon Health, Oxford, BIOS Scientific Publishers (ISBN 1 85996 172 X), pp63–84
23. Kamat, J. P, Devasagayam, T. P. et al (2000) ‘Reactive oxygen species mediated membrane damage induced by fullerene derivatives and its possible biological implications’, Toxicology, vol 155, pp55–61
24. Kim, J. K., Lee, W. K. et al (1999) ‘Mechanism of silica- and titanium dioxide-induced cytotoxicity in alveolar macrophages’, Journal of Toxicology and Environmental Health A, vol 58, pp437–450
25. Kreuter, J. (2001) ‘Nanoparticulate systems for brain delivery of drugs’, Advanced Drug Delivery Reviews, vol 47, pp65–81
26. Kreuter J., Shamenkov D. et al (2002) ‘Apolipoprotein-mediated transport of nanoparticle- bound drugs across the blood–brain barrier’, Journal of Drug Targeting, vol 10, pp317–325
27. Kreyling, W. G., Semmler, M. et al (2002) ‘Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low’, Journal of Toxicology and Environmental Health A, vol 65, pp1513–1530
28. Kunzli, N., Kaiser, R. et al (2000) ‘Public-health impact of outdoor and traffic-related air pollution: a European assessment’, The Lancet, vol 356, pp795–801
29. Lam, C. W., James, J. T. et al (2004) ‘Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation’, Toxicological Sciences, vol 77, pp126–134
30. Li, N., Sioutas, C. et al (2003) ‘Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage’, Environmental Health Perspectives vol 111, pp455–460
31. Ministry of Health (1954) ‘Mortality and morbidity during the London fog of December 1952’. Reports on Public Health and Medical Subjects No. 95, London, Ministry of Health
32. Oberdörster, G. (2000) ‘Toxicology of ultrafine particles: in vivo studies’, Philosophical Transactions of the Royal Society of London, Series A – Mathematical, Physical and Engineering Sciences, vol 358, pp2719–2740
33. Oberdörster, E. (2004) ‘Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass’, Environmental Health Perspectives, vol 112, pp1058–1062
34. Oberdörster, G., Sharp, Z. et al (2002) ‘Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats’, Journal of Toxicology and Environmental Health A, vol 65, pp1531–43
35. Pope, C. A., Thun, M. J. et al (1995) ‘Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults’, American Journal of Respiratory Critical Care Medicine, vol 151(3 Pt 1), pp669–74
36. Rahman, Q., Lohani, M. et al (2002) ‘Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in syrian hamster embryo fibroblasts’, Environmental Health Perspectives, vol 110, pp797–800
37. Raizenne, M., Neas, L. M. et al (1996) ‘Health effects of acid aerosols on North American children: pulmonary function’, Environmental Health Perspectives, vol 104, pp506–14
38. Royal Society and Royal Academy of Engineering (2004) Nanoscience and Nanotechnologies: Opportunities and Uncertainties, London, The Royal Society and The Royal Academy of Engineering
39. Sayes, S. M., Fortner, J. D. et al (2004) ‘The differential cytotoxicity of water-soluble Fullerenes’, Nano Letters, vol 4, pp1881–1887
40. Seaton, A. and MacNee, W. (1995) ‘Particulate air pollution and acute health effects’, The Lancet vol 345, pp176–178
41. Uchino, T. and Tokunaga, H. (2002) ‘Quantitative determination of OH radical generation and its cytotoxicity induced by TiO2–UVA treatment’, Toxicology in Vitro, vol 16, pp629–635