Stromal cells positively and negatively modulate the growth of cancer cells: Stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Kawada, Manabu ^a   Inoue, Hiroyuki ^a   Ohba, Shun Ichi ^a   Yoshida, Junjiro ^a   Masuda, Tohru ^a   Yamasaki, Manabu ^b   Usami, Ihomi ^a   Sakamoto, Shuichi ^a   Abe, Hikaru ^b   Watanabe, Takumi ^b   Yamori, Takao ^c   Shibasaki, Masakatsu ^b   Nomoto, Akio ^a  

^a Microbial Chemistry Research Foundation   (Japan)

^b INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^c CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROSTAGLANDIN E2; S6 KINASE; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; CADHERIN; IL6 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GASTRIC CANCER CELL LINE; GROWTH REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; STROMA CELL; ANIMAL; CELL GROWTH; COCULTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CADHERINS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DINOPROSTONE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; INTERLEUKIN-6; MICE; NEOPLASMS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; STROMAL CELLS; TOR SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84925773852     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119415     Document Type: Article

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