MiR-506 is down-regulated in clear cell renal cell carcinoma and inhibits cell growth and metastasis via targeting FLOT1

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Yang, Feng Qiang ^a   Zhang, Hai Ming ^a   Chen, Shao Jun ^a   Yan, Yang ^a   Zheng, Jun Hua ^a  

^a TONGJI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FLOTILLIN 1; MICRORNA; MICRORNA 506; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; FLOTILLINS; MEMBRANE PROTEIN; MIRN506 MICRORNA, HUMAN;

AGED; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOT1 GENE; G1 PHASE CELL CYCLE CHECKPOINT; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CARCINOMA; LUCIFERASE ASSAY; MAJOR CLINICAL STUDY; MALE; METASTASIS INHIBITION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; 3' UNTRANSLATED REGION; GENE EXPRESSION REGULATION; KIDNEY TUMOR; METABOLISM; METASTASIS; TUMOR INVASION;

3' UNTRANSLATED REGIONS; CARCINOMA, RENAL CELL; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY NEOPLASMS; MEMBRANE PROTEINS; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS;

EID: 84925761230     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120258     Document Type: Article

References (24)

1. Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI. Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system. Pathol Int. 2010; 60:1-8. doi: 10.1111/j.1440-1827. 2009.02477.x PMID: 20055945
2. Cindolo L, Patard JJ, Chiodini P, Schips L, Ficarra V, Tostain J, et al. Comparison of predictive accuracy of four prognostic models for nonmetastatic renal cell carcinoma after nephrectomy: a multicenter European study. Cancer. 2005; 104:1362-1371. PMID: 16116599
3. Karakiewicz PI, Briganti A, Chun FK, Trinh QD, Perrotte P, Ficarra V, et al. Multi-institutional validation of a new renal cancer-specific survival nomogram. J Clin Oncol. 2007; 25:1316-1322. PMID: 17416852
4. Jiang Z, Chu PG, Woda BA, Liu Q, Balaji KC, Rock KL, et al. Combination of quantitative IMP3 and tumor stage: a new system to predict metastasis for patients with localized renal cell carcinomas. Clin Cancer Res. 2008; 14:5579-5584. doi: 10.1158/1078-0432.CCR-08-0504 PMID: 18765551
5. Patil S, Ishill N, Deluca J, Motzer RJ. Stage migration and increasing proportion of favorable-prognosis metastatic renal cell carcinoma patients: implications for clinical trial design and interpretation. Cancer. 2010; 116:347-354. doi: 10.1002/cncr.24713 PMID: 19921736
6. Zeng Y. Principles of micro-RNA production and maturation. Oncogene. 2006; 25:6156-6162. PMID: 17028594
7. de Planell-Saguer M, Rodicio MC. Analytical aspects of microRNA in diagnostics: a review. Anal Chim Acta. 2011; 699:134-152. doi: 10.1016/j.aca.2011.05.025 PMID: 21704768
8. Kasinski AL, Slack FJ. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer. 2011; 11:849-864. doi: 10.1038/ nrc3166 PMID: 22113163
9. Rufino-Palomares EE, Reyes-Zurita FJ, Lupiáñez JA, Medina PP. MicroRNAs as oncogenes and tumor Suppressors. MicroRNAs in Medicine. 2014:223-243.
10. Garzon R, Marcucci G. Potential of microRNAs for cancer diagnostics, prognostication and therapy. Curr Opin Oncol. 2012; 24:655-659. doi: 10.1097/CCO.0b013e328358522c PMID: 23079782
11. Cho WC. MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy. Int J Biochem Cell Biol. 2010; 42:1273-1281. doi: 10.1016/j.biocel.2009.12.014 PMID: 20026422
12. Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, et al. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet. 2005; 37:766-770. PMID: 15965474
13. Banales JM, Sáez E, Úriz M, Sarvide S, Urribarri AD, Splinter P, et al. Upregulation of mir-506 leads to decreased AE2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology (Baltimore, Md). 2012; 56:687. doi: 10.1002/hep.25691 PMID: 22383162
14. Zhao Y, Liu H, Li Y, Wu J, Greenlee AR, Yang C, et al. The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide. Toxicol Lett. 2011; 205:320-326. doi: 10.1016/j.toxlet.2011.06.022 PMID: 21726609
15. Arora H, Qureshi R, Park WY. miR-506 regulates epithelial mesenchymal transition in breast cancer cell lines. PloS one. 2013; 8:e64273. doi: 10.1371/journal.pone.0064273 PMID: 23717581
16. Wen S, Lin Y, Yu Y, Cao S, Zhang R, Yang X, et al. miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer. Oncogene. 2014.
17. Liu G, Sun Y, Ji P, Li X, Cogdell D, Yang D, et al. MiR506 suppresses? proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. J Pathol. 2014; 233:308-318. doi: 10.1002/path.4348 PMID: 24604117
18. Babuke T, Tikkanen R. Dissecting the molecular function of reggie/flotillin proteins. Eur J Cell Biol. 2007; 86:525-532. PMID: 17482313
19. Riento K, Frick M, Schafer I, Nichols BJ. Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase. J Cell Sci. 2009; 122:912-918. doi: 10.1242/jcs.039024 PMID: 19258392
20. Li H, Wang RM, Liu SG, Zhang JP, Luo JY, Zhang BJ, et al. Abnormal expression of FLOT1 correlates with tumor progression and poor survival in patients with non-small cell lung cancer. Tumour Biol. 2014; 35:3311-3315. doi: 10.1007/s13277-013-1434-3 PMID: 24277378
21. Lin C, Wu Z, Lin X, Yu C, Shi T, Zeng Y, et al. Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a. Clinical Cancer Research. 2011; 17:3089-3099. doi: 10.1158/1078-0432.CCR-10-3068 PMID: 21447726
22. Zhang S-H, Wang C-J, Shi L, Li X-H, Zhou J, Song L-B, et al. High expression of FLOT1 is associated with progression and poor prognosis in hepatocellular carcinoma. PloS one. 2013; 8:e64709. PMID: 23840303
23. Iorio MV, Croce CM. microRNA involvement in human cancer. Carcinogenesis. 2012; 33:1126-1133. doi: 10.1093/carcin/bgs140 PMID: 22491715
24. Xiong P, Xiao L, Yang R, Guo Q, Zhao Y, Li W, et al. Flotillin-1 promotes cell growth and metastasis in oral squamous cell carcinoma. Neoplasma. 2012; 60:395-405.