Abnormal expression of FLOT1 correlates with tumor progression and poor survival in patients with non-small cell lung cancer

Tumor Biology

Volumn 35, Issue 4, 2014, Pages 3311-3315

  Li, Hui ^a   Wang, Rui Ming ^b   Liu, Shu Guang ^a   Zhang, Jian Ping ^c   Luo, Jing Yu ^a   Zhang, Bai Jiang ^a   Zhang, Xing Guo ^a  

^a SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^c JINAN MILITARY GENERAL HOSPITAL   (China)

Author keywords

FLOT1; NSCLC; Prognosis

Indexed keywords

FLOTILLIN 1; MESSENGER RNA; PARAFFIN;

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOLECULAR BIOLOGY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; SURVIVAL TIME; TUMOR GROWTH; TUMOR VOLUME;

ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MEMBRANE PROTEINS; MIDDLE AGED;

EID: 84898825972     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-1434-3     Document Type: Article

References (13)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90. doi: 10.3322/caac.20107.
2. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106-30.
3. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 2002;346:92-8. doi: 10.1056/NEJMoa011954.
4. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer. 2003;3(6):453-8. doi: 10.1038/nrc1098.
5. Hunter K, Welch DR, Liu ET. Genetic background is an important determinant of metastatic potential. Nat Genet. 2003;34:23-4.
6. Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997;272:13793-802. doi: 10.1074/jbc.272.21.13793.
7. Babuke T, Tikkanen R. Dissecting the molecular function of reggie/flotillin proteins. Eur J Cell Biol. 2007;86:525-32.
8. Santamaría A, Castellanos E, Gómez V, Benedit P, Renau-Piqueras J, Morote J, et al. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol. 2005;25:1900-11. doi: 10.1128/MCB.25.5.1900-1911.2005.
9. Gómez V, Sesé M, Santamaría A, Martínez JD, Castellanos E, Soler M, et al. Regulation of aurora B kinase by the lipid raft protein flotillin-1. J Biol Chem. 2010;285:20683-90. doi: 10.1074/jbc.M110. 130591.
10. Song L, Gong H, Lin C, Wang C, Liu L, Wu J, et al. Flotillin-1 promotes tumor necrosis factor-α receptor signaling and activation of NF-κB in esophageal squamous cell carcinoma cells. Gastroenterology. 2012;143:995-1005.e12. doi: 10.1053/j.gastro.2012.06.033.
11. Lin C, Wu Z, Lin X, Yu C, Shi T, Zeng Y, et al. Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a. Clin Cancer Res. 2011;17:3089-99. doi: 10.1158/1078-0432.CCR-10-3068.
12. Thorn CC, Freeman TC, Scott N, Guillou PJ, Jayne DG. Laser microdissection expression profiling of marginal edges of colorectal tumours reveals evidence of increased lactate metabolism in the aggressive phenotype. Gut. 2009;58:404-12. doi: 10.1136/gut.2008.157255.
13. Zhang SH, Wang CJ, Shi L, Li XH, Zhou J, Song LB, et al. High expression of FLOT1 is associated with progression and poor prognosis in hepatocellular carcinoma. PLoS One. 2013;8:e64709. doi: 10.1371/journal.pone.0064709.