메뉴 건너뛰기




Volumn 19, Issue 5, 2014, Pages 525-530

Experimental models of cardiac transplantation: Design determines relevance

Author keywords

Heterologous immunity; Humanized mice; Memory T cells

Indexed keywords

HISTOCOMPATIBILITY ANTIGEN;

EID: 84925705023     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0000000000000113     Document Type: Review
Times cited : (13)

References (63)
  • 1
    • 17544399865 scopus 로고    scopus 로고
    • Historic landmarks in clinical transplantation: Conclusions from the consensus conference at the University of California, Los Angeles
    • Groth CG, Brent LB, Calne RY, et al. Historic landmarks in clinical transplantation: conclusions from the consensus conference at the University of California, Los Angeles. World J Surg 2000;24:834-843.
    • (2000) World J Surg , vol.24 , pp. 834-843
    • Groth, C.G.1    Brent, L.B.2    Calne, R.Y.3
  • 2
    • 0017157814 scopus 로고
    • Biological effects of cyclosporin A: A new antilymphocytic agent
    • Borel JF, Feurer C, Gubler HU, Stahelin H. Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions 1976;6:468-475.
    • (1976) Agents Actions , vol.6 , pp. 468-475
    • Borel, J.F.1    Feurer, C.2    Gubler, H.U.3    Stahelin, H.4
  • 3
    • 0017827962 scopus 로고
    • Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A
    • Calne RY, White DJ, Rolles K, et al. Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A. Lancet 1978;1:1183-1185.
    • (1978) Lancet , vol.1 , pp. 1183-1185
    • Calne, R.Y.1    White, D.J.2    Rolles, K.3
  • 4
    • 20044386299 scopus 로고    scopus 로고
    • Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
    • Larsen CP, Pearson TC, Adams AB, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 2005;5:443-453.
    • (2005) Am J Transplant , vol.5 , pp. 443-453
    • Larsen, C.P.1    Pearson, T.C.2    Adams, A.B.3
  • 5
    • 35948959015 scopus 로고    scopus 로고
    • Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
    • Rother RP, Rollins SA, Mojcik CF, et al. Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Nat Biotechnol 2007;25:1256-1264.
    • (2007) Nat Biotechnol , vol.25 , pp. 1256-1264
    • Rother, R.P.1    Rollins, S.A.2    Mojcik, C.F.3
  • 6
    • 0026459468 scopus 로고
    • T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo
    • Turka LA, Linsley PS, Lin H, et al. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc Natl Acad Sci U S A 1992;89:11102-11105.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 11102-11105
    • Turka, L.A.1    Linsley, P.S.2    Lin, H.3
  • 7
    • 40649099165 scopus 로고    scopus 로고
    • Inhibition of terminal complement components in presensitized transplant recipients prevents antibody-mediated rejection leading to long-term graft survival and accommodation
    • Wang H, Arp J, Liu W, et al. Inhibition of terminal complement components in presensitized transplant recipients prevents antibody-mediated rejection leading to long-term graft survival and accommodation. J Immunol 2007;179:4451-4463.
    • (2007) J Immunol , vol.179 , pp. 4451-4463
    • Wang, H.1    Arp, J.2    Liu, W.3
  • 8
    • 84889039328 scopus 로고    scopus 로고
    • Lessons and limits of mouse models
    • Chong AS, Alegre ML, Miller ML, Fairchild RL. Lessons and limits of mouse models. Cold Spring Harb Perspect Med 2013;3:a015495. This recent review includes discussions of mouse models of antibodymediated rejection and tolerance induction in kidney as well as in heart transplants.
    • (2013) Cold Spring Harb Perspect Med , vol.3 , pp. a015495
    • Chong, A.S.1    Alegre, M.L.2    Miller, M.L.3    Fairchild, R.L.4
  • 9
    • 20944443148 scopus 로고    scopus 로고
    • Organ transplantation: How much of the promise has been realized?
    • Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation: how much of the promise has been realized? Nat Med 2005;11:605-613.
    • (2005) Nat Med , vol.11 , pp. 605-613
    • Lechler, R.I.1    Sykes, M.2    Thomson, A.W.3    Turka, L.A.4
  • 10
    • 0036664218 scopus 로고    scopus 로고
    • Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice
    • Valujskikh A, Pantenburg B, Heeger PS. Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. Am J Transplant 2002;2:501-509.
    • (2002) Am J Transplant , vol.2 , pp. 501-509
    • Valujskikh, A.1    Pantenburg, B.2    Heeger, P.S.3
  • 11
    • 48349097977 scopus 로고    scopus 로고
    • Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients
    • Schenk AD, Nozaki T, Rabant M, et al. Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients. Am J Transplant 2008;8:1652-1661.
    • (2008) Am J Transplant , vol.8 , pp. 1652-1661
    • Schenk, A.D.1    Nozaki, T.2    Rabant, M.3
  • 12
    • 73349127838 scopus 로고    scopus 로고
    • Complement-dependent inflammation and injury in a murine model of brain dead donor hearts
    • Atkinson C, Varela JC, Tomlinson S. Complement-dependent inflammation and injury in a murine model of brain dead donor hearts. Circ Res 2009;105:1094-1101.
    • (2009) Circ Res , vol.105 , pp. 1094-1101
    • Atkinson, C.1    Varela, J.C.2    Tomlinson, S.3
  • 13
    • 84886797075 scopus 로고    scopus 로고
    • CD40-independent help by memory CD4 T cells induces pathogenic alloantibody but does not lead to long-lasting humoral immunity
    • Rabant M, Gorbacheva V, Fan R, et al. CD40-independent help by memory CD4 T cells induces pathogenic alloantibody but does not lead to long-lasting humoral immunity. Am J Transplant 2013;13:2831-2841. This study investigates the costimulation requirements for memory CD4 T cells to help B cells produce alloantibodies in the acute and chronic responses to heart transplants.
    • (2013) Am J Transplant , vol.13 , pp. 2831-2841
    • Rabant, M.1    Gorbacheva, V.2    Fan, R.3
  • 14
    • 84896724005 scopus 로고    scopus 로고
    • Endogenous memory CD8 T cells directly mediate cardiac allograft rejection
    • Su CA, Iida S, Abe T, Fairchild RL. Endogenous memory CD8 T cells directly mediate cardiac allograft rejection. Am J Transplant 2014;14:568-579. This study examines the clinically relevant effects of 4-8 h of cold ischemia on early immune responses to heart transplants.
    • (2014) Am J Transplant , vol.14 , pp. 568-579
    • Su, C.A.1    Iida, S.2    Abe, T.3    Fairchild, R.L.4
  • 15
    • 0037028155 scopus 로고    scopus 로고
    • The mosaic structure of variation in the laboratory mouse genome
    • Wade CM, Kulbokas EJ 3rd, Kirby AW, et al. The mosaic structure of variation in the laboratory mouse genome. Nature 2002;420:574-578.
    • (2002) Nature , vol.420 , pp. 574-578
    • Wade, C.M.1    Kulbokas, E.J.2    Kirby, A.W.3
  • 16
    • 79959735506 scopus 로고    scopus 로고
    • Subspecific origin and haplotype diversity in the laboratory mouse
    • Yang H, Wang JR, Didion JP, et al. Subspecific origin and haplotype diversity in the laboratory mouse. Nat Genet 2011;43:648-655.
    • (2011) Nat Genet , vol.43 , pp. 648-655
    • Yang, H.1    Wang, J.R.2    Didion, J.P.3
  • 17
    • 0014942384 scopus 로고
    • Histocompatibility-2 (H-2) polymorphism in wild mice
    • Klein J. Histocompatibility-2 (H-2) polymorphism in wild mice. Science 1970;168:1362-1364.
    • (1970) Science , vol.168 , pp. 1362-1364
    • Klein, J.1
  • 18
    • 84874432272 scopus 로고    scopus 로고
    • Allograft outcomes in outbred mice
    • Reichenbach DK, Li Q, Hoffman RA, et al. Allograft outcomes in outbred mice. Am J Transplant 2013;13:580-588. This study describes the wider spectrum of rejection that occurs when hearts are allografted in more genetically heterogeneous outbred mice.
    • (2013) Am J Transplant , vol.13 , pp. 580-588
    • Reichenbach, D.K.1    Li, Q.2    Hoffman, R.A.3
  • 19
    • 84879675197 scopus 로고    scopus 로고
    • Nanoparticle clearance is governed by Th1/Th2 immunity and strain background
    • Jones SW, Roberts RA, Robbins GR, et al. Nanoparticle clearance is governed by Th1/Th2 immunity and strain background. J Clin Invest 2013;123:3061-3073. An important in-vivo study of the functional consequences of cytokine-induced macrophage polarization.
    • (2013) J Clin Invest , vol.123 , pp. 3061-3073
    • Jones, S.W.1    Roberts, R.A.2    Robbins, G.R.3
  • 20
    • 0034659784 scopus 로고    scopus 로고
    • M-1/M-2 macrophages and the Th1/Th2 paradigm
    • Mills CD, Kincaid K, Alt JM, et al. M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol 2000;164:6166-6173.
    • (2000) J Immunol , vol.164 , pp. 6166-6173
    • Mills, C.D.1    Kincaid, K.2    Alt, J.M.3
  • 21
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: Differences between mouse and human immunology
    • Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol 2004;172:2731-2738.
    • (2004) J Immunol , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 22
    • 84874235143 scopus 로고    scopus 로고
    • Conservation and divergence in the transcriptional programs of the human and mouse immune systems
    • Shay T, Jojic V, Zuk O, et al. Conservation and divergence in the transcriptional programs of the human and mouse immune systems. Proc Natl Acad Sci U S A 2013;110:2946-2951. This study exploits an anatomical variation of the human heart to demonstrate the relevance of anatomical structure on pathological processes in the human coronary artery.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 2946-2951
    • Shay, T.1    Jojic, V.2    Zuk, O.3
  • 23
    • 50549096379 scopus 로고    scopus 로고
    • Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages
    • Petkova SB, Yuan R, Tsaih SW, et al. Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages. Physiol Genomics 2008;34:304-314.
    • (2008) Physiol Genomics , vol.34 , pp. 304-314
    • Petkova, S.B.1    Yuan, R.2    Tsaih, S.W.3
  • 24
    • 0015866545 scopus 로고
    • Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection
    • Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973;16:343-350.
    • (1973) Transplantation , vol.16 , pp. 343-350
    • Corry, R.J.1    Winn, H.J.2    Russell, P.S.3
  • 25
    • 80053015403 scopus 로고    scopus 로고
    • Why are the intramyocardial portions of the coronary arteries spared from arteriosclerosis? Clinical implications
    • Botta DM Jr, Elefteriades JA. Why are the intramyocardial portions of the coronary arteries spared from arteriosclerosis? Clinical implications. Int J Angiol 2009;18:59-61.
    • (2009) Int J Angiol , vol.18 , pp. 59-61
    • Botta, D.M.1    Elefteriades, J.A.2
  • 26
    • 84903742736 scopus 로고    scopus 로고
    • Histologic and immunohistochemical analysis of the antiatherogenic effects of myocardial bridging in the adult human heart
    • Loukas M, Bhatnagar A, Arumugam S, et al. Histologic and immunohistochemical analysis of the antiatherogenic effects of myocardial bridging in the adult human heart. Cardiovasc Pathol 2014;23:198-203.
    • (2014) Cardiovasc Pathol , vol.23 , pp. 198-203
    • Loukas, M.1    Bhatnagar, A.2    Arumugam, S.3
  • 27
    • 80051474244 scopus 로고    scopus 로고
    • Diverse morphologic manifestations of cardiac allograft vasculopathy: A pathologic study of 64 allograft hearts
    • Lu WH, Palatnik K, Fishbein GA, et al. Diverse morphologic manifestations of cardiac allograft vasculopathy: a pathologic study of 64 allograft hearts. J Heart Lung Transplant 2011;30:1044-1050.
    • (2011) J Heart Lung Transplant , vol.30 , pp. 1044-1050
    • Lu, W.H.1    Palatnik, K.2    Fishbein, G.A.3
  • 28
    • 77957579885 scopus 로고    scopus 로고
    • Cardiac allograft vasculopathy: Do adipocytes bridge alloimmune and metabolic risk factors?
    • Wehner JR, Baldwin WM 3rd. Cardiac allograft vasculopathy: do adipocytes bridge alloimmune and metabolic risk factors? Curr Opin Organ Transplant 2010;15:639-644.
    • (2010) Curr Opin Organ Transplant , vol.15 , pp. 639-644
    • Wehner, J.R.1    Baldwin, W.M.2
  • 29
    • 0000682701 scopus 로고
    • The behaviour and fate of skin autografts and skin homografts in rabbits: A report to the War Wounds Committee of the Medical Research Council
    • Medawar PB. The behaviour and fate of skin autografts and skin homografts in rabbits: a report to the War Wounds Committee of the Medical Research Council. J Anat 1944;78(Pt 5):176-199.
    • (1944) J Anat , vol.78 , pp. 176-199
    • Medawar, P.B.1
  • 30
    • 84925720470 scopus 로고    scopus 로고
    • Memory T cells in transplantation
    • Su CA, Fairchild RL. Memory T cells in transplantation. Curr Transplant Rep 2014;1:137-146. This article extensively reviewsmemory T cells in the context of organ transplantation.
    • (2014) Curr Transplant Rep , vol.1 , pp. 137-146
    • Su, C.A.1    Fairchild, R.L.2
  • 31
    • 84874440961 scopus 로고    scopus 로고
    • Pretransplant antithymocyte globulin has increased efficacy in controlling donor-reactive memory T cells in mice
    • Ayasoufi K, Yu H, Fan R, et al. Pretransplant antithymocyte globulin has increased efficacy in controlling donor-reactive memory T cells in mice. Am J Transplant 2013;13:589-599. This study analyzes the effects of a clinically relevant immunosuppressant on different types of T cells.
    • (2013) Am J Transplant , vol.13 , pp. 589-599
    • Ayasoufi, K.1    Yu, H.2    Fan, R.3
  • 32
    • 33645795235 scopus 로고    scopus 로고
    • Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it
    • Neujahr DC, Chen C, Huang X, et al. Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol 2006;176:4632-4639.
    • (2006) J Immunol , vol.176 , pp. 4632-4639
    • Neujahr, D.C.1    Chen, C.2    Huang, X.3
  • 33
    • 20044380331 scopus 로고    scopus 로고
    • Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion
    • Pearl JP, Parris J, Hale DA, et al. Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion. Am J Transplant 2005;5:465-474.
    • (2005) Am J Transplant , vol.5 , pp. 465-474
    • Pearl, J.P.1    Parris, J.2    Hale, D.A.3
  • 34
    • 0034720744 scopus 로고    scopus 로고
    • + T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade
    • + T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade. Transplantation 2000;69:2609-2612.
    • (2000) Transplantation , vol.69 , pp. 2609-2612
    • Ensminger, S.M.1    Witzke, O.2    Spriewald, B.M.3
  • 36
    • 0035889949 scopus 로고    scopus 로고
    • Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory
    • Suresh M, Whitmire JK, Harrington LE, et al. Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. J Immunol 2001;167:5565-5573.
    • (2001) J Immunol , vol.167 , pp. 5565-5573
    • Suresh, M.1    Whitmire, J.K.2    Harrington, L.E.3
  • 37
    • 22844438322 scopus 로고    scopus 로고
    • Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients
    • Augustine JJ, Siu DS, Clemente MJ, et al. Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients. Am J Transplant 2005;5:1971-1975.
    • (2005) Am J Transplant , vol.5 , pp. 1971-1975
    • Augustine, J.J.1    Siu, D.S.2    Clemente, M.J.3
  • 38
    • 0033566737 scopus 로고    scopus 로고
    • Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes
    • Heeger PS, Greenspan NS, Kuhlenschmidt S, et al. Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J Immunol 1999;163:2267-2275.
    • (1999) J Immunol , vol.163 , pp. 2267-2275
    • Heeger, P.S.1    Greenspan, N.S.2    Kuhlenschmidt, S.3
  • 39
    • 0038690218 scopus 로고    scopus 로고
    • Enzyme linked immunosorbent spot (ELISPOT) assay for interferon-gamma independently predicts renal function in kidney transplant recipients
    • Hricik DE, Rodriguez V, Riley J, et al. Enzyme linked immunosorbent spot (ELISPOT) assay for interferon-gamma independently predicts renal function in kidney transplant recipients. Am J Transplant 2003;3:878-884.
    • (2003) Am J Transplant , vol.3 , pp. 878-884
    • Hricik, D.E.1    Rodriguez, V.2    Riley, J.3
  • 40
    • 3042577493 scopus 로고    scopus 로고
    • Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy
    • Poggio ED, Clemente M, Riley J, et al. Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy. J Am Soc Nephrol 2004;15:1952-1960.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1952-1960
    • Poggio, E.D.1    Clemente, M.2    Riley, J.3
  • 41
    • 0019510547 scopus 로고
    • Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virusspecific cytotoxic T lymphocytes
    • Braciale TJ, Andrew ME, Braciale VL. Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virusspecific cytotoxic T lymphocytes. J Exp Med 1981;153:1371-1376.
    • (1981) J Exp Med , vol.153 , pp. 1371-1376
    • Braciale, T.J.1    Andrew, M.E.2    Braciale, V.L.3
  • 42
    • 0042532322 scopus 로고    scopus 로고
    • Heterologous immunity provides a pot-ent barrier to transplantation tolerance
    • Adams AB, Williams MA, Jones TR, et al. Heterologous immunity provides a pot-ent barrier to transplantation tolerance. J Clin Invest 2003;111:1887-1895.
    • (2003) J Clin Invest , vol.111 , pp. 1887-1895
    • Adams, A.B.1    Williams, M.A.2    Jones, T.R.3
  • 43
    • 84861093557 scopus 로고    scopus 로고
    • Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses
    • Kitchens WH, Haridas D, Wagener ME, et al. Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses. Transplantation 2012;93:997-1005.
    • (2012) Transplantation , vol.93 , pp. 997-1005
    • Kitchens, W.H.1    Haridas, D.2    Wagener, M.E.3
  • 44
    • 84855943600 scopus 로고    scopus 로고
    • Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8 (+) memory T cells
    • Kitchens WH, Haridas D, Wagener ME, et al. Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8 (+) memory T cells. Am J Transplant 2012;12:69-80.
    • (2012) Am J Transplant , vol.12 , pp. 69-80
    • Kitchens, W.H.1    Haridas, D.2    Wagener, M.E.3
  • 45
    • 0033961897 scopus 로고    scopus 로고
    • Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody
    • Welsh RM, Markees TG, Woda BA, et al. Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. J Virol 2000;74:2210-2218.
    • (2000) J Virol , vol.74 , pp. 2210-2218
    • Welsh, R.M.1    Markees, T.G.2    Woda, B.A.3
  • 46
    • 84883463377 scopus 로고    scopus 로고
    • Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection
    • Setoguchi K, Hattori Y, Iida S, et al. Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection. Am J Transplant 2013;13:2293-2307.
    • (2013) Am J Transplant , vol.13 , pp. 2293-2307
    • Setoguchi, K.1    Hattori, Y.2    Iida, S.3
  • 47
    • 52449098696 scopus 로고    scopus 로고
    • The importance of cold and warm cardiac ischemia for survival after heart transplantation
    • Banner NR, Thomas HL, Curnow E, et al. The importance of cold and warm cardiac ischemia for survival after heart transplantation. Transplantation 2008;86:542-547.
    • (2008) Transplantation , vol.86 , pp. 542-547
    • Banner, N.R.1    Thomas, H.L.2    Curnow, E.3
  • 48
    • 33846338786 scopus 로고    scopus 로고
    • The effect of ischemic time on survival after heart transplantation varies by donor age: An analysis of the United Network for Organ Sharing database
    • Russo MJ, Chen JM, Sorabella RA, et al. The effect of ischemic time on survival after heart transplantation varies by donor age: an analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg 2007;133:554-559.
    • (2007) J Thorac Cardiovasc Surg , vol.133 , pp. 554-559
    • Russo, M.J.1    Chen, J.M.2    Sorabella, R.A.3
  • 49
    • 72549116180 scopus 로고    scopus 로고
    • Role of TNFalpha in early chemokine production and leukocyte infiltration into heart allografts
    • Ishii D, Schenk AD, Baba S, Fairchild RL. Role of TNFalpha in early chemokine production and leukocyte infiltration into heart allografts. Am J Transplant 2010;10:59-68.
    • (2010) Am J Transplant , vol.10 , pp. 59-68
    • Ishii, D.1    Schenk, A.D.2    Baba, S.3    Fairchild, R.L.4
  • 50
    • 79955544000 scopus 로고    scopus 로고
    • LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming
    • Setoguchi K, Schenk AD, Ishii D, et al. LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming. Am J Transplant 2011;11:923-935. In conjunction with reference 14, these experiments demonstrate that effects of endogenous memory T cells responses to cardiac allografts depend on variables related to the graft as well as the infiltrating T cells.
    • (2011) Am J Transplant , vol.11 , pp. 923-935
    • Setoguchi, K.1    Schenk, A.D.2    Ishii, D.3
  • 51
    • 0025112687 scopus 로고
    • Immunodeficient mice xenografted with human lymphoid cells: New models for in vivo studies of human immunobiology and infectious diseases
    • Mosier DE. Immunodeficient mice xenografted with human lymphoid cells: new models for in vivo studies of human immunobiology and infectious diseases. J Clin Immunol 1990;10:185-191.
    • (1990) J Clin Immunol , vol.10 , pp. 185-191
    • Mosier, D.E.1
  • 52
    • 84860871911 scopus 로고    scopus 로고
    • Human allograft rejection in humanized mice: A historical perspective
    • Brehm MA, Shultz LD. Human allograft rejection in humanized mice: a historical perspective. Cell Mol Immunol 2012;9:225-231.
    • (2012) Cell Mol Immunol , vol.9 , pp. 225-231
    • Brehm, M.A.1    Shultz, L.D.2
  • 53
    • 84903741746 scopus 로고    scopus 로고
    • Humanized mouse models in transplantation research
    • Hogenes M, Huibers M, Kroone C, De Weger R. Humanized mouse models in transplantation research. Transplant Rev (Orlando) 2014;28:103-110. This article extensively reviews humanized mouse models in the context of organ transplantation.
    • (2014) Transplant Rev (Orlando) , vol.28 , pp. 103-110
    • Hogenes, M.1    Huibers, M.2    Kroone, C.3    De Weger, R.4
  • 54
    • 9644275453 scopus 로고    scopus 로고
    • T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase
    • Koh KP, Wang Y, Yi T, et al. T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase. J Clin Invest 2004;114:846-856.
    • (2004) J Clin Invest , vol.114 , pp. 846-856
    • Koh, K.P.1    Wang, Y.2    Yi, T.3
  • 55
    • 34748871414 scopus 로고    scopus 로고
    • Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation
    • Wang Y, Bai Y, Qin L, et al. Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation. Circ Res 2007;101:560-569.
    • (2007) Circ Res , vol.101 , pp. 560-569
    • Wang, Y.1    Bai, Y.2    Qin, L.3
  • 56
    • 59649083728 scopus 로고    scopus 로고
    • Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
    • Rao DA, Eid RE, Qin L, et al. Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection. J Exp Med 2008;205:3145-3158.
    • (2008) J Exp Med , vol.205 , pp. 3145-3158
    • Rao, D.A.1    Eid, R.E.2    Qin, L.3
  • 57
    • 77956633519 scopus 로고    scopus 로고
    • VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling
    • Zhang J, Silva T, Yarovinsky T, et al. VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling. Circ Res 2010;107:408-417.
    • (2010) Circ Res , vol.107 , pp. 408-417
    • Zhang, J.1    Silva, T.2    Yarovinsky, T.3
  • 58
    • 84856165858 scopus 로고    scopus 로고
    • Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model
    • Yi T, Fogal B, Hao Z, et al. Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model. Arterioscler Thromb Vasc Biol 2012;32:353-360.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 353-360
    • Yi, T.1    Fogal, B.2    Hao, Z.3
  • 59
    • 84864463754 scopus 로고    scopus 로고
    • Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
    • Hester J, Schiopu A, Nadig SN, Wood KJ. Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo. Am J Transplant 2012;12:2008-2016.
    • (2012) Am J Transplant , vol.12 , pp. 2008-2016
    • Hester, J.1    Schiopu, A.2    Nadig, S.N.3    Wood, K.J.4
  • 60
    • 77954539326 scopus 로고    scopus 로고
    • In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    • Nadig SN, Wieckiewicz J, Wu DC, et al. In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med 2010;16:809-813.
    • (2010) Nat Med , vol.16 , pp. 809-813
    • Nadig, S.N.1    Wieckiewicz, J.2    Wu, D.C.3
  • 61
    • 80052938981 scopus 로고    scopus 로고
    • Efficient differentiation and function of human macrophages in humanized CSF-1 mice
    • Rathinam C, Poueymirou WT, Rojas J, et al. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 2011;118:3119-3128.
    • (2011) Blood , vol.118 , pp. 3119-3128
    • Rathinam, C.1    Poueymirou, W.T.2    Rojas, J.3
  • 62
    • 79952294749 scopus 로고    scopus 로고
    • Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
    • Rongvaux A, Willinger T, Takizawa H, et al. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci U S A 2011;108:2378-2383.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2378-2383
    • Rongvaux, A.1    Willinger, T.2    Takizawa, H.3
  • 63
    • 84900850997 scopus 로고    scopus 로고
    • Development and function of human innate immune cells in a humanized mouse model
    • Rongvaux A, Willinger T, Martinek J, et al. Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol 2014;32:364-372.
    • (2014) Nat Biotechnol , vol.32 , pp. 364-372
    • Rongvaux, A.1    Willinger, T.2    Martinek, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.