Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behçet Disease

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Kappen, Jasper H ^a   Medina Gomez, Carolina ^a   Van Hagen, P Martin ^a   Stolk, Lisette ^a   Estrada, Karol ^a   Rivadeneira, Fernando ^a   Uitterlinden, Andre G ^a   Stanford, Miles R ^b   Ben Chetrit, Eldat ^d   Wallace, Graham R ^c   Soylu, Merih ^e   Van Laar, Jan A M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^e CUKUROVA UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12P35; IL12A PROTEIN, HUMAN;

ARTICLE; BEHCET DISEASE; CHROMOSOME 3; CITIZEN GROUP; COHORT ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HUMAN; INTERLEUKIN 12A GENE; MAJOR CLINICAL STUDY; MIDDLE EASTERN PEOPLE; SINGLE NUCLEOTIDE POLYMORPHISM; TURK (PEOPLE); WESTERN EUROPEAN; ADOLESCENT; ADULT; AGED; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MALE; META ANALYSIS (TOPIC); MIDDLE AGED; PHENOTYPE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BEHCET SYNDROME; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INTERLEUKIN-12 SUBUNIT P35; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84925702902     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119085     Document Type: Article

References (33)

1. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet's disease. The New England journal of medicine. 1999; 341(17):1284-91. PMID: 10528040
2. Gul A. Behcet's disease: an update on the pathogenesis. Clinical and experimental rheumatology. 2001; 19(5 Suppl 24):S6-12. PMID: 11760403
3. Yazici H, Fresko I, Yurdakul S. Behcet's syndrome: disease manifestations, management, and advances in treatment. Nature clinical practice Rheumatology. 2007; 3(3):148-55. PMID: 17334337
4. Altenburg A, Mahr A, Maldini C, Kneifel CE, Krause L, Kotter I, et al. [Epidemiology and clinical aspects of Adamantiades-Behcet disease in Gemany. Current data]. Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 2012; 109(6):531-41.
5. Gul A, Inanc M, Ocal L, Aral O, Konice M. Familial aggregation of Behcet's disease in Turkey. Annals of the rheumatic diseases. 2000; 59(8):622-5. PMID: 10913059
6. Baranathan V, Stanford MR, Vaughan RW, Kondeatis E, Graham E, Fortune F, et al. The association of the PTPN22 620W polymorphism with Behcet's disease. Annals of the rheumatic diseases. 2007; 66(11):1531-3. PMID: 17660222
7. Kappen JH, Wallace GR, Stolk L, Rivadeneira F, Uitterlinden AG, van Daele PL, et al. Low prevalence of NOD2 SNPs in Behcet's disease suggests protective association in Caucasians. Rheumatology (Oxford). 2009; 48(11):1375-7. doi: 10.1093/rheumatology/kep292 PMID: 19748964
8. Touma Z, Farra C, Hamdan A, Shamseddeen W, Uthman I, Hourani H, et al. TNF polymorphisms in patients with Behcet disease: a meta-analysis. Archives of medical research. 2010; 41(2):142-6. doi: 10. 1016/j.arcmed.2010.02.002 PMID: 20470944
9. Hu K, Yang P, Jiang Z, Hou S, Du L, Li F. STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behcet's disease. Human immunology. 2010; 71(7):723-6. doi: 10.1016/j.humimm.2010.04.007 PMID: 20438790
10. Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, et al. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease. Nature genetics. 2010; 42(8):698-702. doi: 10.1038/ng.625 PMID: 20622878
11. Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, et al. Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. Nature genetics. 2010; 42-(8):703-6. doi: 10.1038/ng.624 PMID: 20622879
12. Xavier JM, Shahram F, Davatchi F, Rosa A, Crespo J, Abdollahi BS, et al. Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behcet's disease. Arthritis and rheumatism. 2012; 64-(8):2761-72. doi: 10.1002/art.34437 PMID: 22378604
13. Khaib Dit Naib O, Aribi M, Idder A, Chiali A, Sairi H, Touitou I, et al. Association Analysis of IL10, TNFalpha, and IL23R-IL12RB2 SNPs with Behcet's Disease Risk in Western Algeria. Frontiers in immunology. 2013; 4:342. doi: 10.3389/fimmu.2013.00342 PMID: 24151497
14. Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, et al. Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B∗51 and ERAP1. Nature genetics. 2013; 45(2):202-7. doi: 10.1038/ng.2520 PMID: 23291587
15. Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Choi JY, et al. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. Annals of the rheumatic diseases. 2013; 72(9):1510-6. doi: 10.1136/annrheumdis-2011-200288 PMID: 23041938
16. Ortiz-Fernandez L, Conde-Jaldon M, Garcia-Lozano JR, Montes-Cano MA, Ortego-Centeno N, Castillo-Palma MJ, et al. GIMAP and Behcet disease: no association in the European population. Annals of the rheumatic diseases. 2014.
17. McCarthy MI, Hirschhorn JN. Genome-wide association studies: potential next steps on a genetic journey. Human molecular genetics. 2008; 17(R2):R156-65. doi: 10.1093/hmg/ddn289 PMID: 18852205
18. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nature genetics. 2006; 38(8):904-9. PMID: 16862161
19. Price AL, Zaitlen NA, Reich D, Patterson N. New approaches to population stratification in genomewide association studies. Nature reviews Genetics. 2010; 11(7):459-63. doi: 10.1038/nrg2813 PMID: 20548291
20. Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease. Lancet. 1990; 335(8697):1078-80. PMID: 1970380
21. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, et al. The Generation R Study: design and cohort update 2012. European journal of epidemiology. 2012; 27-(9):739-56. doi: 10.1007/s10654-012-9735-1 PMID: 23086283
22. Yang J, Lee SH, Goddard ME, Visscher PM. GCTA: a tool for genome-wide complex trait analysis. American journal of human genetics. 2011; 88(1):76-82. doi: 10.1016/j.ajhg.2010.11.011 PMID: 21167468
23. Thornton T, Tang H, Hoffmann TJ, Ochs-Balcom HM, Caan BJ, Risch N. Estimating kinship in admixed populations. American journal of human genetics. 2012; 91(1):122-38. doi: 10.1016/j.ajhg.2012.05.024 PMID: 22748210
24. International HapMap C. The International HapMap Project. Nature. 2003; 426(6968):789-96. PMID: 14685227
25. Kang HM, Sul JH, Service SK, Zaitlen NA, Kong SY, Freimer NB, et al. Variance component model to account for sample structure in genome-wide association studies. Nature genetics. 2010; 42-(4):348-54. doi: 10.1038/ng.548 PMID: 20208533
26. Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010; 26(17):2190-1. doi: 10.1093/bioinformatics/btq340 PMID: 20616382
27. A haplotype map of the human genome. Nature. 2005; 437(7063):1299-320. PMID: 16255080
28. Zaitlen N, Kraft P, Patterson N, Pasaniuc B, Bhatia G, Pollack S, et al. Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. PLoS genetics. 2013; 9(5): e1003520. doi: 10.1371/journal.pgen.1003520 PMID: 23737753
29. Plomin R, Deary IJ. Genetics and intelligence differences: five special findings. Molecular psychiatry. 2014.
30. Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, et al. Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. American journal of human genetics. 2013; 92(6):904-16. doi: 10.1016/j.ajhg.2013.04.025 PMID: 23726366
31. Morris AP. Transethnic meta-analysis of genomewide association studies. Genetic epidemiology. 2011; 35(8):809-22. doi: 10.1002/gepi.20630 PMID: 22125221
32. Hou S, Yang Z, Du L, Jiang Z, Shu Q, Chen Y, et al. Identification of a susceptibility locus in STAT4 for Behcet's disease in Han Chinese in a genome-wide association study. Arthritis and rheumatism. 2012; 64(12):4104-13. doi: 10.1002/art.37708 PMID: 23001997
33. Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Song R, et al. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. Annals of the rheumatic diseases. 2012.