Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy

Magnetic Resonance in Medicine

Volumn 73, Issue 4, 2015, Pages 1401-1406

  Stephen Patrick, P ^a   Kettunen, Mikko I ^a,b   Tee, Sui Seng ^a   Rodrigues, Tiago B ^a   Serrao, Eva ^a   Timm, Kerstin N ^a   McGuire, Sarah ^a   Brindle, Kevin M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

13C MRS; Gene reporter; hyperpolarization; urea transporter

Indexed keywords

GENES; MAGNETIC RESONANCE; MAGNETIC RESONANCE SPECTROSCOPY; MAMMALS; METABOLISM; SURFACE DIFFUSION; TISSUE;

APPARENT DIFFUSION COEFFICIENT; CONTROL TISSUES; DIFFUSION-WEIGHTED MAGNETIC RESONANCE; HYPERPOLARIZATION; IN COMPOSITIONS; REPORTER SYSTEMS; TRANSGENE EXPRESSION; ^13C MRS;

UREA;

CARRIER PROTEIN; UNCLASSIFIED DRUG; UREA; UREA C 13; UREA TRANSPORTER PROTEIN; WATER; CARBON; UREA TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; FLUORESCENCE IMAGING; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN EXPRESSION; REPORTER GENE; STUDENT T TEST; TRANSGENE; ANIMAL; GENETICS; HEK293 CELL LINE; METABOLISM; PROCEDURES; REPRODUCIBILITY; SCID MOUSE; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

ANIMALS; CARBON ISOTOPES; HEK293 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, SCID; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; TRANSGENES; UREA;

EID: 84925651958     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.25254     Document Type: Article

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