Imaging of blood flow using hyperpolarized [13C]urea in preclinical cancer models

Journal of Magnetic Resonance Imaging

Volumn 33, Issue 3, 2011, Pages 692-697

  Von Morze, Cornelius ^a   Larson, Peder E Z ^a   Hu, Simon ^a   Keshari, Kayvan ^a   Wilson, David M ^a   Ardenkjaer Larsen, Jan Henrik ^b   Goga, Andrei ^c   Bok, Robert ^a   Kurhanewicz, John ^a   Vigneron, Daniel B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GE HEALTHCARE   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Blood flow; Cancer model; Carbon 13; Dynamic nuclear polarization (DNP); Hyperpolarized; Urea

Indexed keywords

CARBON 13; IODINE 13; PYRUVIC ACID; TRACER; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CANCER MODEL; CONTROLLED STUDY; HYPERPOLARIZATION; IMAGING; LIVER TUMOR; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STEADY STATE;

ALGORITHMS; ANIMALS; BLOOD FLOW VELOCITY; CARBON ISOTOPES; DIFFUSION; DISEASE MODELS, ANIMAL; HUMANS; KIDNEY; LIVER; MALE; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79952254144     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.22484     Document Type: Article

References (24)

1. Ardenkjaer-Larsen JH, Fridlund B, Gram A, et al. Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A 2003;100:10158-10163. (Pubitemid 37071849)
2. Mansson S, Johansson E, Magnusson P, et al. 13C imaging-a new diagnostic platform. Eur Radiol 2006;16:57-67. (Pubitemid 43103569)
3. Aime S, Dastru W, Gobetto R, Santelia D, Viale A. Agents for polarization enhancement in MRI. Handb Exp Pharmacol 2008 (Pt 1):247-272.
4. Bhattacharya P, Ross BD, Bunger R. Cardiovascular applications of hyperpolarized contrast media and metabolic tracers. Exp Biol Med (Maywood) 2009;234:1395-1416.
5. Chen AP, Albers MJ, Cunningham CH, et al. Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med 2007;58:1099-1106. (Pubitemid 350234196)
6. Gallagher FA, Kettunen MI, Day SE, et al. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature 2008;453:940-943.
7. Golman K, in 't Zandt R, Thaning M. Real-time metabolic imaging. Proc Natl Acad Sci U S A 2006;103:11270-11275.
8. Schroeder MA, Cochlin LE, Heather LC, Clarke K, Radda GK, Tyler DJ. In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Acad Sci U S A 2008;105:12051-12056.
9. Golman K, Ardenkjaer-Larsen JH, Petersson JS, Mansson S, Leunbach I. Molecular imaging with endogenous substances. Proc Natl Acad Sci U S A 2003;100:10435-10439. (Pubitemid 37071896)
10. Johansson E, Månsson S, Wirestam R, et al. Cerebral perfusion assessment by bolus tracking using hyperpolarized 13C. Magn Reson Med 2004;51:464-472. (Pubitemid 38298658)
11. Svensson J, Mansson S, Johansson E, Petersson JS, Olsson LE. Hyperpolarized 13C MR angiography using trueFISP. Magn Reson Med 2003;50:256-262. (Pubitemid 36950844)
12. Wilson DM, Keshari KR, Larson PE, et al. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson 2010;205:141-147.
13. Iwamoto K, Watanabe J, Imai K, Shibata M, Hirate J, Ozeki S. Disposition of urea following intravenous administration to rats. Chem Pharm Bull 1982;30:1422-1429. (Pubitemid 12068328)
14. Sands JM. Molecular approaches to urea transporters. J Am Soc Nephrol 2002;13:2795-2806. (Pubitemid 35216051)
15. Gillies RJ, Schornack PA, Secomb TW, Raghunand N. Causes and effects of heterogeneous perfusion in tumors. Neoplasia 1999;1:197-207.
16. Dunnwald LK, Gralow JR, Ellis GK, et al. Tumor metabolism and blood flow changes by positron emission tomography: relation to survival in patients treated with neoadjuvant chemotherapy for locally advanced breast cancer. J Clin Oncol 2008;26:4449-4457.
17. Komar G, Kauhanen S, Liukko K, et al. Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness. Clin Cancer Res 2009;15:5511-5517.
18. Hu S, Lustig M, Balakrishnan A, et al. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med 2010;63:312-321.
19. Shachaf CM, Kopelman AM, Arvanitis C, et al. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 2004;431:1112-1117. (Pubitemid 39472236)
20. Ostergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I. Mathematical approach and statistical analysis. Magn Reson Med 1996;36:715-725.
21. Pang KS, Barker F III, Schwab AJ, Goresky CA. [14C]urea and 58Co-EDTA as reference indicators in hepatic multiple indicator dilution studies. Am J Physiol 1990;259(Pt 1):G32-G40. (Pubitemid 20233150)
22. Cunningham CH, Chen AP, Albers MJ, et al. Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. J Magn Reson 2007;187:357-362. (Pubitemid 47069025)
23. Rasband WS. ImageJ. U.S. National Institutes of Health, Bethesda, MD. 1997-2005. Available at: http://rsb.info.nih.gov/ij/.
24. Davies B, Morris T. Physiological-parameters in laboratory-animals and humans. Pharmaceut Res 1993;10:1093-1095.