Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein

Current Opinion in Virology

Volumn 11, Issue , 2015, Pages 70-75

  McLellan, Jason S ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; NEUTRALIZING ANTIBODY; RESPIRATORY SYNCYTIAL VIRUS VACCINE; VIRUS FUSION PROTEIN; VIRUS GLYCOPROTEIN; F PROTEIN, HUMAN RESPIRATORY SYNCYTIAL VIRUS; VIRUS ANTIBODY;

ARTICLE; BRONCHIOLITIS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; PROTEIN CONFORMATION;

ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; DRUG DISCOVERY; EPITOPES; HUMANS; PROTEIN CONFORMATION; RESPIRATORY SYNCYTIAL VIRUS VACCINES; VIRAL FUSION PROTEINS;

EID: 84925639111     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2015.03.002     Document Type: Review

References (42)

1. C.B. Hall, E.A. Simoes, and L.J. Anderson Clinical and epidemiologic features of respiratory syncytial virus Curr Top Microbiol Immunol 372 2013 39 57
2. W.P. Glezen, L.H. Taber, A.L. Frank, and J.A. Kasel Risk of primary infection and reinfection with respiratory syncytial virus Am J Dis Child 140 1986 543 546
3. C.B. Hall The burgeoning burden of respiratory syncytial virus among children Infect Disord Drug Targets 12 2012 92 97
4. C.B. Hall, G.A. Weinberg, A.K. Blumkin, K.M. Edwards, M.A. Staat, A.F. Schultz, K.A. Poehling, P.G. Szilagyi, M.R. Griffin, and J.V. Williams Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age Pediatrics 132 2013 e341 e348
5. R. Lozano, M. Naghavi, K. Foreman, S. Lim, K. Shibuya, V. Aboyans, J. Abraham, T. Adair, R. Aggarwal, and S.Y. Ahn Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 Lancet 380 2013 2095 2128
6. S.M. Varga, and T.J. Braciale The adaptive immune response to respiratory syncytial virus Curr Top Microbiol Immunol 372 2013 155 171
7. K. Widmer, Y. Zhu, J.V. Williams, M.R. Griffin, K.M. Edwards, and H.K. Talbot Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults J Infect Dis 206 2012 56 62
8. E.E. Walsh, and A.R. Falsey Respiratory syncytial virus infection in adult populations Infect Disord Drug Targets 12 2012 98 102
9. L.J. Anderson Respiratory syncytial virus vaccine development Semin Immunol 25 2013 160 171
10. R. Rudraraju, B.G. Jones, R. Sealy, S.L. Surman, and J.L. Hurwitz Respiratory syncytial virus: current progress in vaccine development Viruses 5 2013 577 594
11. M. Magro, V. Mas, K. Chappell, M. Vazquez, O. Cano, D. Luque, M.C. Terron, J.A. Melero, and C. Palomo Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention Proc Natl Acad Sci U S A 109 2012 3089 3094
12. P.L. Collins, and J.A. Melero Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years Virus Res 162 2011 80 99
13. The IMpact-RSV Study Group Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants Pediatrics 102 1998 531 537
14. L.J. Anderson, P.R. Dormitzer, D.J. Nokes, R. Rappuoli, A. Roca, and B.S. Graham Strategic priorities for respiratory syncytial virus (RSV) vaccine development Vaccine 31 Suppl. 2 2013 B209 B215
15. J.S. McLellan, W.C. Ray, and M.E. Peeples Structure and function of respiratory syncytial virus surface glycoproteins Curr Top Microbiol Immunol 372 2013 83 104
16. L. Liljeroos, M.A. Krzyzaniak, A. Helenius, and S.J. Butcher Architecture of respiratory syncytial virus revealed by electron cryotomography Proc Natl Acad Sci U S A 110 2013 11133 11138
17. A.S. Yunus, T.P. Jackson, K. Crisafi, I. Burimski, N.R. Kilgore, D. Zoumplis, G.P. Allaway, C.T. Wild, and K. Salzwedel Elevated temperature triggers human respiratory syncytial virus F protein six-helix bundle formation Virology 396 2010 226 237
18. S. Chaiwatpongsakorn, R.F. Epand, P.L. Collins, R.M. Epand, and M.E. Peeples Soluble respiratory syncytial virus fusion protein in the fully cleaved, pretriggered state is triggered by exposure to low-molarity buffer J Virol 85 2011 3968 3977
19. F. Tayyari, D. Marchant, T.J. Moraes, W. Duan, P. Mastrangelo, and R.G. Hegele Identification of nucleolin as a cellular receptor for human respiratory syncytial virus Nat Med 17 2011 1132 1135
20. J.S. McLellan, Y. Yang, B.S. Graham, and P.D. Kwong Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes J Virol 85 2011 7788 7796
21. K.A. Swanson, E.C. Settembre, C.A. Shaw, A.K. Dey, R. Rappuoli, C.W. Mandl, P.R. Dormitzer, and A. Carfi Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers Proc Natl Acad Sci U S A 108 2011 9619 9624
22. L.J. Calder, L. Gonzalez-Reyes, B. Garcia-Barreno, S.A. Wharton, J.J. Skehel, D.C. Wiley, and J.A. Melero Electron microscopy of the human respiratory syncytial virus fusion protein and complexes that it forms with monoclonal antibodies Virology 271 2000 122 131
23. J.S. McLellan, M. Chen, S. Leung, K.W. Graepel, X. Du, Y. Yang, T. Zhou, U. Baxa, E. Yasuda, and T. Beaumont Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody Science 340 2013 1113 1117
24. M. Magro, D. Andreu, P. Gomez-Puertas, J.A. Melero, and C. Palomo Neutralization of human respiratory syncytial virus infectivity by antibodies and low-molecular-weight compounds targeted against the fusion glycoprotein J Virol 84 2010 7970 7982
25. J.A. Beeler, and K.V. Coelingh Neutralization epitopes of the F-glycoprotein of respiratory syncytial virus - effect of mutation upon fusion function J Virol 63 1989 2941 2950
26. J. Arbiza, G. Taylor, J.A. Lopez, J. Furze, S. Wyld, P. Whyte, E.J. Stott, G. Wertz, W. Sullender, and M. Trudel Characterization of two antigenic sites recognized by neutralizing monoclonal antibodies directed against the fusion glycoprotein of human respiratory syncytial virus J Gen Virol 73 Pt 9 1992 2225 2234
27. S. Johnson, C. Oliver, G.A. Prince, V.G. Hemming, D.S. Pfarr, S.C. Wang, M. Dormitzer, J. O'Grady, S. Koenig, and J.K. Tamura Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus J Infect Dis 176 1997 1215 1224
28. H. Wu, D.S. Pfarr, S. Johnson, Y.A. Brewah, R.M. Woods, N.K. Patel, W.I. White, J.F. Young, and P.A. Kiener Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract J Mol Biol 368 2007 652 665
29. J.S. McLellan, M. Chen, A. Kim, Y. Yang, B.S. Graham, and P.D. Kwong Structural basis of respiratory syncytial virus neutralization by motavizumab Nat Struct Mol Biol 17 2010 248 250
30. J.A. Lopez, D. Andreu, C. Carreno, P. Whyte, G. Taylor, and J.A. Melero Conformational constraints of conserved neutralizing epitopes from a major antigenic area of human respiratory syncytial virus fusion glycoprotein J Gen Virol 74 Pt 12 1993 2567 2577
31. J.S. McLellan, B.E. Correia, M. Chen, Y. Yang, B.S. Graham, W.R. Schief, and P.D. Kwong Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus J Mol Biol 409 2011 853 866
32. B.E. Correia, J.T. Bates, R.J. Loomis, G. Baneyx, C. Carrico, J.G. Jardine, P. Rupert, C. Correnti, O. Kalyuzhniy, and V. Vittal Proof of principle for epitope-focused vaccine design Nature 507 2014 201 206
33. S.J. Wu, A. Schmidt, E.J. Beil, N.D. Day, P.J. Branigan, C. Liu, L.L. Gutshall, C. Palomo, J. Furze, and G. Taylor Characterization of the epitope for anti-human respiratory syncytial virus F protein monoclonal antibody 101F using synthetic peptides and genetic approaches J Gen Virol 88 2007 2719 2723
34. J.A. Lopez, R. Bustos, C. Orvell, M. Berois, J. Arbiza, B. Garcia-Barreno, and J.A. Melero Antigenic structure of human respiratory syncytial virus fusion glycoprotein J Virol 72 1998 6922 6928
35. J.S. McLellan, M. Chen, J.S. Chang, Y. Yang, A. Kim, B.S. Graham, and P.D. Kwong Structure of a major antigenic site on the respiratory syncytial virus fusion glycoprotein in complex with neutralizing antibody 101F J Virol 84 2010 12236 12244
36. J.E. Schuster, R.G. Cox, A.K. Hastings, K.L. Boyd, J. Wadia, Z. Chen, D.R. Burton, R.A. Williamson, and J.V. Williams A broadly neutralizing human monoclonal antibody exhibits in vivo efficacy against both human metapneumovirus and respiratory syncytial virus J Infect Dis 211 2015 216 225
37. R. Raghunandan, H. Lu, B. Zhou, M.G. Xabier, M.J. Massare, D.C. Flyer, L.F. Fries, G.E. Smith, and G.M. Glenn An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunization Vaccine 32 2014 6485 6492
38. C. Palomo, V. Mas, M. Vazquez, O. Cano, D. Luque, M.C. Terron, L.J. Calder, and J.A. Melero Polyclonal and monoclonal antibodies specific for the six-helix bundle of the human respiratory syncytial virus fusion glycoprotein as probes of the protein post-fusion conformation Virology 460-461 2014 119 127
39. M.J. Kwakkenbos, S.A. Diehl, E. Yasuda, A.Q. Bakker, C.M. van Geelen, M.V. Lukens, G.M. van Bleek, M.N. Widjojoatmodjo, W.M. Bogers, and H. Mei Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming Nat Med 16 2010 123 128
40. K.A. Swanson, K. Balabanis, Y. Xie, Y. Aggarwal, C. Palomo, V. Mas, C. Metrick, H. Yang, C.A. Shaw, and J.A. Melero A monomeric uncleaved respiratory syncytial virus F antigen retains prefusion-specific neutralizing epitopes J Virol 88 2014 11802 11810
41. D. Corti, S. Bianchi, F. Vanzetta, A. Minola, L. Perez, G. Agatic, B. Guarino, C. Silacci, J. Marcandalli, and B.J. Marsland Cross-neutralization of four paramyxoviruses by a human monoclonal antibody Nature 501 2013 439 443
42. J.S. McLellan, M. Chen, M.G. Joyce, M. Sastry, G.B. Stewart-Jones, Y. Yang, B. Zhang, L. Chen, S. Srivatsan, and A. Zheng Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus Science 342 2013 592 598