PH-Activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence

ACS Nano

Volumn 9, Issue 3, 2015, Pages 2390-2404

  Horev, Benjamin ^a   Klein, Marlise I ^b,e   Hwang, Geelsu ^c   Li, Yong ^c   Kim, Dongyeop ^c   Koo, Hyun ^b,c,d   Benoit, Danielle S W ^a,b  

^a University of Rochester   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA SCHOOL OF DENTAL MEDICINE   (United States)

^e SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

dental caries; dental pellicle; exopolysaccharides; farnesol; matrix; nanoparticles; pH responsive; polymeric micelles; Streptococcus mutans biofilms

Indexed keywords

AMINES; BIOFILMS; HYDROPHOBICITY; HYDROXYAPATITE; MATRIX ALGEBRA; MECHANICAL STABILITY; MICELLES; NANOPARTICLES; POLYSACCHARIDES; SHEAR STRESS; TARGETED DRUG DELIVERY;

DENTAL CARIES; DENTAL PELLICLE; EXOPOLYSACCHARIDES; FARNESOL; PH-RESPONSIVE; POLYMERIC MICELLE; STREPTOCOCCUS MUTANS BIOFILMS;

CONTROLLED DRUG DELIVERY;

BACTERIAL POLYSACCHARIDE; DELAYED RELEASE FORMULATION; DRUG CARRIER; FARNESOL; HYDROXYAPATITE;

BIOFILM; CHEMISTRY; DELAYED RELEASE FORMULATION; DENTAL PELLICLE; DRUG EFFECTS; HUMAN; METABOLISM; MICROBIOLOGY; MOUTH; PATHOGENICITY; PH; PHYSIOLOGY; STREPTOCOCCUS MUTANS; SURFACE PROPERTY; TOPICAL DRUG ADMINISTRATION; VIRULENCE;

ADMINISTRATION, TOPICAL; BIOFILMS; DELAYED-ACTION PREPARATIONS; DENTAL PELLICLE; DRUG CARRIERS; DURAPATITE; FARNESOL; HUMANS; HYDROGEN-ION CONCENTRATION; MOUTH; POLYSACCHARIDES, BACTERIAL; STREPTOCOCCUS MUTANS; SURFACE PROPERTIES; VIRULENCE;

EID: 84925609616     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn507170s     Document Type: Article

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