Longitudinal PET-MRI reveals β 2-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion

Nature Medicine

Volumn 20, Issue 12, 2014, Pages 1485-1492

  Maier, Florian C ^a   Wehrl, Hans F ^a   Schmid, Andreas M ^a   Mannheim, Julia G ^a   Wiehr, Stefan ^a   Lerdkrai, Chommanad ^a   Calaminus, Carsten ^a   Stahlschmidt, Anke ^a   Ye, Lan ^b   Burnet, Michael ^c   Stiller, Detlef ^d   Sabri, Osama ^e   Reischl, Gerald ^a   Staufenbiel, Mathias ^f   Garaschuk, Olga ^a   Jucker, Mathias ^b   Pichler, Bernd J ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Synovo GmbH   (Germany)

^d BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^e UNIVERSITY OF LEIPZIG   (Germany)

^f NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BENZOTHIAZOLE DERIVATIVE; N-METHYL-2-(4'-METHYLAMINOPHENYL)-6-HYDROXYBENZOTHIAZOLE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; CONTROLLED STUDY; DISEASE COURSE; EC50; FEMALE; FRONTAL CORTEX; HEART LEFT VENTRICLE; LONGITUDINAL STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STEADY STATE; VASCULAR AMYLOIDOSIS; AMYLOID PLAQUE; ANIMAL; BRAIN; BRAIN CIRCULATION; BRAIN HEMORRHAGE; DIAGNOSTIC USE; DISEASE MODEL; GENETICS; METABOLISM; MULTIMODAL IMAGING; PATHOLOGY; SCINTIGRAPHY; SCINTISCANNING; TRANSGENIC MOUSE;

MUS MUSCULUS;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BENZOTHIAZOLES; BRAIN; CEREBRAL AMYLOID ANGIOPATHY; CEREBRAL HEMORRHAGE; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; FEMALE; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MICE; MICE, TRANSGENIC; MULTIMODAL IMAGING; PERFUSION IMAGING; PLAQUE, AMYLOID; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 84925581714     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3734     Document Type: Article

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