Expression of APE/Ref-1 in human pancreatic cancer cell line patu-8988 induced by gemcitabine

World Chinese Journal of Digestology

Volumn 15, Issue 12, 2007, Pages 1425-1428

  Xiong, Guang Su ^a   Wu, Shu Ming ^a   Xu, Xiao Jing ^a   Zhou, Jun ^a   Zhu, Hong Yin ^a   Li, En Ling ^a   Mo, Jian Zhong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

APE Ref 1; Gem citabine; Pancreatic neoplasm; Reverse transcription polymerase chain reaction; Western blot

Indexed keywords

EID: 84925569529     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Chinese Source.
2. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ. Cancer statistics, 2005. CA Cancer J Clin 2005; 55: 10-30
3. Evans AR, Limp-Foster M, Kelley MR. Going APE over ref-1. Mutat Res 2000; 461: 83-108
4. Kelley MR, Parsons SH. Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1. Antioxid Redox Signal 2001; 3: 671-683
5. Xu Y, Moore DH, Broshears J, Liu L, Wilson TM, Kelley MR. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. Anticancer Res 1997; 17: 3713-3719
6. Kelley MR, Cheng L, Foster R, Tritt R, Jiang J, Broshears J, Koch M. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer. Clin Cancer Res 2001; 7: 824-830
7. Moore DH, Michael H, Tritt R, Parsons SH, Kelley MR. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers. Clin Cancer Res 2000; 6: 602-609
8. Robertson KA, Bullock HA, Xu Y, Tritt R, Zimmerman E, Ulbright TM, Foster RS, Einhorn LH, Kelley MR. Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Cancer Res 2001; 61: 2220-2225
9. Chinese Source.
10. Chinese Source.
11. Walker LJ, Craig RB, Harris AL, Hickson ID. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res 1994; 22: 4884-4889
12. Herring CJ, West CM, Wilks DP, Davidson SE, Hunter RD, Berry P, Forster G, MacKinnon J, Rafferty JA, Elder RH, Hendry JH, Margison GP. Levels of the DNA repair enzyme human apurinic/ apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers. Br J Cancer 1998; 78: 1128-1133
13. Ramana CV, Boldogh I, Izumi T, Mitra S. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc Natl Acad Sci U S A 1998; 95: 5061-5066
14. Silber JR, Bobola MS, Blank A, Schoeler KD, Haroldson PD, Huynh MB, Kolstoe DD. The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress. Clin Cancer Res 2002; 8: 3008-3018
15. Chinese Source.
16. Magee CJ, Greenhalf W, Howes N, Ghaneh P, Neoptolemos JP. Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications. Surg Oncol 2001; 10: 1-23
17. Moore MJ, Feld R, Hedley D, Oza A, Siu LL. A phase II study of temozolomide in advanced untreated pancreatic cancer. Invest New Drugs 1998; 16: 77-79
18. Pourquier P, Gioffre C, Kohlhagen G, Urasaki Y, Goldwasser F, Hertel LW, Yu S, Pon RT, Gmeiner WH, Pommier Y. Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I. Clin Cancer Res 2002; 8: 2499-2504
19. Lau JP, Weatherdon KL, Skalski V, Hedley DW. Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides. Br J Cancer 2004; 91: 1166-1173